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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000116990

Summary for MYCL

check button Gene summary

Gene informationEnsembl ID

ENSG00000116990

Gene symbol

MYCL

Gene nameMYCL proto-oncogene, bHLH transcription factor
HGNC

7555

Entrez ID

4610

Gene typeprotein_coding
SynonymsMYCL|LMYC|bHLHe38
UniProtAcc

P12524


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for MYCL

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MYCL7.60e+021.07e+002.86e-013.73e+001.92e-044.70e-04LUAD
MYCL6.98e+031.64e+005.41e-013.04e+002.37e-036.96e-03BLCA
MYCL5.15e+02-1.64e+004.57e-01-3.59e+003.37e-041.30e-03CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for MYCL

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for MYCL

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for MYCL

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for MYCL

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for MYCL

check buttonTFs related to MYCL.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ESCAHINFPMYCL4.36e+009.82e-013.65e+001.09e-02Male-biased
ESCAKLF9MYCL3.83e+009.80e-012.92e+003.21e-03Male-biased
ESCATCFL5MYCL4.50e+009.91e-013.61e+003.71e-03Male-biased
ESCAZFP64MYCL3.98e+009.84e-013.07e+003.26e-03Male-biased
ESCAZNF100MYCL4.16e+009.89e-013.08e+001.24e-03Male-biased
ESCAZNF141MYCL4.25e+009.88e-013.36e+003.74e-03Male-biased
ESCAZNF2MYCL4.46e+009.90e-013.59e+004.18e-03Male-biased
ESCAZNF267MYCL3.97e+009.83e-013.09e+003.84e-03Male-biased
ESCAZNF30MYCL3.95e+009.85e-012.94e+001.88e-03Male-biased
ESCAZNF311MYCL4.13e+009.89e-013.06e+001.32e-03Male-biased
ESCAZNF44MYCL3.99e+009.83e-013.11e+003.97e-03Male-biased
ESCAZNF460MYCL4.27e+009.84e-013.50e+007.63e-03Male-biased
ESCAZNF611MYCL4.30e+009.92e-013.14e+008.40e-04Male-biased
ESCAZNF740MYCL4.19e+009.81e-013.46e+009.71e-03Male-biased
ESCAZNF792MYCL4.05e+009.87e-013.00e+001.45e-03Male-biased
ESCAZSCAN22MYCL4.05e+009.80e-013.31e+008.63e-03Male-biased
MESOZFP82MYCL3.24e+008.26e-034.58e+009.85e-01Female-biased
MESOZNF418MYCL2.43e+006.23e-055.03e+009.97e-01Female-biased
UVMPLAG1MYCL4.70e+009.82e-013.19e+006.51e-03Male-biased
UVMZNF141MYCL4.76e+009.82e-013.30e+007.24e-03Male-biased
UVMZNF331MYCL5.00e+009.85e-013.49e+006.78e-03Male-biased
UVMZNF530MYCL4.65e+009.81e-013.15e+006.65e-03Male-biased
UVMZNF682MYCL4.70e+009.80e-013.27e+007.70e-03Male-biased
UVMZNF692MYCL4.91e+009.85e-013.39e+006.48e-03Male-biased

check buttonMYCL related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for MYCL

check buttonRBPs related to ES in MYCL.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonMYCL related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000116990AC010615.2,hsa-mir-212,MYCLMale-specific ceRNATCGA-BLCA

