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Gene: ENSG00000125755 |
Summary for SYMPK |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000125755 | Gene symbol | SYMPK |
| Gene name | symplekin scaffold protein | |
| HGNC | 22935 | |
| Entrez ID | 8189 | |
| Gene type | protein_coding | |
| Synonyms | SYMPK|SYM|SPK|Pta1 | |
| UniProtAcc | Q92797 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for SYMPK |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SYMPK |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SYMPK |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg21570209 | chr19:45864729 | CGI:chr19:45864113-45864550 | promoter | 2.33e-01 | 1.09e-01 | 2.42e+00 | 1.54e-02 | 2.24e-02 | 1.24e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21570209 | chr19:45864729 | CGI:chr19:45864113-45864550 | promoter | 6.81e-01 | 5.22e-01 | 6.85e+00 | 7.23e-12 | 2.08e-11 | 1.58e-01 |
| BRCA | cg05098732 | chr19:45864518 | CGI:chr19:45864113-45864550 | promoter | 2.87e-01 | 1.78e-01 | 3.87e+00 | 1.11e-04 | 1.65e-04 | 1.09e-01 |
| HNSC | cg21570209 | chr19:45864729 | CGI:chr19:45864113-45864550 | promoter | 5.25e-01 | 3.65e-01 | 2.00e+00 | 4.53e-02 | 4.65e-02 | 1.61e-01 |
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Exon skipping events with PSI in TCGA for SYMPK |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SYMPK |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | SYMPK-021 | chr19_45855469_- | 2.95e-01 | 4.32e-01 | -2.56e+00 | 1.05e-02 | 4.20e-02 | -1.37e-01 |
| KIRC | SYMPK-021 | chr19_45862230_- | 2.75e-01 | 3.93e-01 | -2.18e+00 | 2.93e-02 | 4.64e-02 | -1.18e-01 |
| LUAD | SYMPK-021 | chr19_45856755_- | 3.24e-01 | 2.70e-01 | 1.97e+00 | 4.91e-02 | 4.96e-02 | 5.45e-02 |
| LUAD | SYMPK-021 | chr19_45859024_- | 2.63e-01 | 3.49e-01 | -2.08e+00 | 3.74e-02 | 4.54e-02 | -8.54e-02 |
| LUAD | SYMPK-021 | chr19_45860618_- | 3.26e-01 | 4.50e-01 | -1.98e+00 | 4.76e-02 | 4.89e-02 | -1.24e-01 |
| COAD | SYMPK-021 | chr19_45861950_- | 2.69e-01 | 5.32e-01 | -2.06e+00 | 3.90e-02 | 4.48e-02 | -2.63e-01 |
| STAD | SYMPK-021 | chr19_45855677_- | 3.65e-01 | 2.74e-01 | 2.20e+00 | 2.77e-02 | 4.96e-02 | 9.07e-02 |
| ESCA | SYMPK-021 | chr19_45856882_- | 3.13e-01 | 4.19e-01 | -1.97e+00 | 4.83e-02 | 4.99e-02 | -1.06e-01 |
| LAML | SYMPK-021 | chr19_45860755_- | 4.18e-01 | 3.37e-01 | 2.20e+00 | 2.75e-02 | 4.94e-02 | 8.12e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | SYMPK-021 | chr19_45861976_- | 3.24e-01 | 5.17e-01 | -2.19e+00 | 2.82e-02 | 3.80e-02 | -1.93e-01 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SYMPK |
| TFs related to SYMPK. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ASCL1 | SYMPK | 2.37e+00 | 1.56e-03 | 4.16e+00 | 9.80e-01 | Female-biased |
| BRCA | ESR2 | SYMPK | 2.76e+00 | 3.62e-03 | 4.28e+00 | 9.82e-01 | Female-biased |
