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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000114646

Summary for CSPG5

check button Gene summary

Gene informationEnsembl ID

ENSG00000114646

Gene symbol

CSPG5

Gene namechondroitin sulfate proteoglycan 5
HGNC

2467

Entrez ID

10675

Gene typeprotein_coding
SynonymsCSPG5|NGC
UniProtAcc

O95196


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for CSPG5

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for CSPG5

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for CSPG5

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
CHOLcg15988232chr3:47579637CGI:chr3:47577622-47579641UTR,promoter,exon,gene body7.32e-016.14e-011.97e+004.84e-024.84e-021.19e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
THCAcg15988232chr3:47579637CGI:chr3:47577622-47579641UTR,promoter,exon,gene body4.52e-013.24e-012.47e+001.34e-022.03e-021.28e-01
HNSCcg16233920chr3:47580307CGI:chr3:47577622-47579641UTR,promoter,exon,gene body7.57e-018.84e-01-4.28e+001.91e-056.48e-05-1.27e-01
LUSCcg01406312chr3:47579500CGI:chr3:47577622-47579641UTR,promoter,exon,gene body2.63e-011.58e-013.26e+001.10e-032.76e-031.05e-01
LUSCcg24899315chr3:47579529CGI:chr3:47577622-47579641UTR,promoter,exon,gene body3.27e-012.23e-012.60e+009.19e-031.30e-021.03e-01
LUSCcg04289624chr3:47579473CGI:chr3:47577622-47579641UTR,promoter,exon,gene body3.05e-011.73e-013.50e+004.58e-041.57e-031.32e-01
LUSCcg15988232chr3:47579637CGI:chr3:47577622-47579641UTR,promoter,exon,gene body5.53e-014.30e-012.75e+005.95e-039.30e-031.22e-01
COADcg16233920chr3:47580307CGI:chr3:47577622-47579641UTR,promoter,exon,gene body7.03e-018.15e-01-2.45e+001.43e-021.90e-02-1.12e-01
KIRPcg04289624chr3:47579473CGI:chr3:47577622-47579641UTR,promoter,exon,gene body3.47e-012.20e-012.03e+004.21e-024.32e-021.27e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg01406312chr3:47579500CGI:chr3:47577622-47579641UTR,promoter,exon,gene body3.23e-011.76e-012.78e+005.40e-031.38e-021.47e-01
HNSCcg15988232chr3:47579637CGI:chr3:47577622-47579641UTR,promoter,exon,gene body5.99e-014.85e-012.52e+001.17e-022.02e-021.13e-01

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Exon skipping events with PSI in TCGA for CSPG5

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for CSPG5

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for CSPG5

check buttonTFs related to CSPG5.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ESCAZNF441CSPG53.75e+009.80e-012.65e+001.06e-03Male-biased
ESCAZNF792CSPG53.83e+009.81e-012.89e+002.66e-03Male-biased
PCPGPLAGL2CSPG53.94e+009.81e-012.85e+002.56e-03Male-biased

