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Gene: ENSG00000126970 |
Summary for ZC4H2 |
Gene summary |
| Gene information | Ensembl ID | ENSG00000126970 | Gene symbol | ZC4H2 |
| Gene name | zinc finger C4H2-type containing | |
| HGNC | 24931 | |
| Entrez ID | 55906 | |
| Gene type | protein_coding | |
| Synonyms | ZC4H2|HCA127 | |
| UniProtAcc | Q9NQZ6 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ZC4H2 |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ZC4H2 | 2.71e+02 | -1.00e+00 | 3.35e-01 | -3.00e+00 | 2.71e-03 | 5.63e-03 | LUSC |
Top |
Sex-biased somatic mutation for ZC4H2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ZC4H2 |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LGG | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.17e-01 | 3.79e-02 | 1.84e+01 | 7.48e-76 | 1.37e-74 | 2.79e-01 |
| LGG | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 4.05e-01 | 5.04e-02 | 1.85e+01 | 1.47e-76 | 2.76e-75 | 3.55e-01 |
| LGG | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 3.82e-01 | 4.76e-02 | 1.85e+01 | 3.96e-76 | 7.33e-75 | 3.34e-01 |
| LGG | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 5.41e-01 | 6.05e-02 | 1.81e+01 | 5.49e-73 | 9.24e-72 | 4.81e-01 |
| LGG | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 5.38e-01 | 6.58e-01 | -8.43e+00 | 3.45e-17 | 2.26e-16 | -1.20e-01 |
| LGG | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 6.50e-01 | 5.28e-01 | 3.86e+00 | 1.14e-04 | 5.22e-04 | 1.23e-01 |
| LGG | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.25e-01 | 9.00e-02 | 1.88e+01 | 1.15e-78 | 2.32e-77 | 4.35e-01 |
| LGG | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 2.84e-01 | 6.80e-02 | 1.85e+01 | 4.08e-76 | 7.56e-75 | 2.16e-01 |
| LUSC | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.15e-01 | 1.78e-01 | 6.74e+00 | 1.54e-11 | 1.30e-10 | 1.37e-01 |
| LUSC | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 4.18e-01 | 2.04e-01 | 7.51e+00 | 6.09e-14 | 5.48e-13 | 2.14e-01 |
| LUSC | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.58e-01 | 2.25e-01 | 7.75e+00 | 9.02e-15 | 8.32e-14 | 2.33e-01 |
| LUSC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 5.31e-01 | 2.48e-01 | 7.69e+00 | 1.52e-14 | 1.39e-13 | 2.83e-01 |
| LUSC | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 5.04e-01 | 3.50e-01 | 6.05e+00 | 1.43e-09 | 1.14e-08 | 1.54e-01 |
| LUSC | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.50e-01 | 3.42e-01 | 5.07e+00 | 4.07e-07 | 2.97e-06 | 2.08e-01 |
| LUSC | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.67e-01 | 1.32e-01 | 1.17e+01 | 2.29e-31 | 3.03e-30 | 2.35e-01 |
| SKCM | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.24e-01 | 4.27e-02 | 1.61e+01 | 1.73e-58 | 2.98e-57 | 1.81e-01 |
| SKCM | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.41e-01 | 6.72e-02 | 1.58e+01 | 4.51e-56 | 7.38e-55 | 2.74e-01 |
| SKCM | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 3.31e-01 | 4.88e-02 | 1.68e+01 | 4.02e-63 | 7.87e-62 | 2.82e-01 |
| SKCM | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.32e-01 | 8.22e-02 | 1.55e+01 | 2.18e-54 | 3.47e-53 | 3.50e-01 |
| SKCM | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.43e-01 | 2.60e-01 | 9.43e+00 | 4.10e-21 | 3.24e-20 | 1.82e-01 |
| SKCM | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.61e-01 | 1.39e-01 | 1.52e+01 | 1.93e-52 | 2.95e-51 | 3.21e-01 |
