|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000127324 |
Summary for TSPAN8 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000127324 | Gene symbol | TSPAN8 |
| Gene name | tetraspanin 8 | |
| HGNC | 11855 | |
| Entrez ID | 7103 | |
| Gene type | protein_coding | |
| Synonyms | TSPAN8|CO-029 | |
| UniProtAcc | P19075 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TSPAN8 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TSPAN8 | 2.51e+02 | -3.19e+00 | 8.19e-01 | -3.90e+00 | 9.54e-05 | 1.99e-03 | BRCA |
| TSPAN8 | 3.83e+02 | -1.25e+00 | 3.35e-01 | -3.74e+00 | 1.82e-04 | 1.41e-03 | KIRP |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TSPAN8 | 5.74e+02 | -2.96e+00 | 5.44e-01 | -5.45e+00 | 5.14e-08 | 2.26e-07 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TSPAN8 | 5.68e+02 | -1.32e+00 | 5.16e-01 | -2.56e+00 | 1.05e-02 | 1.92e-02 | LUSC |
Top |
Sex-biased somatic mutation for TSPAN8 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TSPAN8 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg17737641 | chr12:71440686 | CGI:chr12:71439412-71440609 | promoter,gene body | 1.76e-01 | 4.13e-01 | -3.32e+00 | 8.98e-04 | 8.83e-03 | -2.37e-01 |
| BRCA | cg21558545 | chr12:71441079 | CGI:chr12:71439412-71440609 | promoter,gene body | 1.31e-01 | 3.15e-01 | -2.65e+00 | 8.00e-03 | 2.45e-02 | -1.84e-01 |
| KICH | cg15909056 | chr12:71443395 | CGI:chr12:71439412-71440609 | promoter | 7.75e-01 | 6.18e-01 | 2.57e+00 | 1.01e-02 | 2.73e-02 | 1.57e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg15909056 | chr12:71443395 | CGI:chr12:71439412-71440609 | promoter | 7.52e-01 | 8.55e-01 | -3.13e+00 | 1.73e-03 | 2.53e-03 | -1.04e-01 |
| LUAD | cg25285440 | chr12:71442738 | CGI:chr12:71439412-71440609 | promoter | 7.14e-01 | 8.77e-01 | -4.00e+00 | 6.38e-05 | 1.93e-04 | -1.63e-01 |
| LUAD | cg15909056 | chr12:71443395 | CGI:chr12:71439412-71440609 | promoter | 6.44e-01 | 7.99e-01 | -2.01e+00 | 4.47e-02 | 4.56e-02 | -1.55e-01 |
| LUSC | cg25285440 | chr12:71442738 | CGI:chr12:71439412-71440609 | promoter | 7.28e-01 | 8.64e-01 | -2.28e+00 | 2.26e-02 | 2.63e-02 | -1.36e-01 |
| LIHC | cg04538585 | chr12:71441957 | CGI:chr12:71439412-71440609 | promoter | 6.49e-01 | 8.62e-01 | -3.10e+00 | 1.96e-03 | 2.88e-03 | -2.12e-01 |
| LIHC | cg06680065 | chr12:71441959 | CGI:chr12:71439412-71440609 | promoter | 6.68e-01 | 8.39e-01 | -2.37e+00 | 1.77e-02 | 2.01e-02 | -1.71e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg17737641 | chr12:71440686 | CGI:chr12:71439412-71440609 | promoter,gene body | 1.76e-01 | 6.92e-02 | 7.84e+00 | 4.57e-15 | 1.67e-14 | 1.07e-01 |
| BRCA | cg25285440 | chr12:71442738 | CGI:chr12:71439412-71440609 | promoter | 7.38e-01 | 9.19e-01 | -9.29e+00 | 1.54e-20 | 8.72e-20 | -1.81e-01 |
| BRCA | cg15909056 | chr12:71443395 | CGI:chr12:71439412-71440609 | promoter | 6.10e-01 | 8.64e-01 | -6.93e+00 | 4.33e-12 | 1.27e-11 | -2.53e-01 |
| COAD | cg04538585 | chr12:71441957 | CGI:chr12:71439412-71440609 | promoter | 6.17e-01 | 4.14e-01 | 2.42e+00 | 1.56e-02 | 2.18e-02 | 2.03e-01 |
| COAD | cg06680065 | chr12:71441959 | CGI:chr12:71439412-71440609 | promoter | 6.19e-01 | 4.38e-01 | 2.48e+00 | 1.30e-02 | 1.91e-02 | 1.81e-01 |
