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Gene: ENSG00000117305 |
Summary for HMGCL |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000117305 | Gene symbol | HMGCL |
| Gene name | 3-hydroxy-3-methylglutaryl-CoA lyase | |
| HGNC | 5005 | |
| Entrez ID | 3155 | |
| Gene type | protein_coding | |
| Synonyms | HMGCL|HL | |
| UniProtAcc | P35914 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for HMGCL |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HMGCL | 6.26e+03 | -3.36e+00 | 3.18e-01 | -1.06e+01 | 4.02e-26 | 1.01e-23 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for HMGCL |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for HMGCL |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for HMGCL |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for HMGCL |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for HMGCL |
| TFs related to HMGCL. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAAD | ZNF121 | HMGCL | 2.57e+00 | 8.24e-04 | 3.84e+00 | 9.82e-01 | Female-biased |
| PAAD | ZNF33A | HMGCL | 2.66e+00 | 1.38e-03 | 3.83e+00 | 9.81e-01 | Female-biased |
| PAAD | ZNF443 | HMGCL | 2.44e+00 | 4.27e-04 | 3.84e+00 | 9.82e-01 | Female-biased |
| HMGCL related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for HMGCL |
| RBPs related to ES in HMGCL. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | HNRNPA2B1 | exon_skip_23154 | 1.07e+01 | 9.82e-01 | 1.03e+01 | 1.63e-02 | Male-biased |
| ACC | RBM3 | exon_skip_23179 | 1.47e+01 | 9.98e-01 | 1.40e+01 | 2.15e-03 | Male-biased |
| UVM | HNRNPA2B1 | exon_skip_23154 | 1.00e+01 | 7.70e-04 | 1.06e+01 | 9.98e-01 | Female-biased |
| THYM | ELAVL2 | exon_skip_23180 | 9.43e+00 | 9.81e-01 | 9.15e+00 | 1.61e-02 | Male-biased |
| DLBC | RBM28 | exon_skip_23163 | 1.23e+01 | 7.74e-03 | 1.26e+01 | 9.92e-01 | Female-biased |
| CHOL | RBM28 | exon_skip_23163 | 1.19e+01 | 3.27e-03 | 1.24e+01 | 9.96e-01 | Female-biased |
| CHOL | RBM3 | exon_skip_23179 | 1.47e+01 | 2.51e-03 | 1.53e+01 | 9.97e-01 | Female-biased |
| KIRP | ZC3H10 | exon_skip_23177 | 6.20e+00 | 2.51e-03 | 6.65e+00 | 9.81e-01 | Female-biased |
| HMGCL related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1474995 | chr1:25135494:G:C | - | 0.0441721115614601 | 0.0408744244551848 | LUAD | Female-baised eQTL |
| rs10917318 | chr1:22841566:C:T | - | 0.0714776090124979 | 0.013771525265202 | COAD | Female-baised eQTL |
| rs16850389 | chr1:14496694:A:G | - | -0.131157665451901 | 0.0212796101272604 | COAD | Female-baised eQTL |
| rs4367747 | chr1:24546685:G:A | - | -0.058440213576314 | 0.0220457089242187 | COAD | Female-baised eQTL |
| rs59992449 | chr1:22837602:G:A | - | 0.068213508793671 | 0.0247963889491911 | COAD | Female-baised eQTL |
| rs196424 | chr1:24543395:A:G | - | -0.0570975388231503 | 0.0267434362414846 | COAD | Female-baised eQTL |
| rs196423 | chr1:24541291:G:T | - | -0.0555381672959183 | 0.0351590514337818 | COAD | Female-baised eQTL |
| rs169053 | chr1:24541513:A:G | - | -0.0555381672959183 | 0.0351590514337818 | COAD | Female-baised eQTL |
| rs196406 | chr1:24517838:C:T | - | -0.0539305751409965 | 0.0413782308942997 | COAD | Female-baised eQTL |
| rs4648994 | chr1:24521709:A:G | - | -0.0539127011099779 | 0.041494081622687 | COAD | Female-baised eQTL |
| rs196415 | chr1:24528059:T:A | - | -0.0532902879083304 | 0.0441660447403042 | COAD | Female-baised eQTL |
| rs3828051 | chr1:30724952:A:G | - | -0.0620603980933358 | 0.044306288714624 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6704440 | chr1:23186554:C:A | - | 0.0757960938452301 | 0.0344001686502469 | BLCA | Male-baised eQTL |
| rs6682882 | chr1:18794403:G:C | - | -0.06625798601027 | 0.0017592438487465 | COAD | Male-baised eQTL |
| rs744528 | chr1:30445606:C:T | - | 0.0692474675113642 | 0.00819527742185852 | COAD | Male-baised eQTL |
| rs1574161 | chr1:30477628:T:A | - | -0.0661195150797984 | 0.0190903941298054 | COAD | Male-baised eQTL |
| rs380445 | chr1:30480382:T:A | - | -0.0681026918511452 | 0.0192314471186528 | COAD | Male-baised eQTL |
| rs1532306 | chr1:33533999:C:A | - | -0.0768764859369694 | 0.0202383108190998 | COAD | Male-baised eQTL |
| rs6703542 | chr1:30478728:A:C | - | 0.0667970173799024 | 0.0219574884679295 | COAD | Male-baised eQTL |
| rs12760034 | chr1:33532436:C:T | - | -0.0697074969299028 | 0.0451729053459141 | COAD | Male-baised eQTL |
| rs2236838 | chr1:18638558:T:C | - | -0.0568596141576904 | 0.0474293069183141 | COAD | Male-baised eQTL |
| rs1532307 | chr1:33534057:T:C | - | -0.0700661972944857 | 0.0479903087373248 | COAD | Male-baised eQTL |
| rs4268325 | chr1:33534163:G:A | - | -0.0700661972944857 | 0.0479903087373248 | COAD | Male-baised eQTL |
| rs1565785 | chr1:33534326:G:A | - | -0.0700661972944857 | 0.0479903087373248 | COAD | Male-baised eQTL |
| rs1565786 | chr1:33534587:T:G | - | -0.0700661972944857 | 0.0479903087373248 | COAD | Male-baised eQTL |
| rs12132091 | chr1:33547229:A:G | - | -0.0716367572049381 | 0.0480018526067814 | COAD | Male-baised eQTL |
| rs12135471 | chr1:33547238:G:A | - | -0.0716367572049381 | 0.0480018526067814 | COAD | Male-baised eQTL |
| rs11260939 | chr1:18163775:A:G | - | 0.0567577788777412 | 0.0480514270452479 | COAD | Male-baised eQTL |
| rs9701796 | chr1:18859635:G:C | - | 0.0645971530271828 | 0.0493539329730988 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000117305 |
| CpG Site: cg13580783 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.278115564133884 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13580783 | chr1:23802077 | gene,exon,UTR | -0.278115564133884 | 1.53789935178269e-05 | -0.3574763343501175 | 4.00183776207781e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_23169 | chr1:23810735:23810799 | Frame-shift | rs12090415 | chr1:22828738:A:G | Distant downstream | 0.0207402209732706 | 0.0481477002361735 | LGG | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of HMGCL |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000117305 | HMGCL | C0268601 | HMG CoA lyase deficiency | 1 | CTD_human |
