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Gene: ENSG00000124813 |
Summary for RUNX2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000124813 | Gene symbol | RUNX2 |
| Gene name | RUNX family transcription factor 2 | |
| HGNC | 10472 | |
| Entrez ID | 860 | |
| Gene type | protein_coding | |
| Synonyms | RUNX2|AML3|PEBP2A1|PEBP2aA1 | |
| UniProtAcc | Q13950 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RUNX2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RUNX2 | 9.66e+02 | 1.39e+00 | 4.30e-01 | 3.22e+00 | 1.26e-03 | 4.04e-03 | BLCA |
| RUNX2 | 1.45e+03 | 1.60e+00 | 4.15e-01 | 3.85e+00 | 1.18e-04 | 1.16e-03 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RUNX2 | 1.26e+03 | 1.32e+00 | 1.05e-01 | 1.26e+01 | 2.16e-36 | 1.40e-35 | BRCA |
Top |
Sex-biased somatic mutation for RUNX2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for RUNX2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg01946401 | chr6:45328364 | CGI:chr6:45377521-45378524 | UTR,promoter,exon,gene body | 6.76e-01 | 8.45e-01 | -2.88e+00 | 3.99e-03 | 5.87e-03 | -1.69e-01 |
| KIRP | cg01946401 | chr6:45328364 | CGI:chr6:45377521-45378524 | UTR,promoter,exon,gene body | 5.50e-01 | 8.32e-01 | -2.35e+00 | 1.86e-02 | 2.17e-02 | -2.81e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg01946401 | chr6:45328364 | CGI:chr6:45377521-45378524 | UTR,promoter,exon,gene body | 4.97e-01 | 6.63e-01 | -2.41e+00 | 1.61e-02 | 2.21e-02 | -1.67e-01 |
Top |
Exon skipping events with PSI in TCGA for RUNX2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for RUNX2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for RUNX2 |
| TFs related to RUNX2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RUNX2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
 |
Top |
Sex-biased RBP-ES network for RUNX2 |
| RBPs related to ES in RUNX2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RUNX2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000124813 | MIR4435-2HG,hsa-mir-582,RUNX2 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000124813 | RASSF8-AS1,hsa-mir-582,RUNX2 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000124813 | LINC00997,hsa-mir-135b,RUNX2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000124813 | AC012368.2,hsa-mir-211,RUNX2 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000124813 | AC034199.1,hsa-mir-211,RUNX2 | Male-specific ceRNA | TCGA-KIRP |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3756906 | chr6:36596035:C:G | - | 0.182594407841834 | 0.0289773695423556 | STAD | Female-baised eQTL |
| rs4711454 | chr6:36587645:C:T | - | 0.182268275414327 | 0.0295715829814977 | STAD | Female-baised eQTL |
| rs76964964 | chr6:36591513:C:T | - | 0.182268275414327 | 0.0295715829814977 | STAD | Female-baised eQTL |
| rs59108254 | chr6:36608376:G:A | - | 0.182268275414327 | 0.0295715829814977 | STAD | Female-baised eQTL |
| rs60633269 | chr6:36608637:C:T | - | 0.182268275414327 | 0.0295715829814977 | STAD | Female-baised eQTL |
| rs113329938 | chr6:36580400:C:T | - | 0.182337904815284 | 0.0296639224910436 | STAD | Female-baised eQTL |
| rs7769540 | chr6:44095162:G:C | - | 0.142223063357318 | 0.0215869667934064 | BLCA | Female-baised eQTL |
| rs55772024 | chr6:44111093:G:A | - | 0.140519917507247 | 0.0251796890048145 | BLCA | Female-baised eQTL |
| rs2015676 | chr6:44107387:G:A | - | 0.13925239747504 | 0.027921306118941 | BLCA | Female-baised eQTL |
| rs7743249 | chr6:44105126:G:A | - | 0.138535995327393 | 0.0313237354428238 | BLCA | Female-baised eQTL |
