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Gene: ENSG00000117133 |
Summary for RPF1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000117133 | Gene symbol | RPF1 |
| Gene name | ribosome production factor 1 homolog | |
| HGNC | 30350 | |
| Entrez ID | 80135 | |
| Gene type | protein_coding | |
| Synonyms | RPF1| | |
| UniProtAcc | Q9H9Y2 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for RPF1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for RPF1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RPF1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg02078520 | chr1:84478615 | CGI:chr1:84479249-84479667 | promoter | 5.21e-01 | 8.40e-01 | -4.36e+00 | 1.32e-05 | 5.26e-04 | -3.19e-01 |
| BLCA | cg10827434 | chr1:84479293 | CGI:chr1:84479249-84479667 | promoter,exon,CDS,gene body | 1.07e-01 | 2.47e-01 | -2.56e+00 | 1.03e-02 | 1.45e-02 | -1.41e-01 |
| BLCA | cg00779393 | chr1:84477820 | CGI:chr1:84479249-84479667 | promoter | 7.90e-01 | 9.21e-01 | -4.33e+00 | 1.51e-05 | 1.19e-04 | -1.31e-01 |
| ESCA | cg02078520 | chr1:84478615 | CGI:chr1:84479249-84479667 | promoter | 5.61e-01 | 7.26e-01 | -2.31e+00 | 2.07e-02 | 4.06e-02 | -1.66e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for RPF1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RPF1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RPF1 |
| TFs related to RPF1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | PLAG1 | RPF1 | 3.19e+00 | 2.90e-03 | 4.32e+00 | 9.90e-01 | Female-biased |
| ACC | ZNF354B | RPF1 | 4.72e+00 | 9.83e-01 | 3.99e+00 | 1.37e-02 | Male-biased |
| ACC | ZNF436 | RPF1 | 3.34e+00 | 6.82e-03 | 4.27e+00 | 9.86e-01 | Female-biased |
| BLCA | PRDM6 | RPF1 | 4.61e+00 | 9.82e-01 | 3.86e+00 | 1.22e-02 | Male-biased |
| BLCA | ZNF182 | RPF1 | 4.86e+00 | 9.87e-01 | 4.05e+00 | 9.66e-03 | Male-biased |
| BLCA | ZNF22 | RPF1 | 4.82e+00 | 9.84e-01 | 4.06e+00 | 1.16e-02 | Male-biased |
| BLCA | ZNF384 | RPF1 | 4.59e+00 | 9.86e-01 | 3.74e+00 | 8.33e-03 | Male-biased |
| BLCA | ZNF487 | RPF1 | 4.74e+00 | 9.84e-01 | 3.98e+00 | 1.19e-02 | Male-biased |
| BLCA | ZNF492 | RPF1 | 4.52e+00 | 9.81e-01 | 3.77e+00 | 1.22e-02 | Male-biased |
| BLCA | ZNF571 | RPF1 | 4.36e+00 | 9.82e-01 | 3.54e+00 | 9.18e-03 | Male-biased |
| BLCA | ZNF613 | RPF1 | 4.71e+00 | 9.87e-01 | 3.86e+00 | 8.25e-03 | Male-biased |
| BLCA | ZNF98 | RPF1 | 4.63e+00 | 9.86e-01 | 3.79e+00 | 8.92e-03 | Male-biased |
| MESO | DMRT3 | RPF1 | 5.06e+00 | 9.89e-01 | 3.78e+00 | 8.11e-03 | Male-biased |
| MESO | DMRTA2 | RPF1 | 5.01e+00 | 9.89e-01 | 3.74e+00 | 8.36e-03 | Male-biased |
| MESO | PLAG1 | RPF1 | 2.82e+00 | 7.75e-03 | 4.16e+00 | 9.80e-01 | Female-biased |
| MESO | SNAI1 | RPF1 | 2.70e+00 | 4.75e-03 | 4.19e+00 | 9.84e-01 | Female-biased |
| MESO | ZNF354B | RPF1 | 4.67e+00 | 9.82e-01 | 3.54e+00 | 1.29e-02 | Male-biased |
| MESO | ZNF436 | RPF1 | 2.91e+00 | 8.53e-03 | 4.23e+00 | 9.80e-01 | Female-biased |
| PAAD | ZNF121 | RPF1 | 3.94e+00 | 1.50e-02 | 4.66e+00 | 9.80e-01 | Female-biased |
| PAAD | ZNF443 | RPF1 | 4.09e+00 | 1.56e-02 | 4.81e+00 | 9.81e-01 | Female-biased |
| RPF1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RPF1 |
| RBPs related to ES in RPF1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RPF1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11165293 | chr1:91709095:G:A | - | 0.11342836467214 | 0.0273613623617215 | STAD | Female-baised eQTL |
| rs11165294 | chr1:91709180:C:T | - | 0.11342836467214 | 0.0273613623617215 | STAD | Female-baised eQTL |
| rs17879478 | chr1:91708165:T:G | - | 0.112759720298113 | 0.0305055051544357 | STAD | Female-baised eQTL |
| rs7519139 | chr1:91708283:A:C | - | 0.109929122331376 | 0.0456043563032834 | STAD | Female-baised eQTL |
| rs7514724 | chr1:91708290:C:T | - | 0.109929122331376 | 0.0456043563032834 | STAD | Female-baised eQTL |
| rs2038931 | chr1:91708858:G:A | - | 0.109929122331376 | 0.0456043563032834 | STAD | Female-baised eQTL |
| rs1125114 | chr1:78576091:G:A | - | 0.178276171527599 | 0.00523239474655331 | LGG | Female-baised eQTL |
| rs12042749 | chr1:78571735:T:C | - | 0.152347788511766 | 0.034194664828416 | LGG | Female-baised eQTL |
| rs12563027 | chr1:85781635:A:G | - | 0.0890659431116164 | 0.0342536294767535 | KIRC | Female-baised eQTL |
| rs61783210 | chr1:76788186:A:G | - | 0.0866500591114476 | 0.0389477612616413 | KIRC | Female-baised eQTL |
| rs61783211 | chr1:76788243:T:C | - | 0.0866500591114476 | 0.0389477612616413 | KIRC | Female-baised eQTL |
| rs12117410 | chr1:76788800:G:C | - | 0.0866500591114476 | 0.0389477612616413 | KIRC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12408872 | chr1:84568427:C:G | - | 0.0500545575584658 | 0.0403856201774948 | LIHC | Male-baised eQTL |
| rs17127810 | chr1:85488826:T:C | - | 0.121006508294928 | 0.0309871149569166 | LGG | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000117133 |
| CpG Site: cg02078520 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.391591776109149 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02078520 | chr1:84478615 | promoter | -0.391591776109149 | 4.91936124240602e-06 | -0.3484653502432147 | 1.0815927453976747e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RPF1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
