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Gene: ENSG00000116062 |
Summary for MSH6 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000116062 | Gene symbol | MSH6 |
| Gene name | mutS homolog 6 | |
| HGNC | 7329 | |
| Entrez ID | 2956 | |
| Gene type | protein_coding | |
| Synonyms | MSH6|MSH-6 | |
| UniProtAcc | P52701 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for MSH6 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for MSH6 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for MSH6 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg02053451 | chr2:47695466 | CGI:chr2:47690749-47691275 | promoter | 8.09e-01 | 9.19e-01 | -4.09e+00 | 4.27e-05 | 1.27e-04 | -1.09e-01 |
| LUSC | cg02053451 | chr2:47695466 | CGI:chr2:47690749-47691275 | promoter | 7.75e-01 | 9.37e-01 | -3.99e+00 | 6.62e-05 | 6.00e-04 | -1.62e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for MSH6 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for MSH6 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for MSH6 |
| TFs related to MSH6. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | FOXR2 | MSH6 | 4.70e+00 | 9.83e-01 | 3.80e+00 | 1.04e-02 | Male-biased |
| LAML | POU3F3 | MSH6 | 4.71e+00 | 9.80e-01 | 3.87e+00 | 1.31e-02 | Male-biased |
| PAAD | ZNF235 | MSH6 | 4.06e+00 | 9.82e-01 | 3.07e+00 | 4.28e-03 | Male-biased |
| PAAD | ZNF287 | MSH6 | 4.10e+00 | 9.82e-01 | 3.14e+00 | 5.20e-03 | Male-biased |
| PAAD | ZNF418 | MSH6 | 4.19e+00 | 9.89e-01 | 2.72e+00 | 3.42e-04 | Male-biased |
| PAAD | ZNF879 | MSH6 | 4.01e+00 | 9.85e-01 | 2.70e+00 | 8.16e-04 | Male-biased |
| READ | ZNF235 | MSH6 | 4.44e+00 | 9.86e-01 | 3.45e+00 | 4.92e-03 | Male-biased |
| READ | ZNF287 | MSH6 | 4.37e+00 | 9.84e-01 | 3.44e+00 | 6.27e-03 | Male-biased |
| READ | ZNF418 | MSH6 | 4.46e+00 | 9.90e-01 | 3.15e+00 | 1.53e-03 | Male-biased |
| READ | ZNF879 | MSH6 | 4.15e+00 | 9.81e-01 | 3.12e+00 | 4.19e-03 | Male-biased |
| SKCM | ZNF418 | MSH6 | 4.74e+00 | 1.72e-02 | 5.55e+00 | 9.80e-01 | Female-biased |
| MSH6 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for MSH6 |
| RBPs related to ES in MSH6. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MSH6 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7564475 | chr2:51000875:T:A | - | 0.186587844637412 | 0.0113933966320831 | READ | Female-baised eQTL |
| rs62134191 | chr2:44821365:G:A | - | 0.270910723619336 | 0.0268671153737437 | PAAD | Female-baised eQTL |
| rs140007483 | chr2:45037032:T:G | - | 0.170132359739946 | 0.00111198289371388 | BLCA | Female-baised eQTL |
| rs148951858 | chr2:45037161:C:T | - | 0.170132359739946 | 0.00111198289371388 | BLCA | Female-baised eQTL |
| rs4952736 | chr2:45048219:T:C | - | 0.170864336705445 | 0.00137474328348036 | BLCA | Female-baised eQTL |
| rs4952734 | chr2:45039683:C:T | - | 0.161401496117764 | 0.0015901398245303 | BLCA | Female-baised eQTL |
| rs149811992 | chr2:45037043:T:C | - | 0.168555049874283 | 0.00196030174313699 | BLCA | Female-baised eQTL |
| rs4952732 | chr2:45033354:A:C | - | 0.151857185664712 | 0.00306500490120544 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs28968188 | chr2:51899358:C:A | - | 0.0929506376084952 | 0.0185636267754836 | LIHC | Male-baised eQTL |