| rs2396166 | chr6:44119396:C:T | - | 0.142409150204693 | 0.0325448226205013 | BLCA | Female-baised eQTL |
| rs4445056 | chr6:44103265:C:T | - | 0.138004709294463 | 0.0335560783692597 | BLCA | Female-baised eQTL |
| rs73429729 | chr6:44118990:C:A | - | 0.154889549716666 | 0.0358052419480527 | BLCA | Female-baised eQTL |
| rs7752653 | chr6:44126071:T:G | - | 0.154889549716666 | 0.0358052419480527 | BLCA | Female-baised eQTL |
| rs7742030 | chr6:44097325:C:T | - | 0.154542760434861 | 0.0380039601218008 | BLCA | Female-baised eQTL |
| rs7742824 | chr6:44097574:G:A | - | 0.154542760434861 | 0.0380039601218008 | BLCA | Female-baised eQTL |
| rs57139546 | chr6:44100008:T:C | - | 0.154542760434861 | 0.0380039601218008 | BLCA | Female-baised eQTL |
| rs4610558 | chr6:44103212:G:T | - | 0.154542760434861 | 0.0380039601218008 | BLCA | Female-baised eQTL |
| rs57576544 | chr6:44104989:T:C | - | 0.154542760434861 | 0.0380039601218008 | BLCA | Female-baised eQTL |
| rs60105057 | chr6:44112982:C:G | - | 0.154542760434861 | 0.0380039601218008 | BLCA | Female-baised eQTL |
| rs2096199 | chr6:44128277:G:A | - | 0.154374918184687 | 0.0390784477349287 | BLCA | Female-baised eQTL |
| rs7773700 | chr6:44129735:T:C | - | 0.154374918184687 | 0.0390784477349287 | BLCA | Female-baised eQTL |
| rs73429745 | chr6:44133685:C:T | - | 0.15226802871387 | 0.0447556250549018 | BLCA | Female-baised eQTL |
| rs66629131 | chr6:44133731:C:G | - | 0.15226802871387 | 0.0447556250549018 | BLCA | Female-baised eQTL |
| rs56168551 | chr6:44136569:G:A | - | 0.15226802871387 | 0.0447556250549018 | BLCA | Female-baised eQTL |
| rs9473139 | chr6:47615629:T:C | - | -0.0272631976839608 | 0.0321850068991984 | LUAD | Female-baised eQTL |
| rs9395287 | chr6:47609328:G:A | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs9357549 | chr6:47611003:G:A | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs9473141 | chr6:47616018:T:C | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs13208188 | chr6:47616355:G:A | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs9463341 | chr6:47617193:G:A | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs1948046 | chr6:47618239:G:C | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs9369718 | chr6:47623669:C:T | - | -0.0271507728967502 | 0.0340044498272688 | LUAD | Female-baised eQTL |
| rs9369677 | chr6:47355518:T:C | - | 0.0416542299797853 | 0.0383380636935348 | LUAD | Female-baised eQTL |
| rs6934265 | chr6:47496228:T:C | - | -0.027192329341742 | 0.0396059290819455 | LUAD | Female-baised eQTL |
| rs6934441 | chr6:47496292:T:G | - | -0.027192329341742 | 0.0396059290819455 | LUAD | Female-baised eQTL |
| rs978448 | chr6:47577322:C:T | - | -0.0267244469715231 | 0.0399776341604877 | LUAD | Female-baised eQTL |
| rs9296566 | chr6:47581390:C:T | - | -0.0267244469715231 | 0.0399776341604877 | LUAD | Female-baised eQTL |
| rs6940729 | chr6:47585184:T:A | - | -0.0267244469715231 | 0.0399776341604877 | LUAD | Female-baised eQTL |
| rs6458576 | chr6:47588373:C:T | - | -0.0267244469715231 | 0.0399776341604877 | LUAD | Female-baised eQTL |
| rs6917252 | chr6:47592231:A:G | - | -0.0267244469715231 | 0.0399776341604877 | LUAD | Female-baised eQTL |
| rs1352029 | chr6:47581209:G:T | - | -0.0269051999095541 | 0.0400905195354523 | LUAD | Female-baised eQTL |
