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Gene: ENSG00000126091 |
Summary for ST3GAL3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000126091 | Gene symbol | ST3GAL3 |
| Gene name | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | |
| HGNC | 10866 | |
| Entrez ID | 6487 | |
| Gene type | protein_coding | |
| Synonyms | ST3GAL3| | |
| UniProtAcc | Q11203 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ST3GAL3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ST3GAL3 | 4.91e+02 | -1.41e+00 | 2.33e-01 | -6.05e+00 | 1.43e-09 | 2.27e-08 | BLCA |
| ST3GAL3 | 1.66e+02 | -1.20e+00 | 1.39e-01 | -8.66e+00 | 4.61e-18 | 7.71e-17 | COAD |
| ST3GAL3 | 4.99e+02 | -1.08e+00 | 4.02e-01 | -2.68e+00 | 7.31e-03 | 1.90e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ST3GAL3 | 2.06e+02 | -1.27e+00 | 2.53e-01 | -5.01e+00 | 5.32e-07 | 5.06e-06 | READ |
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Sex-biased somatic mutation for ST3GAL3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ST3GAL3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg15589689 | chr1:43704718 | CGI:chr1:43706997-43708092 | promoter | 6.94e-01 | 8.00e-01 | -2.19e+00 | 2.84e-02 | 4.00e-02 | -1.07e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg15589689 | chr1:43704718 | CGI:chr1:43706997-43708092 | promoter | 6.14e-01 | 8.77e-01 | -4.08e+00 | 4.52e-05 | 5.47e-04 | -2.63e-01 |
| LUSC | cg08142848 | chr1:43706136 | CGI:chr1:43706997-43708092 | promoter,gene body | 5.40e-01 | 6.44e-01 | -3.20e+00 | 1.38e-03 | 3.24e-03 | -1.04e-01 |
| BLCA | cg15589689 | chr1:43704718 | CGI:chr1:43706997-43708092 | promoter | 6.84e-01 | 8.48e-01 | -3.09e+00 | 1.98e-03 | 3.89e-03 | -1.63e-01 |
| BLCA | cg08142848 | chr1:43706136 | CGI:chr1:43706997-43708092 | promoter,gene body | 5.18e-01 | 6.42e-01 | -3.73e+00 | 1.91e-04 | 6.40e-04 | -1.24e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg08142848 | chr1:43706136 | CGI:chr1:43706997-43708092 | promoter,gene body | 5.68e-01 | 6.77e-01 | -2.85e+00 | 4.30e-03 | 8.53e-03 | -1.09e-01 |
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Exon skipping events with PSI in TCGA for ST3GAL3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ST3GAL3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LAML | ST3GAL3-207 | chr1_43766003_+ | 3.78e-01 | 5.13e-01 | -2.34e+00 | 1.92e-02 | 4.94e-02 | -1.35e-01 |
| LAML | ST3GAL3-207 | chr1_43916759_+ | 3.00e-01 | 2.34e-01 | 2.19e+00 | 2.85e-02 | 4.94e-02 | 6.53e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ST3GAL3 |
| TFs related to ST3GAL3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ST3GAL3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ST3GAL3 |
| RBPs related to ES in ST3GAL3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | PABPN1 | exon_skip_5225 | 6.97e+00 | 4.55e-03 | 7.34e+00 | 9.84e-01 | Female-biased |
| LIHC | HNRNPA2B1 | exon_skip_5230 | 1.20e+01 | 4.82e-03 | 1.25e+01 | 9.95e-01 | Female-biased |
| LUSC | HNRNPA2B1 | exon_skip_5230 | 1.24e+01 | 9.98e-01 | 1.18e+01 | 1.84e-03 | Male-biased |
| LUAD | HNRNPA2B1 | exon_skip_5230 | 1.21e+01 | 2.07e-03 | 1.26e+01 | 9.98e-01 | Female-biased |
| KIRP | HNRNPA2B1 | exon_skip_5230 | 1.21e+01 | 2.38e-03 | 1.26e+01 | 9.97e-01 | Female-biased |
| MESO | HNRNPA2B1 | exon_skip_5230 | 1.19e+01 | 1.56e-03 | 1.25e+01 | 9.98e-01 | Female-biased |
| LGG | SRSF9 | exon_skip_5176 | 7.79e+00 | 1.11e-02 | 8.11e+00 | 9.81e-01 | Female-biased |
| GBM | HNRNPA2B1 | exon_skip_5230 | 1.24e+01 | 9.98e-01 | 1.19e+01 | 1.44e-03 | Male-biased |
| SKCM | HNRNPA2B1 | exon_skip_5230 | 1.18e+01 | 2.68e-03 | 1.23e+01 | 9.97e-01 | Female-biased |
