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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000118257

Summary for NRP2

check button Gene summary

Gene informationEnsembl ID

ENSG00000118257

Gene symbol

NRP2

Gene nameneuropilin 2
HGNC

8005

Entrez ID

8828

Gene typeprotein_coding
SynonymsNRP2|VEGF165R2
UniProtAcc

O60462


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000118257NRP2DB16453ATYR1923BiotechDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for NRP2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
NRP22.20e+03-2.26e+004.78e-01-4.73e+002.22e-061.58e-05BLCA
NRP21.27e+03-1.32e+002.73e-01-4.84e+001.30e-064.80e-06COAD

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
NRP21.52e+03-1.70e+004.60e-01-3.69e+002.22e-049.51e-04READ

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Sex-biased somatic mutation for NRP2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for NRP2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg22367989chr2:205681936CGI:chr2:205681879-205682842promoter7.66e-022.61e-01-2.29e+002.20e-023.63e-02-1.84e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUSCcg01154445chr2:205683447CGI:chr2:205681879-205682842promoter,gene body2.42e-011.09e-012.34e+001.95e-022.34e-021.33e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg01154445chr2:205683447CGI:chr2:205681879-205682842promoter,gene body4.89e-013.46e-015.67e+001.43e-083.15e-081.43e-01

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Exon skipping events with PSI in TCGA for NRP2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for NRP2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for NRP2

check buttonTFs related to NRP2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
PCPGGATA3NRP24.53e+009.84e-013.71e+009.31e-03Male-biased
PCPGIRF6NRP25.13e+009.82e-014.41e+001.52e-02Male-biased
PCPGONECUT1NRP24.58e+009.85e-013.73e+008.26e-03Male-biased
PCPGSOX7NRP23.92e+009.82e-012.53e+005.50e-04Male-biased
PCPGUNCXNRP24.23e+009.88e-013.03e+001.52e-03Male-biased