| BRCA | KLF3 | SYMPK | 2.75e+00 | 3.42e-03 | 4.29e+00 | 9.82e-01 | Female-biased |
| BRCA | NR1H4 | SYMPK | 2.40e+00 | 1.60e-03 | 4.18e+00 | 9.81e-01 | Female-biased |
| BRCA | PATZ1 | SYMPK | 2.65e+00 | 2.75e-03 | 4.26e+00 | 9.82e-01 | Female-biased |
| BRCA | PLAG1 | SYMPK | 2.62e+00 | 1.37e-03 | 4.46e+00 | 9.88e-01 | Female-biased |
| BRCA | PLAGL2 | SYMPK | 2.71e+00 | 3.58e-04 | 4.96e+00 | 9.95e-01 | Female-biased |
| BRCA | SNAI1 | SYMPK | 2.51e+00 | 1.02e-03 | 4.44e+00 | 9.88e-01 | Female-biased |
| BRCA | TCF12 | SYMPK | 2.47e+00 | 1.38e-03 | 4.31e+00 | 9.85e-01 | Female-biased |
| BRCA | TCF3 | SYMPK | 2.53e+00 | 7.73e-04 | 4.55e+00 | 9.90e-01 | Female-biased |
| BRCA | TFAP2A | SYMPK | 2.77e+00 | 2.57e-03 | 4.40e+00 | 9.86e-01 | Female-biased |
| BRCA | TFAP2B | SYMPK | 2.83e+00 | 2.23e-03 | 4.52e+00 | 9.88e-01 | Female-biased |
| BRCA | TFAP2C | SYMPK | 2.78e+00 | 2.76e-03 | 4.39e+00 | 9.85e-01 | Female-biased |
| BRCA | ZFX | SYMPK | 2.27e+00 | 6.13e-04 | 4.36e+00 | 9.87e-01 | Female-biased |
| BRCA | ZIC2 | SYMPK | 2.52e+00 | 1.07e-03 | 4.44e+00 | 9.88e-01 | Female-biased |
| BRCA | ZIC3 | SYMPK | 2.64e+00 | 3.05e-03 | 4.22e+00 | 9.80e-01 | Female-biased |
| BRCA | ZIC5 | SYMPK | 2.83e+00 | 4.76e-03 | 4.27e+00 | 9.80e-01 | Female-biased |
| BRCA | ZNF141 | SYMPK | 2.80e+00 | 2.52e-03 | 4.44e+00 | 9.87e-01 | Female-biased |
| BRCA | ZNF16 | SYMPK | 2.70e+00 | 2.69e-03 | 4.32e+00 | 9.83e-01 | Female-biased |
| BRCA | ZNF264 | SYMPK | 2.66e+00 | 1.56e-03 | 4.46e+00 | 9.88e-01 | Female-biased |
| BRCA | ZNF28 | SYMPK | 2.75e+00 | 2.15e-03 | 4.44e+00 | 9.87e-01 | Female-biased |
| BRCA | ZNF333 | SYMPK | 2.51e+00 | 1.18e-03 | 4.39e+00 | 9.87e-01 | Female-biased |
| BRCA | ZNF415 | SYMPK | 2.67e+00 | 2.55e-03 | 4.31e+00 | 9.83e-01 | Female-biased |
| BRCA | ZNF431 | SYMPK | 2.98e+00 | 5.62e-03 | 4.37e+00 | 9.82e-01 | Female-biased |
| BRCA | ZNF436 | SYMPK | 2.48e+00 | 2.01e-03 | 4.19e+00 | 9.80e-01 | Female-biased |
| BRCA | ZNF479 | SYMPK | 2.86e+00 | 3.42e-03 | 4.41e+00 | 9.85e-01 | Female-biased |
| BRCA | ZNF506 | SYMPK | 2.88e+00 | 3.98e-03 | 4.38e+00 | 9.84e-01 | Female-biased |
| BRCA | ZNF573 | SYMPK | 2.74e+00 | 3.60e-03 | 4.27e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF605 | SYMPK | 2.67e+00 | 2.25e-03 | 4.35e+00 | 9.85e-01 | Female-biased |
| BRCA | ZNF793 | SYMPK | 2.86e+00 | 3.64e-03 | 4.38e+00 | 9.84e-01 | Female-biased |
| BRCA | ZNF891 | SYMPK | 2.78e+00 | 3.06e-03 | 4.36e+00 | 9.84e-01 | Female-biased |
| SYMPK related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SYMPK |
| RBPs related to ES in SYMPK. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | RBM5 | exon_skip_319731 | 8.80e+00 | 2.78e-03 | 9.37e+00 | 9.94e-01 | Female-biased |
| ACC | SAMD4A | exon_skip_319718 | 7.63e+00 | 9.88e-01 | 6.88e+00 | 1.38e-03 | Male-biased |