| rs55754993 | chr2:49711935:A:G | - | 0.0778525487936873 | 0.0277743700924585 | LIHC | Male-baised eQTL |
| rs72880459 | chr2:49726502:T:A | - | 0.0768161029144091 | 0.0310612268873412 | LIHC | Male-baised eQTL |
| rs1369679 | chr2:51928882:C:T | - | 0.0849542196566357 | 0.0434662127603914 | LIHC | Male-baised eQTL |
| rs797695 | chr2:47721559:A:G | gene | -0.0549207628775509 | 0.0460605300189135 | LIHC | Male-baised eQTL |
| rs797702 | chr2:47720913:C:T | gene | -0.0547503986648455 | 0.0463681601180856 | LIHC | Male-baised eQTL |
| rs797701 | chr2:47720923:T:C | gene | -0.0547503986648455 | 0.0463681601180856 | LIHC | Male-baised eQTL |
| rs797698 | chr2:47721143:T:C | gene | -0.0547503986648455 | 0.0463681601180856 | LIHC | Male-baised eQTL |
| rs797696 | chr2:47721250:A:G | gene | -0.0547503986648455 | 0.0463681601180856 | LIHC | Male-baised eQTL |
| rs797700 | chr2:47720962:C:T | gene | -0.0547325505362232 | 0.0476797562387626 | LIHC | Male-baised eQTL |
| rs1401325 | chr2:49739343:G:C | - | 0.0750956085459319 | 0.0483133599878204 | LIHC | Male-baised eQTL |
| rs7370121 | chr2:51892165:G:A | - | 0.0829244776525729 | 0.0489923744745197 | LIHC | Male-baised eQTL |
| rs61046724 | chr2:44538904:T:C | - | 0.0539866701522038 | 0.0423248368630925 | LGG | Male-baised eQTL |
| rs1042820 | chr2:47783419:C:A | gene,CDS,exon,UTR | 0.0584101823384787 | 0.00775099007428395 | KIRC | Male-baised eQTL |
| rs55927047 | chr2:47783515:C:G | gene | 0.0584101823384787 | 0.00775099007428395 | KIRC | Male-baised eQTL |
| rs3136240 | chr2:47784947:C:T | gene,exon | 0.0584101823384787 | 0.00775099007428395 | KIRC | Male-baised eQTL |
| rs3136284 | chr2:47791517:T:C | gene | 0.0561689564633106 | 0.00790032741260065 | KIRC | Male-baised eQTL |
| rs3136235 | chr2:47783919:G:A | gene | 0.0581875951487886 | 0.00832845535091593 | KIRC | Male-baised eQTL |
| rs3136279 | chr2:47790629:C:A | gene | 0.0567935039203513 | 0.00976160130851629 | KIRC | Male-baised eQTL |
| rs3136283 | chr2:47791340:G:T | gene | 0.0567031438594907 | 0.0101035240012963 | KIRC | Male-baised eQTL |
| rs6740018 | chr2:54677683:C:G | - | -0.0741776231830396 | 0.0217567271926626 | KIRC | Male-baised eQTL |
| rs17504446 | chr2:40203471:A:C | - | 0.0399047420451334 | 0.0368433235484855 | KIRC | Male-baised eQTL |
| rs10196182 | chr2:52277882:T:A | - | 0.0413894049477366 | 0.0369251075721617 | KIRC | Male-baised eQTL |
| rs4494801 | chr2:48837672:C:A | - | -0.0501903403879771 | 0.028240001286638 | BLCA | Male-baised eQTL |
| rs1401253 | chr2:57417830:G:T | - | -0.0999789521469452 | 0.0398040029485019 | BLCA | Male-baised eQTL |
| rs12612175 | chr2:48889701:T:C | - | -0.0453810673932848 | 0.0447363904724471 | BLCA | Male-baised eQTL |
| rs11680055 | chr2:44036171:A:T | - | 0.0473409298787552 | 0.047540860446456 | BLCA | Male-baised eQTL |
| rs111454574 | chr2:48455886:C:T | - | 0.0919302077723022 | 0.0498644414333714 | LUAD | Male-baised eQTL |
| rs10177338 | chr2:40128799:G:T | - | 0.0796321129862184 | 7.73402049425432e-05 | COAD | Male-baised eQTL |
