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Gene: ENSG00000119403 |
Summary for PHF19 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000119403 | Gene symbol | PHF19 |
| Gene name | PHD finger protein 19 | |
| HGNC | 24566 | |
| Entrez ID | 26147 | |
| Gene type | protein_coding | |
| Synonyms | PHF19|DKFZP727G051|PCL3|MTF2L1|TDRD19B | |
| UniProtAcc | Q5T6S3 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PHF19 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PHF19 | 6.13e+02 | 1.37e+00 | 3.64e-01 | 3.76e+00 | 1.71e-04 | 7.13e-04 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PHF19 | 1.69e+03 | 1.16e+00 | 1.36e-01 | 8.53e+00 | 1.43e-17 | 1.91e-16 | COAD |
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Sex-biased somatic mutation for PHF19 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PHF19 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg13851767 | chr9:120894486 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.30e-01 | 4.19e-01 | 3.77e+00 | 1.61e-04 | 8.69e-04 | 2.11e-01 |
| LUSC | cg04236137 | chr9:120893609 | CGI:chr9:120894472-120894811 | promoter,gene body | 5.60e-01 | 6.80e-01 | -3.22e+00 | 1.27e-03 | 3.06e-03 | -1.20e-01 |
| LUSC | cg27207079 | chr9:120894473 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.96e-01 | 4.66e-01 | 3.47e+00 | 5.18e-04 | 1.69e-03 | 2.30e-01 |
| LUSC | cg13852822 | chr9:120894943 | CGI:chr9:120894472-120894811 | promoter | 6.09e-01 | 4.15e-01 | 3.17e+00 | 1.52e-03 | 3.46e-03 | 1.95e-01 |
| BLCA | cg13851767 | chr9:120894486 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.04e-01 | 4.18e-01 | 3.60e+00 | 3.13e-04 | 9.27e-04 | 1.86e-01 |
| BLCA | cg04236137 | chr9:120893609 | CGI:chr9:120894472-120894811 | promoter,gene body | 4.99e-01 | 6.15e-01 | -2.80e+00 | 5.12e-03 | 8.29e-03 | -1.15e-01 |
| ESCA | cg13851767 | chr9:120894486 | CGI:chr9:120894472-120894811 | promoter,gene body | 5.93e-01 | 3.82e-01 | 3.46e+00 | 5.31e-04 | 3.37e-02 | 2.11e-01 |
| ESCA | cg27207079 | chr9:120894473 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.58e-01 | 3.86e-01 | 3.58e+00 | 3.39e-04 | 3.37e-02 | 2.72e-01 |
| ESCA | cg13852822 | chr9:120894943 | CGI:chr9:120894472-120894811 | promoter | 5.58e-01 | 3.05e-01 | 3.45e+00 | 5.51e-04 | 3.37e-02 | 2.53e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13851767 | chr9:120894486 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.20e-01 | 3.85e-01 | 1.25e+01 | 1.13e-35 | 3.70e-34 | 2.35e-01 |
| BRCA | cg04236137 | chr9:120893609 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.29e-01 | 7.45e-01 | -8.50e+00 | 1.95e-17 | 8.58e-17 | -1.16e-01 |
| BRCA | cg27207079 | chr9:120894473 | CGI:chr9:120894472-120894811 | promoter,gene body | 6.99e-01 | 4.00e-01 | 1.29e+01 | 5.48e-38 | 2.77e-36 | 2.99e-01 |
| BRCA | cg13852822 | chr9:120894943 | CGI:chr9:120894472-120894811 | promoter | 5.92e-01 | 4.00e-01 | 1.10e+01 | 3.06e-28 | 3.62e-27 | 1.92e-01 |
| KIRP | cg13851767 | chr9:120894486 | CGI:chr9:120894472-120894811 | promoter,gene body | 5.61e-01 | 3.92e-01 | 3.15e+00 | 1.63e-03 | 5.24e-03 | 1.69e-01 |
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Exon skipping events with PSI in TCGA for PHF19 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PHF19 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PHF19 |
| TFs related to PHF19. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PHF19 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PHF19 |
| RBPs related to ES in PHF19. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PHF19 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1429893 | chr9:112091251:C:T | - | -0.0579811055452073 | 0.0326577919260227 | LUAD | Female-baised eQTL |
| rs1367056 | chr9:112091051:A:T | - | -0.0558800891855568 | 0.0396654030832897 | LUAD | Female-baised eQTL |
| rs1334079 | chr9:117035289:T:C | - | 0.0605134631236873 | 0.0433637132857826 | LUAD | Female-baised eQTL |
| rs7047202 | chr9:117087084:A:C | - | 0.0929942148926981 | 0.0452665039908116 | LUAD | Female-baised eQTL |
| rs77047432 | chr9:117088284:C:T | - | 0.0894674407094476 | 0.0484057449620228 | LUAD | Female-baised eQTL |
| rs58399611 | chr9:117089485:C:A | - | 0.0892347163387622 | 0.0492657786291853 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12552701 | chr9:118245214:C:T | - | 0.0524127981572106 | 0.0254154045643698 | KIRC | Male-baised eQTL |
| rs10217645 | chr9:126131093:G:A | - | -0.0572778205974716 | 0.0265044068081536 | BLCA | Male-baised eQTL |
| rs3860165 | chr9:112454484:C:T | - | -0.0604145391770853 | 0.0293129081793073 | COAD | Male-baised eQTL |
| rs1571639 | chr9:112408033:G:T | - | 0.0610449107221261 | 0.0466363762546569 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000119403 |