Top |
Exon skipping events with PSI in TCGA for TSPAN8 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TSPAN8 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TSPAN8 |
| TFs related to TSPAN8. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | ZNF418 | TSPAN8 | 4.64e+00 | 9.95e-01 | 3.17e+00 | 1.29e-03 | Male-biased |
| CHOL | ZNF570 | TSPAN8 | 4.41e+00 | 9.88e-01 | 3.30e+00 | 5.88e-03 | Male-biased |
| CHOL | ZNF879 | TSPAN8 | 4.16e+00 | 9.88e-01 | 2.94e+00 | 3.59e-03 | Male-biased |
| LGG | NKX3-1 | TSPAN8 | 4.67e+00 | 9.83e-01 | 4.22e+00 | 1.16e-02 | Male-biased |
| MESO | BARX2 | TSPAN8 | 5.01e+00 | 9.90e-01 | 3.66e+00 | 6.60e-03 | Male-biased |
| MESO | CDX2 | TSPAN8 | 4.45e+00 | 9.81e-01 | 3.28e+00 | 1.13e-02 | Male-biased |
| MESO | FOXA2 | TSPAN8 | 4.66e+00 | 9.91e-01 | 3.19e+00 | 4.24e-03 | Male-biased |
| MESO | FOXA3 | TSPAN8 | 4.35e+00 | 9.89e-01 | 2.80e+00 | 3.09e-03 | Male-biased |
| MESO | FOXC1 | TSPAN8 | 4.73e+00 | 9.88e-01 | 3.42e+00 | 7.26e-03 | Male-biased |
| MESO | LHX9 | TSPAN8 | 5.27e+00 | 9.83e-01 | 4.18e+00 | 1.49e-02 | Male-biased |
| MESO | LMX1B | TSPAN8 | 4.51e+00 | 9.87e-01 | 3.19e+00 | 6.93e-03 | Male-biased |
| MESO | MEF2A | TSPAN8 | 4.00e+00 | 9.81e-01 | 2.59e+00 | 4.75e-03 | Male-biased |
| MESO | NKX3-1 | TSPAN8 | 4.76e+00 | 9.88e-01 | 3.45e+00 | 7.11e-03 | Male-biased |
| MESO | SIX1 | TSPAN8 | 4.95e+00 | 9.83e-01 | 3.83e+00 | 1.33e-02 | Male-biased |
| MESO | TBP | TSPAN8 | 4.55e+00 | 9.83e-01 | 3.36e+00 | 1.06e-02 | Male-biased |
| MESO | ZKSCAN2 | TSPAN8 | 4.28e+00 | 9.80e-01 | 3.08e+00 | 1.00e-02 | Male-biased |
| MESO | ZNF33B | TSPAN8 | 4.26e+00 | 9.85e-01 | 2.87e+00 | 5.22e-03 | Male-biased |
| READ | BARX2 | TSPAN8 | 4.36e+00 | 6.12e-03 | 5.32e+00 | 9.92e-01 | Female-biased |
| READ | CDX2 | TSPAN8 | 3.65e+00 | 2.72e-03 | 4.83e+00 | 9.93e-01 | Female-biased |
| READ | FOXA2 | TSPAN8 | 4.01e+00 | 6.41e-03 | 4.95e+00 | 9.90e-01 | Female-biased |
| READ | FOXA3 | TSPAN8 | 3.54e+00 | 1.73e-03 | 4.85e+00 | 9.94e-01 | Female-biased |
| READ | FOXL1 | TSPAN8 | 2.83e+00 | 6.39e-04 | 4.42e+00 | 9.91e-01 | Female-biased |
| READ | FOXP2 | TSPAN8 | 3.76e+00 | 7.67e-03 | 4.66e+00 | 9.87e-01 | Female-biased |
| READ | LMX1B | TSPAN8 | 3.64e+00 | 2.36e-03 | 4.86e+00 | 9.94e-01 | Female-biased |
| READ | MEF2A | TSPAN8 | 3.07e+00 | 1.28e-03 | 4.45e+00 | 9.91e-01 | Female-biased |
| READ | MYNN | TSPAN8 | 3.15e+00 | 2.02e-03 | 4.40e+00 | 9.89e-01 | Female-biased |
| READ | MYOD1 | TSPAN8 | 4.36e+00 | 9.84e-01 | 3.42e+00 | 6.00e-03 | Male-biased |
| READ | NKX3-1 | TSPAN8 | 4.09e+00 | 3.36e-03 | 5.21e+00 | 9.94e-01 | Female-biased |
| READ | TBP | TSPAN8 | 3.99e+00 | 9.34e-03 | 4.84e+00 | 9.87e-01 | Female-biased |
| READ | ZKSCAN2 | TSPAN8 | 3.70e+00 | 3.01e-03 | 4.84e+00 | 9.93e-01 | Female-biased |
| READ | ZNF33B | TSPAN8 | 3.51e+00 | 2.96e-03 | 4.66e+00 | 9.92e-01 | Female-biased |
| READ | ZNF354B | TSPAN8 | 3.96e+00 | 5.59e-03 | 4.94e+00 | 9.91e-01 | Female-biased |
| READ | ZNF418 | TSPAN8 | 1.13e+00 | 4.95e-06 | 4.17e+00 | 9.87e-01 | Female-biased |
| READ | ZNF570 | TSPAN8 | 1.88e+00 | 1.26e-04 | 3.97e+00 | 9.82e-01 | Female-biased |
