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Gene: ENSG00000123130 |
Summary for ACOT9 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000123130 | Gene symbol | ACOT9 |
| Gene name | acyl-CoA thioesterase 9 | |
| HGNC | 17152 | |
| Entrez ID | 23597 | |
| Gene type | protein_coding | |
| Synonyms | ACOT9|CGI-16|MT-ACT48|ACATE2 | |
| UniProtAcc | Q9Y305 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ACOT9 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ACOT9 | 2.03e+03 | 1.02e+00 | 1.68e-01 | 6.06e+00 | 1.34e-09 | 3.37e-08 | HNSC |
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Sex-biased somatic mutation for ACOT9 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ACOT9 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for ACOT9 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| COAD | exon_skip_514348 | 1.42e-01 | 3.15e-01 | -4.65e+00 | 3.27e-06 | 3.85e-05 | -1.73e-01 |
| BLCA | exon_skip_514348 | 4.55e-01 | 7.79e-01 | -3.02e+00 | 2.49e-03 | 9.44e-03 | -3.24e-01 |
| CHOL | exon_skip_514348 | 3.47e-01 | 1.52e-01 | 2.41e+00 | 1.58e-02 | 2.87e-02 | 1.96e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_514348 | 4.75e-01 | 7.24e-01 | -1.05e+01 | 1.42e-25 | 5.14e-24 | -2.49e-01 |
| HNSC | exon_skip_514350 | 8.53e-01 | 9.59e-01 | -4.29e+00 | 1.79e-05 | 9.87e-04 | -1.06e-01 |
| KIRP | exon_skip_514348 | 3.61e-01 | 2.29e-01 | 2.51e+00 | 1.22e-02 | 2.80e-02 | 1.31e-01 |
| READ | exon_skip_514348 | 1.36e-01 | 4.12e-01 | -3.41e+00 | 6.58e-04 | 5.86e-03 | -2.76e-01 |
| KICH | exon_skip_514348 | 1.58e-01 | 3.06e-01 | -4.06e+00 | 5.00e-05 | 1.02e-03 | -1.48e-01 |
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RNA A-to-I editing events in TCGA for ACOT9 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | ACOT9-008 | chrX_23702537_- | 2.10e-01 | 2.58e-01 | -2.29e+00 | 2.23e-02 | 4.56e-02 | -4.86e-02 |
| KIRC | ACOT9-008 | chrX_23703455_- | 2.89e-01 | 3.35e-01 | -2.22e+00 | 2.67e-02 | 4.61e-02 | -4.62e-02 |
| LUAD | ACOT9-008 | chrX_23702385_- | 2.79e-01 | 1.92e-01 | 2.95e+00 | 3.22e-03 | 2.16e-02 | 8.71e-02 |
| LGG | ACOT9-008 | chrX_23702523_- | 2.13e-01 | 1.51e-01 | 2.02e+00 | 4.37e-02 | 4.91e-02 | 6.24e-02 |
| SARC | ACOT9-008 | chrX_23702523_- | 1.74e-01 | 1.31e-01 | 2.80e+00 | 5.07e-03 | 4.85e-02 | 4.36e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUSC | ACOT9-008 | chrX_23702537_- | 2.66e-01 | 1.44e-01 | 3.58e+00 | 3.40e-04 | 2.30e-03 | 1.22e-01 |
| LUSC | ACOT9-008 | chrX_23703455_- | 2.74e-01 | 1.89e-01 | 2.95e+00 | 3.14e-03 | 9.43e-03 | 8.44e-02 |
| STAD | ACOT9-008 | chrX_23703415_- | 4.11e-01 | 5.67e-01 | -2.64e+00 | 8.27e-03 | 2.16e-02 | -1.56e-01 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | ACOT9-008 | chrX_23703451_- | 2.80e-01 | 2.03e-01 | 2.11e+00 | 3.48e-02 | 3.78e-02 | 7.66e-02 |
| BRCA | ACOT9-008 | chrX_23703455_- | 3.45e-01 | 2.87e-01 | 2.59e+00 | 9.63e-03 | 1.35e-02 | 5.79e-02 |
| BRCA | ACOT9-008 | chrX_23703461_- | 3.00e-01 | 2.60e-01 | 2.37e+00 | 1.77e-02 | 2.22e-02 | 4.03e-02 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ACOT9 |
| TFs related to ACOT9. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | MEIS1 | ACOT9 | 3.10e+00 | 5.02e-03 | 4.17e+00 | 9.81e-01 | Female-biased |
| LAML | PBX4 | ACOT9 | 3.27e+00 | 4.55e-03 | 4.37e+00 | 9.85e-01 | Female-biased |
| LAML | ZNF525 | ACOT9 | 3.36e+00 | 6.22e-03 | 4.38e+00 | 9.83e-01 | Female-biased |
| SKCM | MSX1 | ACOT9 | 4.24e+00 | 9.82e-01 | 2.45e+00 | 9.57e-04 | Male-biased |
| SKCM | MSX2 | ACOT9 | 4.27e+00 | 9.83e-01 | 2.44e+00 | 8.37e-04 | Male-biased |
| SKCM | PBX4 | ACOT9 | 4.45e+00 | 9.82e-01 | 3.16e+00 | 4.78e-03 | Male-biased |
| SKCM | POU5F1B | ACOT9 | 4.26e+00 | 9.81e-01 | 2.72e+00 | 2.15e-03 | Male-biased |
| SKCM | ZNF418 | ACOT9 | 4.54e+00 | 9.89e-01 | 1.09e+00 | 4.71e-06 | Male-biased |
| SKCM | ZNF525 | ACOT9 | 4.75e+00 | 9.88e-01 | 3.36e+00 | 3.66e-03 | Male-biased |
| SKCM | ZNF879 | ACOT9 | 4.21e+00 | 9.82e-01 | 1.43e+00 | 3.11e-05 | Male-biased |