check buttonCSPG5 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for CSPG5

check buttonRBPs related to ES in CSPG5.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonCSPG5 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4955841chr3:55291709:C:T-0.09140932999448982.27120109893314e-08LUADFemale-baised eQTL
rs74399259chr3:55294115:A:G-0.08742261209274738.19581126873898e-08LUADFemale-baised eQTL
rs4955840chr3:55291577:T:C-0.08248536755276152.54129181671308e-07LUADFemale-baised eQTL
rs11130468chr3:55290285:C:T-0.07955798614376696.12352375393866e-07LUADFemale-baised eQTL
rs78646119chr3:55294249:A:G-0.07922236769761137.27228440827416e-07LUADFemale-baised eQTL
rs76791504chr3:55294256:T:C-0.07922236769761137.27228440827416e-07LUADFemale-baised eQTL
rs34006032chr3:40301022:G:A-0.07107811468720524.80059466410902e-05LUADFemale-baised eQTL
rs11541150chr3:40309786:C:T-0.07107811468720524.80059466410902e-05LUADFemale-baised eQTL
rs34385915chr3:40284512:C:T-0.07072277411840975.56287214715997e-05LUADFemale-baised eQTL
rs13085168chr3:40298941:A:G-0.06824455344834139.64175301224808e-05LUADFemale-baised eQTL
rs7649848chr3:40300220:C:A-0.06824455344834139.64175301224808e-05LUADFemale-baised eQTL
rs4130763chr3:40995981:T:C-0.05391180090706420.00023479440557532LUADFemale-baised eQTL
rs12631736chr3:55269942:G:C-0.05531150417018680.000660638365546597LUADFemale-baised eQTL
rs56414116chr3:55277054:G:A-0.04983893031552130.000836524243880951LUADFemale-baised eQTL
rs79816206chr3:55266747:G:A-0.05409625499941810.000841625238962674LUADFemale-baised eQTL
rs34856047chr3:40250345:C:T-0.05830456661589410.000891942357966399LUADFemale-baised eQTL
rs35981260chr3:40246726:G:A-0.05827055523821440.000899729878165434LUADFemale-baised eQTL
rs6801238chr3:55276616:T:C-0.04894862816779280.000999357999668081LUADFemale-baised eQTL
rs12494065chr3:38749991:C:T-0.05361620193354460.00110070792773803LUADFemale-baised eQTL
rs55830126chr3:55262388:C:G-0.04739121010422930.00163066923727543LUADFemale-baised eQTL
rs56824318chr3:38750575:T:G-0.05036510693298880.00241580122325108LUADFemale-baised eQTL
rs58410551chr3:38750979:A:G-0.05036510693298880.00241580122325108LUADFemale-baised eQTL
rs7630989chr3:38752449:A:G-0.05036510693298880.00241580122325108LUADFemale-baised eQTL
rs79252367chr3:55032686:G:T-0.04032581164234850.0037379480023462LUADFemale-baised eQTL
rs1256355chr3:41586098:A:G--0.04875318133618010.00403206661590187LUADFemale-baised eQTL
rs2700465chr3:41581447:C:A--0.04751734559354680.00516617140069729LUADFemale-baised eQTL
rs2576194chr3:41582521:T:C--0.04745195007736910.0052769413185682LUADFemale-baised eQTL
rs2132328chr3:41582627:T:C--0.04745195007736910.0052769413185682LUADFemale-baised eQTL
rs1256354chr3:41586686:T:G--0.04745195007736910.0052769413185682LUADFemale-baised eQTL
rs2526383chr3:50147105:T:C--0.03822388417545110.00530364174824009LUADFemale-baised eQTL
rs1874354chr3:41516236:A:T--0.04746318796261560.00548729024358945LUADFemale-baised eQTL
rs2643965chr3:41519854:A:G--0.04746318796261560.00548729024358945LUADFemale-baised eQTL
rs71331117chr3:40253300:G:A-0.04995177439094260.00608846442784809LUADFemale-baised eQTL
rs4955893chr3:54768324:A:G-0.04503130979046560.00664727654194717LUADFemale-baised eQTL
rs1691951chr3:41527167:T:C--0.04601799267117430.00750178948439518LUADFemale-baised eQTL
rs1691986chr3:41576929:A:C--0.04527433675661910.00798057036832996LUADFemale-baised eQTL
rs1273205chr3:41578403:G:T--0.04526469174739480.00803271687279535LUADFemale-baised eQTL
rs4928044chr3:54059637:C:T-0.04694032895641880.00896430740241224LUADFemale-baised eQTL