| SKCM | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 2.86e-01 | 6.27e-02 | 1.73e+01 | 5.20e-67 | 1.17e-65 | 2.23e-01 |
| STAD | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.10e-01 | 8.03e-02 | 1.18e+01 | 2.69e-32 | 4.39e-31 | 2.30e-01 |
| STAD | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.80e-01 | 8.68e-02 | 1.24e+01 | 1.46e-35 | 2.59e-34 | 2.93e-01 |
| STAD | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.54e-01 | 1.07e-01 | 1.18e+01 | 3.86e-32 | 6.28e-31 | 3.46e-01 |
| STAD | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.89e-01 | 9.68e-02 | 1.25e+01 | 1.19e-35 | 2.11e-34 | 3.93e-01 |
| STAD | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.32e-01 | 3.28e-01 | 7.14e+00 | 9.06e-13 | 7.60e-12 | 1.03e-01 |
| STAD | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.94e-01 | 2.43e-01 | 8.47e+00 | 2.42e-17 | 2.52e-16 | 2.51e-01 |
| STAD | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.31e-01 | 1.67e-01 | 1.13e+01 | 1.24e-29 | 1.90e-28 | 3.64e-01 |
| STAD | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.76e-01 | 1.03e-01 | 1.28e+01 | 2.67e-37 | 4.95e-36 | 2.72e-01 |
| SARC | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.27e-01 | 2.77e-02 | 1.28e+01 | 1.01e-37 | 4.09e-36 | 1.99e-01 |
| SARC | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.58e-01 | 4.71e-02 | 1.28e+01 | 1.08e-37 | 4.35e-36 | 3.11e-01 |
| SARC | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 3.24e-01 | 4.50e-02 | 1.28e+01 | 1.75e-37 | 6.94e-36 | 2.79e-01 |
| SARC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.46e-01 | 4.90e-02 | 1.29e+01 | 3.85e-38 | 1.61e-36 | 3.97e-01 |
| SARC | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.60e-01 | 2.62e-01 | 5.26e+00 | 1.44e-07 | 1.09e-06 | 1.98e-01 |
| SARC | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.95e-01 | 8.64e-02 | 1.35e+01 | 8.40e-42 | 6.24e-40 | 4.09e-01 |
| SARC | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 2.60e-01 | 5.81e-02 | 1.27e+01 | 6.81e-37 | 2.59e-35 | 2.02e-01 |
| PCPG | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 2.04e-01 | 2.81e-02 | 1.16e+01 | 3.83e-31 | 1.92e-29 | 1.76e-01 |
| PCPG | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 2.50e-01 | 2.48e-02 | 1.16e+01 | 3.83e-31 | 1.92e-29 | 2.25e-01 |
| PCPG | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 3.78e-01 | 2.23e-02 | 1.16e+01 | 3.83e-31 | 1.92e-29 | 3.56e-01 |
| PCPG | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.21e-01 | 2.85e-01 | 5.59e+00 | 2.29e-08 | 1.17e-07 | 1.36e-01 |
| PCPG | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 3.73e-01 | 6.22e-02 | 1.16e+01 | 3.83e-31 | 1.92e-29 | 3.11e-01 |
| PCPG | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.40e-01 | 5.11e-02 | 1.16e+01 | 3.83e-31 | 1.92e-29 | 2.89e-01 |
| PAAD | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.75e-01 | 3.20e-02 | 1.10e+01 | 4.17e-28 | 9.77e-27 | 2.43e-01 |
| PAAD | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.59e-01 | 4.79e-02 | 1.10e+01 | 4.45e-28 | 1.04e-26 | 3.11e-01 |
| PAAD | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.13e-01 | 5.05e-02 | 1.11e+01 | 1.85e-28 | 4.50e-27 | 3.62e-01 |
| PAAD | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.88e-01 | 4.55e-02 | 1.11e+01 | 1.29e-28 | 3.20e-27 | 4.42e-01 |