| rs12619513 | chr2:52305736:G:A | - | 0.143563142125938 | 0.000149035209179897 | COAD | Male-baised eQTL |
| rs10183046 | chr2:40130109:C:G | - | 0.0779096860885189 | 0.000197678475646925 | COAD | Male-baised eQTL |
| rs13433080 | chr2:40119363:G:A | - | 0.074140943578246 | 0.00032644663408393 | COAD | Male-baised eQTL |
| rs67997642 | chr2:40118082:G:A | - | 0.0734424643894013 | 0.000343304150186034 | COAD | Male-baised eQTL |
| rs4140823 | chr2:40135816:G:A | - | 0.0754122976505784 | 0.000352428537626297 | COAD | Male-baised eQTL |
| rs2110921 | chr2:40136576:C:T | - | 0.0748561271401323 | 0.00040558762475906 | COAD | Male-baised eQTL |
| rs13008919 | chr2:50506407:G:T | - | 0.093393573585356 | 0.000670729569641342 | COAD | Male-baised eQTL |
| rs6726118 | chr2:41607201:G:C | - | 0.133319144036215 | 0.000703222306448288 | COAD | Male-baised eQTL |
| rs17025097 | chr2:40104023:A:G | - | 0.0745308974404135 | 0.00109022684949727 | COAD | Male-baised eQTL |
| rs5543 | chr2:40114465:G:A | - | 0.0679979305868576 | 0.00118712474375708 | COAD | Male-baised eQTL |
| rs13405865 | chr2:40122022:T:G | - | 0.0693725306514461 | 0.00122728271443322 | COAD | Male-baised eQTL |
| rs13002785 | chr2:37778165:G:A | - | 0.0976618403501408 | 0.00172948440316536 | COAD | Male-baised eQTL |
| rs13030234 | chr2:50502430:C:T | - | 0.0898637933927006 | 0.00221581661274855 | COAD | Male-baised eQTL |
| rs13385233 | chr2:40149984:G:A | - | 0.0661521396786957 | 0.00282500317306683 | COAD | Male-baised eQTL |
| rs2241175 | chr2:50495790:G:T | - | 0.0779373796565968 | 0.00318124768395115 | COAD | Male-baised eQTL |
| rs6725307 | chr2:50486875:C:A | - | 0.0789612666720065 | 0.0032173297086947 | COAD | Male-baised eQTL |
| rs11897793 | chr2:50519571:T:A | - | 0.0841603537909338 | 0.00423076907880331 | COAD | Male-baised eQTL |
| rs3792000 | chr2:40097834:C:G | - | 0.074365114959387 | 0.0045470871377681 | COAD | Male-baised eQTL |
| rs1014428 | chr2:50509069:T:G | - | 0.0804016057976453 | 0.00460494018467341 | COAD | Male-baised eQTL |
| rs11677316 | chr2:40079303:A:G | - | 0.0746459958411843 | 0.00490477374373962 | COAD | Male-baised eQTL |
| rs11688696 | chr2:40079600:G:A | - | 0.0746459958411843 | 0.00490477374373962 | COAD | Male-baised eQTL |
| rs75128745 | chr2:40079818:G:T | - | 0.0746459958411843 | 0.00490477374373962 | COAD | Male-baised eQTL |
| rs58528267 | chr2:40080868:C:T | - | 0.0746459958411843 | 0.00490477374373962 | COAD | Male-baised eQTL |
| rs76002236 | chr2:40081061:C:T | - | 0.0746459958411843 | 0.00490477374373962 | COAD | Male-baised eQTL |
| rs7559799 | chr2:50503178:T:C | - | 0.0781428807559185 | 0.0052605656856697 | COAD | Male-baised eQTL |
| rs72880025 | chr2:50511136:C:G | - | 0.0797632118830366 | 0.00556790511476118 | COAD | Male-baised eQTL |
| rs11125314 | chr2:50511261:T:C | - | 0.0797632118830366 | 0.00556790511476118 | COAD | Male-baised eQTL |
| rs12052344 | chr2:40085410:C:G | - | 0.0726794381250034 | 0.00645074224375707 | COAD | Male-baised eQTL |
| rs61562635 | chr2:40068487:C:A | - | 0.0745874492061495 | 0.00658550435489065 | COAD | Male-baised eQTL |