rs2643983chr3:41555864:T:A--0.04275686631206080.00997159508162979LUADFemale-baised eQTL
rs1565962chr3:41515498:A:G--0.04239110160447220.0100556419538835LUADFemale-baised eQTL
rs117581646chr3:57070742:T:C-0.0366830069978370.0113186625147922LUADFemale-baised eQTL
rs11719697chr3:57071023:G:C-0.0366830069978370.0113186625147922LUADFemale-baised eQTL
rs6797763chr3:38730078:T:C-0.04267019585607870.0116814293448677LUADFemale-baised eQTL
rs77679291chr3:57069096:T:C-0.03676136320914930.0117340421127409LUADFemale-baised eQTL
rs78227129chr3:57071785:A:G-0.03672417299028380.0119453927519017LUADFemale-baised eQTL
rs1691977chr3:41512799:G:A--0.04138057222700880.0124233632133186LUADFemale-baised eQTL
rs12636899chr3:57074523:C:A-0.03731290123617060.0135354127112682LUADFemale-baised eQTL
rs72866235chr3:38730492:A:G-0.04109111753310260.0136440955801489LUADFemale-baised eQTL
rs6783199chr3:57077611:T:A--0.03699894316043670.0138762740513789LUADFemale-baised eQTL
rs12639280chr3:41498561:C:T--0.04166497847220140.0159227554605432LUADFemale-baised eQTL
rs17081304chr3:41782940:T:C-0.04112164196913120.0160990204594706LUADFemale-baised eQTL
rs1989839chr3:50341515:A:G-0.03546204998831060.016586347172014LUADFemale-baised eQTL
rs6445852chr3:57088334:T:C--0.03626775770301560.0166357203171697LUADFemale-baised eQTL
rs9311641chr3:57091352:C:T--0.03626775770301560.0166357203171697LUADFemale-baised eQTL
rs72867808chr3:38758004:G:A-0.04053152175810740.0167765494255565LUADFemale-baised eQTL
rs9826171chr3:40250386:C:T-0.04317351732211550.0170833086972164LUADFemale-baised eQTL
rs57838764chr3:50337137:T:C-0.03531492860729560.0176087669557022LUADFemale-baised eQTL
rs11922599chr3:41557228:C:A--0.03991096101065450.0176733213691002LUADFemale-baised eQTL
rs7613493chr3:41488856:C:T--0.04118373359039350.0177244354608339LUADFemale-baised eQTL
rs4485691chr3:41561573:G:T--0.03988352581115390.0178592141816525LUADFemale-baised eQTL
rs7649874chr3:41562250:C:T--0.03988352581115390.0178592141816525LUADFemale-baised eQTL
rs903649chr3:41503454:G:A--0.03961982726941870.0178937775259038LUADFemale-baised eQTL
rs2055185chr3:41506866:C:T--0.03961982726941870.0178937775259038LUADFemale-baised eQTL
rs12496750chr3:38758692:G:A-0.03988571386527850.0183268418238106LUADFemale-baised eQTL
rs34270527chr3:54063198:A:T-0.04197722889675860.0210235387703067LUADFemale-baised eQTL
rs1495700chr3:41491378:C:A--0.04023903445846270.021173126188676LUADFemale-baised eQTL
rs80242482chr3:57068822:C:T-0.03375284166571970.0211988528114128LUADFemale-baised eQTL
rs71327066chr3:46444801:G:A-0.04050962901058950.0212552306661209LUADFemale-baised eQTL
rs6445857chr3:57113101:A:G--0.03508594836182120.0229485267092262LUADFemale-baised eQTL
rs7633611chr3:41493629:G:T--0.03817496948364620.0229616408894051LUADFemale-baised eQTL
rs9821613chr3:41558933:A:T--0.03836154762278020.0234255494186212LUADFemale-baised eQTL
rs62254321chr3:56515503:T:C-0.03410059282766690.0237186970017277LUADFemale-baised eQTL
rs11129941chr3:42138187:T:C-0.03674566335848380.0239637978563859LUADFemale-baised eQTL
rs7430731chr3:57120794:A:G--0.0348850778703170.0243066145572755LUADFemale-baised eQTL
rs11923099chr3:40737129:C:G-0.04097462477896930.0251095864901898LUADFemale-baised eQTL
rs4575869chr3:41512178:C:G--0.03754914151934260.0253987889195653LUADFemale-baised eQTL
rs78138837chr3:50306747:A:G-0.03316590302720690.0259789769893047LUADFemale-baised eQTL
rs9814254chr3:57105397:T:C--0.03431422665025180.0274986189641086LUADFemale-baised eQTL
rs6808743chr3:57065778:T:C-0.0344293195397270.0280423759649134LUADFemale-baised eQTL