| rs7349860 | chr6:47529501:T:C | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs9395278 | chr6:47564947:T:A | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs12196733 | chr6:47568524:A:G | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs9367287 | chr6:47571389:G:A | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs4711884 | chr6:47572754:A:G | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs9369714 | chr6:47573119:G:A | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs2046464 | chr6:47573645:T:C | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs9369715 | chr6:47573761:T:G | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs9395280 | chr6:47575952:T:A | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs2275446 | chr6:47582147:T:C | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs923146 | chr6:47607661:G:A | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs6908162 | chr6:47608700:A:G | - | -0.0266387801997006 | 0.0405978881144142 | LUAD | Female-baised eQTL |
| rs1485781 | chr6:47595030:C:T | - | -0.0266551036063801 | 0.0416217035068025 | LUAD | Female-baised eQTL |
| rs4715021 | chr6:47480151:A:G | - | -0.0266107584708116 | 0.0432870944560916 | LUAD | Female-baised eQTL |
| rs4711886 | chr6:47587809:A:C | - | -0.0264408482416139 | 0.0449459443149492 | LUAD | Female-baised eQTL |
| rs9367280 | chr6:47485350:A:G | - | -0.0264215868258463 | 0.0458751109031865 | LUAD | Female-baised eQTL |
| rs4715022 | chr6:47488329:G:A | - | -0.0264215868258463 | 0.0458751109031865 | LUAD | Female-baised eQTL |
| rs9369700 | chr6:47489725:G:C | - | -0.0263142518964337 | 0.0474788896943341 | LUAD | Female-baised eQTL |
| rs9369701 | chr6:47490052:A:T | - | -0.0263142518964337 | 0.0474788896943341 | LUAD | Female-baised eQTL |
| rs9357540 | chr6:47492674:A:G | - | -0.0263142518964337 | 0.0474788896943341 | LUAD | Female-baised eQTL |
| rs9357542 | chr6:47493531:A:G | - | -0.0263142518964337 | 0.0474788896943341 | LUAD | Female-baised eQTL |
| rs9394653 | chr6:40109781:T:C | - | 0.0353650746773739 | 0.0474932645030586 | LUAD | Female-baised eQTL |
| rs9473121 | chr6:47498657:G:C | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs1564926 | chr6:47502410:T:C | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs9369705 | chr6:47502785:C:A | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs9395264 | chr6:47507286:T:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs9369708 | chr6:47514458:A:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs9381569 | chr6:47514583:G:A | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs9296560 | chr6:47516315:G:C | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs7767598 | chr6:47517362:G:A | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs1352027 | chr6:47524386:C:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs4711881 | chr6:47525710:A:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs1352030 | chr6:47527988:T:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs4711882 | chr6:47535567:G:A | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs9395273 | chr6:47536660:A:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs7753753 | chr6:47537481:G:A | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs7767662 | chr6:47545340:A:G | - | -0.0264647999698852 | 0.047543597535633 | LUAD | Female-baised eQTL |
| rs7757703 | chr6:47610969:G:A | - | -0.0263108854720771 | 0.0480295662227521 | LUAD | Female-baised eQTL |
| rs74323814 | chr6:42995433:C:T | - | 0.118191945480393 | 0.00571591431009343 | COAD | Female-baised eQTL |
| rs376953130 | chr6:45674513:C:G | - | 0.1446925038161 | 0.00676590326759528 | COAD | Female-baised eQTL |
| rs3793023 | chr6:43015021:A:C | - | 0.116967711303837 | 0.00724359186346272 | COAD | Female-baised eQTL |
| rs4711621 | chr6:40284883:A:G | - | -0.142180057712033 | 0.00747628882195035 | COAD | Female-baised eQTL |