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2889739chr1:39523036:A:G-0.135486855440110.000166687063436062LUSCFemale-baised eQTL
rs77853107chr1:39128327:T:C-0.1283989752383210.000173860670118047LUSCFemale-baised eQTL
rs60767579chr1:38051797:C:T-0.1284038560022770.000731658224921064LUSCFemale-baised eQTL
rs61186346chr1:38057373:G:T-0.1284038560022770.000731658224921064LUSCFemale-baised eQTL
rs508546chr1:33663877:C:T--0.1242068978260220.001295600883846LUSCFemale-baised eQTL
rs17449603chr1:46768061:A:G-0.1183247700708530.00164338160502185LUSCFemale-baised eQTL
rs11205918chr1:38068193:C:T-0.1206594273502820.00185980734430859LUSCFemale-baised eQTL
rs557147chr1:38080528:G:A-0.120608476447930.001918353791245LUSCFemale-baised eQTL
rs12131530chr1:38080626:C:G-0.120608476447930.001918353791245LUSCFemale-baised eQTL
rs474975chr1:38081267:A:C-0.120608476447930.001918353791245LUSCFemale-baised eQTL
rs550582chr1:38081582:T:C-0.120608476447930.001918353791245LUSCFemale-baised eQTL
rs534782chr1:38083175:G:A-0.120608476447930.001918353791245LUSCFemale-baised eQTL
rs72918865chr1:38083627:T:C-0.120608476447930.001918353791245LUSCFemale-baised eQTL
rs477471chr1:38087754:T:C-0.1205867110266570.00193735252565022LUSCFemale-baised eQTL
rs1690553chr1:33643600:T:G-0.1159886172715690.00255345796165204LUSCFemale-baised eQTL
rs514427chr1:33636872:A:G-0.1159403461520440.00257938776453269LUSCFemale-baised eQTL
rs72662047chr1:33641043:C:T-0.1159403461520440.00257938776453269LUSCFemale-baised eQTL
rs597802chr1:33632393:T:C-0.1099631023364580.0046998191601605LUSCFemale-baised eQTL
rs677357chr1:33632662:T:C-0.1099631023364580.0046998191601605LUSCFemale-baised eQTL
rs603854chr1:33633130:T:C-0.1099631023364580.0046998191601605LUSCFemale-baised eQTL
rs472484chr1:33633157:A:G-0.1099631023364580.0046998191601605LUSCFemale-baised eQTL
rs651972chr1:33631155:G:A-0.1099347224950920.00475344052388814LUSCFemale-baised eQTL
rs510533chr1:33648074:G:A-0.1092785045842590.00525119282094624LUSCFemale-baised eQTL
rs640394chr1:33648892:G:A-0.1092785045842590.00525119282094624LUSCFemale-baised eQTL
rs590210chr1:33649668:T:C-0.1093240586767790.00529239599119659LUSCFemale-baised eQTL
rs653470chr1:33647945:A:G-0.1091949783887290.00537931583272904LUSCFemale-baised eQTL
rs12121956chr1:38053013:T:C-0.1077548189171960.00557114596997107LUSCFemale-baised eQTL
rs513593chr1:33667254:C:G--0.1101401844645310.0056926826703807LUSCFemale-baised eQTL
rs617090chr1:33671866:C:G--0.1101401844645310.0056926826703807LUSCFemale-baised eQTL
rs6656365chr1:33674400:G:A--0.1101401844645310.0056926826703807LUSCFemale-baised eQTL
rs138051876chr1:33675755:G:C--0.1101401844645310.0056926826703807LUSCFemale-baised eQTL
rs532377chr1:33664184:A:T--0.1102662286058430.00576360490743191LUSCFemale-baised eQTL
rs642676chr1:33664541:C:T--0.1102662286058430.00576360490743191LUSCFemale-baised eQTL
rs629139chr1:33671512:A:T--0.1100382345081850.00583686632685138LUSCFemale-baised eQTL
rs2480244chr1:33687594:C:T--0.1100552167215490.00595713052057456LUSCFemale-baised eQTL
rs617364chr1:33688415:G:A--0.1100552167215490.00595713052057456LUSCFemale-baised eQTL
rs11210273chr1:41482073:G:A-0.1106429167482220.00722559421026315LUSCFemale-baised eQTL
rs906229chr1:36723370:C:T-0.1011543982275560.00854592408304638LUSCFemale-baised eQTL
