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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000122966

Summary for CIT

check button Gene summary

Gene informationEnsembl ID

ENSG00000122966

Gene symbol

CIT

Gene namecitron rho-interacting serine/threonine kinase
HGNC

1985

Entrez ID

11113

Gene typeprotein_coding
SynonymsCIT|KIAA0949|STK21|CRIK|CITK
UniProtAcc

O14578


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000122966CITDB12010FostamatinibSmallMoleculeDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for CIT

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
CIT1.95e+031.08e+001.62e-016.68e+002.45e-111.78e-10HNSC
CIT2.06e+031.22e+001.62e-017.54e+004.58e-141.39e-12STAD
CIT4.99e+021.82e+005.19e-013.51e+004.42e-041.65e-03CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
CIT6.16e+031.04e+002.67e-013.88e+001.04e-042.68e-04KIRC
CIT4.86e+031.13e+003.25e-013.48e+004.92e-041.15e-03KICH
CIT1.35e+031.96e+008.73e-022.24e+013.45e-1111.72e-109BRCA

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Sex-biased somatic mutation for CIT

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for CIT

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
GBMcg15886307chr12:119877865CGI:chr12:119877043-119877365promoter3.13e-014.79e-013.08e+002.05e-037.47e-03-1.66e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LIHCcg15886307chr12:119877865CGI:chr12:119877043-119877365promoter6.59e-015.54e-012.65e+008.10e-031.01e-021.05e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for CIT

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for CIT

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for CIT

check buttonTFs related to CIT.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
LAMLLHX2CIT4.69e+009.82e-013.81e+001.13e-02Male-biased
LAMLNKX3-1CIT4.17e+009.80e-013.10e+005.27e-03Male-biased
SARCBPTFCIT4.16e+009.81e-013.52e+005.97e-03Male-biased
SARCGSX1CIT4.66e+009.81e-014.14e+001.35e-02Male-biased

check buttonCIT related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for CIT

check buttonRBPs related to ES in CIT.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
LUADHNRNPA1L2exon_skip_971961.28e+019.91e-011.25e+018.64e-03Male-biased
LGGESRP2exon_skip_972036.37e+002.29e-036.85e+009.83e-01Female-biased

check buttonCIT related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000122966Z95331.1,hsa-mir-142,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AL031716.1,hsa-mir-142,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966ALMS1-IT1,hsa-mir-142,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966OPA1-AS1,hsa-mir-154,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC092683.1,hsa-mir-154,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966DLEU2L,hsa-mir-154,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC106037.2,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966Z95331.1,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AL022322.2,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966LINC01409,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966SLX1A-SULT1A3,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC002310.2,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC004943.2,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AP000265.1,hsa-mir-20b,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966BDNF-AS,hsa-mir-653,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966LINC01409,hsa-mir-653,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC138393.3,hsa-mir-653,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC092535.2,hsa-mir-653,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC010478.1,hsa-mir-653,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC109460.3,hsa-mir-653,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC020658.3,hsa-mir-873,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AL022322.2,hsa-mir-873,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966PCBP1-AS1,hsa-mir-873,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966Z97832.2,hsa-mir-873,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966C9orf163,hsa-mir-873,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC012313.3,hsa-mir-873,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC106037.2,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966Z95331.1,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966LINC01409,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AL022322.2,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC087854.1,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966SLX1A-SULT1A3,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC002310.2,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AC004943.2,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966AP000265.1,hsa-mir-93,CITMale-specific ceRNATCGA-HNSC
ENSG00000122966OLMALINC,hsa-mir-20b,CITMale-specific ceRNATCGA-THCA