| PAAD | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.32e-01 | 2.71e-01 | 7.99e+00 | 1.33e-15 | 1.50e-14 | 1.61e-01 |
| PAAD | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.92e-01 | 1.72e-01 | 9.94e+00 | 2.81e-23 | 4.87e-22 | 3.20e-01 |
| PAAD | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.94e-01 | 9.76e-02 | 1.08e+01 | 5.26e-27 | 1.12e-25 | 3.97e-01 |
| PAAD | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 4.24e-01 | 6.94e-02 | 1.12e+01 | 3.36e-29 | 9.21e-28 | 3.55e-01 |
| READ | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.47e-01 | 1.46e-02 | 8.48e+00 | 2.29e-17 | 4.34e-16 | 3.32e-01 |
| READ | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.67e-01 | 2.15e-02 | 8.49e+00 | 2.15e-17 | 4.34e-16 | 3.46e-01 |
| READ | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.27e-01 | 1.92e-02 | 8.49e+00 | 2.15e-17 | 4.34e-16 | 4.08e-01 |
| READ | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.65e-01 | 1.95e-02 | 8.49e+00 | 2.15e-17 | 4.34e-16 | 4.46e-01 |
| READ | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 3.82e-01 | 1.03e-01 | 8.29e+00 | 1.18e-16 | 1.66e-15 | 2.79e-01 |
| READ | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.32e-01 | 6.02e-02 | 8.49e+00 | 2.15e-17 | 4.34e-16 | 4.71e-01 |
| READ | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.82e-01 | 4.41e-02 | 8.49e+00 | 2.15e-17 | 4.34e-16 | 3.38e-01 |
| GBM | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 4.37e-01 | 1.77e-01 | 4.24e+00 | 2.27e-05 | 1.25e-04 | 2.60e-01 |
| GBM | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 5.61e-01 | 3.23e-01 | 2.85e+00 | 4.41e-03 | 1.40e-02 | 2.38e-01 |
| GBM | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 5.84e-01 | 2.26e-01 | 4.62e+00 | 3.75e-06 | 2.35e-05 | 3.58e-01 |
| GBM | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 6.80e-01 | 3.75e-01 | 2.83e+00 | 4.61e-03 | 1.44e-02 | 3.06e-01 |
| GBM | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.32e-01 | 3.36e-01 | 2.78e+00 | 5.47e-03 | 1.64e-02 | 1.96e-01 |
| GBM | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.86e-01 | 1.89e-01 | 4.17e+00 | 3.09e-05 | 1.68e-04 | 1.96e-01 |
| ESCA | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.47e-01 | 1.32e-01 | 5.05e+00 | 4.51e-07 | 3.18e-06 | 2.15e-01 |
| ESCA | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 4.17e-01 | 1.57e-01 | 5.04e+00 | 4.63e-07 | 3.25e-06 | 2.60e-01 |
| ESCA | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 5.05e-01 | 2.03e-01 | 4.94e+00 | 8.00e-07 | 5.50e-06 | 3.02e-01 |
| ESCA | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 5.47e-01 | 1.88e-01 | 5.19e+00 | 2.16e-07 | 1.56e-06 | 3.59e-01 |
| ESCA | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 5.87e-01 | 3.48e-01 | 2.83e+00 | 4.67e-03 | 1.61e-02 | 2.39e-01 |
| ESCA | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.58e-01 | 2.75e-01 | 4.22e+00 | 2.44e-05 | 1.43e-04 | 2.84e-01 |
| ESCA | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.53e-01 | 1.43e-01 | 5.71e+00 | 1.14e-08 | 9.12e-08 | 2.10e-01 |
| LAML | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.43e-01 | 2.97e-02 | 9.80e+00 | 1.17e-22 | 1.44e-21 | 3.14e-01 |
| LAML | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 4.61e-01 | 4.94e-02 | 9.75e+00 | 1.92e-22 | 2.18e-21 | 4.11e-01 |
| LAML | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.92e-01 | 5.21e-02 | 9.86e+00 | 6.35e-23 | 8.87e-22 | 4.40e-01 |
