|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000124784 |
Summary for RIOK1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000124784 | Gene symbol | RIOK1 |
| Gene name | RIO kinase 1 | |
| HGNC | 18656 | |
| Entrez ID | 83732 | |
| Gene type | protein_coding | |
| Synonyms | RIOK1|AD034|FLJ30006|bA288G3.1|RRP10 | |
| UniProtAcc | Q9BRS2 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000124784 | RIOK1 | DB12010 | Fostamatinib | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RIOK1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RIOK1 | 2.22e+03 | 1.17e+00 | 1.00e-01 | 1.16e+01 | 2.50e-31 | 2.23e-30 | LUSC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for RIOK1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for RIOK1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for RIOK1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for RIOK1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for RIOK1 |
| TFs related to RIOK1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF487 | RIOK1 | 4.60e+00 | 9.84e-01 | 3.35e+00 | 9.52e-03 | Male-biased |
| BRCA | ZNF879 | RIOK1 | 4.49e+00 | 9.81e-01 | 3.31e+00 | 1.13e-02 | Male-biased |
| CHOL | BARX2 | RIOK1 | 4.40e+00 | 9.88e-01 | 3.31e+00 | 6.21e-03 | Male-biased |
| CHOL | FOXE1 | RIOK1 | 3.87e+00 | 9.83e-01 | 2.58e+00 | 2.52e-03 | Male-biased |
| CHOL | FOXG1 | RIOK1 | 3.88e+00 | 9.85e-01 | 2.29e+00 | 7.03e-04 | Male-biased |
| CHOL | NKX2-2 | RIOK1 | 4.39e+00 | 9.85e-01 | 3.39e+00 | 9.13e-03 | Male-biased |
| CHOL | NKX3-1 | RIOK1 | 4.45e+00 | 9.93e-01 | 3.01e+00 | 1.46e-03 | Male-biased |
| CHOL | POU2F1 | RIOK1 | 4.10e+00 | 9.85e-01 | 2.97e+00 | 5.22e-03 | Male-biased |
| CHOL | POU2F2 | RIOK1 | 4.34e+00 | 9.92e-01 | 2.95e+00 | 1.86e-03 | Male-biased |
| CHOL | POU2F3 | RIOK1 | 4.57e+00 | 9.89e-01 | 3.49e+00 | 6.71e-03 | Male-biased |
| CHOL | POU3F3 | RIOK1 | 4.21e+00 | 9.91e-01 | 2.64e+00 | 7.65e-04 | Male-biased |
| CHOL | POU4F1 | RIOK1 | 4.27e+00 | 9.90e-01 | 2.96e+00 | 2.57e-03 | Male-biased |
| CHOL | POU4F2 | RIOK1 | 4.11e+00 | 9.87e-01 | 2.90e+00 | 3.78e-03 | Male-biased |
| CHOL | POU5F1 | RIOK1 | 4.13e+00 | 9.89e-01 | 2.81e+00 | 2.32e-03 | Male-biased |
| CHOL | SIX1 | RIOK1 | 4.17e+00 | 9.82e-01 | 3.17e+00 | 8.98e-03 | Male-biased |
| CHOL | ZNF260 | RIOK1 | 3.98e+00 | 9.82e-01 | 2.89e+00 | 6.01e-03 | Male-biased |
| CHOL | ZNF35 | RIOK1 | 3.97e+00 | 9.86e-01 | 2.58e+00 | 1.73e-03 | Male-biased |
| CHOL | ZNF418 | RIOK1 | 3.89e+00 | 9.86e-01 | 1.92e+00 | 1.15e-04 | Male-biased |
| CHOL | ZNF570 | RIOK1 | 3.90e+00 | 9.86e-01 | 2.25e+00 | 5.18e-04 | Male-biased |
| CHOL | ZNF879 | RIOK1 | 3.92e+00 | 9.87e-01 | 2.15e+00 | 3.02e-04 | Male-biased |
| MESO | ZNF418 | RIOK1 | 3.78e+00 | 1.55e-02 | 4.92e+00 | 9.81e-01 | Female-biased |
| PAAD | BARX2 | RIOK1 | 3.58e+00 | 3.28e-03 | 4.61e+00 | 9.92e-01 | Female-biased |
| PAAD | BATF | RIOK1 | 3.53e+00 | 2.92e-03 | 4.57e+00 | 9.92e-01 | Female-biased |
| PAAD | ETV1 | RIOK1 | 3.99e+00 | 9.84e-01 | 2.76e+00 | 1.23e-03 | Male-biased |