| rs4464774 | chr6:40281863:A:G | - | -0.139821798967063 | 0.00847080096201967 | COAD | Female-baised eQTL |
| rs2038867 | chr6:40282093:A:G | - | -0.139821798967063 | 0.00847080096201967 | COAD | Female-baised eQTL |
| rs6917703 | chr6:40283197:A:G | - | -0.139821798967063 | 0.00847080096201967 | COAD | Female-baised eQTL |
| rs2031523 | chr6:40283495:C:T | - | -0.139821798967063 | 0.00847080096201967 | COAD | Female-baised eQTL |
| rs3805944 | chr6:43077724:G:T | - | 0.11235246238747 | 0.00920154452177848 | COAD | Female-baised eQTL |
| rs200084915 | chr6:51669188:G:C | - | 0.121174302119046 | 0.0110856787137385 | COAD | Female-baised eQTL |
| rs141814825 | chr6:51671263:C:G | - | 0.121174302119046 | 0.0110856787137385 | COAD | Female-baised eQTL |
| rs59329059 | chr6:43080276:C:T | - | 0.111072313942697 | 0.0111915474757924 | COAD | Female-baised eQTL |
| rs6906559 | chr6:51664186:A:G | - | 0.120701309180836 | 0.0118221546010253 | COAD | Female-baised eQTL |
| rs7752484 | chr6:51653204:G:T | - | 0.120125936216654 | 0.0127716221872327 | COAD | Female-baised eQTL |
| rs1987439 | chr6:40280843:C:T | - | -0.132957039813867 | 0.0155864842534755 | COAD | Female-baised eQTL |
| rs1987440 | chr6:40280849:C:A | - | -0.132957039813867 | 0.0155864842534755 | COAD | Female-baised eQTL |
| rs6925198 | chr6:45168040:A:G | - | 0.139062405875947 | 0.0194949094146946 | COAD | Female-baised eQTL |
| rs60499694 | chr6:45666829:T:C | - | 0.133874341869042 | 0.0202932545151601 | COAD | Female-baised eQTL |
| rs61046945 | chr6:45669466:A:G | - | 0.133874341869042 | 0.0202932545151601 | COAD | Female-baised eQTL |
| rs1325554 | chr6:40284142:T:A | - | -0.113443540537694 | 0.0203459152228393 | COAD | Female-baised eQTL |
| rs58033063 | chr6:45666846:T:A | - | 0.133432027416367 | 0.0212734803843555 | COAD | Female-baised eQTL |
| rs9381134 | chr6:42082621:G:C | - | 0.0954184197500609 | 0.0224297582352567 | COAD | Female-baised eQTL |
| rs1325551 | chr6:40291575:T:G | - | -0.109278231736988 | 0.028262940484286 | COAD | Female-baised eQTL |
| rs13212421 | chr6:44721957:C:G | - | 0.128149995723008 | 0.0335703755466673 | COAD | Female-baised eQTL |
| rs9474507 | chr6:53378006:G:A | - | 0.0839290309141304 | 0.0376584100209252 | COAD | Female-baised eQTL |
| rs7746080 | chr6:35944492:A:G | - | 0.0999840899520465 | 0.0488717424413021 | COAD | Female-baised eQTL |
| rs9470177 | chr6:35945141:T:C | - | 0.0999840899520465 | 0.0488717424413021 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4714854 | chr6:45480197:A:T | gene | 0.120753149163579 | 0.0420594134225412 | SARC | Male-baised eQTL |
| rs6904352 | chr6:37760843:G:C | - | 0.0813448029153077 | 0.0065830923324931 | KIRC | Male-baised eQTL |
| rs74577143 | chr6:37760983:T:C | - | 0.0813448029153077 | 0.0065830923324931 | KIRC | Male-baised eQTL |
| rs77011928 | chr6:37761332:G:T | - | 0.0813448029153077 | 0.0065830923324931 | KIRC | Male-baised eQTL |
| rs77953170 | chr6:37761430:C:G | - | 0.0813448029153077 | 0.0065830923324931 | KIRC | Male-baised eQTL |
| rs74775846 | chr6:43676140:T:A | - | 0.0543585971680136 | 0.0213630370077317 | KIRC | Male-baised eQTL |
| rs60569395 | chr6:43673133:A:G | - | 0.0530915040482056 | 0.0231805921603831 | KIRC | Male-baised eQTL |
| rs60568338 | chr6:43673144:T:C | - | 0.0530915040482056 | 0.0231805921603831 | KIRC | Male-baised eQTL |
| rs7749233 | chr6:45828006:A:G | - | -0.0502232348219476 | 0.0301420600894846 | KIRC | Male-baised eQTL |
| rs1449646 | chr6:45784719:C:T | - | 0.0687730228016065 | 0.0379580289243269 | KIRC | Male-baised eQTL |