| SKCM | NKX3-1 | TSPAN8 | 5.01e+00 | 9.80e-01 | 4.06e+00 | 1.35e-02 | Male-biased |
| UVM | BARX2 | TSPAN8 | 4.64e+00 | 9.83e-01 | 2.92e+00 | 4.24e-03 | Male-biased |
| UVM | FOXF2 | TSPAN8 | 4.86e+00 | 9.80e-01 | 3.56e+00 | 1.02e-02 | Male-biased |
| UVM | FOXI1 | TSPAN8 | 4.86e+00 | 9.80e-01 | 3.56e+00 | 1.03e-02 | Male-biased |
| UVM | HESX1 | TSPAN8 | 4.86e+00 | 9.84e-01 | 3.32e+00 | 6.23e-03 | Male-biased |
| UVM | LHX9 | TSPAN8 | 5.01e+00 | 9.85e-01 | 3.51e+00 | 6.93e-03 | Male-biased |
| UVM | NKX3-1 | TSPAN8 | 4.58e+00 | 9.83e-01 | 2.70e+00 | 2.90e-03 | Male-biased |
| TSPAN8 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TSPAN8 |
| RBPs related to ES in TSPAN8. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | RBM46 | exon_skip_94695 | 8.74e+00 | 1.44e-02 | 9.06e+00 | 9.82e-01 | Female-biased |
| CHOL | RALY | exon_skip_94684 | 7.25e+00 | 6.20e-03 | 7.71e+00 | 9.84e-01 | Female-biased |
| CHOL | TIA1 | exon_skip_94684 | 7.16e+00 | 6.30e-03 | 7.62e+00 | 9.84e-01 | Female-biased |
| TSPAN8 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1822506 | chr12:73521901:C:T | - | 0.121298306345803 | 0.00014216100358439 | SARC | Female-baised eQTL |
| rs12372666 | chr12:73551951:G:C | - | 0.0802211024131503 | 0.0281226877848137 | SARC | Female-baised eQTL |
| rs12830414 | chr12:78434042:T:C | - | 0.129651586590834 | 0.0131956877406998 | KIRC | Female-baised eQTL |
| rs1036050 | chr12:78449395:G:C | - | 0.125939607018254 | 0.016594647505151 | KIRC | Female-baised eQTL |
| rs17045310 | chr12:78426166:T:C | - | 0.125788646711595 | 0.0170363748998796 | KIRC | Female-baised eQTL |
| rs73136298 | chr12:78379539:C:T | - | 0.119467959680868 | 0.0238438896418838 | KIRC | Female-baised eQTL |
| rs73136285 | chr12:78347077:C:T | - | 0.119459911571558 | 0.0245427485264356 | KIRC | Female-baised eQTL |
| rs148453636 | chr12:79040084:C:T | - | 0.203500557168445 | 2.05505531977272e-05 | BLCA | Female-baised eQTL |
| rs78501551 | chr12:61951941:C:G | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs75904183 | chr12:61955075:G:A | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs74770451 | chr12:61961712:G:A | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs118086090 | chr12:61963194:G:A | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs78579592 | chr12:61967013:T:A | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs79276666 | chr12:61967279:G:T | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs78912378 | chr12:61978347:C:G | - | 0.146370516024944 | 0.000498866257338367 | BLCA | Female-baised eQTL |
| rs80063690 | chr12:61918320:C:T | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs76243609 | chr12:61919921:G:A | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs74528177 | chr12:61921512:G:A | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs146545802 | chr12:61926223:G:T | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs76849371 | chr12:61932403:A:G | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs113302936 | chr12:61932692:G:A | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs141378111 | chr12:61932725:C:T | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs80276132 | chr12:61933311:A:T | - | 0.146320133280514 | 0.000513363832983364 | BLCA | Female-baised eQTL |