rs60434489chr3:54058916:C:T-0.04020218530585720.0281192333894461LUADFemale-baised eQTL
rs11719296chr3:57083313:A:G--0.034010128821680.0282210797640828LUADFemale-baised eQTL
rs9874645chr3:57083488:A:G--0.034010128821680.0282210797640828LUADFemale-baised eQTL
rs1691952chr3:41490648:T:C--0.03941844440026540.0294240741840755LUADFemale-baised eQTL
rs75563240chr3:42113887:C:T-0.03581411650703090.0298282093756307LUADFemale-baised eQTL
rs11717604chr3:57069603:C:T-0.03221295141910480.0301882774660674LUADFemale-baised eQTL
rs2129821chr3:57101952:C:A--0.03363387694067680.0322629174919761LUADFemale-baised eQTL
rs12629572chr3:50287241:T:G-0.03160414267658490.0327717776954732LUADFemale-baised eQTL
rs35750877chr3:53065571:A:G-0.03510928333400470.0353206016374577LUADFemale-baised eQTL
rs35088929chr3:46446246:A:C-0.03712489023876510.0359328251623538LUADFemale-baised eQTL
rs1795317chr3:41490049:C:T--0.03724781839340480.0373626371543326LUADFemale-baised eQTL
rs9849674chr3:40256226:T:C-0.03842231275215170.0377716853548043LUADFemale-baised eQTL
rs12631455chr3:41498532:T:G--0.03518142614237120.0378608076226979LUADFemale-baised eQTL
rs11715513chr3:38708892:G:A-0.03202886031233610.0401751666110132LUADFemale-baised eQTL
rs34754279chr3:53065538:C:T-0.03484060330909240.0403913842694367LUADFemale-baised eQTL
rs80256390chr3:53065578:C:T-0.03484060330909240.0403913842694367LUADFemale-baised eQTL
rs74459344chr3:53065579:A:G-0.03484060330909240.0403913842694367LUADFemale-baised eQTL
rs71301811chr3:53065318:T:C-0.03502040527872230.0405268298721788LUADFemale-baised eQTL
rs9846606chr3:40435451:C:T-0.03781091125562430.0426882441195843LUADFemale-baised eQTL
rs1495695chr3:41488291:A:G--0.03447494500579590.0452217580749216LUADFemale-baised eQTL
rs7644787chr3:41776616:A:G-0.03477765580647570.0455690703531719LUADFemale-baised eQTL
rs7373160chr3:41492151:G:T--0.0343570975918050.0471362457114642LUADFemale-baised eQTL
rs2230895chr3:46448875:G:A-0.03524604265368310.0473474921281609LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs58645732chr3:42657983:C:T-0.08200568894838730.00100247125819374LUADMale-baised eQTL
rs35384559chr3:42648017:T:C-0.07956754251827560.00159837106975267LUADMale-baised eQTL
rs3733059chr3:42666621:C:T-0.07958362979470530.0019701615669282LUADMale-baised eQTL
rs3733060chr3:42666623:A:T-0.07958362979470530.0019701615669282LUADMale-baised eQTL
rs66933062chr3:42667226:C:T-0.0811640990973980.00242061284294267LUADMale-baised eQTL
rs13064597chr3:42661773:G:T-0.07771186042006670.0026661830544114LUADMale-baised eQTL
rs13086680chr3:42670649:G:A-0.07723188740779750.00309138540282551LUADMale-baised eQTL
rs34721465chr3:42672620:G:A-0.07721258068132330.00372007249761756LUADMale-baised eQTL
rs3733061chr3:42666675:C:G-0.07487132139140040.00388801138516668LUADMale-baised eQTL
rs67174294chr3:42661058:G:A-0.07247629305354150.00514739280269429LUADMale-baised eQTL
rs67165547chr3:42660927:A:G-0.06162653997783310.0117156143769586LUADMale-baised eQTL
rs2290976chr3:42667140:G:A-0.06330177760489920.0121131424844355LUADMale-baised eQTL
rs1508209chr3:42462128:G:A-0.04217730788997670.0293013469289327LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000114646
CpG Site: cg07032164
Position to Gene: gene,exon,CDS,UTR
Male Effect: -
Female Effect: -0.0596249934276925

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg07032164chr3:47577623gene,exon,CDS,UTR-0.05962499342769257.18982283970557e-05-0.32416125607073791.1923308594680568e-07LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of CSPG5

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000114646CSPG5C0036341Schizophrenia2PSYGENET