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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000115507

Summary for OTX1

check button Gene summary

Gene informationEnsembl ID

ENSG00000115507

Gene symbol

OTX1

Gene nameorthodenticle homeobox 1
HGNC

8521

Entrez ID

5013

Gene typeprotein_coding
SynonymsOTX1|
UniProtAcc

P32242


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for OTX1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
OTX18.70e+021.40e+004.14e-013.39e+007.04e-044.80e-03ESCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for OTX1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for OTX1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg18126442chr2:63048733CGI:chr2:63047340-63052295promoter5.67e-017.09e-01-2.64e+008.25e-032.48e-02-1.41e-01
BRCAcg00445126chr2:63048875CGI:chr2:63047340-63052295promoter5.31e-016.73e-01-2.39e+001.69e-023.28e-02-1.41e-01
BRCAcg06192497chr2:63049081CGI:chr2:63047340-63052295promoter5.27e-017.44e-01-2.57e+001.02e-022.68e-02-2.17e-01
BRCAcg22197050chr2:63049048CGI:chr2:63047340-63052295promoter5.63e-017.10e-01-2.07e+003.82e-024.51e-02-1.47e-01
BRCAcg02606403chr2:63049133CGI:chr2:63047340-63052295promoter4.55e-016.28e-01-2.47e+001.36e-023.00e-02-1.73e-01
SARCcg18126442chr2:63048733CGI:chr2:63047340-63052295promoter5.70e-014.45e-014.05e+005.15e-052.84e-041.25e-01
SARCcg00445126chr2:63048875CGI:chr2:63047340-63052295promoter4.92e-013.85e-013.23e+001.25e-034.14e-031.07e-01
UVMcg01940425chr2:63049430CGI:chr2:63047340-63052295promoter1.03e-012.09e-01-2.57e+001.03e-022.21e-02-1.06e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg06192497chr2:63049081CGI:chr2:63047340-63052295promoter2.79e-011.26e-013.14e+001.71e-032.50e-031.53e-01
KIRCcg01940425chr2:63049430CGI:chr2:63047340-63052295promoter2.85e-011.52e-012.82e+004.76e-036.18e-031.33e-01
THCAcg18126442chr2:63048733CGI:chr2:63047340-63052295promoter3.19e-011.95e-013.29e+001.00e-033.13e-031.23e-01
THCAcg00445126chr2:63048875CGI:chr2:63047340-63052295promoter3.20e-012.08e-012.37e+001.80e-022.50e-021.11e-01
THCAcg06192497chr2:63049081CGI:chr2:63047340-63052295promoter1.52e-013.75e-024.02e+005.86e-054.11e-041.15e-01
THCAcg03957108chr2:63049410CGI:chr2:63047340-63052295promoter3.00e-011.56e-014.25e+002.12e-052.05e-041.43e-01
THCAcg10658666chr2:63049583CGI:chr2:63047340-63052295promoter3.72e-012.40e-013.64e+002.74e-041.23e-031.32e-01
LUSCcg14174204chr2:63049565CGI:chr2:63047340-63052295promoter1.43e-012.46e-01-4.18e+002.88e-055.26e-04-1.03e-01
LUSCcg10658666chr2:63049583CGI:chr2:63047340-63052295promoter1.72e-013.00e-01-4.16e+003.19e-055.26e-04-1.28e-01
LUSCcg08210688chr2:63049588CGI:chr2:63047340-63052295promoter1.30e-012.40e-01-4.05e+005.21e-055.63e-04-1.10e-01
LUSCcg10487970chr2:63049895CGI:chr2:63047340-63052295promoter1.43e-012.45e-01-4.24e+002.20e-055.26e-04-1.02e-01
BLCAcg08210688chr2:63049588CGI:chr2:63047340-63052295promoter1.53e-012.58e-01-3.88e+001.03e-044.08e-04-1.05e-01
