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Gene: ENSG00000120324 |
Summary for PCDHB10 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000120324 | Gene symbol | PCDHB10 |
| Gene name | protocadherin beta 10 | |
| HGNC | 8681 | |
| Entrez ID | 56126 | |
| Gene type | protein_coding | |
| Synonyms | PCDHB10| | |
| UniProtAcc | Q9UN67 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PCDHB10 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PCDHB10 | 1.74e+02 | 1.16e+00 | 2.33e-01 | 4.97e+00 | 6.70e-07 | 2.43e-06 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for PCDHB10 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PCDHB10 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg25142947 | chr5:141186729 | CGI:chr5:141188643-141189545 | promoter | 7.56e-01 | 8.69e-01 | -2.56e+00 | 1.05e-02 | 2.61e-02 | -1.13e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg18865832 | chr5:141186902 | CGI:chr5:141188643-141189545 | promoter | 8.68e-01 | 7.62e-01 | 2.80e+00 | 5.09e-03 | 1.63e-02 | 1.07e-01 |
| CHOL | cg25360147 | chr5:141187090 | CGI:chr5:141188643-141189545 | promoter | 2.07e-01 | 6.52e-02 | 2.43e+00 | 1.50e-02 | 2.65e-02 | 1.42e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for PCDHB10 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PCDHB10 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PCDHB10 |
| TFs related to PCDHB10. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | FOXC2 | PCDHB10 | 5.32e+00 | 9.86e-01 | 4.57e+00 | 1.24e-02 | Male-biased |
| ACC | FOXD2 | PCDHB10 | 6.48e+00 | 9.87e-01 | 5.73e+00 | 1.25e-02 | Male-biased |
| ACC | FOXG1 | PCDHB10 | 5.93e+00 | 9.89e-01 | 5.13e+00 | 1.01e-02 | Male-biased |
| BRCA | ZNF235 | PCDHB10 | 4.68e+00 | 1.53e-02 | 5.77e+00 | 9.83e-01 | Female-biased |
| CHOL | FOXD2 | PCDHB10 | 6.10e+00 | 1.76e-02 | 6.89e+00 | 9.82e-01 | Female-biased |
| CHOL | FOXG1 | PCDHB10 | 5.59e+00 | 1.50e-02 | 6.42e+00 | 9.84e-01 | Female-biased |
| ESCA | ZNF235 | PCDHB10 | 3.37e+00 | 1.91e-03 | 4.53e+00 | 9.93e-01 | Female-biased |
| ESCA | ZNF287 | PCDHB10 | 3.51e+00 | 3.60e-03 | 4.53e+00 | 9.92e-01 | Female-biased |
| GBM | CTCFL | PCDHB10 | 6.16e+00 | 9.98e-01 | 4.33e+00 | 1.05e-03 | Male-biased |
| GBM | ZBTB17 | PCDHB10 | 4.77e+00 | 9.95e-01 | 2.95e+00 | 9.67e-04 | Male-biased |
| GBM | ZNF2 | PCDHB10 | 6.64e+00 | 9.93e-01 | 5.40e+00 | 6.59e-03 | Male-biased |
| GBM | ZNF341 | PCDHB10 | 5.09e+00 | 9.96e-01 | 3.37e+00 | 1.41e-03 | Male-biased |
| GBM | ZNF674 | PCDHB10 | 6.56e+00 | 9.96e-01 | 5.07e+00 | 3.17e-03 | Male-biased |
| GBM | ZNF823 | PCDHB10 | 5.64e+00 | 9.92e-01 | 4.41e+00 | 6.91e-03 | Male-biased |
| PAAD | CTCFL | PCDHB10 | 3.56e+00 | 5.57e-03 | 4.49e+00 | 9.88e-01 | Female-biased |
| PAAD | ZBTB17 | PCDHB10 | 3.60e+00 | 8.04e-03 | 4.45e+00 | 9.85e-01 | Female-biased |
| PAAD | ZNF341 | PCDHB10 | 3.73e+00 | 1.29e-02 | 4.48e+00 | 9.81e-01 | Female-biased |
| SARC | CTCFL | PCDHB10 | 4.77e+00 | 9.92e-01 | 4.01e+00 | 3.03e-03 | Male-biased |
| SARC | FOXC2 | PCDHB10 | 5.52e+00 | 1.06e-02 | 6.16e+00 | 9.89e-01 | Female-biased |
| SARC | FOXD2 | PCDHB10 | 6.57e+00 | 1.63e-02 | 7.13e+00 | 9.83e-01 | Female-biased |
| SARC | FOXG1 | PCDHB10 | 6.17e+00 | 1.12e-02 | 6.80e+00 | 9.88e-01 | Female-biased |
| SARC | ZNF2 | PCDHB10 | 5.93e+00 | 9.97e-01 | 5.10e+00 | 2.05e-03 | Male-biased |
| SARC | ZNF235 | PCDHB10 | 3.95e+00 | 1.09e-03 | 5.00e+00 | 9.96e-01 | Female-biased |
| SARC | ZNF287 | PCDHB10 | 4.05e+00 | 1.92e-03 | 5.00e+00 | 9.95e-01 | Female-biased |
| SARC | ZNF492 | PCDHB10 | 4.73e+00 | 3.97e-03 | 5.54e+00 | 9.95e-01 | Female-biased |
| SARC | ZNF570 | PCDHB10 | 5.61e+00 | 3.96e-03 | 6.43e+00 | 9.96e-01 | Female-biased |
| SARC | ZNF674 | PCDHB10 | 5.41e+00 | 9.95e-01 | 4.66e+00 | 3.18e-03 | Male-biased |
| UVM | ZNF570 | PCDHB10 | 5.87e+00 | 9.83e-01 | 4.76e+00 | 1.53e-02 | Male-biased |
| PCDHB10 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PCDHB10 |
| RBPs related to ES in PCDHB10. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PCDHB10 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1004234 | chr5:132421409:A:G | - | -0.21271796855267 | 0.0221752948540031 | GBM | Female-baised eQTL |
| rs11737987 | chr5:141456942:A:C | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs10072917 | chr5:141457168:C:T | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs4551132 | chr5:141458340:G:C | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs61275874 | chr5:141459095:G:A | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs7446907 | chr5:141459909:G:A | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs10051366 | chr5:141460128:T:C | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs10058360 | chr5:141460614:G:A | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs12186717 | chr5:141461456:T:C | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs7717600 | chr5:141462253:A:C | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs6888081 | chr5:141463726:A:G | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs58523023 | chr5:141463797:T:C | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs62379197 | chr5:141464138:G:A | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs11167751 | chr5:141464816:G:A | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs7704812 | chr5:141465922:T:A | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs10054619 | chr5:141466035:C:T | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs6870144 | chr5:141467285:T:G | - | 0.17208776028099 | 0.0468545444198459 | GBM | Female-baised eQTL |
| rs7727021 | chr5:141434785:T:A | - | 0.172776910332779 | 0.0492419979556685 | GBM | Female-baised eQTL |
| rs7703679 | chr5:141434830:C:A | - | 0.172776910332779 | 0.0492419979556685 | GBM | Female-baised eQTL |
| rs10035418 | chr5:141437664:A:G | - | 0.172776910332779 | 0.0492419979556685 | GBM | Female-baised eQTL |
| rs1059029 | chr5:141443156:A:G | - | 0.172776910332779 | 0.0492419979556685 | GBM | Female-baised eQTL |
| rs7713034 | chr5:141449848:T:C | - | 0.172776910332779 | 0.0492419979556685 | GBM | Female-baised eQTL |
| rs10491398 | chr5:142490368:G:A | - | 0.442955400502893 | 0.0359943008644373 | KIRP | Female-baised eQTL |
| rs35704701 | chr5:135275933:C:T | - | 0.133465942303695 | 0.0162092569675757 | LUSC | Female-baised eQTL |
| rs10515469 | chr5:135276382:G:A | - | 0.129427540417077 | 0.0221147328657763 | LUSC | Female-baised eQTL |
| rs3852206 | chr5:132079743:G:A | - | 0.061380494450393 | 0.0187960429599107 | LGG | Female-baised eQTL |
| rs743564 | chr5:132075186:T:C | - | 0.0604696282677516 | 0.0245685287261875 | LGG | Female-baised eQTL |
| rs17516457 | chr5:132254694:T:C | - | 0.057320158114181 | 0.0387324182296601 | LGG | Female-baised eQTL |
| rs55722650 | chr5:132271607:C:T | - | 0.057526142440957 | 0.0461207845755395 | LGG | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11742478 | chr5:135887151:C:A | - | 0.0745672469635713 | 0.0104994832070707 | LUSC | Male-baised eQTL |
| rs67442593 | chr5:135888704:C:T | - | 0.0745672469635713 | 0.0104994832070707 | LUSC | Male-baised eQTL |
| rs68185054 | chr5:135888770:T:C | - | 0.0745672469635713 | 0.0104994832070707 | LUSC | Male-baised eQTL |
| rs60646393 | chr5:135889066:G:A | - | 0.0724056793236284 | 0.0156236240258896 | LUSC | Male-baised eQTL |
| rs58183315 | chr5:135889076:G:A | - | 0.0724056793236284 | 0.0156236240258896 | LUSC | Male-baised eQTL |
| rs72793109 | chr5:135901424:C:T | - | 0.072852316065422 | 0.0208718623558105 | LUSC | Male-baised eQTL |
| rs72793114 | chr5:135909886:G:C | - | 0.0745656676127859 | 0.0257523079665864 | LUSC | Male-baised eQTL |
| rs1799962 | chr5:135896167:T:C | - | 0.0724992508030355 | 0.0305249504525356 | LUSC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PCDHB10 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