| HNSC | HNRNPA2B1 | exon_skip_5230 | 1.20e+01 | 6.49e-03 | 1.24e+01 | 9.93e-01 | Female-biased |
| ST3GAL3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000126091 | LINC01278,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | LINC00163,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | BX284668.2,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | CACNA1C-AS1,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | AC116447.1,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | AC104794.3,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | ENTPD1-AS1,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | MEG3,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000126091 | AC012313.3,hsa-mir-665,ST3GAL3 | Male-specific ceRNA | TCGA-BLCA |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7515066 | chr1:41611244:G:A | - | -0.187981733746709 | 0.0182120397869812 | GBM | Female-baised eQTL |
| rs2810568 | chr1:41588576:A:G | - | 0.191345613561477 | 0.0303828583536821 | GBM | Female-baised eQTL |
| rs653369 | chr1:41536705:A:T | - | 0.191326310985966 | 0.0308078919033171 | GBM | Female-baised eQTL |
| rs607586 | chr1:41538708:C:T | - | 0.191326310985966 | 0.0308078919033171 | GBM | Female-baised eQTL |
| rs1885654 | chr1:41541517:C:A | - | 0.18895182283834 | 0.0363463273431385 | GBM | Female-baised eQTL |
| rs1084462 | chr1:41549718:G:A | - | 0.188475196710818 | 0.0380694451858317 | GBM | Female-baised eQTL |
| rs2759252 | chr1:41556183:G:A | - | 0.188475196710818 | 0.0380694451858317 | GBM | Female-baised eQTL |
| rs10749832 | chr1:41576135:G:A | - | -0.183170586544383 | 0.0388752535223644 | GBM | Female-baised eQTL |
| rs2759254 | chr1:41570012:G:C | - | 0.183123453822718 | 0.0390057492467039 | GBM | Female-baised eQTL |
| rs7550496 | chr1:41578163:G:A | - | -0.182768807415596 | 0.0397855841128124 | GBM | Female-baised eQTL |
| rs1535505 | chr1:41560481:G:A | - | 0.192023951718667 | 0.0418620988352639 | GBM | Female-baised eQTL |
| rs941971 | chr1:41575222:T:C | - | 0.179452340722875 | 0.0431919484769838 | GBM | Female-baised eQTL |
| rs1815257 | chr1:41575808:A:C | - | 0.179452340722875 | 0.0431919484769838 | GBM | Female-baised eQTL |
| rs2759251 | chr1:41576078:G:C | - | 0.179452340722875 | 0.0431919484769838 | GBM | Female-baised eQTL |
| rs941972 | chr1:41575069:T:C | - | 0.175300742543424 | 0.0495123487553819 | GBM | Female-baised eQTL |
| rs11584399 | chr1:39523340:G:A | - | 0.156337428178147 | 0.0205462012292831 | LUSC | Female-baised eQTL |
| rs2359106 | chr1:34497074:A:G | - | 0.0813263244548481 | 0.00561505222894786 | LUAD | Female-baised eQTL |
| rs319991 | chr1:48651222:G:C | - | -0.0720677478674864 | 0.0188407854307763 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11263922 | chr1:36610491:T:C | - | -0.0627181922135548 | 0.0467351121233734 | LGG | Male-baised eQTL |
| rs113102763 | chr1:45474458:C:T | - | 0.0761878420566339 | 0.0012926039463964 | KIRC | Male-baised eQTL |
| rs142500356 | chr1:45184436:T:C | - | -0.0542437610728524 | 0.00460966471599921 | KIRC | Male-baised eQTL |
| rs116144719 | chr1:36403703:G:C | - | 0.0804003206574575 | 0.0425721810211759 | LUAD | Male-baised eQTL |
| rs3918003 | chr1:36465772:C:T | - | 0.0837230426574032 | 0.0484160913311997 | LUAD | Male-baised eQTL |
| rs272821 | chr1:36212515:C:A | - | 0.126690330662835 | 0.0315497424356031 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ST3GAL3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000126091 | ST3GAL3 | C1970200 | MENTAL RETARDATION, AUTOSOMAL RECESSIVE 12 | 1 | CTD_human |