| rs6920060 | chr6:45824061:G:T | - | -0.0476649550036762 | 0.0486158864876013 | KIRC | Male-baised eQTL |
| rs41273696 | chr6:49698017:A:T | - | 0.189438819612614 | 1.06840304785827e-05 | COAD | Male-baised eQTL |
| rs79133460 | chr6:49691593:C:A | - | 0.200346665819706 | 1.29129070196653e-05 | COAD | Male-baised eQTL |
| rs12215348 | chr6:49702639:A:T | - | 0.185857716711706 | 1.85340312138969e-05 | COAD | Male-baised eQTL |
| rs12205904 | chr6:49704775:G:T | - | 0.185857716711706 | 1.85340312138969e-05 | COAD | Male-baised eQTL |
| rs12203129 | chr6:49708394:C:T | - | 0.185857716711706 | 1.85340312138969e-05 | COAD | Male-baised eQTL |
| rs12208319 | chr6:49716509:C:T | - | 0.185857716711706 | 1.85340312138969e-05 | COAD | Male-baised eQTL |
| rs10456626 | chr6:49743419:A:G | - | 0.181902365747783 | 6.03586740917575e-05 | COAD | Male-baised eQTL |
| rs10456627 | chr6:49743809:A:G | - | 0.181902365747783 | 6.03586740917575e-05 | COAD | Male-baised eQTL |
| rs9349118 | chr6:39385262:A:G | - | 0.119586743908798 | 0.000202812893764904 | COAD | Male-baised eQTL |
| rs12332794 | chr6:47795746:A:T | - | 0.0799703856784539 | 0.000236165616879732 | COAD | Male-baised eQTL |
| rs75572411 | chr6:49762433:T:C | - | 0.160549463202205 | 0.000400293267538688 | COAD | Male-baised eQTL |
| rs9357325 | chr6:40422626:G:A | - | 0.149473040959681 | 0.00051980469072938 | COAD | Male-baised eQTL |
| rs12206157 | chr6:49776809:T:C | - | 0.15433039551965 | 0.000629954979965145 | COAD | Male-baised eQTL |
| rs74744608 | chr6:49757044:C:T | - | 0.153791569358448 | 0.000674742378435421 | COAD | Male-baised eQTL |
| rs4385313 | chr6:55656011:T:A | - | 0.0641018311401062 | 0.000726747958644061 | COAD | Male-baised eQTL |
| rs80203215 | chr6:49754302:T:C | - | 0.15308685918974 | 0.000749850437650046 | COAD | Male-baised eQTL |
| rs1946508 | chr6:49757910:T:A | - | 0.148072792469399 | 0.00101630951762386 | COAD | Male-baised eQTL |
| rs77319090 | chr6:49799537:G:A | - | 0.145938665495521 | 0.00133760642064806 | COAD | Male-baised eQTL |
| rs9473652 | chr6:49757050:C:T | - | 0.0841135186309652 | 0.00134282720439018 | COAD | Male-baised eQTL |
| rs9369202 | chr6:40422267:C:T | - | 0.122003627824846 | 0.00176470264452976 | COAD | Male-baised eQTL |
| rs9296621 | chr6:49783669:A:T | - | 0.0794910808435294 | 0.00241546303375557 | COAD | Male-baised eQTL |
| rs9462738 | chr6:41696763:G:T | - | 0.0583674368974576 | 0.00350061329253407 | COAD | Male-baised eQTL |
| rs2653364 | chr6:55300492:C:T | - | -0.0736023774645142 | 0.00507799109827474 | COAD | Male-baised eQTL |
| rs2653355 | chr6:55289348:C:A | - | -0.0728391321955476 | 0.00542667392153511 | COAD | Male-baised eQTL |
| rs2653356 | chr6:55291566:A:G | - | -0.0728391321955476 | 0.00542667392153511 | COAD | Male-baised eQTL |
| rs1738263 | chr6:38775476:C:T | - | -0.0961507770071986 | 0.00683275162318203 | COAD | Male-baised eQTL |
| rs3734329 | chr6:37331337:C:G | - | 0.106244065397882 | 0.00700081374446503 | COAD | Male-baised eQTL |
| rs9349154 | chr6:40420859:A:G | - | 0.12279191188291 | 0.00776399637060234 | COAD | Male-baised eQTL |
| rs73737212 | chr6:49648409:A:C | - | 0.154885045610291 | 0.00839587862050417 | COAD | Male-baised eQTL |
| rs4637639 | chr6:40415277:A:G | - | -0.0706118345962099 | 0.00870521387785176 | COAD | Male-baised eQTL |
| rs6915565 | chr6:42224844:G:A | - | 0.0817103019718457 | 0.00903257310668814 | COAD | Male-baised eQTL |
| rs6931028 | chr6:42225326:A:T | - | 0.0817103019718457 | 0.00903257310668814 | COAD | Male-baised eQTL |