| UVM | SNRPA | exon_skip_319743 | 8.54e+00 | 5.21e-03 | 8.89e+00 | 9.90e-01 | Female-biased |
| UVM | ZC3H10 | exon_skip_319760 | 9.32e+00 | 9.96e-01 | 8.82e+00 | 9.83e-04 | Male-biased |
| THYM | RBM5 | exon_skip_319731 | 9.35e+00 | 9.89e-01 | 9.01e+00 | 7.48e-03 | Male-biased |
| THYM | SNRPA | exon_skip_319743 | 8.98e+00 | 9.87e-01 | 8.65e+00 | 8.26e-03 | Male-biased |
| LIHC | SAMD4A | exon_skip_319718 | 7.58e+00 | 9.89e-01 | 6.62e+00 | 2.55e-04 | Male-biased |
| LIHC | SNRPA | exon_skip_319743 | 9.00e+00 | 9.85e-01 | 8.61e+00 | 1.04e-02 | Male-biased |
| LUSC | FXR2 | exon_skip_319762 | 9.94e+00 | 9.80e-01 | 9.63e+00 | 1.78e-02 | Male-biased |
| DLBC | PCBP2 | exon_skip_319758 | 6.73e+00 | 9.80e-01 | 6.29e+00 | 3.30e-03 | Male-biased |
| DLBC | SNRPA | exon_skip_319743 | 8.51e+00 | 1.01e-02 | 8.84e+00 | 9.85e-01 | Female-biased |
| LUAD | FXR2 | exon_skip_319762 | 9.95e+00 | 9.92e-01 | 9.57e+00 | 5.80e-03 | Male-biased |
| CHOL | SAMD4A | exon_skip_319759 | 8.75e+00 | 9.90e-01 | 8.24e+00 | 4.35e-03 | Male-biased |
| KIRP | FXR2 | exon_skip_319762 | 9.48e+00 | 5.16e-03 | 9.87e+00 | 9.93e-01 | Female-biased |
| KIRP | SAMD4A | exon_skip_319759 | 8.14e+00 | 1.23e-03 | 8.66e+00 | 9.93e-01 | Female-biased |
| BRCA | FXR2 | exon_skip_319762 | 1.00e+01 | 9.82e-01 | 9.51e+00 | 1.62e-02 | Male-biased |
| BRCA | HNRNPA1L2 | exon_skip_319718 | 1.13e+01 | 9.98e-01 | 1.03e+01 | 1.36e-03 | Male-biased |
| BRCA | SAMD4A | exon_skip_319718 | 6.48e+00 | 1.11e-03 | 7.85e+00 | 9.90e-01 | Female-biased |
| ESCA | FXR2 | exon_skip_319762 | 9.55e+00 | 1.35e-02 | 9.95e+00 | 9.85e-01 | Female-biased |
| ESCA | ZC3H10 | exon_skip_319760 | 8.93e+00 | 9.95e-03 | 9.37e+00 | 9.87e-01 | Female-biased |
| THCA | FXR2 | exon_skip_319762 | 9.75e+00 | 9.91e-01 | 9.43e+00 | 7.14e-03 | Male-biased |
| THCA | SNRPA | exon_skip_319743 | 8.89e+00 | 9.83e-01 | 8.61e+00 | 1.24e-02 | Male-biased |
| PCPG | BRUNOL6 | exon_skip_319769 | 8.80e+00 | 9.94e-01 | 8.27e+00 | 9.22e-04 | Male-biased |
| PCPG | RBM5 | exon_skip_319731 | 8.91e+00 | 2.52e-03 | 9.34e+00 | 9.94e-01 | Female-biased |
| PCPG | SAMD4A | exon_skip_319759 | 8.14e+00 | 8.60e-03 | 8.47e+00 | 9.85e-01 | Female-biased |
| MESO | BRUNOL6 | exon_skip_319769 | 8.79e+00 | 9.88e-01 | 8.40e+00 | 6.48e-03 | Male-biased |
| LGG | SAMD4A | exon_skip_319718 | 7.41e+00 | 9.84e-01 | 7.02e+00 | 5.48e-03 | Male-biased |
| GBM | SAMD4A | exon_skip_319718 | 7.06e+00 | 9.86e-01 | 6.48e+00 | 8.64e-04 | Male-biased |
| KICH | SAMD4A | exon_skip_319759 | 8.54e+00 | 9.91e-01 | 8.08e+00 | 2.49e-03 | Male-biased |
| BLCA | FXR2 | exon_skip_319762 | 9.55e+00 | 8.68e-03 | 9.92e+00 | 9.89e-01 | Female-biased |
| BLCA | SAMD4A | exon_skip_319759 | 7.94e+00 | 1.12e-02 | 8.28e+00 | 9.81e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_319724 | 5.40e+00 | 8.45e-05 | 6.37e+00 | 9.81e-01 | Female-biased |