| LAML | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 5.43e-01 | 5.28e-02 | 9.62e+00 | 6.39e-22 | 6.42e-21 | 4.90e-01 |
| LAML | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 6.00e-01 | 3.47e-01 | 5.36e+00 | 8.51e-08 | 3.36e-07 | 2.52e-01 |
| LAML | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 5.40e-01 | 1.11e-01 | 9.73e+00 | 2.32e-22 | 2.58e-21 | 4.28e-01 |
| LAML | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 4.24e-01 | 7.45e-02 | 9.63e+00 | 5.71e-22 | 5.81e-21 | 3.50e-01 |
| THYM | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.44e-01 | 4.89e-02 | 8.24e+00 | 1.72e-16 | 1.24e-15 | 1.95e-01 |
| THYM | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.54e-01 | 6.60e-02 | 8.25e+00 | 1.58e-16 | 1.14e-15 | 2.88e-01 |
| THYM | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.07e-01 | 6.61e-02 | 8.42e+00 | 3.92e-17 | 3.04e-16 | 3.41e-01 |
| THYM | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 5.04e-01 | 7.00e-02 | 8.51e+00 | 1.80e-17 | 1.45e-16 | 4.34e-01 |
| THYM | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 5.21e-01 | 2.25e-01 | 7.19e+00 | 6.64e-13 | 3.52e-12 | 2.96e-01 |
| THYM | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.69e-01 | 1.10e-01 | 8.28e+00 | 1.26e-16 | 9.17e-16 | 3.59e-01 |
| THYM | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 4.51e-01 | 1.07e-01 | 8.60e+00 | 8.24e-18 | 6.80e-17 | 3.44e-01 |
| MESO | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.03e-01 | 2.68e-02 | 5.82e+00 | 5.85e-09 | 6.90e-08 | 1.76e-01 |
| MESO | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 2.91e-01 | 4.20e-02 | 5.87e+00 | 4.45e-09 | 5.48e-08 | 2.49e-01 |
| MESO | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 3.41e-01 | 4.40e-02 | 5.82e+00 | 5.85e-09 | 6.90e-08 | 2.97e-01 |
| MESO | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 3.76e-01 | 4.01e-02 | 5.83e+00 | 5.46e-09 | 6.50e-08 | 3.36e-01 |
| MESO | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.88e-01 | 3.10e-01 | 2.83e+00 | 4.68e-03 | 1.76e-02 | 1.78e-01 |
| MESO | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.40e-01 | 8.91e-02 | 5.60e+00 | 2.08e-08 | 2.15e-07 | 3.51e-01 |
| MESO | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 2.72e-01 | 7.05e-02 | 5.30e+00 | 1.17e-07 | 1.07e-06 | 2.01e-01 |
| UVM | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 1.38e-01 | 1.76e-02 | 6.67e+00 | 2.60e-11 | 2.22e-10 | 1.20e-01 |
| UVM | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 2.19e-01 | 2.56e-02 | 7.60e+00 | 2.99e-14 | 9.97e-13 | 1.93e-01 |
| UVM | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 2.62e-01 | 2.28e-02 | 7.57e+00 | 3.74e-14 | 1.04e-12 | 2.39e-01 |
| UVM | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 3.50e-01 | 2.26e-02 | 7.41e+00 | 1.22e-13 | 1.98e-12 | 3.28e-01 |
| UVM | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 3.92e-01 | 5.16e-02 | 7.64e+00 | 2.21e-14 | 9.97e-13 | 3.40e-01 |
| UVM | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.04e-01 | 6.15e-02 | 6.57e+00 | 5.01e-11 | 4.11e-10 | 2.43e-01 |
| ACC | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.05e-01 | 5.07e-02 | 7.15e+00 | 8.76e-13 | 1.54e-11 | 2.54e-01 |
| ACC | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 6.16e-01 | 3.71e-01 | 3.38e+00 | 7.16e-04 | 3.98e-03 | 2.44e-01 |