| rs2916260 | chr6:40414972:T:C | - | -0.0702360604737381 | 0.00910502633148315 | COAD | Male-baised eQTL |
| rs4329094 | chr6:40415075:A:C | - | -0.0702360604737381 | 0.00910502633148315 | COAD | Male-baised eQTL |
| rs4714942 | chr6:46521471:G:A | - | -0.0555192912611316 | 0.0105687753393867 | COAD | Male-baised eQTL |
| rs2811229 | chr6:55288889:G:A | - | -0.0694362015496648 | 0.0108225776704151 | COAD | Male-baised eQTL |
| rs9382477 | chr6:55294851:T:C | - | -0.0694362015496648 | 0.0108225776704151 | COAD | Male-baised eQTL |
| rs11968621 | chr6:47829161:C:T | - | -0.0544272029259205 | 0.0137453436339106 | COAD | Male-baised eQTL |
| rs7766181 | chr6:53944181:C:G | - | -0.0526845437870919 | 0.014817223478194 | COAD | Male-baised eQTL |
| rs1738236 | chr6:38797195:T:A | - | -0.0947624532245898 | 0.0152111148123584 | COAD | Male-baised eQTL |
| rs9394690 | chr6:40422036:C:T | - | 0.128777471915215 | 0.0166003803689077 | COAD | Male-baised eQTL |
| rs9381619 | chr6:47825555:T:C | - | -0.0537024004710457 | 0.0166693438730615 | COAD | Male-baised eQTL |
| rs1527688 | chr6:46519924:A:T | - | -0.0528144188636268 | 0.0172201298373892 | COAD | Male-baised eQTL |
| rs1699007 | chr6:38615592:T:C | - | -0.0509249443277384 | 0.0186797373135433 | COAD | Male-baised eQTL |
| rs9464005 | chr6:53942817:A:G | - | -0.0605518199794582 | 0.0221323266155057 | COAD | Male-baised eQTL |
| rs10948197 | chr6:44999753:T:C | - | 0.0506003499599833 | 0.0247185653448209 | COAD | Male-baised eQTL |
| rs4714175 | chr6:38683065:A:G | - | -0.0493807776731592 | 0.0247302134898447 | COAD | Male-baised eQTL |
| rs763018 | chr6:36321368:A:C | - | 0.0468993738458308 | 0.0259895820277664 | COAD | Male-baised eQTL |
| rs9395887 | chr6:53888079:T:C | - | 0.0476281988586232 | 0.0259913510892685 | COAD | Male-baised eQTL |
| rs12196155 | chr6:53943044:C:A | - | -0.058112003898076 | 0.0301005490778391 | COAD | Male-baised eQTL |
| rs9471628 | chr6:41694561:G:A | - | 0.0501327246342937 | 0.0305885074957358 | COAD | Male-baised eQTL |
| rs13206269 | chr6:52133348:G:A | - | -0.0517166864479313 | 0.0350802683092647 | COAD | Male-baised eQTL |
| rs1937147 | chr6:52122655:A:G | - | -0.0512874569377793 | 0.0359178052971321 | COAD | Male-baised eQTL |
| rs1537666 | chr6:52126622:A:C | - | -0.0512874569377793 | 0.0359178052971321 | COAD | Male-baised eQTL |
| rs9395707 | chr6:51707717:G:A | - | 0.0504521384273459 | 0.0362315138374341 | COAD | Male-baised eQTL |
| rs17665217 | chr6:50328845:T:C | - | 0.107477753354371 | 0.0372561468338411 | COAD | Male-baised eQTL |
| rs9370096 | chr6:52050158:G:A | - | 0.0493065123172851 | 0.0396937097820845 | COAD | Male-baised eQTL |
| rs1896983 | chr6:52052752:G:A | - | 0.0493065123172851 | 0.0396937097820845 | COAD | Male-baised eQTL |
| rs55848540 | chr6:43180314:C:T | - | 0.0897081707792934 | 0.0403712182444442 | COAD | Male-baised eQTL |
| rs75541429 | chr6:43182040:G:A | - | 0.0897081707792934 | 0.0403712182444442 | COAD | Male-baised eQTL |
| rs79492059 | chr6:43182851:A:T | - | 0.0897081707792934 | 0.0403712182444442 | COAD | Male-baised eQTL |
| rs113955756 | chr6:43183448:C:T | - | 0.0897081707792934 | 0.0403712182444442 | COAD | Male-baised eQTL |
| rs10434859 | chr6:52046609:C:T | - | 0.0486755039164158 | 0.042827092219002 | COAD | Male-baised eQTL |
| rs2465020 | chr6:51374838:T:C | - | -0.0481933304914982 | 0.0435872326495183 | COAD | Male-baised eQTL |
