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Gene: ENSG00000119772 |
Summary for DNMT3A |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000119772 | Gene symbol | DNMT3A |
| Gene name | DNA methyltransferase 3 alpha | |
| HGNC | 2978 | |
| Entrez ID | 1788 | |
| Gene type | protein_coding | |
| Synonyms | DNMT3A| | |
| UniProtAcc | Q9Y6K1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000119772 | DNMT3A | DB00721 | Procaine | SmallMoleculeDrug |
| ENSG00000119772 | DNMT3A | DB01262 | Decitabine | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
| ENSG00000119772 | DNMT3A | DB01262 | Decitabine | SmallMoleculeDrug | Myeloproliferative Neoplasms |
Top |
Structure and expression level for DNMT3A |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DNMT3A | 1.46e+03 | 1.69e+00 | 2.71e-01 | 6.25e+00 | 4.16e-10 | 6.31e-09 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for DNMT3A |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for DNMT3A |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg22731525 | chr2:25343359 | CGI:chr2:25340440-25342735 | promoter | 7.96e-01 | 9.06e-01 | -2.82e+00 | 4.83e-03 | 7.92e-03 | -1.10e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for DNMT3A |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for DNMT3A |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for DNMT3A |
| TFs related to DNMT3A. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DNMT3A related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for DNMT3A |
| RBPs related to ES in DNMT3A. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | RBM4 | exon_skip_337451 | 8.17e+00 | 9.82e-01 | 7.86e+00 | 1.00e-02 | Male-biased |
| MESO | RBM4 | exon_skip_337451 | 8.04e+00 | 4.65e-03 | 8.46e+00 | 9.89e-01 | Female-biased |
| DNMT3A related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2732942 | chr2:17962064:C:T | - | -0.298892771829636 | 0.0262560533220682 | HNSC | Female-baised eQTL |
| rs869633 | chr2:28495382:C:T | - | 0.0414673866286486 | 0.0203226271196322 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs340747 | chr2:16271447:A:C | - | 0.0499129273908761 | 0.0446788094970047 | BLCA | Male-baised eQTL |
| rs73223882 | chr2:20107119:C:A | - | 0.118820831222453 | 0.0125252752319888 | LUAD | Male-baised eQTL |
| rs4359599 | chr2:29736624:T:G | - | 0.10264732882616 | 0.0214337525443988 | LUAD | Male-baised eQTL |
| rs9309676 | chr2:29935319:T:C | - | 0.0566207774955627 | 0.0295108282937824 | LUAD | Male-baised eQTL |
| rs13013527 | chr2:29947137:A:G | - | -0.0558740278491913 | 0.0349276792351855 | LUAD | Male-baised eQTL |
| rs6734559 | chr2:29931609:G:T | - | 0.0552122753199932 | 0.0356516825247956 | LUAD | Male-baised eQTL |
| rs11127245 | chr2:29931710:T:C | - | 0.0552122753199932 | 0.0356516825247956 | LUAD | Male-baised eQTL |
| rs11897176 | chr2:29931982:T:C | - | 0.0552122753199932 | 0.0356516825247956 | LUAD | Male-baised eQTL |
| rs4077892 | chr2:29929319:C:T | - | 0.0558873732110577 | 0.0362870082355932 | LUAD | Male-baised eQTL |
| rs4233755 | chr2:29930166:G:A | - | 0.0553262788811781 | 0.0376116784917487 | LUAD | Male-baised eQTL |
| rs4274563 | chr2:29934520:C:T | - | 0.0549256756230937 | 0.0377065207512281 | LUAD | Male-baised eQTL |
| rs10204083 | chr2:29934617:T:C | - | 0.0549256756230937 | 0.0377065207512281 | LUAD | Male-baised eQTL |
| rs10204274 | chr2:29934826:T:C | - | 0.0549256756230937 | 0.0377065207512281 | LUAD | Male-baised eQTL |
| rs11127246 | chr2:29931944:C:T | - | 0.0549390126968471 | 0.0378738744464373 | LUAD | Male-baised eQTL |
| rs11127247 | chr2:29932027:C:T | - | 0.0549390126968471 | 0.0378738744464373 | LUAD | Male-baised eQTL |
| rs4377297 | chr2:29932185:A:G | - | 0.0549390126968471 | 0.0378738744464373 | LUAD | Male-baised eQTL |
| rs4494695 | chr2:29736551:T:G | - | 0.0968400955411692 | 0.0384019224001846 | LUAD | Male-baised eQTL |
| rs6729092 | chr2:29932956:T:A | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs6738960 | chr2:29932966:G:A | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs10469979 | chr2:29933223:G:A | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs10469980 | chr2:29933289:C:T | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs10469981 | chr2:29933437:A:G | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs72857559 | chr2:29933779:T:C | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs9309675 | chr2:29934081:C:T | - | 0.0548582668984202 | 0.0384323258241177 | LUAD | Male-baised eQTL |