| ACC | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 3.28e-01 | 2.15e-02 | 7.23e+00 | 4.87e-13 | 9.29e-12 | 3.07e-01 |
| ACC | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.60e-01 | 1.69e-02 | 7.43e+00 | 1.09e-13 | 2.87e-12 | 2.43e-01 |
| ACC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.64e-01 | 2.13e-02 | 7.47e+00 | 8.02e-14 | 2.68e-12 | 4.43e-01 |
| ACC | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.18e-01 | 2.37e-02 | 7.47e+00 | 8.02e-14 | 2.68e-12 | 2.94e-01 |
| ACC | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.94e-01 | 7.78e-02 | 7.39e+00 | 1.47e-13 | 3.50e-12 | 4.16e-01 |
| KICH | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 2.05e-01 | 5.19e-02 | 6.05e+00 | 1.43e-09 | 1.97e-08 | 1.53e-01 |
| KICH | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 2.09e-01 | 4.54e-02 | 6.24e+00 | 4.38e-10 | 6.99e-09 | 1.64e-01 |
| KICH | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 2.74e-01 | 5.15e-02 | 6.23e+00 | 4.77e-10 | 7.49e-09 | 2.22e-01 |
| KICH | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 2.94e-01 | 1.84e-01 | 4.00e+00 | 6.23e-05 | 4.54e-04 | 1.09e-01 |
| KICH | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 3.87e-01 | 2.49e-01 | 3.54e+00 | 4.08e-04 | 2.49e-03 | 1.38e-01 |
| KICH | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 3.22e-01 | 9.22e-02 | 6.23e+00 | 4.77e-10 | 7.49e-09 | 2.30e-01 |
| KICH | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 2.70e-01 | 8.56e-02 | 5.62e+00 | 1.87e-08 | 2.06e-07 | 1.85e-01 |
| DLBC | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 2.88e-01 | 1.04e-01 | 4.30e+00 | 1.68e-05 | 1.12e-04 | 1.84e-01 |
| DLBC | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.27e-01 | 1.09e-01 | 4.39e+00 | 1.15e-05 | 8.08e-05 | 2.18e-01 |
| DLBC | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 4.07e-01 | 1.52e-01 | 3.89e+00 | 1.00e-04 | 4.83e-04 | 2.56e-01 |
| DLBC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.36e-01 | 1.20e-01 | 4.35e+00 | 1.39e-05 | 9.56e-05 | 3.16e-01 |
| DLBC | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 4.82e-01 | 1.63e-01 | 4.35e+00 | 1.39e-05 | 9.56e-05 | 3.19e-01 |
| DLBC | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.81e-01 | 1.50e-01 | 4.37e+00 | 1.27e-05 | 8.79e-05 | 2.31e-01 |
| CHOL | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.63e-01 | 1.87e-02 | 5.09e+00 | 3.51e-07 | 4.92e-06 | 3.45e-01 |
| CHOL | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 4.68e-01 | 3.10e-02 | 5.09e+00 | 3.51e-07 | 4.92e-06 | 4.37e-01 |
| CHOL | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 5.01e-01 | 2.45e-02 | 5.09e+00 | 3.51e-07 | 4.92e-06 | 4.77e-01 |
| CHOL | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 5.36e-01 | 2.45e-02 | 5.09e+00 | 3.51e-07 | 4.92e-06 | 5.12e-01 |
| CHOL | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 3.90e-01 | 2.51e-01 | 2.45e+00 | 1.42e-02 | 2.68e-02 | 1.39e-01 |
| CHOL | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 6.17e-01 | 7.30e-02 | 5.09e+00 | 3.51e-07 | 4.92e-06 | 5.44e-01 |
| CHOL | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 4.00e-01 | 4.95e-02 | 5.09e+00 | 3.51e-07 | 4.92e-06 | 3.50e-01 |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 2.84e-01 | 1.79e-01 | 4.97e+00 | 6.83e-07 | 2.61e-06 | 1.05e-01 |
| KIRC | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 2.53e-01 | 1.49e-01 | 3.97e+00 | 7.19e-05 | 1.53e-04 | 1.05e-01 |
