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Gene: ENSG00000124486 |
Summary for USP9X |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000124486 | Gene symbol | USP9X |
| Gene name | ubiquitin specific peptidase 9 X-linked | |
| HGNC | 12632 | |
| Entrez ID | 8239 | |
| Gene type | protein_coding | |
| Synonyms | USP9X|DFFRX|FAF|MRX99 | |
| UniProtAcc | Q93008 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for USP9X |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for USP9X |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for USP9X |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LAML | cg05181110 | chrX:41085107 | CGI:chrX:41084420-41086667 | promoter | 1.71e-01 | 4.65e-02 | 9.04e+00 | 1.54e-19 | 1.21e-18 | 1.25e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for USP9X |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for USP9X |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | USP9X-001 | chrX_41198953_+ | 3.36e-01 | 1.87e-01 | 2.33e+00 | 1.97e-02 | 4.96e-02 | 1.50e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for USP9X |
| TFs related to USP9X. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF418 | USP9X | 4.10e+00 | 1.39e-02 | 5.21e+00 | 9.83e-01 | Female-biased |
| USP9X related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for USP9X |
| RBPs related to ES in USP9X. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | KHDRBS3 | exon_skip_509795 | 9.20e+00 | 3.11e-03 | 9.60e+00 | 9.94e-01 | Female-biased |
| UVM | RBM46 | exon_skip_509801 | 8.36e+00 | 4.20e-03 | 8.74e+00 | 9.90e-01 | Female-biased |
| UVM | SFPQ | exon_skip_509801 | 9.65e+00 | 1.50e-03 | 1.01e+01 | 9.97e-01 | Female-biased |
| LIHC | RBM41 | exon_skip_509803 | 7.49e+00 | 7.89e-03 | 7.91e+00 | 9.83e-01 | Female-biased |
| COAD | DAZAP1 | exon_skip_509788 | 1.34e+01 | 9.95e-01 | 1.30e+01 | 5.18e-03 | Male-biased |
| LUAD | DAZAP1 | exon_skip_509788 | 1.34e+01 | 9.96e-01 | 1.30e+01 | 3.34e-03 | Male-biased |
| ESCA | KHDRBS3 | exon_skip_509795 | 8.72e+00 | 1.17e-02 | 9.15e+00 | 9.85e-01 | Female-biased |
| ESCA | SRSF7 | exon_skip_509783 | 1.14e+01 | 1.17e-02 | 1.19e+01 | 9.88e-01 | Female-biased |
| THCA | DAZAP1 | exon_skip_509788 | 1.34e+01 | 1.00e+00 | 1.28e+01 | 1.79e-04 | Male-biased |
| PCPG | KHDRBS1 | exon_skip_509801 | 7.39e+00 | 9.86e-01 | 6.95e+00 | 2.51e-03 | Male-biased |
| PCPG | KHDRBS3 | exon_skip_509795 | 9.47e+00 | 9.87e-01 | 9.14e+00 | 9.81e-03 | Male-biased |
| PCPG | PTBP1 | exon_skip_509795 | 7.13e+00 | 9.81e-01 | 6.76e+00 | 6.13e-03 | Male-biased |
| MESO | KHDRBS3 | exon_skip_509795 | 9.47e+00 | 9.93e-01 | 9.03e+00 | 4.44e-03 | Male-biased |
| MESO | SFPQ | exon_skip_509801 | 9.32e+00 | 4.69e-03 | 9.74e+00 | 9.93e-01 | Female-biased |
| GBM | RBM46 | exon_skip_509792 | 9.85e+00 | 6.20e-03 | 1.02e+01 | 9.92e-01 | Female-biased |
| PAAD | DAZAP1 | exon_skip_509788 | 1.30e+01 | 1.35e-03 | 1.35e+01 | 9.98e-01 | Female-biased |
| PAAD | ZFP36 | exon_skip_509792 | 7.46e+00 | 9.83e-01 | 7.13e+00 | 6.93e-03 | Male-biased |
| PAAD | ZNF638 | exon_skip_509791 | 1.07e+01 | 1.86e-02 | 1.09e+01 | 9.80e-01 | Female-biased |
| KICH | DAZAP1 | exon_skip_509788 | 1.35e+01 | 9.99e-01 | 1.29e+01 | 8.68e-04 | Male-biased |
| KICH | KHDRBS3 | exon_skip_509795 | 8.94e+00 | 4.41e-03 | 9.34e+00 | 9.92e-01 | Female-biased |
| KICH | ZNF638 | exon_skip_509791 | 1.12e+01 | 9.97e-01 | 1.07e+01 | 2.18e-03 | Male-biased |
| USP9X related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of USP9X |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000124486 | USP9X | C3806746 | MENTAL RETARDATION, X-LINKED 99 | 1 | CTD_human |
| ENSG00000124486 | USP9X | C4225416 | MENTAL RETARDATION, X-LINKED 99, SYNDROMIC, FEMALE-RESTRICTED | 1 | CTD_human |