rs644477chr1:33670674:A:T--0.1048985308277290.00927626616143839LUSCFemale-baised eQTL
rs12758772chr1:34465856:G:A-0.1016870161488640.0102777046958496LUSCFemale-baised eQTL
rs477882chr1:38081625:G:A-0.1024787051849280.012327706388364LUSCFemale-baised eQTL
rs67093630chr1:42090011:T:G-0.1007454545204370.0156447887723977LUSCFemale-baised eQTL
rs72658212chr1:33303648:C:T-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs117311352chr1:33309362:C:G-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs149592187chr1:33310176:G:A-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs72658217chr1:33311542:T:C-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs56111574chr1:33313939:A:C-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs77898537chr1:33314213:C:T-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs72658222chr1:33315771:A:C-0.09313234833519010.0179714115060573LUSCFemale-baised eQTL
rs625757chr1:33684285:G:A--0.09850110198849240.0194187480419693LUSCFemale-baised eQTL
rs512527chr1:33683153:G:A--0.09844013969217260.0197647897858741LUSCFemale-baised eQTL
rs785105chr1:39731198:T:C-0.08463191953516520.0201743612113802LUSCFemale-baised eQTL
rs11590973chr1:41460981:C:T-0.09590883760606410.0204750788920453LUSCFemale-baised eQTL
rs60873474chr1:41461119:G:A-0.09590883760606410.0204750788920453LUSCFemale-baised eQTL
rs57590210chr1:42107951:C:T-0.09565879682492520.0240213544232528LUSCFemale-baised eQTL
rs74836434chr1:42108511:A:T-0.09565879682492520.0240213544232528LUSCFemale-baised eQTL
rs58217148chr1:42096163:A:G-0.09566303795838730.0241337029432618LUSCFemale-baised eQTL
rs72953293chr1:42090222:C:G-0.09562504732146430.0244314671695756LUSCFemale-baised eQTL
rs61779334chr1:39517350:C:G-0.08478436913223020.0246512057644799LUSCFemale-baised eQTL
rs12142615chr1:41473424:T:C-0.09812562405604130.0249386163599539LUSCFemale-baised eQTL
rs12143601chr1:41474351:T:C-0.09812562405604130.0249386163599539LUSCFemale-baised eQTL
rs529714chr1:33671848:C:T--0.09449219607158130.025389663753916LUSCFemale-baised eQTL
rs16835356chr1:33323042:C:T-0.08921808846616960.0264639086830646LUSCFemale-baised eQTL
rs72658229chr1:33323329:G:A-0.08921808846616960.0264639086830646LUSCFemale-baised eQTL
rs72658232chr1:33323376:G:C-0.08921808846616960.0264639086830646LUSCFemale-baised eQTL
rs72658237chr1:33328815:T:C-0.08921808846616960.0264639086830646LUSCFemale-baised eQTL
rs16835363chr1:33329452:C:T-0.08921808846616960.0264639086830646LUSCFemale-baised eQTL
rs41265891chr1:33331290:C:A-0.08921808846616960.0264639086830646LUSCFemale-baised eQTL
rs16835424chr1:33391506:C:T-0.08061874627443010.0282056158747538LUSCFemale-baised eQTL
rs72658260chr1:33357993:G:C-0.08849780911911930.0299847522120432LUSCFemale-baised eQTL
rs11206277chr1:39535654:G:A-0.0854599279082230.0323316416389645LUSCFemale-baised eQTL
rs71654257chr1:42754456:G:T-0.09252000776801770.0348163525696215LUSCFemale-baised eQTL
rs3738502chr1:42755516:C:T-0.09252000776801770.0348163525696215LUSCFemale-baised eQTL
rs3738503chr1:42757636:C:T-0.09252000776801770.0348163525696215LUSCFemale-baised eQTL
rs11585208chr1:42756768:C:T-0.09248230576830420.0352432461182067LUSCFemale-baised eQTL
rs12744838chr1:42763388:G:A-0.09248230576830420.0352432461182067LUSCFemale-baised eQTL