| rs75307605 | chr12:61947613:G:A | - | 0.146294186285461 | 0.000516156952537548 | BLCA | Female-baised eQTL |
| rs1437495 | chr12:67183950:T:C | - | 0.130664083460355 | 0.00105874553239438 | BLCA | Female-baised eQTL |
| rs1517735 | chr12:76186717:T:C | - | 0.105261654463744 | 0.00129858094162229 | BLCA | Female-baised eQTL |
| rs11178413 | chr12:70773525:A:C | - | 0.161721838704107 | 0.00173436695356951 | BLCA | Female-baised eQTL |
| rs112769843 | chr12:61914884:C:T | - | 0.13124159184933 | 0.00252926147090553 | BLCA | Female-baised eQTL |
| rs182898937 | chr12:61995973:T:C | - | 0.137758014130308 | 0.00398712814060542 | BLCA | Female-baised eQTL |
| rs79007480 | chr12:61998599:T:G | - | 0.136286343873368 | 0.00474779995933765 | BLCA | Female-baised eQTL |
| rs79931889 | chr12:61995981:C:A | - | 0.136210107815681 | 0.00485786874889652 | BLCA | Female-baised eQTL |
| rs77043770 | chr12:61997807:T:A | - | 0.136210107815681 | 0.00485786874889652 | BLCA | Female-baised eQTL |
| rs2304821 | chr12:70569839:G:A | - | 0.109168250913892 | 0.00656123902119066 | BLCA | Female-baised eQTL |
| rs76836446 | chr12:79030234:C:G | - | 0.132656399415602 | 0.00933687422225078 | BLCA | Female-baised eQTL |
| rs78066018 | chr12:62001939:C:A | - | 0.127963662713962 | 0.00950033098946177 | BLCA | Female-baised eQTL |
| rs74908221 | chr12:62002131:C:T | - | 0.127963662713962 | 0.00950033098946177 | BLCA | Female-baised eQTL |
| rs79000854 | chr12:62004337:A:G | - | 0.127963662713962 | 0.00950033098946177 | BLCA | Female-baised eQTL |
| rs80155130 | chr12:62004636:G:A | - | 0.127963662713962 | 0.00950033098946177 | BLCA | Female-baised eQTL |
| rs78497597 | chr12:62004942:T:C | - | 0.127963662713962 | 0.00950033098946177 | BLCA | Female-baised eQTL |
| rs71458172 | chr12:74162170:G:C | - | 0.138663771160015 | 0.00955878950486758 | BLCA | Female-baised eQTL |
| rs71458173 | chr12:74162237:C:A | - | 0.138663771160015 | 0.00955878950486758 | BLCA | Female-baised eQTL |
| rs61921608 | chr12:65947255:G:A | - | 0.131348368382966 | 0.00965336753585443 | BLCA | Female-baised eQTL |
| rs3115954 | chr12:65961169:G:A | - | 0.129970949307702 | 0.0112719421278267 | BLCA | Female-baised eQTL |
| rs77034711 | chr12:65972967:T:A | - | 0.129970949307702 | 0.0112719421278267 | BLCA | Female-baised eQTL |
| rs77548748 | chr12:65976024:G:T | - | 0.129970949307702 | 0.0112719421278267 | BLCA | Female-baised eQTL |
| rs61921613 | chr12:65984202:A:C | - | 0.129951775366482 | 0.0114086562079667 | BLCA | Female-baised eQTL |
| rs61921614 | chr12:65985138:G:A | - | 0.129951775366482 | 0.0114086562079667 | BLCA | Female-baised eQTL |
| rs59463618 | chr12:74302089:C:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67210415 | chr12:74304201:G:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67073582 | chr12:74305085:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs117562670 | chr12:74306110:C:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67399695 | chr12:74307603:C:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67664467 | chr12:74313786:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67526050 | chr12:74315377:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs7485096 | chr12:74315689:T:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1834669 | chr12:74316983:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs7487290 | chr12:74318770:T:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs68026423 | chr12:74318775:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1346248 | chr12:74319116:T:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1019694 | chr12:74319323:C:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1019693 | chr12:74319342:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1019692 | chr12:74319500:T:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1019690 | chr12:74319597:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs2012005 | chr12:74320313:T:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs2012003 | chr12:74320331:T:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs2162395 | chr12:74320485:T:C | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs1365534 | chr12:74320776:A:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs72652864 | chr12:74321596:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67619450 | chr12:74321638:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs66756307 | chr12:74321919:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67773463 | chr12:74321974:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs66472931 | chr12:74322164:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs141754606 | chr12:74322387:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs72652865 | chr12:74322426:C:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs142865472 | chr12:74322480:A:G | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs17113335 | chr12:74322756:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs68173977 | chr12:74322977:G:A | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs67249120 | chr12:74323327:C:T | - | 0.115517640002327 | 0.0128349968064733 | BLCA | Female-baised eQTL |
| rs2717420 | chr12:70633736:G:A | - | 0.0937027285432052 | 0.0184796351064941 | BLCA | Female-baised eQTL |
| rs71458168 | chr12:74104710:C:A | - | 0.128608129954667 | 0.0197502897888115 | BLCA | Female-baised eQTL |
| rs71458169 | chr12:74126143:C:T | - | 0.128608129954667 | 0.0197502897888115 | BLCA | Female-baised eQTL |
| rs11180027 | chr12:74330935:A:G | - | 0.109589746376278 | 0.0213704651445204 | BLCA | Female-baised eQTL |
| rs79426606 | chr12:67584980:G:C | - | 0.128093181329828 | 0.0225416351641146 | BLCA | Female-baised eQTL |
| rs61921615 | chr12:65986896:T:C | - | 0.120147290372114 | 0.025731467878274 | BLCA | Female-baised eQTL |
| rs1899216 | chr12:61957515:G:A | - | -0.0953173664480283 | 0.026791176648899 | BLCA | Female-baised eQTL |
| rs11180015 | chr12:74318539:C:T | - | 0.105342125470591 | 0.0287518285548155 | BLCA | Female-baised eQTL |
| rs3741979 | chr12:81151646:G:A | - | 0.103477145975746 | 0.030695711378303 | BLCA | Female-baised eQTL |