| rs80048375 | chr2:40084205:G:A | - | 0.0725027808398531 | 0.00675785537620771 | COAD | Male-baised eQTL |
| rs10167639 | chr2:40150480:C:G | - | 0.061490804244473 | 0.00785358117907221 | COAD | Male-baised eQTL |
| rs60456982 | chr2:40095462:G:T | - | 0.0708655865581037 | 0.00827985437053457 | COAD | Male-baised eQTL |
| rs12989656 | chr2:46060415:G:T | - | 0.06105406664301 | 0.00861577152574079 | COAD | Male-baised eQTL |
| rs2160208 | chr2:40082143:T:C | - | 0.0708029440189603 | 0.00946359271171557 | COAD | Male-baised eQTL |
| rs57547123 | chr2:40085011:C:T | - | 0.0697233692338981 | 0.0107611185067934 | COAD | Male-baised eQTL |
| rs10198783 | chr2:53007612:G:A | - | 0.0497642884799783 | 0.0109123781219832 | COAD | Male-baised eQTL |
| rs72943662 | chr2:40083110:C:A | - | 0.0697231951135781 | 0.0109814006062881 | COAD | Male-baised eQTL |
| rs67915885 | chr2:53050892:C:G | - | 0.0505685845051288 | 0.0110087117890398 | COAD | Male-baised eQTL |
| rs60901813 | chr2:50518554:A:C | - | 0.0752318388651772 | 0.0115851193714557 | COAD | Male-baised eQTL |
| rs72943625 | chr2:40074354:G:A | - | 0.0690926056155264 | 0.0127363031710842 | COAD | Male-baised eQTL |
| rs2727875 | chr2:52345979:G:A | - | 0.0558275377864125 | 0.0135417242583901 | COAD | Male-baised eQTL |
| rs13025792 | chr2:46058907:A:G | - | 0.0571045220027952 | 0.0136837841474169 | COAD | Male-baised eQTL |
| rs59426043 | chr2:40081249:A:G | - | 0.0678396461464221 | 0.0156834996780636 | COAD | Male-baised eQTL |
| rs7581256 | chr2:50523290:C:T | - | 0.0736036659074611 | 0.0171098528771773 | COAD | Male-baised eQTL |
| rs34842944 | chr2:50524017:A:G | - | 0.0731944360978186 | 0.0175391729996929 | COAD | Male-baised eQTL |
| rs2110677 | chr2:40082316:A:G | - | 0.06650281537824 | 0.0189049209134502 | COAD | Male-baised eQTL |
| rs11895850 | chr2:50504083:A:G | - | 0.0668122134595317 | 0.0193263300733174 | COAD | Male-baised eQTL |
| rs72943657 | chr2:40082537:C:T | - | 0.0660961020336211 | 0.0194460677441312 | COAD | Male-baised eQTL |
| rs35675719 | chr2:37776546:C:T | - | 0.0762713392390957 | 0.0199093221662933 | COAD | Male-baised eQTL |
| rs934221 | chr2:37777226:A:G | - | 0.0762713392390957 | 0.0199093221662933 | COAD | Male-baised eQTL |
| rs7581530 | chr2:50523397:G:C | - | 0.0718222373666286 | 0.0217673689603983 | COAD | Male-baised eQTL |
| rs6741926 | chr2:37777305:T:C | - | 0.0729019512357297 | 0.0219068209500284 | COAD | Male-baised eQTL |
| rs12151434 | chr2:40091104:G:C | - | 0.0624475908247565 | 0.0234846243092738 | COAD | Male-baised eQTL |
| rs10495872 | chr2:37776472:A:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs934220 | chr2:37776937:A:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs6755455 | chr2:37777362:A:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs12996847 | chr2:37777850:A:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs4670214 | chr2:37777905:A:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs13002603 | chr2:37778117:G:A | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs4670215 | chr2:37778420:T:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs17021284 | chr2:37778536:A:C | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs7607596 | chr2:37778639:A:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs7595294 | chr2:37778807:T:C | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs7598115 | chr2:37778951:T:G | - | 0.0726841362716426 | 0.0236634866393578 | COAD | Male-baised eQTL |
