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Gene: ENSG00000116525 |
Summary for TRIM62 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000116525 | Gene symbol | TRIM62 |
| Gene name | tripartite motif containing 62 | |
| HGNC | 25574 | |
| Entrez ID | 55223 | |
| Gene type | protein_coding | |
| Synonyms | TRIM62|FLJ10759|DEAR1 | |
| UniProtAcc | Q9BVG3 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TRIM62 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for TRIM62 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TRIM62 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03036777 | chr1:33183218 | CGI:chr1:33180725-33182272 | promoter | 5.44e-01 | 3.66e-01 | 3.49e+00 | 4.85e-04 | 5.93e-03 | 1.78e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg15575967 | chr1:33183133 | CGI:chr1:33180725-33182272 | promoter | 4.42e-01 | 6.65e-01 | -3.94e+00 | 8.07e-05 | 6.42e-04 | -2.24e-01 |
| LUSC | cg03036777 | chr1:33183218 | CGI:chr1:33180725-33182272 | promoter | 5.45e-01 | 7.96e-01 | -4.08e+00 | 4.52e-05 | 5.47e-04 | -2.51e-01 |
| COAD | cg25274008 | chr1:33183047 | CGI:chr1:33180725-33182272 | promoter | 7.01e-01 | 8.47e-01 | -2.32e+00 | 2.05e-02 | 2.52e-02 | -1.47e-01 |
| BLCA | cg25342005 | chr1:33183055 | CGI:chr1:33180725-33182272 | promoter | 5.98e-01 | 7.39e-01 | -2.01e+00 | 4.45e-02 | 4.56e-02 | -1.41e-01 |
| BLCA | cg03036777 | chr1:33183218 | CGI:chr1:33180725-33182272 | promoter | 5.17e-01 | 6.75e-01 | -2.81e+00 | 5.00e-03 | 8.14e-03 | -1.58e-01 |
| LIHC | cg17109517 | chr1:33180772 | CGI:chr1:33180725-33182272 | promoter,gene body | 5.06e-01 | 2.89e-01 | 4.02e+00 | 5.81e-05 | 1.28e-04 | 2.17e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg25274008 | chr1:33183047 | CGI:chr1:33180725-33182272 | promoter | 5.22e-01 | 7.23e-01 | -7.82e+00 | 5.22e-15 | 1.90e-14 | -2.01e-01 |
| BRCA | cg25342005 | chr1:33183055 | CGI:chr1:33180725-33182272 | promoter | 4.78e-01 | 6.39e-01 | -8.37e+00 | 5.71e-17 | 2.42e-16 | -1.61e-01 |
| BRCA | cg15575967 | chr1:33183133 | CGI:chr1:33180725-33182272 | promoter | 4.14e-01 | 6.08e-01 | -1.14e+01 | 5.60e-30 | 8.13e-29 | -1.94e-01 |
| KIRC | cg17109517 | chr1:33180772 | CGI:chr1:33180725-33182272 | promoter,gene body | 1.88e-01 | 7.33e-02 | 3.22e+00 | 1.27e-03 | 5.07e-03 | 1.15e-01 |
| HNSC | cg25274008 | chr1:33183047 | CGI:chr1:33180725-33182272 | promoter | 8.08e-01 | 6.52e-01 | 2.54e+00 | 1.09e-02 | 1.95e-02 | 1.56e-01 |
| HNSC | cg25342005 | chr1:33183055 | CGI:chr1:33180725-33182272 | promoter | 7.25e-01 | 5.81e-01 | 2.36e+00 | 1.81e-02 | 2.60e-02 | 1.44e-01 |
| HNSC | cg03036777 | chr1:33183218 | CGI:chr1:33180725-33182272 | promoter | 5.22e-01 | 4.20e-01 | 2.28e+00 | 2.23e-02 | 2.95e-02 | 1.02e-01 |
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Exon skipping events with PSI in TCGA for TRIM62 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TRIM62 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TRIM62 |
| TFs related to TRIM62. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | NHLH1 | TRIM62 | 2.60e+00 | 2.14e-03 | 3.79e+00 | 9.81e-01 | Female-biased |
| ACC | PATZ1 | TRIM62 | 2.57e+00 | 2.00e-03 | 3.77e+00 | 9.80e-01 | Female-biased |
| ACC | ZNF320 | TRIM62 | 2.71e+00 | 3.20e-03 | 3.81e+00 | 9.80e-01 | Female-biased |
| ACC | ZNF417 | TRIM62 | 3.02e+00 | 4.77e-03 | 4.03e+00 | 9.84e-01 | Female-biased |
| ACC | ZNF454 | TRIM62 | 2.54e+00 | 1.15e-03 | 3.88e+00 | 9.85e-01 | Female-biased |
| ACC | ZNF891 | TRIM62 | 2.82e+00 | 3.89e-03 | 3.87e+00 | 9.81e-01 | Female-biased |
| DLBC | ZNF418 | TRIM62 | 4.63e+00 | 9.92e-01 | 3.40e+00 | 2.46e-03 | Male-biased |
| READ | ZNF418 | TRIM62 | 4.56e+00 | 9.82e-01 | 3.75e+00 | 1.03e-02 | Male-biased |
| SARC | PRDM6 | TRIM62 | 4.03e+00 | 9.84e-01 | 2.38e+00 | 2.08e-05 | Male-biased |
| SARC | ZNF121 | TRIM62 | 4.06e+00 | 9.84e-01 | 3.19e+00 | 1.63e-03 | Male-biased |
| SARC | ZNF418 | TRIM62 | 4.13e+00 | 9.87e-01 | 1.98e+00 | 1.61e-06 | Male-biased |
| TRIM62 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TRIM62 |
| RBPs related to ES in TRIM62. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TRIM62 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3905365 | chr1:37248987:C:A | - | 0.181478639737439 | 0.0301654506834756 | SARC | Female-baised eQTL |
| rs807254 | chr1:25789053:C:T | - | 0.456070733286688 | 0.00016134531367829 | KIRP | Female-baised eQTL |
| rs61778226 | chr1:30914674:T:G | - | 0.175231437948195 | 0.00413517870809597 | KIRP | Female-baised eQTL |
| rs807250 | chr1:25791658:G:A | - | 0.332038772370106 | 0.00415152714335168 | KIRP | Female-baised eQTL |
| rs12024115 | chr1:41068685:C:T | - | 0.0658625843831886 | 0.00155555080729996 | LUAD | Female-baised eQTL |
| rs13375139 | chr1:30218866:C:T | - | 0.0379548882132963 | 0.023432776728462 | LUAD | Female-baised eQTL |
| rs6675193 | chr1:38793002:C:T | - | 0.0360801069717872 | 0.0255144507911092 | LUAD | Female-baised eQTL |
| rs13375398 | chr1:30220335:A:G | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs13374985 | chr1:30220469:G:A | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs56245189 | chr1:30220777:T:C | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs60780074 | chr1:30220966:C:T | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs12406694 | chr1:30221112:C:T | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs11806668 | chr1:30221851:C:T | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs12566428 | chr1:30223161:C:G | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs59296486 | chr1:30223349:T:C | - | 0.0367852163093665 | 0.0304706267009571 | LUAD | Female-baised eQTL |
| rs7538272 | chr1:38801022:C:A | - | 0.0356393997648516 | 0.0305253940047557 | LUAD | Female-baised eQTL |
| rs12407735 | chr1:30224092:C:T | - | 0.0356484862174086 | 0.0307549002838746 | LUAD | Female-baised eQTL |
| rs59765152 | chr1:30218970:C:T | - | 0.0368530795265309 | 0.0314566321130767 | LUAD | Female-baised eQTL |
| rs12405032 | chr1:30219104:G:A | - | 0.0368530795265309 | 0.0314566321130767 | LUAD | Female-baised eQTL |
| rs16833425 | chr1:30223527:A:G | - | 0.0360913808848847 | 0.0330604308997517 | LUAD | Female-baised eQTL |
| rs12406818 | chr1:30219350:T:C | - | 0.0365607621777368 | 0.0335824372570152 | LUAD | Female-baised eQTL |
| rs12405055 | chr1:30219420:G:T | - | 0.0365607621777368 | 0.0335824372570152 | LUAD | Female-baised eQTL |
| rs2142714 | chr1:30219751:G:A | - | 0.0365607621777368 | 0.0335824372570152 | LUAD | Female-baised eQTL |
| rs2142713 | chr1:30219801:T:C | - | 0.0365607621777368 | 0.0335824372570152 | LUAD | Female-baised eQTL |
| rs2142712 | chr1:30224196:C:G | - | 0.0358390111623936 | 0.0361523737786954 | LUAD | Female-baised eQTL |
| rs12407702 | chr1:30223776:C:G | - | 0.036050604839966 | 0.0388154924832439 | LUAD | Female-baised eQTL |
