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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000116473

Summary for RAP1A

check button Gene summary

Gene informationEnsembl ID

ENSG00000116473

Gene symbol

RAP1A

Gene nameRAP1A, member of RAS oncogene family
HGNC

9855

Entrez ID

5906

Gene typeprotein_coding
SynonymsRAP1A|KREV-1|SMGP21
UniProtAcc

P62834


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for RAP1A

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
RAP1A5.46e+03-1.29e+001.41e-01-9.13e+007.01e-207.18e-18STAD

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
RAP1A2.27e+03-1.82e+002.13e-01-8.55e+001.18e-171.66e-15READ

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Sex-biased somatic mutation for RAP1A

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for RAP1A

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for RAP1A

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for RAP1A

∗Please access CAeditome for RNA editing annotation.
check buttonLandscape of RNA editing events across multiple cancer types.
ED heatmap

check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre
STADRAP1A-004chr1_111668773_+2.43e-011.41e-012.43e+001.52e-024.96e-021.02e-01
STADRAP1A-004chr1_111668909_+2.38e-011.69e-012.26e+002.38e-024.96e-026.81e-02

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for RAP1A

check buttonTFs related to RAP1A.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
DLBCPRDM6RAP1A4.33e+009.87e-013.22e+003.67e-03Male-biased
DLBCZNF182RAP1A4.23e+009.85e-013.16e+004.23e-03Male-biased
DLBCZNF22RAP1A4.27e+009.87e-013.13e+003.25e-03Male-biased
DLBCZNF235RAP1A4.50e+009.92e-013.10e+001.31e-03Male-biased
DLBCZNF287RAP1A4.35e+009.89e-013.07e+001.97e-03Male-biased
DLBCZNF418RAP1A5.32e+009.89e-014.44e+009.32e-03Male-biased
DLBCZNF487RAP1A4.36e+009.88e-013.23e+003.41e-03Male-biased
DLBCZNF492RAP1A4.26e+009.81e-013.35e+008.06e-03Male-biased
DLBCZNF613RAP1A4.35e+009.82e-013.46e+008.85e-03Male-biased
DLBCZNF879RAP1A4.89e+009.88e-013.98e+008.14e-03Male-biased
MESOAIRERAP1A4.60e+009.93e-012.87e+001.65e-03Male-biased
MESOBCL6BRAP1A4.15e+009.81e-012.84e+006.84e-03Male-biased
MESOCDX2RAP1A4.33e+009.91e-012.19e+003.61e-04Male-biased
MESOE2F7RAP1A4.26e+009.85e-012.86e+005.26e-03Male-biased
MESOEVX2RAP1A4.18e+009.88e-012.30e+009.23e-04Male-biased
MESOFOXD2RAP1A4.57e+009.94e-012.21e+001.67e-04Male-biased
MESOFOXE1RAP1A3.96e+009.85e-011.77e+002.96e-04Male-biased
MESOFOXG1RAP1A3.90e+009.83e-011.25e+006.25e-05Male-biased
MESOFOXJ2RAP1A3.82e+009.81e-011.64e+003.05e-04Male-biased
MESOFOXL1RAP1A3.96e+009.85e-011.47e+001.04e-04Male-biased
MESOFOXQ1RAP1A4.45e+009.93e-012.25e+002.96e-04Male-biased
MESOHOXC10RAP1A4.45e+009.93e-012.33e+003.90e-04Male-biased
MESOIRF1RAP1A4.07e+009.87e-011.85e+002.68e-04Male-biased
MESOMEF2ARAP1A3.93e+009.84e-011.56e+001.61e-04Male-biased
MESOMSX1RAP1A4.48e+009.93e-012.19e+002.19e-04Male-biased
MESOMSX2RAP1A4.52e+009.94e-012.20e+002.01e-04Male-biased
MESOMYNNRAP1A4.19e+009.89e-012.04e+003.47e-04Male-biased
MESOPOU2F1RAP1A4.32e+009.91e-012.42e+008.64e-04Male-biased
MESOPOU3F2RAP1A4.12e+009.88e-011.55e+008.06e-05Male-biased
MESOSOX15RAP1A4.81e+009.95e-012.79e+005.88e-04Male-biased
MESOSOX9RAP1A4.32e+009.91e-012.09e+002.66e-04Male-biased
MESOSTAT5BRAP1A4.26e+009.90e-012.34e+008.28e-04Male-biased
MESOYY1RAP1A4.14e+009.86e-012.55e+002.58e-03Male-biased
MESOZNF136RAP1A4.20e+009.89e-012.32e+009.41e-04Male-biased
MESOZNF175RAP1A4.27e+009.90e-012.05e+002.77e-04Male-biased
MESOZNF25RAP1A4.01e+009.86e-011.34e+006.02e-05Male-biased
MESOZNF250RAP1A4.59e+009.93e-012.79e+001.28e-03Male-biased
MESOZNF276RAP1A5.24e+009.88e-014.01e+009.63e-03Male-biased
MESOZNF317RAP1A4.44e+009.91e-012.70e+001.58e-03Male-biased
MESOZNF354BRAP1A4.55e+009.93e-012.54e+006.11e-04Male-biased
MESOZNF418RAP1A4.07e+009.87e-013.88e-012.23e-06Male-biased
MESOZNF74RAP1A4.40e+009.90e-012.80e+002.64e-03Male-biased
PCPGSOX15RAP1A4.29e+009.84e-013.37e+005.68e-03Male-biased

