|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000120328 |
Summary for PCDHB12 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000120328 | Gene symbol | PCDHB12 |
| Gene name | protocadherin beta 12 | |
| HGNC | 8683 | |
| Entrez ID | 56124 | |
| Gene type | protein_coding | |
| Synonyms | PCDHB12|PCDH-BETA12 | |
| UniProtAcc | Q9Y5F1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PCDHB12 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for PCDHB12 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PCDHB12 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg04646173 | chr5:141207216 | CGI:chr5:141210172-141211085 | promoter | 6.93e-01 | 5.46e-01 | 5.83e+00 | 5.53e-09 | 9.40e-08 | 1.48e-01 |
| ESCA | cg15548198 | chr5:141208567 | CGI:chr5:141210172-141211085 | promoter | 4.63e-01 | 5.81e-01 | 1.99e+00 | 4.67e-02 | 4.92e-02 | -1.18e-01 |
| UVM | cg15548198 | chr5:141208567 | CGI:chr5:141210172-141211085 | promoter | 4.83e-01 | 6.76e-01 | 2.56e+00 | 1.06e-02 | 2.26e-02 | -1.93e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg07899016 | chr5:141208727 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 5.20e-01 | 3.93e-01 | 3.74e+00 | 1.86e-04 | 3.52e-04 | 1.27e-01 |
| HNSC | cg17047981 | chr5:141208649 | CGI:chr5:141210172-141211085 | promoter | 2.01e-01 | 6.02e-02 | 3.17e+00 | 1.52e-03 | 2.58e-03 | 1.41e-01 |
| HNSC | cg17007628 | chr5:141208852 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 7.51e-01 | 6.48e-01 | 2.92e+00 | 3.53e-03 | 5.29e-03 | 1.03e-01 |
| LUSC | cg17047981 | chr5:141208649 | CGI:chr5:141210172-141211085 | promoter | 1.54e-01 | 3.66e-02 | 2.63e+00 | 8.46e-03 | 1.22e-02 | 1.18e-01 |
| LUSC | cg15548198 | chr5:141208567 | CGI:chr5:141210172-141211085 | promoter | 5.91e-01 | 4.46e-01 | 3.35e+00 | 7.97e-04 | 2.24e-03 | 1.45e-01 |
| LUSC | cg07899016 | chr5:141208727 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 5.30e-01 | 4.00e-01 | 2.45e+00 | 1.43e-02 | 1.83e-02 | 1.31e-01 |
| LUSC | cg17007628 | chr5:141208852 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 7.54e-01 | 6.52e-01 | 2.26e+00 | 2.41e-02 | 2.76e-02 | 1.02e-01 |
| COAD | cg07899016 | chr5:141208727 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 6.43e-01 | 5.38e-01 | 2.82e+00 | 4.83e-03 | 8.03e-03 | 1.05e-01 |
| LIHC | cg04646173 | chr5:141207216 | CGI:chr5:141210172-141211085 | promoter | 5.46e-01 | 7.41e-01 | -3.52e+00 | 4.25e-04 | 7.42e-04 | -1.95e-01 |
| LIHC | cg15548198 | chr5:141208567 | CGI:chr5:141210172-141211085 | promoter | 2.41e-01 | 4.15e-01 | 2.65e+00 | 8.10e-03 | 1.01e-02 | -1.74e-01 |
| LIHC | cg07899016 | chr5:141208727 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 2.84e-01 | 4.04e-01 | -4.88e+00 | 1.08e-06 | 3.96e-06 | -1.19e-01 |
| LIHC | cg19727817 | chr5:141208809 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 3.53e-01 | 4.54e-01 | -4.12e+00 | 3.72e-05 | 8.64e-05 | -1.00e-01 |
| LIHC | cg17007628 | chr5:141208852 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 4.66e-01 | 6.05e-01 | -2.23e+00 | 2.55e-02 | 2.78e-02 | -1.38e-01 |
| ESCA | cg15548198 | chr5:141208567 | CGI:chr5:141210172-141211085 | promoter | 5.81e-01 | 3.34e-01 | 2.26e+00 | 2.36e-02 | 4.17e-02 | 2.47e-01 |
| CHOL | cg07899016 | chr5:141208727 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 5.55e-01 | 4.22e-01 | 2.14e+00 | 3.25e-02 | 3.87e-02 | 1.33e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg17007628 | chr5:141208852 | CGI:chr5:141210172-141211085 | UTR,promoter,exon,gene body | 7.12e-01 | 5.95e-01 | 2.50e+00 | 1.24e-02 | 1.84e-02 | 1.17e-01 |
Top |
Exon skipping events with PSI in TCGA for PCDHB12 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PCDHB12 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PCDHB12 |
| TFs related to PCDHB12. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF418 | PCDHB12 | 6.05e+00 | 9.81e-01 | 5.38e+00 | 1.84e-02 | Male-biased |
| CHOL | FOXG1 | PCDHB12 | 5.75e+00 | 1.06e-03 | 7.24e+00 | 9.99e-01 | Female-biased |
| CHOL | SOX13 | PCDHB12 | 6.58e+00 | 1.69e-02 | 7.38e+00 | 9.83e-01 | Female-biased |
| CHOL | SOX14 | PCDHB12 | 6.93e+00 | 7.53e-03 | 7.94e+00 | 9.92e-01 | Female-biased |
| CHOL | SOX17 | PCDHB12 | 6.61e+00 | 8.67e-03 | 7.59e+00 | 9.91e-01 | Female-biased |
| CHOL | SOX6 | PCDHB12 | 6.74e+00 | 9.51e-03 | 7.69e+00 | 9.90e-01 | Female-biased |
| CHOL | TEAD4 | PCDHB12 | 5.51e+00 | 1.07e-02 | 6.43e+00 | 9.89e-01 | Female-biased |
| CHOL | ZNF175 | PCDHB12 | 5.99e+00 | 2.81e-03 | 7.25e+00 | 9.97e-01 | Female-biased |
| CHOL | ZNF25 | PCDHB12 | 5.46e+00 | 2.19e-04 | 7.29e+00 | 1.00e+00 | Female-biased |
| CHOL | ZNF354A | PCDHB12 | 6.83e+00 | 5.19e-03 | 7.93e+00 | 9.95e-01 | Female-biased |
| CHOL | ZNF418 | PCDHB12 | 4.62e+00 | 4.78e-05 | 6.74e+00 | 1.00e+00 | Female-biased |
| GBM | ZNF16 | PCDHB12 | 6.23e+00 | 9.88e-01 | 5.16e+00 | 1.13e-02 | Male-biased |
| GBM | ZNF2 | PCDHB12 | 6.65e+00 | 9.94e-01 | 5.35e+00 | 5.56e-03 | Male-biased |
| PCDHB12 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PCDHB12 |
| RBPs related to ES in PCDHB12. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PCDHB12 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PCDHB12 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
