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Gene: ENSG00000120438 |
Summary for TCP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000120438 | Gene symbol | TCP1 |
| Gene name | t-complex 1 | |
| HGNC | 11655 | |
| Entrez ID | 6950 | |
| Gene type | protein_coding | |
| Synonyms | TCP1|D6S230E|CCT1|Ccta | |
| UniProtAcc | P17987 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TCP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for TCP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TCP1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for TCP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TCP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | TCP1-005 | chr6_159783440_- | 4.21e-01 | 2.33e-01 | 2.43e+00 | 1.50e-02 | 4.96e-02 | 1.88e-01 |
| ESCA | TCP1-005 | chr6_159783440_- | 4.55e-01 | 2.12e-01 | 2.81e+00 | 4.99e-03 | 4.99e-02 | 2.43e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TCP1 |
| TFs related to TCP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PRDM6 | TCP1 | 4.21e+00 | 9.85e-01 | 2.50e+00 | 2.33e-03 | Male-biased |
| BRCA | ZNF182 | TCP1 | 4.27e+00 | 9.85e-01 | 2.73e+00 | 3.91e-03 | Male-biased |
| BRCA | ZNF22 | TCP1 | 4.30e+00 | 9.86e-01 | 2.71e+00 | 3.39e-03 | Male-biased |
| BRCA | ZNF225 | TCP1 | 4.15e+00 | 9.82e-01 | 2.66e+00 | 4.59e-03 | Male-biased |
| BRCA | ZNF235 | TCP1 | 4.54e+00 | 9.91e-01 | 2.76e+00 | 1.89e-03 | Male-biased |
| BRCA | ZNF287 | TCP1 | 4.39e+00 | 9.89e-01 | 2.69e+00 | 2.47e-03 | Male-biased |
| BRCA | ZNF418 | TCP1 | 4.25e+00 | 9.84e-01 | 2.75e+00 | 4.30e-03 | Male-biased |
| BRCA | ZNF487 | TCP1 | 4.30e+00 | 9.87e-01 | 2.58e+00 | 2.28e-03 | Male-biased |
| BRCA | ZNF613 | TCP1 | 4.10e+00 | 9.81e-01 | 2.64e+00 | 4.78e-03 | Male-biased |
| BRCA | ZNF98 | TCP1 | 4.06e+00 | 9.80e-01 | 2.54e+00 | 3.98e-03 | Male-biased |
| DLBC | ZNF418 | TCP1 | 3.28e+00 | 8.96e-03 | 4.20e+00 | 9.80e-01 | Female-biased |
| LAML | ZNF418 | TCP1 | 4.03e+00 | 9.81e-01 | 2.48e+00 | 8.04e-04 | Male-biased |
| TCP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TCP1 |
| RBPs related to ES in TCP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ANKHD1 | exon_skip_463187 | 1.48e+01 | 9.98e-01 | 1.41e+01 | 2.11e-03 | Male-biased |
| ACC | ANKHD1 | exon_skip_463192 | 1.48e+01 | 9.97e-01 | 1.42e+01 | 3.17e-03 | Male-biased |
| ACC | QKI | exon_skip_463216 | 1.54e+01 | 9.99e-01 | 1.46e+01 | 1.21e-03 | Male-biased |
| UVM | QKI | exon_skip_463216 | 1.52e+01 | 1.71e-04 | 1.59e+01 | 1.00e+00 | Female-biased |
| THYM | ANKHD1 | exon_skip_463187 | 1.46e+01 | 1.00e+00 | 1.39e+01 | 1.74e-04 | Male-biased |
| LIHC | FMR1 | exon_skip_463195 | 8.29e+00 | 1.13e-02 | 8.67e+00 | 9.83e-01 | Female-biased |
| KIRP | FMR1 | exon_skip_463195 | 8.21e+00 | 2.65e-03 | 8.65e+00 | 9.91e-01 | Female-biased |
| BRCA | ANKHD1 | exon_skip_463192 | 1.39e+01 | 9.84e-01 | 1.34e+01 | 1.55e-02 | Male-biased |
| BRCA | QKI | exon_skip_463216 | 1.51e+01 | 9.94e-01 | 1.44e+01 | 5.97e-03 | Male-biased |
| ESCA | QKI | exon_skip_463216 | 1.47e+01 | 1.14e-02 | 1.51e+01 | 9.89e-01 | Female-biased |
| READ | PABPC5 | exon_skip_463211 | 9.43e+00 | 9.95e-01 | 8.97e+00 | 2.41e-03 | Male-biased |
| READ | QKI | exon_skip_463216 | 1.50e+01 | 9.98e-01 | 1.46e+01 | 2.39e-03 | Male-biased |
| THCA | QKI | exon_skip_463216 | 1.53e+01 | 9.99e-01 | 1.48e+01 | 9.14e-04 | Male-biased |
| MESO | ANKHD1 | exon_skip_463192 | 1.28e+01 | 1.02e-03 | 1.34e+01 | 9.99e-01 | Female-biased |
| PAAD | ANKHD1 | exon_skip_463192 | 1.37e+01 | 1.00e+00 | 1.30e+01 | 1.69e-04 | Male-biased |
| PAAD | QKI | exon_skip_463216 | 1.51e+01 | 1.67e-04 | 1.58e+01 | 1.00e+00 | Female-biased |
| KIRC | QKI | exon_skip_463216 | 1.46e+01 | 1.02e-03 | 1.52e+01 | 9.99e-01 | Female-biased |
| KICH | QKI | exon_skip_463216 | 1.46e+01 | 3.56e-04 | 1.53e+01 | 1.00e+00 | Female-biased |