| rs1334947 | chr6:52125466:T:A | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs1537668 | chr6:52125695:A:G | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs1000868 | chr6:52126409:T:C | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs9474156 | chr6:52127009:T:C | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs16882113 | chr6:52127297:T:C | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs2096389 | chr6:52128142:G:C | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs9474157 | chr6:52128380:T:C | - | -0.049411201891348 | 0.0489139333548858 | COAD | Male-baised eQTL |
| rs2490133 | chr6:48779256:G:A | - | 0.0436845585621592 | 0.0499871507601246 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000124813 |
| CpG Site: cg05217983 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.428052280103946 | |
 | Gene ID: ENSG00000124813 |
| CpG Site: cg15587041 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.428052280103946 | |
 | Gene ID: ENSG00000124813 |
| CpG Site: cg22328837 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.341208903146966 | |
 | Gene ID: ENSG00000124813 |
| CpG Site: cg10832949 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: 0.137105340267778 | |
 | Gene ID: ENSG00000124813 |
| CpG Site: cg15587041 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.463767315752126 | |
 | Gene ID: ENSG00000124813 |
| CpG Site: cg01133215 | |
| Position to Gene: gene,exon,CDS,UTR | |
| Male Effect: -0.452103194123772 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01133215 | chr6:45431944 | gene,exon,CDS,UTR | -0.452103194123772 | 3.53664198724092e-21 | -0.5489120921361095 | 2.1268704985739155e-25 | BLCA |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05217983 | chr6:45439130 | gene | -0.428052280103946 | 6.37387196573451e-12 | -0.389348329302932 | 9.075095493292409e-15 | THCA |
| cg15587041 | chr6:45625922 | gene | -0.428052280103946 | 6.37387196573451e-12 | -0.389348329302932 | 9.075095493292409e-15 | THCA |
| cg22328837 | chr6:45454383 | gene | -0.341208903146966 | 9.35146240252633e-06 | -0.43910299848594414 | 2.6425712136882598e-08 | COAD |
| cg10832949 | chr6:45423046 | gene | 0.137105340267778 | 9.70912475447577e-05 | 0.38662382689250074 | 1.3181804064397897e-06 | COAD |
| cg15587041 | chr6:45625922 | gene | -0.463767315752126 | 1.59240753544813e-36 | -0.7177101456791134 | 1.716144302066502e-41 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of RUNX2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000124813 | RUNX2 | C0003872 | Arthritis, Psoriatic | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0008928 | Cleidocranial Dysplasia | 3 | CTD_human |
| ENSG00000124813 | RUNX2 | C0009171 | Cocaine Abuse | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0029410 | Osteoarthritis of hip | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0029463 | Osteosarcoma | 2 | CTD_human |
| ENSG00000124813 | RUNX2 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0040427 | Tooth Abnormalities | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0041948 | Uremia | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0086189 | Drug Withdrawal Symptoms | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0087169 | Withdrawal Symptoms | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0243057 | Stomatognathic System Abnormalities | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0524730 | Odontome | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0600427 | Cocaine Dependence | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C0949690 | Spondylarthritis | 1 | CTD_human |
| ENSG00000124813 | RUNX2 | C1834969 | Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly | 1 | CTD_human |