check buttonNRP2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for NRP2

check buttonRBPs related to ES in NRP2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonNRP2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs13424127chr2:212416523:T:C-0.2277290574006330.0359102180499345GBMFemale-baised eQTL
rs13385225chr2:212416588:A:G-0.2277290574006330.0359102180499345GBMFemale-baised eQTL
rs77959765chr2:212417370:T:G-0.2277290574006330.0359102180499345GBMFemale-baised eQTL
rs13408977chr2:212405124:G:A-0.2297234854466450.0378188535624778GBMFemale-baised eQTL
rs79264447chr2:212419234:G:A-0.2257897710132620.0423860970825399GBMFemale-baised eQTL
rs13387495chr2:212420333:T:C-0.2257897710132620.0423860970825399GBMFemale-baised eQTL
rs1505348chr2:212426598:C:A-0.2257897710132620.0423860970825399GBMFemale-baised eQTL
rs1505349chr2:212426782:A:C-0.2257897710132620.0423860970825399GBMFemale-baised eQTL
rs10193290chr2:212427095:G:A-0.2257897710132620.0423860970825399GBMFemale-baised eQTL
rs78063670chr2:212431127:C:T-0.2257897710132620.0423860970825399GBMFemale-baised eQTL
rs115951538chr2:205073977:A:C-0.1590931880997520.0204135207972116SARCFemale-baised eQTL
rs79024572chr2:205080242:G:T-0.1583943830154320.0221176616009184SARCFemale-baised eQTL
rs139976161chr2:208787136:A:T-0.08394769578023330.0149587436179237LUADFemale-baised eQTL
rs115823494chr2:208790279:G:T-0.08394769578023330.0149587436179237LUADFemale-baised eQTL
rs76571384chr2:208792538:C:G-0.08394769578023330.0149587436179237LUADFemale-baised eQTL
rs114159053chr2:208784699:C:G-0.08407243320455990.0166453411625769LUADFemale-baised eQTL
rs77755740chr2:208818892:C:T-0.08121475255974420.0222731627619623LUADFemale-baised eQTL
rs978469chr2:208794322:T:C-0.07902329927019240.0246255958565935LUADFemale-baised eQTL
rs75258610chr2:208796712:A:G-0.07943263672385580.0256613343392932LUADFemale-baised eQTL
rs75591687chr2:208800024:C:T-0.07943263672385580.0256613343392932LUADFemale-baised eQTL
rs113461833chr2:208806641:G:A-0.07943263672385580.0256613343392932LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs13396837chr2:214660265:C:T-0.2499086616518190.00210919935506321GBMMale-baised eQTL
rs35437698chr2:214667560:C:G-0.2499086616518190.00210919935506321GBMMale-baised eQTL
rs12620862chr2:214668089:T:G-0.2499086616518190.00210919935506321GBMMale-baised eQTL
rs1012165chr2:201646207:C:T-0.09010496965648190.0218837734901374LGGMale-baised eQTL
rs13036106chr2:198173113:C:G--0.05154690451027710.0173777635706048BLCAMale-baised eQTL
rs11890712chr2:198174104:T:A--0.049838146727780.0266907939407618BLCAMale-baised eQTL
rs1434292chr2:198174105:A:T--0.049838146727780.0266907939407618BLCAMale-baised eQTL
rs961805chr2:204727004:C:T-0.05797057063380660.00350194192192096LUADMale-baised eQTL
rs80345797chr2:204724849:G:A-0.06192547310344050.00579307412689662LUADMale-baised eQTL
rs28366983chr2:204726452:C:T-0.05269687715657450.00994162066843112LUADMale-baised eQTL
rs7595278chr2:204687868:G:A-0.0688987229095820.014435347457293LUADMale-baised eQTL
rs10804139chr2:204512982:A:G--0.0478372094244360.0368478542978265LUADMale-baised eQTL
rs7590658chr2:204510410:G:A--0.04754911254662420.041997972848604LUADMale-baised eQTL
rs2887915chr2:210689850:C:T-0.05559479663599640.00640574261864416COADMale-baised eQTL
rs5002316chr2:210680500:T:C-0.05380988304026760.0155532134342886COADMale-baised eQTL
rs4142153chr2:210681194:C:G-0.05326820407804770.0171504077514827COADMale-baised eQTL
rs1521646chr2:212179530:G:C-0.05201611797119860.0174977448335611COADMale-baised eQTL
rs17416799chr2:212184710:A:G-0.05200213361410040.0192620594524986COADMale-baised eQTL
rs10171279chr2:210683362:G:C-0.04969357687423690.0219177431887944COADMale-baised eQTL
rs11887861chr2:210683969:C:A-0.04969357687423690.0219177431887944COADMale-baised eQTL
rs2371015chr2:210684885:C:T-0.04969357687423690.0219177431887944COADMale-baised eQTL
rs11693640chr2:212181454:T:C-0.05040187850801840.0237135323492363COADMale-baised eQTL
rs12052282chr2:212180515:A:C-0.05011029350024410.0260892175497294COADMale-baised eQTL
rs10195020chr2:210792502:T:G-0.04800107198175880.0280911587103235COADMale-baised eQTL
rs13407289chr2:212204009:C:T-0.04774677987776950.032897458069812COADMale-baised eQTL
rs17344880chr2:212181891:C:T-0.04860002297248660.0351668448978764COADMale-baised eQTL
rs1521661chr2:212218379:T:A-0.04661492625154840.0364152596780556COADMale-baised eQTL
rs10048673chr2:212218557:A:G-0.04661492625154840.0364152596780556COADMale-baised eQTL
rs4142152chr2:210681319:C:T-0.05005833082017210.0409650823050548COADMale-baised eQTL
rs35863145chr2:210682605:G:A-0.05005833082017210.0409650823050548COADMale-baised eQTL
rs4310998chr2:210687165:C:T-0.04975136500717210.044062798850866COADMale-baised eQTL
rs2371016chr2:210687220:G:C-0.04975136500717210.044062798850866COADMale-baised eQTL
rs9288420chr2:210687897:G:A-0.04975136500717210.044062798850866COADMale-baised eQTL
rs2371018chr2:210689997:T:C-0.04975136500717210.044062798850866COADMale-baised eQTL
rs10194936chr2:210683713:A:G-0.04965604365428220.0441718860546168COADMale-baised eQTL
rs12623361chr2:210680242:C:T-0.04948011698719880.0455328560867702COADMale-baised eQTL
rs4375810chr2:212229687:T:C-0.04515057332612310.0457377796218453COADMale-baised eQTL
rs4673654chr2:212228678:C:A-0.04504923184873320.0465724716700867COADMale-baised eQTL
rs11694300chr2:212227303:T:C-0.04494074129838930.0486491552306123COADMale-baised eQTL
rs11677095chr2:212227355:A:G-0.04494074129838930.0486491552306123COADMale-baised eQTL
rs883501chr2:205791940:A:Tgene0.06182952409507590.0487616545240095COADMale-baised eQTL
rs11689207chr2:210754847:A:G-0.04745370704165140.048827837599252COADMale-baised eQTL
rs10048819chr2:212225956:T:G-0.04498860334185990.0493635953703783COADMale-baised eQTL
rs7560301chr2:212226873:C:T-0.04498860334185990.0493635953703783COADMale-baised eQTL
rs11676942chr2:212226991:A:T-0.04498860334185990.0493635953703783COADMale-baised eQTL
rs59602419chr2:210683096:A:G-0.04911773744762760.0497217044995762COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000118257
CpG Site: cg17455088
Position to Gene: gene,enhancer
Male Effect: -
Female Effect: -0.210073139983216
eQTM boxplot analysisGene ID: ENSG00000118257
CpG Site: cg05025612
Position to Gene: gene,exon,CDS
Male Effect: -
Female Effect: 0.100696918911421
eQTM boxplot analysisGene ID: ENSG00000118257
CpG Site: cg09343667
Position to Gene: gene
Male Effect: -0.326462066129936
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg09343667chr2:205707332gene-0.3264620661299367.99164217704584e-07-0.329783797318715779.27390302580898e-09LGG