LIHCcg14174204chr2:63049565CGI:chr2:63047340-63052295promoter1.67e-012.79e-01-5.26e+001.45e-077.17e-07-1.11e-01
CHOLcg18126442chr2:63048733CGI:chr2:63047340-63052295promoter5.37e-012.84e-012.65e+007.96e-031.92e-022.53e-01
CHOLcg00445126chr2:63048875CGI:chr2:63047340-63052295promoter4.98e-012.68e-012.43e+001.50e-022.65e-022.30e-01
CHOLcg06192497chr2:63049081CGI:chr2:63047340-63052295promoter5.71e-011.46e-012.36e+001.83e-022.92e-024.25e-01
CHOLcg13433250chr2:63048819CGI:chr2:63047340-63052295promoter5.56e-013.53e-012.65e+007.96e-031.92e-022.04e-01
CHOLcg22197050chr2:63049048CGI:chr2:63047340-63052295promoter4.97e-013.18e-012.14e+003.25e-023.87e-021.79e-01
CHOLcg02606403chr2:63049133CGI:chr2:63047340-63052295promoter4.48e-012.18e-012.21e+002.70e-023.50e-022.31e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg18126442chr2:63048733CGI:chr2:63047340-63052295promoter5.67e-014.47e-017.32e+002.54e-138.17e-131.21e-01
BRCAcg00445126chr2:63048875CGI:chr2:63047340-63052295promoter5.31e-013.81e-018.51e+001.74e-177.68e-171.50e-01
BRCAcg06192497chr2:63049081CGI:chr2:63047340-63052295promoter5.27e-012.82e-018.26e+001.51e-166.19e-162.45e-01
BRCAcg01940425chr2:63049430CGI:chr2:63047340-63052295promoter3.41e-011.39e-015.76e+008.57e-091.93e-082.02e-01
BRCAcg15862215chr2:63049875CGI:chr2:63047340-63052295promoter2.43e-019.64e-022.12e+003.41e-023.51e-021.47e-01
BRCAcg13433250chr2:63048819CGI:chr2:63047340-63052295promoter5.27e-013.91e-018.94e+003.87e-191.95e-181.36e-01
BRCAcg22197050chr2:63049048CGI:chr2:63047340-63052295promoter5.63e-013.90e-018.90e+005.54e-192.75e-181.73e-01
BRCAcg02606403chr2:63049133CGI:chr2:63047340-63052295promoter4.55e-012.33e-019.97e+002.13e-231.55e-222.22e-01
BRCAcg03957108chr2:63049410CGI:chr2:63047340-63052295promoter4.16e-012.53e-015.31e+001.09e-072.22e-071.64e-01
THCAcg13471114chr2:63049849CGI:chr2:63047340-63052295promoter2.17e-011.11e-012.21e+002.68e-023.10e-021.06e-01
HNSCcg18126442chr2:63048733CGI:chr2:63047340-63052295promoter2.85e-011.37e-012.45e+001.41e-022.25e-021.49e-01
HNSCcg00445126chr2:63048875CGI:chr2:63047340-63052295promoter2.21e-011.01e-012.15e+003.16e-023.67e-021.19e-01
HNSCcg00431699chr2:63051696CGI:chr2:63047340-63052295promoter,exon,gene body4.04e-012.16e-012.78e+005.40e-031.38e-021.88e-01
BLCAcg00431699chr2:63051696CGI:chr2:63047340-63052295promoter,exon,gene body4.38e-012.72e-012.69e+007.17e-031.42e-021.66e-01
KIRPcg15862215chr2:63049875CGI:chr2:63047340-63052295promoter2.01e-018.84e-022.42e+001.54e-022.25e-021.13e-01
KIRPcg22197050chr2:63049048CGI:chr2:63047340-63052295promoter4.54e-013.23e-012.26e+002.36e-022.99e-021.31e-01

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Exon skipping events with PSI in TCGA for OTX1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for OTX1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for OTX1

check buttonTFs related to OTX1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonOTX1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.
related_gene