| SKCM | SNRPA | exon_skip_319743 | 9.02e+00 | 9.90e-01 | 8.61e+00 | 5.58e-03 | Male-biased |
| SKCM | ZC3H10 | exon_skip_319724 | 6.01e+00 | 3.95e-04 | 6.76e+00 | 9.84e-01 | Female-biased |
| HNSC | BRUNOL6 | exon_skip_319769 | 8.41e+00 | 8.21e-03 | 8.76e+00 | 9.87e-01 | Female-biased |
| HNSC | SAMD4A | exon_skip_319718 | 7.20e+00 | 9.87e-01 | 6.57e+00 | 8.39e-04 | Male-biased |
| SARC | ZC3H10 | exon_skip_319760 | 9.45e+00 | 9.81e-01 | 9.13e+00 | 1.64e-02 | Male-biased |
| SYMPK related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs62106911 | chr19:51669824:G:A | - | 0.138160028243066 | 0.0476479616600832 | READ | Female-baised eQTL |
| rs10418303 | chr19:52640363:C:T | - | 0.104499083012272 | 0.0208786890525545 | LIHC | Female-baised eQTL |
| rs2286474 | chr19:38355629:G:A | - | 0.0995544438519278 | 0.0262223799615569 | LIHC | Female-baised eQTL |
| rs3745954 | chr19:38361813:C:T | - | 0.0995544438519278 | 0.0262223799615569 | LIHC | Female-baised eQTL |
| rs75530589 | chr19:38322410:G:C | - | 0.0959279279816505 | 0.0338566417019092 | LIHC | Female-baised eQTL |
| rs77870528 | chr19:38340644:G:A | - | 0.0959279279816505 | 0.0338566417019092 | LIHC | Female-baised eQTL |
| rs117437511 | chr19:38342160:G:A | - | 0.0959279279816505 | 0.0338566417019092 | LIHC | Female-baised eQTL |
| rs79570957 | chr19:38344518:T:C | - | 0.0959279279816505 | 0.0338566417019092 | LIHC | Female-baised eQTL |
| rs11671598 | chr19:53003952:G:A | - | 0.0911909715769875 | 0.0340023569945389 | LIHC | Female-baised eQTL |
| rs73068756 | chr19:53003989:G:A | - | 0.0911909715769875 | 0.0340023569945389 | LIHC | Female-baised eQTL |
| rs11665696 | chr19:53005725:C:T | - | 0.0911695600392929 | 0.0345243907644865 | LIHC | Female-baised eQTL |
| rs1650934 | chr19:53006446:C:A | - | 0.0911695600392929 | 0.0345243907644865 | LIHC | Female-baised eQTL |
| rs11667093 | chr19:53007392:C:T | - | 0.0911695600392929 | 0.0345243907644865 | LIHC | Female-baised eQTL |
| rs73068769 | chr19:53007833:C:T | - | 0.0911695600392929 | 0.0345243907644865 | LIHC | Female-baised eQTL |
| rs111609838 | chr19:52996314:T:C | - | 0.0910017346762754 | 0.0353247949770195 | LIHC | Female-baised eQTL |
| rs11667011 | chr19:52999769:G:C | - | 0.0882845014129926 | 0.0427658510921818 | LIHC | Female-baised eQTL |
| rs10500313 | chr19:52999853:C:G | - | 0.0882845014129926 | 0.0427658510921818 | LIHC | Female-baised eQTL |
| rs11670490 | chr19:53003289:A:G | - | 0.088031649127344 | 0.0439294173322301 | LIHC | Female-baised eQTL |
| rs1661906 | chr19:53006425:A:T | - | 0.0876324163093898 | 0.0467397827953124 | LIHC | Female-baised eQTL |
| rs4112253 | chr19:54282167:G:C | - | -0.0962740266190131 | 0.0353346033202393 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs117482736 | chr19:53735510:T:A | - | 0.0781213697171869 | 0.000283991174397683 | LIHC | Male-baised eQTL |