| PAAD | FOXE1 | RIOK1 | 2.84e+00 | 2.84e-03 | 3.88e+00 | 9.81e-01 | Female-biased |
| PAAD | HNF1B | RIOK1 | 3.66e+00 | 6.13e-03 | 4.56e+00 | 9.88e-01 | Female-biased |
| PAAD | NKX2-2 | RIOK1 | 3.63e+00 | 7.23e-03 | 4.50e+00 | 9.87e-01 | Female-biased |
| PAAD | NKX3-1 | RIOK1 | 3.46e+00 | 3.13e-03 | 4.50e+00 | 9.91e-01 | Female-biased |
| PAAD | PBX2 | RIOK1 | 3.53e+00 | 4.19e-03 | 4.51e+00 | 9.90e-01 | Female-biased |
| PAAD | POU2F1 | RIOK1 | 3.08e+00 | 2.35e-03 | 4.16e+00 | 9.87e-01 | Female-biased |
| PAAD | POU2F2 | RIOK1 | 3.30e+00 | 2.04e-03 | 4.42e+00 | 9.91e-01 | Female-biased |
| PAAD | POU2F3 | RIOK1 | 3.81e+00 | 3.84e-03 | 4.81e+00 | 9.92e-01 | Female-biased |
| PAAD | POU3F3 | RIOK1 | 3.05e+00 | 5.73e-04 | 4.40e+00 | 9.92e-01 | Female-biased |
| PAAD | POU4F1 | RIOK1 | 3.35e+00 | 2.42e-03 | 4.43e+00 | 9.91e-01 | Female-biased |
| PAAD | POU4F2 | RIOK1 | 3.15e+00 | 1.54e-03 | 4.31e+00 | 9.90e-01 | Female-biased |
| PAAD | POU5F1 | RIOK1 | 3.14e+00 | 3.33e-03 | 4.16e+00 | 9.86e-01 | Female-biased |
| PAAD | SIX1 | RIOK1 | 3.14e+00 | 3.45e-03 | 4.15e+00 | 9.86e-01 | Female-biased |
| PAAD | SPI1 | RIOK1 | 2.66e+00 | 1.38e-03 | 3.83e+00 | 9.81e-01 | Female-biased |
| PAAD | ZNF200 | RIOK1 | 4.45e+00 | 9.92e-01 | 2.83e+00 | 1.57e-04 | Male-biased |
| PAAD | ZNF250 | RIOK1 | 3.64e+00 | 5.98e-03 | 4.55e+00 | 9.88e-01 | Female-biased |
| PAAD | ZNF260 | RIOK1 | 3.14e+00 | 6.84e-03 | 4.02e+00 | 9.80e-01 | Female-biased |
| PAAD | ZNF35 | RIOK1 | 2.98e+00 | 3.21e-03 | 4.01e+00 | 9.84e-01 | Female-biased |
| THYM | BARX2 | RIOK1 | 3.96e+00 | 1.11e-02 | 4.62e+00 | 9.82e-01 | Female-biased |
| THYM | NKX2-2 | RIOK1 | 4.01e+00 | 1.29e-02 | 4.64e+00 | 9.80e-01 | Female-biased |
| THYM | NKX3-1 | RIOK1 | 3.79e+00 | 8.32e-03 | 4.52e+00 | 9.84e-01 | Female-biased |
| THYM | POU3F3 | RIOK1 | 3.49e+00 | 4.90e-03 | 4.35e+00 | 9.85e-01 | Female-biased |
| THYM | POU4F1 | RIOK1 | 3.56e+00 | 7.25e-03 | 4.32e+00 | 9.82e-01 | Female-biased |
| THYM | POU4F2 | RIOK1 | 3.47e+00 | 7.47e-03 | 4.22e+00 | 9.80e-01 | Female-biased |
| THYM | ZNF418 | RIOK1 | 3.08e+00 | 1.98e-03 | 4.16e+00 | 9.85e-01 | Female-biased |
| RIOK1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for RIOK1 |
| RBPs related to ES in RIOK1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | SART3 | exon_skip_447812 | 8.46e+00 | 9.04e-03 | 8.92e+00 | 9.87e-01 | Female-biased |
| THCA | ZFP36 | exon_skip_447809 | 8.96e+00 | 7.66e-03 | 9.27e+00 | 9.89e-01 | Female-biased |
| GBM | ZFP36 | exon_skip_447809 | 9.09e+00 | 8.71e-03 | 9.44e+00 | 9.88e-01 | Female-biased |
| KICH | SRSF1 | exon_skip_447810 | 6.61e+00 | 3.20e-03 | 7.04e+00 | 9.83e-01 | Female-biased |
| RIOK1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1737541 | chr6:649113:T:C | - | -0.150057028754234 | 0.00488693904712968 | HNSC | Female-baised eQTL |
| rs1099772 | chr6:645892:C:G | - | -0.140392277401661 | 0.0173982020529067 | HNSC | Female-baised eQTL |
| rs1150872 | chr6:636646:G:C | - | -0.13570858227422 | 0.0205638647927104 | HNSC | Female-baised eQTL |