| UVM | ZNF418 | ACOT9 | 4.51e+00 | 9.84e-01 | 1.94e+00 | 5.03e-04 | Male-biased |
| ACOT9 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ACOT9 |
| RBPs related to ES in ACOT9. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | NCL | exon_skip_514336 | 9.65e+00 | 1.41e-02 | 9.97e+00 | 9.84e-01 | Female-biased |
| UVM | NCL | exon_skip_514336 | 9.56e+00 | 1.79e-03 | 1.00e+01 | 9.96e-01 | Female-biased |
| UVM | TARDBP | exon_skip_514344 | 7.15e+00 | 4.13e-03 | 7.52e+00 | 9.85e-01 | Female-biased |
| THYM | NCL | exon_skip_514336 | 9.73e+00 | 9.98e-03 | 1.01e+01 | 9.88e-01 | Female-biased |
| COAD | PABPC3 | exon_skip_514334 | 7.93e+00 | 7.70e-03 | 8.28e+00 | 9.85e-01 | Female-biased |
| THCA | ZFP36 | exon_skip_514335 | 9.36e+00 | 9.90e-01 | 9.04e+00 | 6.52e-03 | Male-biased |
| PCPG | PABPC3 | exon_skip_514334 | 8.08e+00 | 1.18e-02 | 8.39e+00 | 9.81e-01 | Female-biased |
| MESO | NCL | exon_skip_514336 | 9.63e+00 | 5.47e-03 | 1.00e+01 | 9.93e-01 | Female-biased |
| GBM | ZFP36 | exon_skip_514335 | 9.09e+00 | 8.89e-03 | 9.44e+00 | 9.88e-01 | Female-biased |
| BLCA | ZFP36 | exon_skip_514335 | 9.27e+00 | 9.88e-01 | 8.89e+00 | 8.11e-03 | Male-biased |
| ACOT9 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg04292836 | |
| Position to Gene: gene | |
| Male Effect: -0.312320883391462 | |
| Female Effect: 0.142861174330451 | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg05826817 | |
| Position to Gene: gene | |
| Male Effect: -0.0908335842083204 | |
| Female Effect: - | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg10293293 | |
| Position to Gene: gene | |
| Male Effect: -0.12484375588965 | |
| Female Effect: - | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg12166502 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.129035895673598 | |
| Female Effect: - | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg16680922 | |
| Position to Gene: gene | |
| Male Effect: -0.119191064336017 | |
| Female Effect: - | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg04292836 | |
| Position to Gene: gene | |
| Male Effect: -0.122623345193155 | |
| Female Effect: - | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg17396400 | |
| Position to Gene: gene | |
| Male Effect: -0.134339516271395 | |
| Female Effect: - | |
 | Gene ID: ENSG00000123130 |
| CpG Site: cg05826817 | |
| Position to Gene: gene | |
| Male Effect: -0.0467635239967342 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05826817 | chrX:23742343 | gene | -0.0908335842083204 | 7.46760804974937e-05 | -0.3318293792789969 | 3.939435535846685e-07 | LUAD |
| cg10293293 | chrX:23742988 | gene | -0.12484375588965 | 3.57036185080996e-33 | -0.6646477819113515 | 1.5559866524025747e-35 | LGG |
| cg12166502 | chrX:23743214 | gene,exon,UTR | -0.129035895673598 | 8.1364772210699e-16 | -0.48645892503460836 | 1.420157973341752e-18 | LGG |
| cg16680922 | chrX:23743375 | gene | -0.119191064336017 | 1.88890853094369e-09 | -0.38409669371855426 | 1.3561954745961181e-11 | LGG |
| cg04292836 | chrX:23743367 | gene | -0.122623345193155 | 3.09304369785412e-09 | -0.3809047700802695 | 2.232629883537241e-11 | LGG |
| cg17396400 | chrX:23743342 | gene | -0.134339516271395 | 1.73722885879671e-06 | -0.32108954607155354 | 2.4945645862035608e-08 | LGG |
| cg05826817 | chrX:23742343 | gene | -0.0467635239967342 | 1.01980145359847e-06 | -0.32947979017103535 | 3.725763792566647e-09 | BLCA |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
| cg04292836 | chrX:23743367 | CGI:chrX:23742953-23743493 | gene | -0.312320883391462 | 0.0221553271740542 | 0.142861174330451 | 0.0223350374551953 | -0.3318875527680393 | 0.0008422548574731562 | 0.4315152313477121 | 6.43282886334622e-05 | - | PAAD |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ACOT9 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000123130 | ACOT9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
