|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000124570 |
Summary for SERPINB6 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000124570 | Gene symbol | SERPINB6 |
| Gene name | serpin family B member 6 | |
| HGNC | 8950 | |
| Entrez ID | 5269 | |
| Gene type | protein_coding | |
| Synonyms | SERPINB6|PTI|CAP | |
| UniProtAcc | P35237 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000124570 | SERPINB6 | DB00055 | Drotrecogin alfa | BiotechDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SERPINB6 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SERPINB6 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SERPINB6 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| PAAD | cg11112615 | chr6:2970390 | CGI:chr6:2970852-2971728 | promoter,gene body | 4.29e-01 | 2.90e-01 | 7.65e+00 | 1.97e-14 | 2.09e-13 | 1.39e-01 |
| ACC | cg01137047 | chr6:2970643 | CGI:chr6:2970852-2971728 | promoter,gene body | 2.77e-01 | 4.21e-01 | -2.89e+00 | 3.83e-03 | 1.44e-02 | -1.43e-01 |
| ACC | cg11112615 | chr6:2970390 | CGI:chr6:2970852-2971728 | promoter,gene body | 3.42e-01 | 4.48e-01 | -2.00e+00 | 4.57e-02 | 4.79e-02 | -1.07e-01 |
| CHOL | cg11112615 | chr6:2970390 | CGI:chr6:2970852-2971728 | promoter,gene body | 8.28e-01 | 6.82e-01 | 1.97e+00 | 4.84e-02 | 4.84e-02 | 1.47e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg11112615 | chr6:2970390 | CGI:chr6:2970852-2971728 | promoter,gene body | 6.59e-01 | 4.19e-01 | 2.54e+00 | 1.10e-02 | 1.49e-02 | 2.39e-01 |
| LUSC | cg01137047 | chr6:2970643 | CGI:chr6:2970852-2971728 | promoter,gene body | 5.56e-01 | 3.52e-01 | 4.02e+00 | 5.76e-05 | 5.76e-04 | 2.04e-01 |
| ESCA | cg11112615 | chr6:2970390 | CGI:chr6:2970852-2971728 | promoter,gene body | 5.81e-01 | 2.05e-01 | 2.40e+00 | 1.63e-02 | 3.88e-02 | 3.76e-01 |
| CHOL | cg01137047 | chr6:2970643 | CGI:chr6:2970852-2971728 | promoter,gene body | 4.04e-01 | 5.48e-01 | -2.73e+00 | 6.38e-03 | 1.82e-02 | -1.44e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SERPINB6 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SERPINB6 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SERPINB6 |
| TFs related to SERPINB6. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SERPINB6 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SERPINB6 |
| RBPs related to ES in SERPINB6. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | SART3 | exon_skip_455808 | 7.02e+00 | 9.83e-01 | 6.55e+00 | 3.27e-03 | Male-biased |
| UVM | NCL | exon_skip_455806 | 7.60e+00 | 6.24e-03 | 7.94e+00 | 9.85e-01 | Female-biased |
| LUAD | KHDRBS1 | exon_skip_455777 | 1.05e+01 | 9.81e-01 | 1.02e+01 | 1.81e-02 | Male-biased |
| KIRP | KHDRBS1 | exon_skip_455777 | 1.04e+01 | 3.36e-03 | 1.08e+01 | 9.95e-01 | Female-biased |
| ESCA | KHDRBS1 | exon_skip_455777 | 1.00e+01 | 1.65e-02 | 1.04e+01 | 9.82e-01 | Female-biased |
| THCA | KHDRBS1 | exon_skip_455777 | 1.05e+01 | 9.95e-01 | 1.02e+01 | 3.93e-03 | Male-biased |
| LGG | KHDRBS1 | exon_skip_455777 | 1.06e+01 | 9.90e-01 | 1.02e+01 | 9.10e-03 | Male-biased |
| LGG | NCL | exon_skip_455807 | 7.49e+00 | 2.18e-03 | 7.97e+00 | 9.89e-01 | Female-biased |
| PAAD | KHDRBS1 | exon_skip_455777 | 1.08e+01 | 9.95e-01 | 1.04e+01 | 3.80e-03 | Male-biased |
| SARC | KHDRBS1 | exon_skip_455777 | 1.03e+01 | 7.29e-03 | 1.07e+01 | 9.92e-01 | Female-biased |
| SERPINB6 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs62406129 | chr6:9890809:T:A | - | 0.155910800466556 | 0.0187850505817729 | SARC | Female-baised eQTL |