| rs1213054 | chr6:638691:C:G | - | -0.13570858227422 | 0.0205638647927104 | HNSC | Female-baised eQTL |
| rs9405836 | chr6:600423:C:T | - | -0.133655684423972 | 0.0491947816875313 | HNSC | Female-baised eQTL |
| rs1766848 | chr6:656555:G:T | - | 0.117920062308383 | 0.0496213757265177 | HNSC | Female-baised eQTL |
| rs6920094 | chr6:6032164:A:G | - | -0.0552618611420051 | 0.0119289809219426 | LUAD | Female-baised eQTL |
| rs582125 | chr6:6033199:A:G | - | -0.0552618611420051 | 0.0119289809219426 | LUAD | Female-baised eQTL |
| rs582126 | chr6:6033201:A:G | - | -0.0552618611420051 | 0.0119289809219426 | LUAD | Female-baised eQTL |
| rs665449 | chr6:6027582:C:T | - | -0.0548648052933585 | 0.0132650592208034 | LUAD | Female-baised eQTL |
| rs9328071 | chr6:1825232:T:G | - | 0.042922945911245 | 0.0257007266093729 | LUAD | Female-baised eQTL |
| rs7756581 | chr6:6025809:T:C | - | -0.0509954217277906 | 0.0294634652465932 | LUAD | Female-baised eQTL |
| rs9405287 | chr6:6034330:A:T | - | -0.0486771736275006 | 0.0359193285506338 | LUAD | Female-baised eQTL |
| rs7740251 | chr6:11934401:A:G | - | 0.108301249660576 | 0.0215394949953949 | COAD | Female-baised eQTL |
| rs79260350 | chr6:11943284:G:A | - | 0.100651917759394 | 0.0234969468361284 | COAD | Female-baised eQTL |
| rs16872095 | chr6:11945545:A:G | - | 0.100651917759394 | 0.0234969468361284 | COAD | Female-baised eQTL |
| rs62395428 | chr6:11941206:G:C | - | 0.0993445718792983 | 0.0307934910332415 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4716306 | chr6:10106234:G:A | - | -0.0518604764254247 | 0.0150532622584373 | BLCA | Male-baised eQTL |
| rs9392627 | chr6:4724616:A:G | - | 0.0421785700956425 | 0.0223208276247367 | BLCA | Male-baised eQTL |
| rs9392061 | chr6:4718869:G:A | - | -0.0415745660880173 | 0.0262403189642506 | BLCA | Male-baised eQTL |
| rs11242975 | chr6:4723480:A:G | - | 0.0415792028953822 | 0.0271654336469086 | BLCA | Male-baised eQTL |
| rs4373400 | chr6:4721572:T:C | - | 0.0409903808714883 | 0.0288638624334936 | BLCA | Male-baised eQTL |
| rs6597093 | chr6:4720367:T:C | - | 0.0402831268569665 | 0.033520424615687 | BLCA | Male-baised eQTL |
| rs11242976 | chr6:4724165:G:C | - | 0.040811004972926 | 0.0336217241864112 | BLCA | Male-baised eQTL |
| rs10484333 | chr6:14346124:G:A | - | 0.0935378214329488 | 0.0494822313796077 | BLCA | Male-baised eQTL |
| rs9503728 | chr6:3762038:G:A | - | 0.0617149298938809 | 0.0254081826097517 | COAD | Male-baised eQTL |
| rs6926083 | chr6:13417805:T:C | - | 0.0962124964131095 | 0.0327374556778693 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000124784 |
| CpG Site: cg23282964 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.388956868323993 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23282964 | chr6:7417547 | gene,exon,UTR | -0.388956868323993 | 7.68851255622039e-05 | -0.33679954308520954 | 3.098067194635094e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of RIOK1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