rs11210267chr1:41480960:A:G-0.09375622110906370.0363887459265976LUSCFemale-baised eQTL
rs11210269chr1:41481664:G:A-0.09375622110906370.0363887459265976LUSCFemale-baised eQTL
rs12566493chr1:33343395:T:C-0.08564203071593970.0377716704354123LUSCFemale-baised eQTL
rs7534135chr1:33422769:C:T-0.08570115088919780.038202397634615LUSCFemale-baised eQTL
rs55860530chr1:33434058:C:T-0.08568236493862160.0383348058475309LUSCFemale-baised eQTL
rs72660106chr1:33423112:T:G-0.08570122167561020.0386654458725161LUSCFemale-baised eQTL
rs10493053chr1:33423207:T:C-0.08569251591684250.0387233253907799LUSCFemale-baised eQTL
rs55798146chr1:33429048:T:C-0.08568225824148920.0387710184382381LUSCFemale-baised eQTL
rs16835467chr1:33426737:T:C-0.08563712702159280.0390414013999821LUSCFemale-baised eQTL
rs72660114chr1:33427582:C:A-0.08563712702159280.0390414013999821LUSCFemale-baised eQTL
rs11210560chr1:41994779:A:T-0.08685437415917090.0390542158765438LUSCFemale-baised eQTL
rs72668106chr1:36739904:G:T-0.0842173469060750.0391406344433521LUSCFemale-baised eQTL
rs11210199chr1:41460577:C:T-0.08782548818963840.0416120445577097LUSCFemale-baised eQTL
rs11584399chr1:39523340:G:A-0.07869137368728240.0473002952599221LUSCFemale-baised eQTL
rs4078261chr1:36515022:A:T-0.0701377000347920.0473393820446251LUSCFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11209130chr1:38224439:A:G-0.03403571744872740.035882299090113LUSCMale-baised eQTL
rs10915084chr1:30338004:T:C--0.02719324896481480.0367958680017131LUSCMale-baised eQTL
rs11209146chr1:38225806:C:G-0.03308590190534360.0402480223839048LUSCMale-baised eQTL
rs12077373chr1:30343521:A:C--0.02646360993077070.0411977972673396LUSCMale-baised eQTL
rs4949256chr1:30337303:C:T--0.02683979637064260.041632844765468LUSCMale-baised eQTL
rs12071443chr1:30343611:G:A--0.02637525440193360.0427488740417987LUSCMale-baised eQTL
rs12758361chr1:46869185:G:A-0.06252578996687180.0285592741959916STADMale-baised eQTL
rs12404046chr1:30727031:A:T-0.05440599564406610.0396294963989854BLCAMale-baised eQTL
rs6600282chr1:38963262:G:C--0.06689479829581345.22902367977688e-05LUADMale-baised eQTL
rs9662216chr1:38952689:G:A--0.05501225554725440.00127354080479877LUADMale-baised eQTL
rs57213592chr1:38956702:A:G--0.05501225554725440.00127354080479877LUADMale-baised eQTL
rs4475740chr1:38959817:A:G--0.05056344008482950.00239088571297383LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000116990
CpG Site: cg16163765
Position to Gene: gene,exon,UTR
Male Effect: -0.490797684551961
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg16163765chr1:39899827gene,exon,UTR-0.4907976845519613.70319983739905e-64-0.86762278843307781.0777731164064074e-68LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of MYCL

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000116990MYCLC0025149Medulloblastoma1CTD_human
ENSG00000116990MYCLC0033578Prostatic Neoplasms1CTD_human
ENSG00000116990MYCLC0149925Small cell carcinoma of lung1CTD_human
ENSG00000116990MYCLC0205833Medullomyoblastoma1CTD_human
ENSG00000116990MYCLC0278510Childhood Medulloblastoma1CTD_human
ENSG00000116990MYCLC0278876Adult Medulloblastoma1CTD_human
ENSG00000116990MYCLC0376358Malignant neoplasm of prostate1CTD_human
ENSG00000116990MYCLC0751291Desmoplastic Medulloblastoma1CTD_human
ENSG00000116990MYCLC1275668Melanotic medulloblastoma1CTD_human