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Gene: ENSG00000116584 |
Summary for ARHGEF2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000116584 | Gene symbol | ARHGEF2 |
| Gene name | Rho/Rac guanine nucleotide exchange factor 2 | |
| HGNC | 682 | |
| Entrez ID | 9181 | |
| Gene type | protein_coding | |
| Synonyms | ARHGEF2|LFP40|GEF-H1|KIAA0651|P40|Lfc|GEFH1 | |
| UniProtAcc | Q92974 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ARHGEF2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ARHGEF2 | 7.66e+03 | 1.05e+00 | 1.14e-01 | 9.24e+00 | 2.42e-20 | 1.38e-18 | THCA |
| ARHGEF2 | 4.11e+03 | -1.27e+00 | 9.97e-02 | -1.27e+01 | 4.69e-37 | 5.50e-36 | LUSC |
| ARHGEF2 | 2.16e+03 | 1.53e+00 | 4.35e-01 | 3.52e+00 | 4.31e-04 | 1.61e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ARHGEF2 | 1.40e+03 | 1.52e+00 | 2.17e-01 | 7.01e+00 | 2.43e-12 | 3.73e-11 | LIHC |
Top |
Sex-biased somatic mutation for ARHGEF2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ARHGEF2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for ARHGEF2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ARHGEF2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ARHGEF2 |
| TFs related to ARHGEF2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ARHGEF2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ARHGEF2 |
| RBPs related to ES in ARHGEF2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | IGF2BP1 | exon_skip_32719 | 9.94e+00 | 9.76e-03 | 1.03e+01 | 9.89e-01 | Female-biased |
| MESO | IGF2BP1 | exon_skip_32719 | 9.85e+00 | 3.71e-03 | 1.03e+01 | 9.95e-01 | Female-biased |
| PAAD | IGF2BP1 | exon_skip_32719 | 9.84e+00 | 1.69e-03 | 1.03e+01 | 9.97e-01 | Female-biased |
| ARHGEF2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000116584 | TMEM147-AS1,hsa-mir-412,ARHGEF2 | Female-specific ceRNA | TCGA-LIHC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17373343 | chr1:163721185:T:C | - | 0.153909237650686 | 0.0425637382457867 | READ | Female-baised eQTL |
| rs2055549 | chr1:160606990:C:A | - | -0.272994690199104 | 0.00208028743590244 | GBM | Female-baised eQTL |
| rs2369724 | chr1:160605709:G:A | - | -0.242677774600884 | 0.0156709720827498 | GBM | Female-baised eQTL |
| rs10797079 | chr1:160589320:T:G | - | -0.240052093439631 | 0.0195346838191351 | GBM | Female-baised eQTL |
| rs977018 | chr1:160579942:G:A | - | -0.226608205425216 | 0.0235436609622609 | GBM | Female-baised eQTL |
| rs1875766 | chr1:160580490:G:A | - | -0.226608205425216 | 0.0235436609622609 | GBM | Female-baised eQTL |
| rs11265439 | chr1:160582684:C:T | - | -0.226608205425216 | 0.0235436609622609 | GBM | Female-baised eQTL |
| rs143264429 | chr1:160583854:A:G | - | -0.226608205425216 | 0.0235436609622609 | GBM | Female-baised eQTL |
| rs7539149 | chr1:160586398:C:T | - | -0.226608205425216 | 0.0235436609622609 | GBM | Female-baised eQTL |
| rs12072476 | chr1:160586922:A:G | - | -0.226608205425216 | 0.0235436609622609 | GBM | Female-baised eQTL |
| rs2118424 | chr1:160588271:A:T | - | -0.227247063473326 | 0.0317599476114145 | GBM | Female-baised eQTL |
| rs7546013 | chr1:160589855:A:G | - | -0.227247063473326 | 0.0317599476114145 | GBM | Female-baised eQTL |
| rs7556477 | chr1:160590077:G:A | - | -0.227247063473326 | 0.0317599476114145 | GBM | Female-baised eQTL |
| rs10737177 | chr1:160590226:T:C | - | -0.227247063473326 | 0.0317599476114145 | GBM | Female-baised eQTL |
| rs11265441 | chr1:160591465:C:T | - | -0.227247063473326 | 0.0317599476114145 | GBM | Female-baised eQTL |
| rs10797080 | chr1:160591860:G:A | - | -0.227247063473326 | 0.0317599476114145 | GBM | Female-baised eQTL |
| rs10797081 | chr1:160591981:A:T | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs2118425 | chr1:160593368:T:G | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs4332357 | chr1:160593985:C:T | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs4565710 | chr1:160594684:T:C | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs10908791 | chr1:160594766:G:A | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs7550663 | chr1:160595269:C:T | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs6690086 | chr1:160598053:C:G | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs11265448 | chr1:160601639:C:T | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs10908795 | chr1:160602048:C:G | - | -0.223806416066962 | 0.0387619579134248 | GBM | Female-baised eQTL |