| BLCA | QKI | exon_skip_463216 | 1.53e+01 | 9.46e-04 | 1.59e+01 | 9.99e-01 | Female-biased |
| HNSC | QKI | exon_skip_463216 | 1.47e+01 | 4.54e-04 | 1.54e+01 | 1.00e+00 | Female-biased |
| SARC | QKI | exon_skip_463216 | 1.57e+01 | 9.99e-01 | 1.51e+01 | 7.57e-04 | Male-biased |
| TCP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9459455 | chr6:165575543:T:C | - | -0.237133072671517 | 0.0156781148313706 | READ | Female-baised eQTL |
| rs2987292 | chr6:165580147:T:C | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs1547681 | chr6:165582715:C:G | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs1410482 | chr6:165582953:C:T | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs1576185 | chr6:165585477:C:T | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs7740364 | chr6:165586407:C:T | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs2987294 | chr6:165586533:T:C | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs3008053 | chr6:165587751:C:T | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs1328377 | chr6:165587828:G:C | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs1328378 | chr6:165587958:T:C | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs3008062 | chr6:165589280:C:T | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs2987295 | chr6:165589909:A:T | - | -0.215001417630401 | 0.0171429914786153 | READ | Female-baised eQTL |
| rs1547682 | chr6:165582740:A:G | - | -0.217023333176357 | 0.0240083905397726 | READ | Female-baised eQTL |
| rs7771248 | chr6:165588621:A:G | - | -0.217023333176357 | 0.0240083905397726 | READ | Female-baised eQTL |
| rs1328376 | chr6:165587135:C:A | - | -0.203477519882622 | 0.029551059310709 | READ | Female-baised eQTL |
| rs479273 | chr6:165301517:G:A | - | 0.136377340353221 | 0.00283217494901306 | SARC | Female-baised eQTL |
| rs7766683 | chr6:169342155:A:G | - | -0.145011244145786 | 0.00111123883893752 | LGG | Female-baised eQTL |
| rs1902064 | chr6:156401256:C:T | - | 0.0642773040721236 | 0.0362718479213803 | LGG | Female-baised eQTL |
| rs1902065 | chr6:156401326:C:T | - | 0.0642773040721236 | 0.0362718479213803 | LGG | Female-baised eQTL |
| rs1157356 | chr6:156400084:C:T | - | 0.0626262325505063 | 0.0495043674209563 | LGG | Female-baised eQTL |
| rs9480273 | chr6:156168307:T:A | - | 0.0439843235701426 | 0.0244727468199532 | LUAD | Female-baised eQTL |
| rs1954949 | chr6:162343124:A:T | - | 0.0930160804869558 | 0.032077856302408 | LUAD | Female-baised eQTL |
| rs10457098 | chr6:156155964:T:C | - | 0.0655288959057157 | 0.0325624878756689 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4628111 | chr6:156227435:T:A | - | 0.0821974678239386 | 0.0357641011584671 | LIHC | Male-baised eQTL |
| rs62427493 | chr6:155690993:C:T | - | 0.122349329356925 | 0.0267907737200561 | STAD | Male-baised eQTL |
| rs7738381 | chr6:164235019:A:C | - | -0.0745660884108927 | 0.0432145881430089 | BLCA | Male-baised eQTL |
| rs7771463 | chr6:162238240:G:C | - | 0.0819074584120654 | 0.0306315897087451 | COAD | Male-baised eQTL |
| rs12175150 | chr6:162240413:G:C | - | 0.080849421429348 | 0.036622174205031 | COAD | Male-baised eQTL |
| rs12529991 | chr6:154339605:T:C | - | 0.0842375626432288 | 0.036895201280373 | COAD | Male-baised eQTL |
| rs6455649 | chr6:159490548:G:A | - | -0.102265430985469 | 0.0434900777004729 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000120438 |
| CpG Site: cg24280851 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.437057429335361 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg24280851 | chr6:159780955 | gene,exon,CDS | -0.437057429335361 | 1.01841722001927e-19 | -0.5385037625452541 | 5.556826494236225e-23 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TCP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000120438 | TCP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000120438 | TCP1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