| rs13035987 | chr2:37779124:T:G | - | 0.0724730400330918 | 0.0256499848820369 | COAD | Male-baised eQTL |
| rs13010402 | chr2:37779623:A:C | - | 0.0724730400330918 | 0.0256499848820369 | COAD | Male-baised eQTL |
| rs13010959 | chr2:37779736:C:G | - | 0.0724730400330918 | 0.0256499848820369 | COAD | Male-baised eQTL |
| rs17021304 | chr2:37779784:C:T | - | 0.0724730400330918 | 0.0256499848820369 | COAD | Male-baised eQTL |
| rs12612349 | chr2:40245907:C:T | - | 0.0724980113514708 | 0.0257551616917054 | COAD | Male-baised eQTL |
| rs367865 | chr2:38459992:G:A | - | 0.0510763434582534 | 0.0287732422588484 | COAD | Male-baised eQTL |
| rs2121927 | chr2:46161553:G:A | - | 0.0600333487285523 | 0.0315097695737406 | COAD | Male-baised eQTL |
| rs870141 | chr2:46161823:T:G | - | 0.0600333487285523 | 0.0315097695737406 | COAD | Male-baised eQTL |
| rs281474 | chr2:46174837:G:A | - | 0.0619362014460469 | 0.0361403279148404 | COAD | Male-baised eQTL |
| rs11685939 | chr2:43719596:C:A | - | 0.0541657054773835 | 0.0400844058864318 | COAD | Male-baised eQTL |
| rs13016362 | chr2:50521349:T:C | - | 0.0653409562729666 | 0.0402162558810938 | COAD | Male-baised eQTL |
| rs281477 | chr2:46173338:A:C | - | 0.0614591929908354 | 0.0404382143233585 | COAD | Male-baised eQTL |
| rs11695317 | chr2:38460356:A:C | - | -0.0488382018353995 | 0.0404441477668467 | COAD | Male-baised eQTL |
| rs6747490 | chr2:55966283:A:G | - | -0.046672492397363 | 0.0459166763896528 | COAD | Male-baised eQTL |
| rs7589519 | chr2:37775273:G:A | - | 0.0713432223514273 | 0.0465443619252675 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000116062 |
| CpG Site: cg19570558 | |
| Position to Gene: gene | |
| Male Effect: -0.29951350815091 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19570558 | chr2:47785786 | gene | -0.29951350815091 | 8.45989560600721e-12 | -0.4945810788291229 | 8.677241060011833e-15 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MSH6 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000116062 | MSH6 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 5 | CTD_human |
| ENSG00000116062 | MSH6 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0265325 | Turcot syndrome (disorder) | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0549473 | Thyroid carcinoma | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C0920269 | Microsatellite Instability | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 5 | CTD_human |
| ENSG00000116062 | MSH6 | C1721098 | Replication Error Phenotype | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C1833477 | COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5 | 1 | CTD_human |
| ENSG00000116062 | MSH6 | C4552100 | Lynch Syndrome | 5 | CTD_human |