| rs2999861 | chr1:163274850:G:C | - | -0.0993295318248565 | 0.0150797977246563 | LUSC | Female-baised eQTL |
| rs3010369 | chr1:163292799:T:C | - | -0.0982053034248152 | 0.0178770196191043 | LUSC | Female-baised eQTL |
| rs6426895 | chr1:165080434:C:T | - | 0.0932411691140597 | 0.0210112545425131 | LUSC | Female-baised eQTL |
| rs6662890 | chr1:165112923:G:C | - | 0.0749401514058802 | 0.0443407888046199 | LUSC | Female-baised eQTL |
| rs12079498 | chr1:165091699:G:C | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs12086541 | chr1:165102062:G:A | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs12098145 | chr1:165102441:C:T | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs61663037 | chr1:165102883:T:C | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs58274323 | chr1:165102898:A:T | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs149016359 | chr1:165105518:G:A | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs148538461 | chr1:165106999:C:G | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs10494431 | chr1:165110395:A:G | - | 0.0901222287660993 | 0.0451469380508179 | LUSC | Female-baised eQTL |
| rs12089903 | chr1:165091428:C:A | - | 0.0900661052841247 | 0.0459969617534511 | LUSC | Female-baised eQTL |
| rs12084006 | chr1:165094948:G:A | - | 0.0900661052841247 | 0.0459969617534511 | LUSC | Female-baised eQTL |
| rs7515229 | chr1:165097482:T:C | - | 0.0900661052841247 | 0.0459969617534511 | LUSC | Female-baised eQTL |
| rs1587032 | chr1:165099520:G:A | - | 0.0900661052841247 | 0.0459969617534511 | LUSC | Female-baised eQTL |
| rs56323509 | chr1:165100359:C:T | - | 0.0900661052841247 | 0.0459969617534511 | LUSC | Female-baised eQTL |
| rs7546010 | chr1:165097200:G:A | - | 0.0901747742267095 | 0.046428464574371 | LUSC | Female-baised eQTL |
| rs72700421 | chr1:165074974:C:T | - | 0.086007864463404 | 0.0478879141734021 | LUSC | Female-baised eQTL |
| rs79825227 | chr1:158812675:C:G | - | 0.0891025845839602 | 0.0495442224322557 | LUSC | Female-baised eQTL |
| rs76848939 | chr1:158812910:A:T | - | 0.0891025845839602 | 0.0495442224322557 | LUSC | Female-baised eQTL |
| rs10749662 | chr1:151420468:C:T | - | 0.0563766498788761 | 0.0253510364033753 | LUAD | Female-baised eQTL |
| rs56371448 | chr1:161767916:C:A | - | 0.104532959682512 | 0.0312741426387977 | LUAD | Female-baised eQTL |
| rs4657099 | chr1:161767943:C:T | - | 0.104532959682512 | 0.0312741426387977 | LUAD | Female-baised eQTL |
| rs12036441 | chr1:161854829:G:A | - | 0.10096353889443 | 0.0397077600356882 | LUAD | Female-baised eQTL |
| rs2274533 | chr1:151423306:T:C | - | 0.0548369635940856 | 0.0417713893864101 | LUAD | Female-baised eQTL |
| rs2271013 | chr1:161784012:T:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12040648 | chr1:161786686:C:T | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs60035080 | chr1:161790080:T:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs2070150 | chr1:161791486:G:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs10917955 | chr1:161796205:T:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs10918004 | chr1:161815833:G:A | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs56310275 | chr1:161819194:G:A | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs10494358 | chr1:161819244:G:A | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs6695284 | chr1:161823970:A:G | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12403862 | chr1:161827558:A:G | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs114914091 | chr1:161829222:C:T | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12032355 | chr1:161832552:C:A | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12031400 | chr1:161834090:G:A | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs7535349 | chr1:161836566:G:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs1394068 | chr1:161843012:G:A | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs1394069 | chr1:161843130:C:T | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12044770 | chr1:161854031:A:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs955852 | chr1:161861020:A:C | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12025560 | chr1:161878000:T:G | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs12028953 | chr1:161882563:A:T | - | 0.100010805042237 | 0.0433303556604922 | LUAD | Female-baised eQTL |
| rs2879842 | chr1:161845957:T:A | - | 0.0997049524490487 | 0.0446873832595873 | LUAD | Female-baised eQTL |
| rs16863838 | chr1:161765328:G:C | - | 0.10208473647703 | 0.0446939252810272 | LUAD | Female-baised eQTL |
| rs12124569 | chr1:165157200:T:C | - | 0.0652674082885969 | 0.0464670852806828 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs56228539 | chr1:147246274:A:G | - | 0.0709994688764844 | 0.0130250543744971 | COAD | Male-baised eQTL |
| rs61246702 | chr1:147250925:A:G | - | 0.0709994688764844 | 0.0130250543744971 | COAD | Male-baised eQTL |
| rs7514759 | chr1:147253708:G:C | - | 0.0709994688764844 | 0.0130250543744971 | COAD | Male-baised eQTL |
| rs7548980 | chr1:147255322:G:A | - | 0.0709994688764844 | 0.0130250543744971 | COAD | Male-baised eQTL |
| rs7556121 | chr1:163194438:A:G | - | 0.0742667042346757 | 0.0160555064568226 | COAD | Male-baised eQTL |
| rs12137214 | chr1:163192668:A:G | - | 0.0729559096892503 | 0.0238593240350249 | COAD | Male-baised eQTL |
| rs7519727 | chr1:163196285:T:G | - | 0.0729408094701527 | 0.0244628412160908 | COAD | Male-baised eQTL |
| rs80250762 | chr1:163202398:G:A | - | 0.0729408094701527 | 0.0244628412160908 | COAD | Male-baised eQTL |
| rs12143177 | chr1:163205721:G:A | - | 0.0729408094701527 | 0.0244628412160908 | COAD | Male-baised eQTL |
| rs370786875 | chr1:147067792:G:A | - | -0.0537565018345779 | 0.0252563415660246 | COAD | Male-baised eQTL |
| rs573916 | chr1:147070346:G:A | - | -0.052175443541748 | 0.0300922064093069 | COAD | Male-baised eQTL |
| rs7549021 | chr1:163191673:A:G | - | 0.0687664896321221 | 0.0303095929082419 | COAD | Male-baised eQTL |
| rs12140584 | chr1:163192567:G:C | - | 0.0687664896321221 | 0.0303095929082419 | COAD | Male-baised eQTL |
| rs12119530 | chr1:163193400:C:A | - | 0.0687664896321221 | 0.0303095929082419 | COAD | Male-baised eQTL |
| rs12138943 | chr1:163193406:T:A | - | 0.0687664896321221 | 0.0303095929082419 | COAD | Male-baised eQTL |
| rs12140110 | chr1:163194654:T:A | - | 0.0687664896321221 | 0.0303095929082419 | COAD | Male-baised eQTL |
| rs12119417 | chr1:163193039:C:G | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs7513108 | chr1:163193987:T:G | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs7556104 | chr1:163194382:A:G | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs7556112 | chr1:163194408:A:C | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs12142767 | chr1:163194643:G:A | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs4656388 | chr1:163195474:G:T | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs4656389 | chr1:163195562:A:C | - | 0.0708308781150389 | 0.03174877951055 | COAD | Male-baised eQTL |
| rs7521266 | chr1:163194333:G:A | - | 0.0699178726428561 | 0.0421116671734414 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000116584 |
| CpG Site: cg12587087 | |
| Position to Gene: gene | |
| Male Effect: -0.434095349120588 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg12587087 | chr1:156002116 | gene | -0.434095349120588 | 1.08671925415929e-15 | -0.5545719597552573 | 2.207652513920106e-19 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_32725 | chr1:155966819:155966887 | Frame-shift | rs943549 | chr1:156900823:G:A | Distant upstream | -0.0164825576097073 | 0.0146204855228624 | THCA | Female-baised sQTL |