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Sex-biased RBP-ES network for OTX1

check buttonRBPs related to ES in OTX1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonOTX1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000115507AL359853.1,hsa-mir-195,OTX1Female-specific ceRNATCGA-THCA

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs72884996chr2:61241626:T:C-0.2390535262818510.000257932315660744GBMFemale-baised eQTL
rs76426372chr2:61315314:C:T-0.2315732191372060.00244167536451808GBMFemale-baised eQTL
rs72884995chr2:61236974:T:C-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs9967730chr2:61286719:G:T-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs72886814chr2:61287287:G:A-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs2067549chr2:61288270:G:C-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs2067548chr2:61288446:A:G-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs112834063chr2:61294497:C:A-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs11889702chr2:61297247:C:T-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs72886828chr2:61297984:C:T-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs113655904chr2:61482057:T:C-0.2183053277470070.00594438575194096GBMFemale-baised eQTL
rs76353526chr2:61891379:G:A-0.2272139152234170.00801004967871792GBMFemale-baised eQTL
rs901532chr2:62536212:C:T-0.2041774089110860.0130313504955844GBMFemale-baised eQTL
rs76477273chr2:61832252:A:C-0.2028137899499970.0137927686637354GBMFemale-baised eQTL
rs7569467chr2:61852132:T:G-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs6715556chr2:61854986:C:G-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs78036384chr2:61859883:C:T-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs77986008chr2:61861930:C:T-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs76248080chr2:61873245:G:T-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs17514211chr2:61881258:C:A-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs151311929chr2:61882143:G:C-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs41281525chr2:61888641:G:A-0.1947380328235880.045312124575671GBMFemale-baised eQTL
rs6721993chr2:56963522:C:T-0.1197159795064420.0367617890245812LUSCFemale-baised eQTL
rs6722435chr2:56963703:G:A-0.1197159795064420.0367617890245812LUSCFemale-baised eQTL
rs7600910chr2:59849134:A:T-0.05395893760625580.00397394971158144LUADFemale-baised eQTL
rs6751340chr2:53960480:A:G-0.05930481643551260.00784974502785558LUADFemale-baised eQTL
rs1362468chr2:65669269:G:A-0.0501562418763440.0286391265912485LUADFemale-baised eQTL
rs2072469chr2:59858805:C:T-0.04788580068715820.0304624719197225LUADFemale-baised eQTL
rs67297386chr2:59859150:A:G-0.04788580068715820.0304624719197225LUADFemale-baised eQTL
rs17050470chr2:59859260:G:C-0.04788580068715820.0304624719197225LUADFemale-baised eQTL
rs7556914chr2:59846412:A:G-0.04569067021074740.0328076318054991LUADFemale-baised eQTL
rs2072470chr2:59858275:A:G-0.04526768631695370.0437287321741989LUADFemale-baised eQTL
rs6706213chr2:59862013:A:C-0.04526768631695370.0437287321741989LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4318420chr2:69035988:C:T-0.05101904294299270.00241573027900106HNSCMale-baised eQTL
rs6723508chr2:54828491:G:A-0.04149568363821760.0143655377528863HNSCMale-baised eQTL
rs76263432chr2:54791201:G:A-0.04806620973841810.0225375587592036HNSCMale-baised eQTL
rs78871734chr2:54793078:G:A-0.04806620973841810.0225375587592036HNSCMale-baised eQTL
rs10177161chr2:65868766:G:A-0.04901782157842490.0358627742472397HNSCMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000115507
CpG Site: cg10640333
Position to Gene: gene,exon,enhancer
Male Effect: -0.313364501538139
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000115507
CpG Site: cg10271192
Position to Gene: gene,enhancer
Male Effect: -0.400512978017673
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg10640333chr2:63053490gene,exon,enhancer-0.3133645015381391.99171878329812e-10-0.472730765831893448.13447438490619e-14LUAD
cg10271192chr2:63052510gene,enhancer-0.4005129780176732.44398401564709e-09-0.409208700806641851.4431485814466034e-12LUSC

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of OTX1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource