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Gene: ENSG00000119669 |
Summary for IRF2BPL |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000119669 | Gene symbol | IRF2BPL |
| Gene name | interferon regulatory factor 2 binding protein like | |
| HGNC | 14282 | |
| Entrez ID | 64207 | |
| Gene type | protein_coding | |
| Synonyms | IRF2BPL|EAP1|KIAA1865 | |
| UniProtAcc | Q9H1B7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for IRF2BPL |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| IRF2BPL | 2.52e+03 | -1.03e+00 | 1.50e-01 | -6.85e+00 | 7.62e-12 | 5.83e-11 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| IRF2BPL | 3.69e+03 | -1.03e+00 | 2.15e-01 | -4.78e+00 | 1.78e-06 | 3.45e-05 | STAD |
| IRF2BPL | 1.26e+03 | -1.00e+00 | 1.47e-01 | -6.82e+00 | 9.17e-12 | 1.29e-10 | LIHC |
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Sex-biased somatic mutation for IRF2BPL |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for IRF2BPL |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg24570624 | chr14:77026935 | CGI:chr14:77025595-77028755 | promoter,exon,CDS,gene body | 1.71e-01 | 3.40e-01 | 3.12e+00 | 1.81e-03 | 5.90e-03 | -1.69e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg01553004 | chr14:77029329 | CGI:chr14:77025595-77028755 | promoter | 3.87e-01 | 5.66e-01 | -3.66e+00 | 2.52e-04 | 1.10e-03 | -1.79e-01 |
| KIRP | cg24570624 | chr14:77026935 | CGI:chr14:77025595-77028755 | promoter,exon,CDS,gene body | 3.13e-01 | 1.90e-01 | 3.37e+00 | 7.56e-04 | 1.44e-03 | 1.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for IRF2BPL |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for IRF2BPL |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for IRF2BPL |
| TFs related to IRF2BPL. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | KLF1 | IRF2BPL | 4.15e+00 | 9.85e-01 | 2.96e+00 | 2.64e-03 | Male-biased |
| BLCA | KLF5 | IRF2BPL | 4.06e+00 | 9.82e-01 | 2.97e+00 | 3.49e-03 | Male-biased |
| BLCA | KLF9 | IRF2BPL | 4.26e+00 | 9.88e-01 | 3.02e+00 | 2.21e-03 | Male-biased |
| BLCA | SP1 | IRF2BPL | 4.25e+00 | 9.89e-01 | 2.80e+00 | 1.08e-03 | Male-biased |
| BLCA | SP3 | IRF2BPL | 4.16e+00 | 9.85e-01 | 2.96e+00 | 2.49e-03 | Male-biased |
| BLCA | ZNF180 | IRF2BPL | 4.25e+00 | 9.88e-01 | 2.89e+00 | 1.46e-03 | Male-biased |
| BLCA | ZNF267 | IRF2BPL | 4.29e+00 | 9.88e-01 | 3.07e+00 | 2.38e-03 | Male-biased |
| BLCA | ZNF30 | IRF2BPL | 4.42e+00 | 9.91e-01 | 3.05e+00 | 1.46e-03 | Male-biased |
| BLCA | ZNF304 | IRF2BPL | 4.30e+00 | 9.89e-01 | 3.02e+00 | 1.96e-03 | Male-biased |
| BLCA | ZNF383 | IRF2BPL | 4.07e+00 | 9.83e-01 | 2.94e+00 | 3.09e-03 | Male-biased |
| BLCA | ZNF441 | IRF2BPL | 4.34e+00 | 9.90e-01 | 2.91e+00 | 1.16e-03 | Male-biased |
| BLCA | ZNF529 | IRF2BPL | 4.09e+00 | 9.83e-01 | 2.95e+00 | 3.01e-03 | Male-biased |
| BLCA | ZNF543 | IRF2BPL | 4.32e+00 | 9.88e-01 | 3.17e+00 | 2.99e-03 | Male-biased |
| BLCA | ZNF548 | IRF2BPL | 4.16e+00 | 9.84e-01 | 3.10e+00 | 3.92e-03 | Male-biased |
| BLCA | ZNF566 | IRF2BPL | 4.19e+00 | 9.84e-01 | 3.16e+00 | 4.34e-03 | Male-biased |
| BLCA | ZNF792 | IRF2BPL | 4.21e+00 | 9.87e-01 | 2.99e+00 | 2.36e-03 | Male-biased |
| IRF2BPL related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for IRF2BPL |
| RBPs related to ES in IRF2BPL. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| IRF2BPL related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000119669 | FAM87A,hsa-mir-193a,IRF2BPL | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000119669 | DANCR,hsa-mir-193a,IRF2BPL | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000119669 | AP000688.2,hsa-mir-500b,IRF2BPL | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000119669 | MAP4K3-DT,hsa-mir-500b,IRF2BPL | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000119669 | AC105339.2,hsa-mir-141,IRF2BPL | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000119669 | AC105339.2,hsa-mir-200a,IRF2BPL | Female-specific ceRNA | TCGA-LIHC |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs182098277 | chr14:72983413:C:T | - | 0.174285018813557 | 0.00819896580326764 | PAAD | Male-baised eQTL |
| rs2535924 | chr14:72972278:A:G | - | -0.159204874976698 | 0.0170106528133909 | PAAD | Male-baised eQTL |
| rs111624972 | chr14:71806854:A:C | - | 0.0587527978035982 | 0.00528073360690496 | KIRC | Male-baised eQTL |
| rs17768054 | chr14:71864892:G:A | - | 0.0769576631683951 | 0.00608732472033399 | KIRC | Male-baised eQTL |
| rs75595000 | chr14:71855091:G:C | - | 0.0748456698398295 | 0.00752100879605513 | KIRC | Male-baised eQTL |
| rs3946194 | chr14:75885054:G:A | - | -0.195896277044702 | 0.00408506753366924 | LUAD | Male-baised eQTL |
| rs78082570 | chr14:72988901:T:C | - | 0.13854272112292 | 0.0204275211528207 | LUAD | Male-baised eQTL |
| rs61986508 | chr14:72989505:G:C | - | 0.13854272112292 | 0.0204275211528207 | LUAD | Male-baised eQTL |
| rs77373518 | chr14:72980233:T:A | - | 0.147892051230771 | 0.0207543997239586 | LUAD | Male-baised eQTL |
| rs61986497 | chr14:72983154:G:A | - | 0.137805439018782 | 0.0219738051142348 | LUAD | Male-baised eQTL |
| rs4903342 | chr14:75704028:T:C | - | 0.162204942505211 | 0.0288863228670345 | LUAD | Male-baised eQTL |
| rs61988555 | chr14:72972127:T:C | - | 0.13500700646907 | 0.0466972990626873 | LUAD | Male-baised eQTL |
| rs61986488 | chr14:72973959:T:C | - | 0.134666612958097 | 0.0479057420078256 | LUAD | Male-baised eQTL |
| rs61986489 | chr14:72973990:T:C | - | 0.134666612958097 | 0.0479057420078256 | LUAD | Male-baised eQTL |
| rs61986491 | chr14:72977282:T:C | - | 0.134666612958097 | 0.0479057420078256 | LUAD | Male-baised eQTL |
| rs17491249 | chr14:72977508:G:A | - | 0.134666612958097 | 0.0479057420078256 | LUAD | Male-baised eQTL |
| rs2332706 | chr14:72003360:A:G | - | 0.0442088651038029 | 0.0359620894687939 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000119669 |
| CpG Site: cg13017813 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.247259243278194 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13017813 | chr14:77024680 | gene,exon,UTR | -0.247259243278194 | 8.02781609659975e-05 | -0.31384395570809337 | 3.10545325156612e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of IRF2BPL |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000119669 | IRF2BPL | C0004238 | Atrial Fibrillation | 1 | CTD_human |
| ENSG00000119669 | IRF2BPL | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
| ENSG00000119669 | IRF2BPL | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
| ENSG00000119669 | IRF2BPL | C3468561 | familial atrial fibrillation | 1 | CTD_human |