| rs349875 | chr12:61949349:C:G | - | 0.0939356927706443 | 0.0321589531052635 | BLCA | Female-baised eQTL |
| rs1920706 | chr12:61960588:C:A | - | -0.0939356927706443 | 0.0321589531052635 | BLCA | Female-baised eQTL |
| rs11114782 | chr12:81179446:A:G | - | 0.100540075978881 | 0.0354085495328402 | BLCA | Female-baised eQTL |
| rs11114785 | chr12:81193567:T:C | - | 0.100540075978881 | 0.0354085495328402 | BLCA | Female-baised eQTL |
| rs11114789 | chr12:81208937:A:C | - | 0.100540075978881 | 0.0354085495328402 | BLCA | Female-baised eQTL |
| rs11403459 | chr12:78024997:G:A | - | 0.109033842004727 | 0.0394388132487191 | BLCA | Female-baised eQTL |
| rs74474181 | chr12:62028605:G:A | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs76371503 | chr12:62031837:A:G | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs76553537 | chr12:62032835:A:T | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs77336174 | chr12:62034568:C:T | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs76074364 | chr12:62035702:T:C | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs117170925 | chr12:62036035:C:T | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs138700811 | chr12:62043518:G:A | - | 0.106628478755627 | 0.0396441402216307 | BLCA | Female-baised eQTL |
| rs76718972 | chr12:62008970:A:G | - | 0.106523981441983 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs75078651 | chr12:62010021:T:C | - | 0.106523981441983 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs193059397 | chr12:62010949:G:A | - | 0.106523981441983 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs79576139 | chr12:62012996:C:T | - | 0.106523981441983 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs79144287 | chr12:62015184:T:A | - | 0.106523981441983 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs78154814 | chr12:62015501:T:A | - | 0.106523981441983 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs75721557 | chr12:62047210:G:C | - | 0.106537851546159 | 0.0406378420023955 | BLCA | Female-baised eQTL |
| rs140819303 | chr12:62050429:G:T | - | 0.106537851546159 | 0.0406378420023955 | BLCA | Female-baised eQTL |
| rs74545235 | chr12:62052676:G:T | - | 0.106537851546159 | 0.0406378420023955 | BLCA | Female-baised eQTL |
| rs76836869 | chr12:62057572:T:C | - | 0.106537851546159 | 0.0406378420023955 | BLCA | Female-baised eQTL |
| rs149372847 | chr12:62058886:G:A | - | 0.106537851546159 | 0.0406378420023955 | BLCA | Female-baised eQTL |
| rs7313729 | chr12:72312036:A:G | - | -0.0915115473787604 | 0.0486864136064946 | BLCA | Female-baised eQTL |
| rs771527 | chr12:77520328:A:G | - | 0.0659874954620753 | 0.00106012389259885 | LUAD | Female-baised eQTL |
| rs78001262 | chr12:77535601:A:G | - | 0.0551723605200088 | 0.00672284750172329 | LUAD | Female-baised eQTL |
| rs771840 | chr12:77601202:A:T | - | 0.0626188213930966 | 0.00853248542945939 | LUAD | Female-baised eQTL |
| rs696070 | chr12:77612103:C:T | - | 0.0466165990739344 | 0.0119587384546916 | LUAD | Female-baised eQTL |
| rs34334882 | chr12:70720238:G:T | - | 0.0543453496498306 | 0.0125049296084929 | LUAD | Female-baised eQTL |
| rs36107429 | chr12:70720816:C:A | - | 0.0543453496498306 | 0.0125049296084929 | LUAD | Female-baised eQTL |