check buttonRAP1A related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for RAP1A

check buttonRBPs related to ES in RAP1A.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
THYMCNOT4exon_skip_89078.47e+003.49e-038.88e+009.92e-01Female-biased
PAADCNOT4exon_skip_89078.85e+009.93e-018.45e+002.57e-03Male-biased

check buttonRAP1A related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11801226chr1:107732983:A:T-0.1723127035052730.00469994360678022LUSCFemale-baised eQTL
rs148443508chr1:107736843:A:G-0.1802116131538420.0117686822533218LUSCFemale-baised eQTL
rs147762141chr1:107737482:C:T-0.1802116131538420.0117686822533218LUSCFemale-baised eQTL
rs12406345chr1:107740025:G:A-0.1802116131538420.0117686822533218LUSCFemale-baised eQTL
rs12405204chr1:107739590:A:T-0.1797809027731910.0124314387737912LUSCFemale-baised eQTL
rs17019880chr1:107745598:T:C-0.1766412885625190.0164578584020699LUSCFemale-baised eQTL
rs72705642chr1:107746647:G:T-0.1766412885625190.0164578584020699LUSCFemale-baised eQTL
rs6670623chr1:104709296:G:C-0.07839652507605890.0347389035451056LGGFemale-baised eQTL
rs5015332chr1:103848043:C:T-0.06134583983835460.0155219386661874LUADFemale-baised eQTL
rs7513434chr1:110643707:C:T-0.07855184777179790.0409076581455395LUADFemale-baised eQTL
rs1021880chr1:109881907:A:G-0.09504238406175220.0427226565158242LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2488756chr1:112408668:C:T-0.8780887581402171.46251350632236e-10PCPGMale-baised eQTL
rs2483331chr1:112410341:A:C-0.8780887581402171.46251350632236e-10PCPGMale-baised eQTL
rs12062571chr1:109974995:T:C-0.2173675897530660.000639975574495508PCPGMale-baised eQTL
rs269139chr1:112076834:G:T-0.2150134570120070.00366566054339111PCPGMale-baised eQTL
rs2492508chr1:112398512:G:A-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs2995761chr1:112398941:T:G-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs2488760chr1:112399517:A:G-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs1891706chr1:112399962:G:A-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs2999473chr1:112400828:G:A-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs2999474chr1:112400961:G:A-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs2999475chr1:112401075:G:A-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs1936047chr1:112403737:C:T-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs1777604chr1:112407256:A:G-0.4417772089651420.00720869312556022PCPGMale-baised eQTL
rs798016chr1:116799778:C:T-0.183799134716440.0130208363810823PCPGMale-baised eQTL
rs798005chr1:116802737:C:T-0.183799134716440.0130208363810823PCPGMale-baised eQTL
rs798027chr1:116795558:A:T-0.1754295541853790.0324810430114959PCPGMale-baised eQTL
rs798026chr1:116795566:T:A-0.1754295541853790.0324810430114959PCPGMale-baised eQTL
rs7527471chr1:106597490:T:C-0.1645125702017040.0335459304923936PCPGMale-baised eQTL
rs1088460chr1:116788073:T:A-0.1741825038302760.0367443199529559PCPGMale-baised eQTL
rs73009073chr1:116791892:G:A-0.1741825038302760.0367443199529559PCPGMale-baised eQTL
rs10923147chr1:116792719:C:G-0.1741825038302760.0367443199529559PCPGMale-baised eQTL
rs6701708chr1:111969573:C:T-0.07826862155032780.0298460687032515LGGMale-baised eQTL
rs10747433chr1:102952517:A:C--0.07289696787039560.0405165879243737BLCAMale-baised eQTL
rs1966958chr1:102953541:A:G--0.07289696787039560.0405165879243737BLCAMale-baised eQTL
rs10754372chr1:118209333:G:C-0.03305488652772360.0437846547805348BLCAMale-baised eQTL
rs12140435chr1:118209995:G:A-0.03322197047002320.0440986278536614BLCAMale-baised eQTL
rs10923519chr1:118210207:T:G-0.03301460528690470.0448464072781745BLCAMale-baised eQTL
rs2154354chr1:118212640:G:C-0.03301460528690470.0448464072781745BLCAMale-baised eQTL