| rs12408182 | chr1:30223822:A:G | - | 0.036050604839966 | 0.0388154924832439 | LUAD | Female-baised eQTL |
| rs12408493 | chr1:30223830:T:C | - | 0.036050604839966 | 0.0388154924832439 | LUAD | Female-baised eQTL |
| rs12408508 | chr1:30223992:T:C | - | 0.036050604839966 | 0.0388154924832439 | LUAD | Female-baised eQTL |
| rs12406768 | chr1:30224065:G:C | - | 0.036050604839966 | 0.0388154924832439 | LUAD | Female-baised eQTL |
| rs2179164 | chr1:30224539:A:G | - | 0.0355499873588591 | 0.0414092393461822 | LUAD | Female-baised eQTL |
| rs12406034 | chr1:30219312:C:G | - | 0.0358072287708366 | 0.0416487201995132 | LUAD | Female-baised eQTL |
| rs200268556 | chr1:30219017:A:C | - | 0.0356721611830779 | 0.044917691401378 | LUAD | Female-baised eQTL |
| rs11264027 | chr1:37339195:G:T | - | 0.0354535767526483 | 0.0466416201216441 | LUAD | Female-baised eQTL |
| rs57234941 | chr1:37340158:A:G | - | 0.0354535767526483 | 0.0466416201216441 | LUAD | Female-baised eQTL |
| rs58793672 | chr1:37333085:G:A | - | 0.0353507720707679 | 0.0486445615775414 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs56148301 | chr1:42301866:T:C | - | 0.0946030837812716 | 0.0105429132924066 | STAD | Male-baised eQTL |
| rs34834740 | chr1:30417152:T:A | - | 0.0586497651327568 | 0.00372631888049651 | KIRC | Male-baised eQTL |
| rs61766225 | chr1:30389876:G:A | - | 0.0571878738363691 | 0.00410758762576489 | KIRC | Male-baised eQTL |
| rs6666654 | chr1:40503391:C:T | - | 0.0674941269882427 | 0.0225861577972296 | KIRC | Male-baised eQTL |
| rs74489195 | chr1:40024519:A:C | - | 0.0483979462719286 | 0.0234460816222774 | KIRC | Male-baised eQTL |
| rs4660373 | chr1:40022182:C:T | - | 0.049591463848723 | 0.0258713287510777 | KIRC | Male-baised eQTL |
| rs493564 | chr1:29180588:A:C | - | -0.0837825499387943 | 0.0387730558706547 | LUAD | Male-baised eQTL |
| rs143601327 | chr1:28939633:G:A | - | 0.12256379902078 | 0.0489243640340507 | LUAD | Male-baised eQTL |
| rs7367713 | chr1:35690831:C:T | - | -0.0679675987642317 | 0.0191140630152019 | COAD | Male-baised eQTL |
| rs4653145 | chr1:35691494:T:C | - | -0.0679675987642317 | 0.0191140630152019 | COAD | Male-baised eQTL |
| rs11264194 | chr1:35729771:C:T | - | 0.075950911099208 | 0.0237159008588697 | COAD | Male-baised eQTL |
| rs61783811 | chr1:29532366:G:A | - | -0.0575799700399489 | 0.0380353447100367 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000116525 |
| CpG Site: cg06851000 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.423760902540511 | |
 | Gene ID: ENSG00000116525 |
| CpG Site: cg10975001 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.423760902540511 | |
 | Gene ID: ENSG00000116525 |
| CpG Site: cg15575967 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.247918505340102 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06851000 | chr1:33161508 | gene | -0.423760902540511 | 6.86150642703825e-19 | -0.5619187470689905 | 1.2621733494999647e-22 | LUAD |
| cg10975001 | chr1:33161554 | gene | -0.423760902540511 | 6.86150642703825e-19 | -0.5619187470689905 | 1.2621733494999647e-22 | LUAD |
| cg15575967 | chr1:33183133 | promoter | -0.247918505340102 | 3.75553189690772e-05 | -0.3088625176873651 | 4.867488327091964e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TRIM62 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