| rs4600601 | chr2:29928887:T:C | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs4564737 | chr2:29928915:G:A | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs7581099 | chr2:29928945:A:G | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs4332879 | chr2:29929112:C:T | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs4077891 | chr2:29929660:T:C | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs4233754 | chr2:29930087:T:C | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs4077502 | chr2:29930183:A:C | - | 0.0550336341835056 | 0.0398423816527025 | LUAD | Male-baised eQTL |
| rs4274562 | chr2:29934251:C:G | - | 0.054653595634808 | 0.0399881528526687 | LUAD | Male-baised eQTL |
| rs10201571 | chr2:34703013:C:T | - | 0.0580507950677194 | 0.0417528463386545 | LUAD | Male-baised eQTL |
| rs6547983 | chr2:29928751:G:A | - | 0.0543163927315996 | 0.0441102177630063 | LUAD | Male-baised eQTL |
| rs7606164 | chr2:18314685:C:G | - | 0.0609069830736063 | 0.0281528413322829 | COAD | Male-baised eQTL |
| rs6714554 | chr2:17827621:G:A | - | -0.0545292457236487 | 0.0422861897524209 | COAD | Male-baised eQTL |
| rs868933 | chr2:20171165:G:T | - | -0.0649126368658987 | 0.0436072453044734 | COAD | Male-baised eQTL |
| rs7596153 | chr2:17828224:C:T | - | -0.0549640358227834 | 0.0436250969908318 | COAD | Male-baised eQTL |
| rs7559828 | chr2:17828408:T:C | - | -0.0549640358227834 | 0.0436250969908318 | COAD | Male-baised eQTL |
| rs1516919 | chr2:18316182:C:A | - | 0.060232757171079 | 0.0491990213809251 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000119772 |
| CpG Site: cg15150970 | |
| Position to Gene: gene | |
| Male Effect: -0.230556930855719 | |
| Female Effect: - | |
 | Gene ID: ENSG00000119772 |
| CpG Site: cg05544807 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.394097889202732 | |
 | Gene ID: ENSG00000119772 |
| CpG Site: cg11354105 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.181568102307529 | |
 | Gene ID: ENSG00000119772 |
| CpG Site: cg15150970 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.408252071227081 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15150970 | chr2:25250660 | gene | -0.230556930855719 | 4.64412520452734e-07 | -0.37143937186631126 | 5.6768111814372463e-08 | KIRP |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05544807 | chr2:25253047 | gene | -0.394097889202732 | 2.18704042416549e-07 | -0.3745274838303682 | 6.506349120854752e-10 | LUAD |
| cg11354105 | chr2:25252936 | gene | -0.181568102307529 | 3.08966945207163e-06 | -0.35893594060053424 | 3.6040729799973286e-09 | LUAD |
| cg15150970 | chr2:25250660 | gene | -0.408252071227081 | 5.32754296522405e-10 | -0.520831696808422 | 7.793413507890645e-14 | SKCM |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of DNMT3A |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000119772 | DNMT3A | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0010346 | Crohn Disease | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0013336 | Dwarfism | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0018273 | Growth Disorders | 2 | CTD_human |
| ENSG00000119772 | DNMT3A | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0023465 | Acute monocytic leukemia | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0024121 | Lung Neoplasms | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0025958 | Microcephaly | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0036920 | Sezary Syndrome | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0079774 | Peripheral T-Cell Lymphoma | 2 | CTD_human |
| ENSG00000119772 | DNMT3A | C0156147 | Crohn's disease of large bowel | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0267380 | Crohn's disease of the ileum | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0282631 | Facies | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0678202 | Regional enteritis | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0678222 | Breast Carcinoma | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0917816 | Mental deficiency | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C0949272 | IIeocolitis | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C1956147 | Microlissencephaly | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C3496069 | cocaine use | 1 | PSYGENET |
| ENSG00000119772 | DNMT3A | C3714756 | Intellectual Disability | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C3853041 | Severe Congenital Microcephaly | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C4014545 | Tatton Brown Rahman syndrome | 1 | CTD_human |
| ENSG00000119772 | DNMT3A | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