| CpG Site: cg04236137 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.377268294243943 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04236137 | chr9:120893609 | gene,promoter | -0.377268294243943 | 5.67096382091938e-05 | -0.4585602297234706 | 1.7701948771809362e-07 | STAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs10760078 | chr9:120132522:C:T | Distant downstream | 0.031535045580091 | 0.0343546580630843 | COAD | Female-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs10760079 | chr9:120140587:T:C | Distant downstream | 0.0317868096531219 | 0.0368070199520424 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs114907376 | chr9:121386136:G:A | Distant upstream | -0.0443851979102819 | 0.00993419282539759 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs76189070 | chr9:121433751:G:A | Distant upstream | -0.042687581295579 | 0.0147408952374399 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs12552897 | chr9:121407281:A:T | Distant upstream | -0.042556217028188 | 0.0152984013486862 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs115517301 | chr9:121408770:A:C | Distant upstream | -0.042556217028188 | 0.0152984013486862 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs149005861 | chr9:121415614:G:A | Distant upstream | -0.042556217028188 | 0.0152984013486862 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs77487147 | chr9:121426432:C:T | Distant upstream | -0.042556217028188 | 0.0152984013486862 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs12553464 | chr9:121447797:T:A | Distant upstream | -0.042556217028188 | 0.0152984013486862 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs76295567 | chr9:121455998:G:A | Distant upstream | -0.042556217028188 | 0.0152984013486862 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs77613151 | chr9:121475784:G:A | Distant upstream | -0.0407750087312291 | 0.0181875852205142 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs77552913 | chr9:121457390:G:A | Distant upstream | -0.03801550016054 | 0.0232024947626751 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs147697695 | chr9:121415333:C:T | Distant upstream | -0.0385230550874483 | 0.0323751733405853 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs80322618 | chr9:121423499:G:T | Distant upstream | -0.0385230550874483 | 0.0323751733405853 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs147570603 | chr9:121436915:G:A | Distant upstream | -0.0385230550874483 | 0.0323751733405853 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs74547047 | chr9:121443237:G:A | Distant upstream | -0.0385230550874483 | 0.0323751733405853 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs76734271 | chr9:121403275:G:A | Distant upstream | -0.0368287070300818 | 0.036767132985571 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs113737975 | chr9:121406093:G:A | Distant upstream | -0.0368287070300818 | 0.036767132985571 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs16910623 | chr9:121453740:G:A | Distant upstream | -0.0368287070300818 | 0.036767132985571 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs7025103 | chr9:121484382:C:T | Distant upstream | 0.0362112873834908 | 0.0464674615859919 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs76150224 | chr9:121387688:T:G | Distant upstream | -0.037090273039933 | 0.0489306784723667 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs2153623 | chr9:121396966:T:C | Distant upstream | -0.037090273039933 | 0.0489306784723667 | LGG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs11999192 | chr9:120110533:A:T | Distant downstream | -0.164816736018957 | 0.0204106058392585 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs59504680 | chr9:120121445:G:T | Distant downstream | -0.164816736018957 | 0.0204106058392585 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs12004145 | chr9:120054823:A:G | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs184684309 | chr9:120061259:A:G | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs12115511 | chr9:120064423:C:T | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs73543424 | chr9:120066574:T:C | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs189019939 | chr9:120068450:T:A | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs61254203 | chr9:120068804:C:G | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs78208896 | chr9:120073994:A:C | Distant downstream | -0.276190148571429 | 0.0320599024510939 | PCPG | Male-baised sQTL |
| exon_skip_506602 | chr9:120861917:120862005 | Frame-shift | rs11506925 | chr9:120430041:C:G | Distant downstream | -0.157149582178218 | 0.0420729305683765 | PCPG | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_506602 |
| CpG Site: cg00403579 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.164187286581299 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_506602 | chr9:120861917:120862005 | cg00403579 | chr9:121771713 | Distant upstream | 0.164187286581299 | 2.74965679395771e-05 | 0.3271148320633554 | 0.00028214687474406775 | Frame-shift | SARC |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PHF19 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