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg17455088chr2:205686742gene,enhancer-0.2100731399832161.25411794586234e-09-0.419961654692496472.5667581069234302e-12LUAD
cg05025612chr2:205776364gene,exon,CDS0.1006969189114216.31132930220972e-050.456980510679783071.7493797648477572e-07LIHC

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of NRP2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000118257NRP2C0004352Autistic Disorder1CTD_human
ENSG00000118257NRP2C0022333Jacksonian Seizure1CTD_human
ENSG00000118257NRP2C0036572Seizures1CTD_human
ENSG00000118257NRP2C0149958Complex partial seizures1CTD_human
ENSG00000118257NRP2C0234533Generalized seizures1CTD_human
ENSG00000118257NRP2C0234535Clonic Seizures1CTD_human
ENSG00000118257NRP2C0270824Visual seizure1CTD_human
ENSG00000118257NRP2C0270844Tonic Seizures1CTD_human
ENSG00000118257NRP2C0270846Epileptic drop attack1CTD_human
ENSG00000118257NRP2C0422850Seizures, Somatosensory1CTD_human
ENSG00000118257NRP2C0422852Seizures, Auditory1CTD_human
ENSG00000118257NRP2C0422853Olfactory seizure1CTD_human
ENSG00000118257NRP2C0422854Gustatory seizure1CTD_human
ENSG00000118257NRP2C0422855Vertiginous seizure1CTD_human
ENSG00000118257NRP2C0494475Tonic - clonic seizures1CTD_human
ENSG00000118257NRP2C0751056Non-epileptic convulsion1CTD_human
ENSG00000118257NRP2C0751110Single Seizure1CTD_human
ENSG00000118257NRP2C0751123Atonic Absence Seizures1CTD_human
ENSG00000118257NRP2C0751494Convulsive Seizures1CTD_human
ENSG00000118257NRP2C0751495Seizures, Focal1CTD_human
ENSG00000118257NRP2C0751496Seizures, Sensory1CTD_human
ENSG00000118257NRP2C3495874Nonepileptic Seizures1CTD_human
ENSG00000118257NRP2C4048158Convulsions1CTD_human
ENSG00000118257NRP2C4316903Absence Seizures1CTD_human
ENSG00000118257NRP2C4317109Epileptic Seizures1CTD_human
ENSG00000118257NRP2C4317123Myoclonic Seizures1CTD_human
ENSG00000118257NRP2C4505436Generalized Absence Seizures1CTD_human