| rs12820562 | chr12:70723117:T:C | - | 0.0544056872571845 | 0.0155533697951074 | LUAD | Female-baised eQTL |
| rs34127480 | chr12:70718834:A:G | - | 0.0526907758742017 | 0.0167581573474032 | LUAD | Female-baised eQTL |
| rs34211279 | chr12:70721008:C:T | - | 0.0507602892803721 | 0.0170854766817963 | LUAD | Female-baised eQTL |
| rs35049602 | chr12:70718465:C:G | - | 0.0493248643671375 | 0.0219507031943585 | LUAD | Female-baised eQTL |
| rs35722473 | chr12:70705489:C:A | - | 0.0494590481768571 | 0.0233400876174227 | LUAD | Female-baised eQTL |
| rs34370304 | chr12:70709521:C:T | - | 0.0480155430680135 | 0.0275910722879671 | LUAD | Female-baised eQTL |
| rs12827715 | chr12:70710653:C:T | - | 0.0480155430680135 | 0.0275910722879671 | LUAD | Female-baised eQTL |
| rs711072 | chr12:77510297:T:C | - | 0.0530125942987205 | 0.0290273414261439 | LUAD | Female-baised eQTL |
| rs12824973 | chr12:70706667:G:A | - | 0.0481355314322435 | 0.0291294134428705 | LUAD | Female-baised eQTL |
| rs12824655 | chr12:70706759:A:C | - | 0.0481355314322435 | 0.0291294134428705 | LUAD | Female-baised eQTL |
| rs35456305 | chr12:70735033:A:G | - | 0.0508283432795987 | 0.030266869730876 | LUAD | Female-baised eQTL |
| rs12810786 | chr12:70711492:G:A | - | 0.0503167835528196 | 0.0311121066571152 | LUAD | Female-baised eQTL |
| rs12824419 | chr12:70706521:C:T | - | 0.046805781805742 | 0.0340808826471241 | LUAD | Female-baised eQTL |
| rs711074 | chr12:77511247:T:A | - | 0.0506084243577319 | 0.0366014244912984 | LUAD | Female-baised eQTL |
| rs17043283 | chr12:77296501:A:T | - | 0.0506364601199485 | 0.0429969446895839 | LUAD | Female-baised eQTL |
| rs7967279 | chr12:70357495:G:A | - | 0.0323795931680511 | 0.0462122524405635 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74566036 | chr12:71884514:A:G | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs17815179 | chr12:71886649:T:C | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs17227353 | chr12:71888111:G:C | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs41421853 | chr12:71895032:G:T | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs74993327 | chr12:71903985:A:G | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs12581846 | chr12:71913632:C:T | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs11178983 | chr12:71913857:C:G | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs7955650 | chr12:71926290:T:C | - | 0.143359197952891 | 0.0437439783089553 | PAAD | Male-baised eQTL |
| rs11175711 | chr12:65277041:C:T | - | 0.182227349934348 | 0.00117798398813189 | SARC | Male-baised eQTL |
| rs10506509 | chr12:66870438:T:C | - | 0.0450874672852363 | 0.0412675512917255 | BLCA | Male-baised eQTL |
| rs34320621 | chr12:62133120:C:A | - | 0.05549487449076 | 0.0316662794010822 | LUAD | Male-baised eQTL |
| rs17827216 | chr12:66796213:G:A | - | 0.0663056555046148 | 0.0319785347667477 | LUAD | Male-baised eQTL |
| rs2580957 | chr12:73696801:A:G | - | -0.0570896745533469 | 0.0324681319497651 | LUAD | Male-baised eQTL |
| rs73178296 | chr12:73732681:T:C | - | 0.110494473959545 | 0.0377772838494394 | LUAD | Male-baised eQTL |