| exon_skip_32725 | chr1:155966819:155966887 | Frame-shift | rs2768744 | chr1:156902357:G:A | Distant upstream | -0.0161300188651173 | 0.0194415183737466 | THCA | Female-baised sQTL |
| exon_skip_32725 | chr1:155966819:155966887 | Frame-shift | rs2768745 | chr1:156902975:T:C | Distant upstream | -0.0160837880146833 | 0.0211862450973639 | THCA | Female-baised sQTL |
| exon_skip_32725 | chr1:155966819:155966887 | Frame-shift | rs11264579 | chr1:156903671:T:C | Distant upstream | 0.0160879809644182 | 0.0212346322609725 | THCA | Female-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs822522 | chr1:155868074:G:C | Distant downstream | 0.0533037129919741 | 0.000113993842924852 | COAD | Female-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs16836580 | chr1:154972571:G:A | Distant downstream | -0.0564382741849411 | 0.00480604640134017 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs682020 | chr1:155745738:T:A | Distant downstream | -0.0522516522534587 | 0.00931113947619679 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs111982496 | chr1:155742854:C:T | Distant downstream | -0.0636342331229475 | 0.0147006810193349 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs821549 | chr1:155739604:C:T | Distant downstream | -0.0606616267978784 | 0.0221657265524999 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs171167 | chr1:155711804:T:C | Distant downstream | -0.0489370633353772 | 0.0408581193862569 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs348206 | chr1:155712542:A:G | Distant downstream | -0.0489370633353772 | 0.0408581193862569 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs9427223 | chr1:155720050:T:C | Distant downstream | -0.0489370633353772 | 0.0408581193862569 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs9426929 | chr1:155723608:G:C | Distant downstream | -0.0489370633353772 | 0.0408581193862569 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs548809 | chr1:155732270:A:C | Distant downstream | -0.0489370633353772 | 0.0408581193862569 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs59706606 | chr1:155754623:A:G | Distant downstream | -0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs11803678 | chr1:155755740:A:C | Distant downstream | -0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs1624846 | chr1:155780945:T:C | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs1749421 | chr1:155782753:G:A | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs2686255 | chr1:155789995:G:A | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs1765284 | chr1:155802845:A:G | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs822018 | chr1:155807480:G:C | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs28460554 | chr1:155810105:C:T | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs822482 | chr1:155831122:A:G | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs7530726 | chr1:155836200:G:A | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs822499 | chr1:155841888:C:T | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs822500 | chr1:155842263:G:A | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs2363012 | chr1:155847675:C:T | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs822488 | chr1:155851983:G:A | Distant downstream | 0.0478832742171976 | 0.0450873939496174 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs598176 | chr1:155737762:T:C | Distant downstream | -0.0478222576727972 | 0.0458388941253734 | LUAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs11803917 | chr1:156141787:C:T | Distant upstream | -0.0529644837301732 | 0.0217804405607085 | COAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs12058004 | chr1:156142545:A:T | Distant upstream | -0.0529644837301732 | 0.0217804405607085 | COAD | Male-baised sQTL |
| exon_skip_32723 | chr1:155965630:155965760 | Frame-shift | rs73006722 | chr1:156146015:C:T | Distant upstream | -0.0491484070009079 | 0.038957530520825 | COAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ARHGEF2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