| rs7255175 | chr19:53734780:G:A | - | 0.0801788446239925 | 0.000335249764477495 | LIHC | Male-baised eQTL |
| rs10415792 | chr19:38564664:C:T | - | 0.065138512376354 | 0.00056391495213724 | LIHC | Male-baised eQTL |
| rs117175310 | chr19:38572979:G:C | - | 0.064946179903254 | 0.000609999844658735 | LIHC | Male-baised eQTL |
| rs117910351 | chr19:53735449:T:C | - | 0.0742510285866655 | 0.000699374658442688 | LIHC | Male-baised eQTL |
| rs145909773 | chr19:53733289:G:A | - | 0.0741617578845348 | 0.0010576351628464 | LIHC | Male-baised eQTL |
| rs7251091 | chr19:54424928:G:C | - | 0.0668379530228737 | 0.00110419351391046 | LIHC | Male-baised eQTL |
| rs79339718 | chr19:53731973:C:T | - | 0.0713520998978282 | 0.00131134614848582 | LIHC | Male-baised eQTL |
| rs1966386 | chr19:38576756:C:T | - | 0.0615733885022348 | 0.00135637220365185 | LIHC | Male-baised eQTL |
| rs1468570 | chr19:38576877:G:A | - | 0.0615733885022348 | 0.00135637220365185 | LIHC | Male-baised eQTL |
| rs114763132 | chr19:38577176:G:A | - | 0.0615733885022348 | 0.00135637220365185 | LIHC | Male-baised eQTL |
| rs4801804 | chr19:38577256:G:A | - | 0.0615733885022348 | 0.00135637220365185 | LIHC | Male-baised eQTL |
| rs12459409 | chr19:38575718:G:A | - | 0.0601693171480123 | 0.00190414539611077 | LIHC | Male-baised eQTL |
| rs111531254 | chr19:53729639:G:A | - | 0.0661883555604353 | 0.0031070647041166 | LIHC | Male-baised eQTL |
| rs117908957 | chr19:53729648:T:A | - | 0.0661883555604353 | 0.0031070647041166 | LIHC | Male-baised eQTL |
| rs4802617 | chr19:38577410:C:T | - | 0.0561219089978225 | 0.00543712349881956 | LIHC | Male-baised eQTL |
| rs10411339 | chr19:53734373:A:G | - | 0.0661280361569785 | 0.00558035352238352 | LIHC | Male-baised eQTL |
| rs80291474 | chr19:40157152:G:A | - | 0.0589985011348999 | 0.0075949532483304 | LIHC | Male-baised eQTL |
| rs76437829 | chr19:40172231:A:C | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs77601247 | chr19:40172756:A:G | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs505666 | chr19:40174483:C:A | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs75445547 | chr19:40177013:C:A | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs74586650 | chr19:40177461:C:G | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs74571141 | chr19:40177525:T:G | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs77150601 | chr19:40177540:C:T | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs76672924 | chr19:40177624:T:A | - | 0.0581706555085543 | 0.0079795666670902 | LIHC | Male-baised eQTL |
| rs75857113 | chr19:40163958:G:A | - | 0.0578724401222826 | 0.00868881665806959 | LIHC | Male-baised eQTL |