| rs1798078 | chr12:71201343:A:T | gene | -0.0704445578483845 | 0.00275845460491511 | COAD | Male-baised eQTL |
| rs6581994 | chr12:71226489:T:A | gene | -0.0689401986172433 | 0.00559629779031574 | COAD | Male-baised eQTL |
| rs7314537 | chr12:71226345:A:G | gene | -0.0680567491482292 | 0.00633112821184601 | COAD | Male-baised eQTL |
| rs4760915 | chr12:71240332:T:C | gene | -0.0686836729628829 | 0.00872470673042456 | COAD | Male-baised eQTL |
| rs6421232 | chr12:71229125:G:A | gene | -0.0652048693525901 | 0.0104786645084483 | COAD | Male-baised eQTL |
| rs1390202 | chr12:71215629:T:C | gene | -0.0674030708062322 | 0.0105376236846331 | COAD | Male-baised eQTL |
| rs1588493 | chr12:71204448:A:G | gene | -0.0646731104957088 | 0.0117639913957056 | COAD | Male-baised eQTL |
| rs1390201 | chr12:71214747:C:T | gene | -0.0643153383827327 | 0.0121817038467266 | COAD | Male-baised eQTL |
| rs1620771 | chr12:71198923:T:G | gene | -0.0657708171312114 | 0.0125129180616971 | COAD | Male-baised eQTL |
| rs1705256 | chr12:71207877:T:G | gene | -0.0642767380051251 | 0.0134541655117519 | COAD | Male-baised eQTL |
| rs1510940 | chr12:71252165:T:A | gene | -0.0618918370353842 | 0.0170819323390473 | COAD | Male-baised eQTL |
| rs4760790 | chr12:71241014:A:G | gene | -0.062351205591038 | 0.025639284386119 | COAD | Male-baised eQTL |
| rs1353362 | chr12:71219496:C:T | gene | -0.0618276000580562 | 0.0266477981362247 | COAD | Male-baised eQTL |
| rs1798071 | chr12:71205621:C:A | gene | -0.0595153251370176 | 0.0268771097392576 | COAD | Male-baised eQTL |
| rs1135509 | chr12:69820508:C:G | - | 0.0826358131035127 | 0.027605910273987 | COAD | Male-baised eQTL |
| rs12371668 | chr12:69821780:C:T | - | 0.0826358131035127 | 0.027605910273987 | COAD | Male-baised eQTL |
| rs7306184 | chr12:71224423:C:T | gene | -0.0593476159800992 | 0.0357717882241564 | COAD | Male-baised eQTL |
| rs7954034 | chr12:69403020:G:A | - | -0.0768110502730801 | 0.0426482566647319 | COAD | Male-baised eQTL |
| rs789558 | chr12:69938930:C:T | - | -0.0578273866894922 | 0.0474076203300274 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000127324 |
| CpG Site: cg15684563 | |
| Position to Gene: gene | |
| Male Effect: -0.0952953956152242 | |
| Female Effect: - | |
 | Gene ID: ENSG00000127324 |
| CpG Site: cg02965411 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.295873760599767 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15684563 | chr12:71158408 | gene | -0.0952953956152242 | 9.54400811231532e-07 | -0.4081057916212708 | 4.90385873254564e-10 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02965411 | chr12:71158146 | gene | -0.295873760599767 | 8.13759442006677e-07 | -0.52740265966762 | 6.2995225000615515e-09 | STAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TSPAN8 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000127324 | TSPAN8 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| ENSG00000127324 | TSPAN8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ENSG00000127324 | TSPAN8 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
| ENSG00000127324 | TSPAN8 | C0036341 | Schizophrenia | 1 | PSYGENET |