| rs7451438 | chr6:10499516:C:T | - | 0.224800972215418 | 0.0367384616924486 | KIRP | Female-baised eQTL |
| rs2714347 | chr6:7267080:G:A | - | 0.0618407217792936 | 0.0286501499874877 | LGG | Female-baised eQTL |
| rs1883629 | chr6:1050077:T:G | - | -0.119696620341022 | 0.0320518236508014 | BLCA | Female-baised eQTL |
| rs240680 | chr6:1051011:A:G | - | -0.119696620341022 | 0.0320518236508014 | BLCA | Female-baised eQTL |
| rs9406246 | chr6:1054485:T:C | - | -0.119696620341022 | 0.0320518236508014 | BLCA | Female-baised eQTL |
| rs240678 | chr6:1045854:C:T | - | -0.118422792521314 | 0.0366909278583682 | BLCA | Female-baised eQTL |
| rs240681 | chr6:1051524:A:G | - | -0.114872011931203 | 0.0490000387101795 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3778554 | chr6:1915285:A:G | - | 0.299714240972154 | 4.60897102004837e-05 | PCPG | Male-baised eQTL |
| rs6927686 | chr6:1907675:G:C | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs9503043 | chr6:1907879:A:G | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs10484693 | chr6:1909874:C:T | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs3778551 | chr6:1911138:C:A | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs7758904 | chr6:1914336:T:G | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs7754925 | chr6:1914406:A:G | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs7754929 | chr6:1914407:A:C | - | 0.256000406121159 | 0.00110577958513089 | PCPG | Male-baised eQTL |
| rs13190775 | chr6:1887973:G:A | - | 0.200774900462195 | 0.0112444686421335 | PCPG | Male-baised eQTL |
| rs35946812 | chr6:1890329:C:T | - | 0.200184578322821 | 0.0118991365494987 | PCPG | Male-baised eQTL |
| rs13197177 | chr6:1890731:T:C | - | 0.199730950067576 | 0.0123440533164541 | PCPG | Male-baised eQTL |
| rs3823279 | chr6:1896365:T:G | - | 0.196450868797693 | 0.0173834245170199 | PCPG | Male-baised eQTL |
| rs17772389 | chr6:1909938:C:T | - | 0.183191975771565 | 0.0420180380000857 | PCPG | Male-baised eQTL |
| rs7743523 | chr6:448247:C:T | - | 0.0309566112854984 | 0.0462812080313949 | KIRC | Male-baised eQTL |
| rs7756248 | chr6:448425:T:C | - | 0.0309566112854984 | 0.0462812080313949 | KIRC | Male-baised eQTL |
| rs7767018 | chr6:448453:G:A | - | 0.0308798754625535 | 0.047199842220098 | KIRC | Male-baised eQTL |
| rs9406014 | chr6:782060:G:T | - | -0.0497412245078343 | 0.016166508326585 | BLCA | Male-baised eQTL |
| rs7743921 | chr6:782953:C:T | - | -0.0471924205298694 | 0.0279626112375711 | BLCA | Male-baised eQTL |
| rs1986345 | chr6:785010:C:G | - | -0.0461548514529013 | 0.0332271885174162 | BLCA | Male-baised eQTL |
| rs13210514 | chr6:780176:T:C | - | -0.0443614350563598 | 0.0459751309796757 | BLCA | Male-baised eQTL |
| rs9392868 | chr6:779191:G:A | - | -0.0441158567996071 | 0.0487169388120249 | BLCA | Male-baised eQTL |
| rs4959698 | chr6:2670399:G:A | - | 0.0868695523403005 | 0.0271341787210057 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000124570 |
| CpG Site: cg01137047 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.390015982380908 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01137047 | chr6:2970643 | gene,promoter | -0.390015982380908 | 5.34231661093939e-11 | -0.46798265197446104 | 1.548088375127214e-13 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SERPINB6 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000124570 | SERPINB6 | C3150704 | DEAFNESS, AUTOSOMAL RECESSIVE 91 | 1 | CTD_human |