| LUAD | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 1.70e-01 | 2.71e-02 | 2.54e+00 | 1.11e-02 | 1.45e-02 | 1.43e-01 |
| LUAD | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 2.16e-01 | 2.54e-02 | 2.64e+00 | 8.23e-03 | 1.13e-02 | 1.90e-01 |
| LUAD | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 1.98e-01 | 2.43e-02 | 2.92e+00 | 3.51e-03 | 5.57e-03 | 1.73e-01 |
| LUAD | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 3.08e-01 | 7.30e-02 | 3.72e+00 | 1.98e-04 | 4.98e-04 | 2.35e-01 |
| HNSC | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 3.87e-01 | 7.12e-02 | 4.57e+00 | 4.86e-06 | 2.10e-05 | 3.16e-01 |
| HNSC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.72e-01 | 3.72e-02 | 5.05e+00 | 4.33e-07 | 2.98e-06 | 4.35e-01 |
| HNSC | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.53e-01 | 2.87e-01 | 4.10e+00 | 4.05e-05 | 1.22e-04 | 1.66e-01 |
| HNSC | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 5.78e-01 | 2.16e-01 | 4.40e+00 | 1.10e-05 | 4.10e-05 | 3.62e-01 |
| HNSC | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 6.00e-01 | 1.47e-01 | 5.47e+00 | 4.38e-08 | 5.29e-07 | 4.52e-01 |
| HNSC | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 2.44e-01 | 7.71e-02 | 3.18e+00 | 1.49e-03 | 2.54e-03 | 1.67e-01 |
| LUSC | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 1.78e-01 | 1.52e-02 | 3.23e+00 | 1.25e-03 | 3.02e-03 | 1.63e-01 |
| LUSC | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 2.04e-01 | 2.42e-02 | 2.70e+00 | 6.96e-03 | 1.05e-02 | 1.80e-01 |
| LUSC | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 2.25e-01 | 2.17e-02 | 2.69e+00 | 7.05e-03 | 1.06e-02 | 2.03e-01 |
| LUSC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 2.48e-01 | 2.07e-02 | 3.13e+00 | 1.73e-03 | 3.78e-03 | 2.27e-01 |
| LUSC | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 3.42e-01 | 7.08e-02 | 2.65e+00 | 8.12e-03 | 1.18e-02 | 2.71e-01 |
| ESCA | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 1.57e-01 | 2.33e-02 | 2.53e+00 | 1.14e-02 | 3.68e-02 | 1.33e-01 |
| ESCA | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 2.03e-01 | 2.20e-02 | 2.37e+00 | 1.77e-02 | 3.94e-02 | 1.81e-01 |
| ESCA | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 3.52e-01 | 2.03e-01 | 2.06e+00 | 3.89e-02 | 4.64e-02 | 1.49e-01 |
| ESCA | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 3.48e-01 | 1.60e-01 | 2.08e+00 | 3.71e-02 | 4.58e-02 | 1.87e-01 |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13214937 | chrX:65034735 | CGI:chrX:65034528-65035411 | promoter | 3.95e-01 | 2.14e-01 | 9.57e+00 | 1.03e-21 | 6.45e-21 | 1.80e-01 |
| BRCA | cg22055524 | chrX:65034787 | CGI:chrX:65034528-65035411 | promoter | 5.13e-01 | 3.72e-01 | 8.54e+00 | 1.29e-17 | 5.75e-17 | 1.41e-01 |
| BRCA | cg09834142 | chrX:65035335 | CGI:chrX:65034528-65035411 | promoter | 5.46e-01 | 4.26e-01 | 7.47e+00 | 7.88e-14 | 2.63e-13 | 1.20e-01 |
| BRCA | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 3.50e-01 | 4.60e-01 | -8.41e+00 | 4.20e-17 | 1.80e-16 | -1.10e-01 |
| BRCA | cg24978383 | chrX:65035081 | CGI:chrX:65034528-65035411 | promoter | 6.20e-01 | 4.72e-01 | 1.08e+01 | 5.26e-27 | 5.45e-26 | 1.47e-01 |
| BLCA | cg23169382 | chrX:65034360 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.25e-01 | 5.39e-01 | -2.24e+00 | 2.54e-02 | 3.17e-02 | -1.14e-01 |