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10846567chr12:123875570:G:T--0.0538725683171090.0115537237662935LUADFemale-baised eQTL
rs1317312chr12:123879584:G:C--0.05328623831652720.0133771643846403LUADFemale-baised eQTL
rs10734909chr12:123866485:T:C--0.05235969691167730.0173652207664855LUADFemale-baised eQTL
rs10773045chr12:123867119:A:G--0.05235478876061480.0173838571634397LUADFemale-baised eQTL
rs7300037chr12:123882530:T:C--0.05166257942961890.018804770491146LUADFemale-baised eQTL
rs7297429chr12:123883031:A:C--0.05166257942961890.018804770491146LUADFemale-baised eQTL
rs10773043chr12:123866157:T:C--0.05210005441753470.0195125898753901LUADFemale-baised eQTL
rs1882489chr12:123879894:T:A--0.05050158553021650.0227228242036423LUADFemale-baised eQTL
rs11057378chr12:123866286:C:T--0.05121206473763090.0229691929802207LUADFemale-baised eQTL
rs10773044chr12:123867118:G:A--0.05133268201149560.0233354436912151LUADFemale-baised eQTL
rs9669530chr12:123885264:C:A--0.05073258591161290.023336162125686LUADFemale-baised eQTL
rs11057383chr12:123884874:T:C--0.05002376283128680.0236596539989927LUADFemale-baised eQTL
rs10846566chr12:123868823:G:A--0.0507107860181590.0248076661980069LUADFemale-baised eQTL
rs11057382chr12:123878342:C:T--0.05015565144435540.0260381668762055LUADFemale-baised eQTL
rs12228611chr12:123877514:C:T--0.04994536948159610.0280274380925702LUADFemale-baised eQTL
rs11057379chr12:123871110:G:A--0.04973028829386990.028248041767129LUADFemale-baised eQTL
rs117806800chr12:125308186:A:G-0.09966343328427890.0306495539784604LUADFemale-baised eQTL
rs12425883chr12:125305453:G:C-0.09257706399735530.042020366122134LUADFemale-baised eQTL
rs73233351chr12:125305637:G:A-0.09257706399735530.042020366122134LUADFemale-baised eQTL
rs7975979chr12:123866402:A:C--0.04834633092695320.0426023686821633LUADFemale-baised eQTL
rs73233352chr12:125305639:T:C-0.09238835458836150.0426039789093343LUADFemale-baised eQTL
rs4930727chr12:123864396:T:C--0.04906902132416060.0431917064733222LUADFemale-baised eQTL
rs7314963chr12:123865897:C:T--0.04833656165622110.0434187435318836LUADFemale-baised eQTL
rs1922258chr12:123869110:T:C--0.04770260254265320.0466735086162587LUADFemale-baised eQTL
rs11057381chr12:123873310:G:C--0.04784515656586850.0470109723358618LUADFemale-baised eQTL
rs4767836chr12:119641748:G:A--0.06881652118437840.00111633805755349COADFemale-baised eQTL
rs2301655chr12:119640772:T:C--0.06661671315734390.00138723305157298COADFemale-baised eQTL
rs1123790chr12:119641317:G:C--0.06661671315734390.00138723305157298COADFemale-baised eQTL
rs4767835chr12:119640136:G:T--0.05167416448395690.0143879255796576COADFemale-baised eQTL
rs1406452chr12:118884532:A:T--0.04208150188404150.0227970522022191COADFemale-baised eQTL
rs4767733chr12:118885190:T:A--0.04208150188404150.0227970522022191COADFemale-baised eQTL
rs2698060chr12:118882929:G:A--0.0424416911153440.0263017638141054COADFemale-baised eQTL
rs2698061chr12:118883157:A:G--0.0424416911153440.0263017638141054COADFemale-baised eQTL
rs2730432chr12:118883242:C:A--0.0424416911153440.0263017638141054COADFemale-baised eQTL
rs2730434chr12:118881949:T:A--0.04204500380465860.0315590541626256COADFemale-baised eQTL
rs7316295chr12:119619615:T:C--0.04745949552898690.0327952969626189COADFemale-baised eQTL
rs1406451chr12:118880153:A:C--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs2698070chr12:118880216:G:A--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs4303287chr12:118880659:G:T--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs2730436chr12:118880872:T:C--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs2178280chr12:118881190:G:A--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs2178281chr12:118881459:C:G--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs2698055chr12:118881541:G:A--0.04156538700292640.0328845627586132COADFemale-baised eQTL
rs2253853chr12:118879859:T:A--0.04119046317488190.0334335315413701COADFemale-baised eQTL
rs11064843chr12:119612949:T:G--0.04739890576858390.0336885288475078COADFemale-baised eQTL
rs10774504chr12:119599856:G:C--0.04852755452477720.0362878403988671COADFemale-baised eQTL
rs56030803chr12:128701565:A:G-0.07544172933218330.0403335355807806COADFemale-baised eQTL
rs7302992chr12:128702884:G:T-0.07544172933218330.0403335355807806COADFemale-baised eQTL
rs10849674chr12:119597300:G:A--0.04737520753707730.0423758572625604COADFemale-baised eQTL
rs12579854chr12:119602130:G:A--0.04737520753707730.0423758572625604COADFemale-baised eQTL
rs7954674chr12:119602462:T:G--0.04737520753707730.0423758572625604COADFemale-baised eQTL
rs7295362chr12:119601897:G:C--0.04710713034346070.0452897519845116COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10850802chr12:117229072:C:T-0.06466423070489050.0123363131320055BLCAMale-baised eQTL
rs2293045chr12:117224805:C:G-0.06437771046725060.0133042985002005BLCAMale-baised eQTL
rs9658490chr12:117232493:C:G-0.0627325963356360.0156854068369779BLCAMale-baised eQTL
rs11057722chr12:124640528:G:A-0.05377704152131260.0266203937815988BLCAMale-baised eQTL
rs61939097chr12:128074970:G:A-0.08991854656780550.0427039477746507LUADMale-baised eQTL
rs73144750chr12:128075058:T:C-0.08991854656780550.0427039477746507LUADMale-baised eQTL
rs112728070chr12:125589413:C:T-0.182348150101450.00545622406932481COADMale-baised eQTL
rs60311188chr12:125588247:A:T-0.1481270173376230.00814897620805559COADMale-baised eQTL
rs16919232chr12:125585265:C:G-0.1382922161538760.0114914017666243COADMale-baised eQTL
rs61944572chr12:124871925:A:G-0.1612565909773790.0267340764509988COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000122966
CpG Site: cg00009001
Position to Gene: gene
Male Effect: -0.275411012900647
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg00009001chr12:119714085gene-0.2754110129006477.06659968998226e-06-0.33127973405029192.7666380840845633e-08LUSC

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of CIT

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000122966CITC4310723MICROCEPHALY 17, PRIMARY, AUTOSOMAL RECESSIVE1CTD_human