| rs113260680 | chr19:53794738:C:T | - | 0.0594318301550687 | 0.0142889283619114 | LIHC | Male-baised eQTL |
| rs113974323 | chr19:53799051:C:T | - | 0.0573068207831224 | 0.0203217318883762 | LIHC | Male-baised eQTL |
| rs10410581 | chr19:53793980:G:T | - | 0.0523471258482989 | 0.0396930553771201 | LIHC | Male-baised eQTL |
| rs67485804 | chr19:53794169:T:C | - | 0.0523471258482989 | 0.0396930553771201 | LIHC | Male-baised eQTL |
| rs10409778 | chr19:53793783:C:A | - | 0.0520461498746745 | 0.0423213099710913 | LIHC | Male-baised eQTL |
| rs185041563 | chr19:42206087:A:T | - | 0.0460967071240695 | 0.0424882783129615 | LIHC | Male-baised eQTL |
| rs73612300 | chr19:51243997:T:C | - | 0.0428276450947889 | 0.0463570852408486 | KIRC | Male-baised eQTL |
| rs3760707 | chr19:49581197:T:C | - | 0.0687846454203483 | 0.0282145831988354 | COAD | Male-baised eQTL |
| rs3745474 | chr19:49583549:C:T | - | 0.0687846454203483 | 0.0282145831988354 | COAD | Male-baised eQTL |
| rs145692331 | chr19:50006399:G:A | - | 0.129707720507474 | 0.0342742771809528 | COAD | Male-baised eQTL |
| rs113205442 | chr19:49582170:G:A | - | 0.0653192248729706 | 0.0366059111809298 | COAD | Male-baised eQTL |
| rs3745473 | chr19:49583369:T:C | - | 0.0653192248729706 | 0.0366059111809298 | COAD | Male-baised eQTL |
| rs73057994 | chr19:49588016:C:A | - | 0.066572404118084 | 0.0391844435526366 | COAD | Male-baised eQTL |
| rs2288920 | chr19:49588541:G:T | - | 0.0657681895593304 | 0.0407928400457634 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000125755 |
| CpG Site: cg05905309 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.436965190384424 | |
 | Gene ID: ENSG00000125755 |
| CpG Site: cg27118825 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.229589629650269 | |
| Female Effect: - | |
 | Gene ID: ENSG00000125755 |
| CpG Site: cg15455864 | |
| Position to Gene: gene,exon,CDS,UTR | |
| Male Effect: -0.229589629650269 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg27118825 | chr19:45815490 | gene,exon,UTR | -0.229589629650269 | 2.14905292444539e-19 | -0.5777025438112595 | 6.3661182169772996e-24 | LIHC |
| cg15455864 | chr19:45816140 | gene,exon,CDS,UTR | -0.229589629650269 | 2.14905292444539e-19 | -0.5777025438112595 | 6.3661182169772996e-24 | LIHC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05905309 | chr19:45861068 | gene | -0.436965190384424 | 9.56935124042468e-27 | -0.6379352790208422 | 1.5407039262353626e-30 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SYMPK |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000125755 | SYMPK | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| ENSG00000125755 | SYMPK | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| ENSG00000125755 | SYMPK | C0235874 | Disease Exacerbation | 1 | CTD_human |
| ENSG00000125755 | SYMPK | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