| LIHC | cg17292622 | chrX:65034776 | CGI:chrX:65034528-65035411 | promoter | 4.19e-01 | 5.19e-01 | -2.50e+00 | 1.23e-02 | 1.64e-02 | -1.00e-01 |
| LIHC | cg06392956 | chrX:65034529 | CGI:chrX:65034528-65035411 | promoter,gene body | 4.01e-01 | 5.23e-01 | -3.14e+00 | 1.71e-03 | 3.44e-03 | -1.21e-01 |
| LIHC | cg02805922 | chrX:65035672 | CGI:chrX:65034528-65035411 | promoter | 3.20e-01 | 4.48e-01 | -3.52e+00 | 4.33e-04 | 1.18e-03 | -1.29e-01 |
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Exon skipping events with PSI in TCGA for ZC4H2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Landscape of exon skipping events across multiple cancer types. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for ZC4H2 |
| ∗Please access CAeditome for RNA editing annotation. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ZC4H2 |
TFs related to ZC4H2.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | LHX2 | ZC4H2 | 4.29e+00 | 9.83e-01 | 3.17e+00 | 4.55e-03 | Male-biased |
| LAML | POU5F1B | ZC4H2 | 4.07e+00 | 9.82e-01 | 2.59e+00 | 1.09e-03 | Male-biased |
| LAML | SKOR1 | ZC4H2 | 4.17e+00 | 9.82e-01 | 2.98e+00 | 3.43e-03 | Male-biased |
| LAML | SKOR2 | ZC4H2 | 4.30e+00 | 9.83e-01 | 3.22e+00 | 5.28e-03 | Male-biased |
| LAML | SOX21 | ZC4H2 | 4.05e+00 | 9.80e-01 | 2.70e+00 | 1.85e-03 | Male-biased |
| LAML | SRY | ZC4H2 | 4.26e+00 | 9.86e-01 | 2.78e+00 | 1.11e-03 | Male-biased |
| LAML | ZNF354A | ZC4H2 | 4.07e+00 | 9.82e-01 | 2.58e+00 | 1.04e-03 | Male-biased |
| LAML | ZNF354B | ZC4H2 | 4.01e+00 | 9.80e-01 | 2.50e+00 | 9.45e-04 | Male-biased |
| SARC | LHX2 | ZC4H2 | 4.31e+00 | 9.81e-01 | 3.73e+00 | 8.99e-03 | Male-biased |
ZC4H2 related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ZC4H2 |
RBPs related to ES in ZC4H2.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | ENOX1 | exon_skip_515282 | 7.64e+00 | 9.81e-01 | 7.29e+00 | 8.99e-03 | Male-biased |
ZC4H2 related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg24978383 | chrX:65035081 | promoter | -0.0633691378430415 | 4.66728931450027e-05 | -0.3449724190123455 | 1.2519631938845905e-07 | LUAD |
| cg07508090 | chrX:64976463 | gene,exon,UTR | -0.120301202098533 | 1.91403992610786e-07 | -0.4113536185938612 | 2.1539509589366887e-10 | STAD |
| cg09834142 | chrX:65035335 | promoter | -0.0872485468109123 | 6.16229686163928e-07 | -0.39987415007739335 | 7.457360142046273e-10 | STAD |
| cg24978383 | chrX:65035081 | promoter | -0.0812120963217998 | 2.06578299270701e-06 | -0.387906515943575 | 2.5904353573105174e-09 | STAD |
| cg09834142 | chrX:65035335 | promoter | -0.0707773882538606 | 1.08602493720784e-06 | -0.32629898936613466 | 5.3576817285093714e-09 | BLCA |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ZC4H2 |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000126970 | ZC4H2 | C0025958 | Microcephaly | 1 | CTD_human |
| ENSG00000126970 | ZC4H2 | C0796200 | Wieacker-Wolff syndrome | 1 | CTD_human |
| ENSG00000126970 | ZC4H2 | C1839735 | MILES-CARPENTER X-LINKED MENTAL RETARDATION SYNDROME | 1 | CTD_human |
| ENSG00000126970 | ZC4H2 | C1844934 | Arthrogryposis multiplex congenita, distal, X-linked | 1 | CTD_human |
| ENSG00000126970 | ZC4H2 | C1956147 | Microlissencephaly | 1 | CTD_human |
| ENSG00000126970 | ZC4H2 | C3853041 | Severe Congenital Microcephaly | 1 | CTD_human |