rs4658975chr1:118214137:A:G-0.03301460528690470.0448464072781745BLCAMale-baised eQTL
rs12136216chr1:118209785:A:G-0.03290976442394290.0472913069956321BLCAMale-baised eQTL
rs12137016chr1:118210017:A:G-0.03290976442394290.0472913069956321BLCAMale-baised eQTL
rs7535558chr1:109908496:T:C--0.03740278231948170.0485716247559867BLCAMale-baised eQTL
rs2615984chr1:102958032:A:G--0.0706222390074150.0497404614042872BLCAMale-baised eQTL
rs2615985chr1:102959396:G:A--0.0706222390074150.0497404614042872BLCAMale-baised eQTL
rs1841834chr1:102962833:G:A--0.0706222390074150.0497404614042872BLCAMale-baised eQTL
rs11164647chr1:102967131:T:C--0.0706222390074150.0497404614042872BLCAMale-baised eQTL
rs6662599chr1:102967386:A:G--0.0706222390074150.0497404614042872BLCAMale-baised eQTL
rs2615990chr1:102968914:G:A--0.0706222390074150.0497404614042872BLCAMale-baised eQTL
rs1537955chr1:102010756:T:C-0.06741023188089570.00530690890194706COADMale-baised eQTL
rs17484544chr1:115461911:C:T-0.088852342970650.00533345265472186COADMale-baised eQTL
rs12030625chr1:110573333:G:C-0.06973251716700350.00605356057333975COADMale-baised eQTL
rs498439chr1:115451055:G:T-0.08440101084065010.0063896495773844COADMale-baised eQTL
rs17539492chr1:107679844:T:G-0.09489421917971810.00709355987712797COADMale-baised eQTL
rs61803527chr1:102018242:T:C-0.06467237656644680.00854466928534833COADMale-baised eQTL
rs486296chr1:115447162:A:G-0.08435985255355150.00894340155228COADMale-baised eQTL
rs563998chr1:115447515:A:C-0.08435985255355150.00894340155228COADMale-baised eQTL
rs563992chr1:115447521:A:G-0.08435985255355150.00894340155228COADMale-baised eQTL
rs527278chr1:115449235:G:T-0.08435985255355150.00894340155228COADMale-baised eQTL
rs532431chr1:115449602:A:G-0.08435985255355150.00894340155228COADMale-baised eQTL
rs61799134chr1:115452560:G:T-0.08184779552533760.00923968121515735COADMale-baised eQTL
rs17556126chr1:115455859:T:G-0.08448544940622870.00993886556886414COADMale-baised eQTL
rs72731691chr1:102022988:C:T-0.06377771616867570.0107361687734343COADMale-baised eQTL
rs476283chr1:115447354:C:T-0.0819766898292110.0127528582734032COADMale-baised eQTL
rs563980chr1:115447525:G:A-0.0819766898292110.0127528582734032COADMale-baised eQTL
rs7529711chr1:102009187:T:C-0.06071510847574260.0198367720810695COADMale-baised eQTL
rs538861chr1:115445146:A:G-0.07912021979383080.0239637076818552COADMale-baised eQTL
rs17484432chr1:115458858:T:C-0.07618622356044130.0244906604370917COADMale-baised eQTL
rs17556264chr1:115459363:A:G-0.07618622356044130.0244906604370917COADMale-baised eQTL
rs80057683chr1:115701545:C:T-0.06929984011224940.0252404662515202COADMale-baised eQTL
rs508813chr1:115446092:T:C-0.07670706636184260.0274580235417329COADMale-baised eQTL
rs7541344chr1:115709305:C:A-0.06826250305156670.0277757258558873COADMale-baised eQTL
rs4915034chr1:107305328:G:A-0.1137299689410620.0289706869548008COADMale-baised eQTL
rs2336126chr1:108098283:A:G--0.05913839606507090.041244843189743COADMale-baised eQTL
rs3811013chr1:115691462:T:A-0.06498238454041730.0422014912591388COADMale-baised eQTL
rs11578766chr1:115704057:G:A-0.06398906310012090.044326097914258COADMale-baised eQTL
rs2645288chr1:118957860:G:C--0.06867111320362550.0446609390822119COADMale-baised eQTL
rs35939222chr1:115703922:A:C-0.06367521261011750.0458749286004727COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000116473
CpG Site: cg01918604
Position to Gene: gene
Male Effect: -
Female Effect: -0.316858519336588

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg01918604chr1:111565319gene-0.3168585193365883.03486525609685e-06-0.396585460079305841.229522866545862e-06SARC

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of RAP1A

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource