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Gene: ENSG00000114378 |
Summary for HYAL1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000114378 | Gene symbol | HYAL1 |
| Gene name | hyaluronidase 1 | |
| HGNC | 5320 | |
| Entrez ID | 3373 | |
| Gene type | protein_coding | |
| Synonyms | HYAL1|LUCA1|HYAL-1 | |
| UniProtAcc | Q12794 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for HYAL1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HYAL1 | 1.24e+03 | -1.35e+00 | 3.33e-01 | -4.04e+00 | 5.25e-05 | 4.72e-03 | ACC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HYAL1 | 2.59e+03 | -1.03e+00 | 2.42e-01 | -4.26e+00 | 2.05e-05 | 5.85e-05 | KIRP |
| HYAL1 | 4.21e+03 | -3.14e+00 | 4.27e-01 | -7.36e+00 | 1.85e-13 | 5.72e-12 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HYAL1 | 1.80e+02 | -1.60e+00 | 4.64e-01 | -3.45e+00 | 5.64e-04 | 5.38e-03 | BLCA |
| HYAL1 | 6.98e+03 | 1.08e+00 | 2.13e-01 | 5.10e+00 | 3.46e-07 | 1.39e-06 | KICH |
| HYAL1 | 2.02e+02 | -1.55e+00 | 1.30e-01 | -1.20e+01 | 5.45e-33 | 3.11e-32 | BRCA |
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Sex-biased somatic mutation for HYAL1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for HYAL1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg04380576 | chr3:50313359 | CGI:chr3:50320022-50320252 | promoter | 8.24e-01 | 9.39e-01 | -3.36e+00 | 7.84e-04 | 2.21e-03 | -1.15e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for HYAL1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for HYAL1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for HYAL1 |
| TFs related to HYAL1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | ZNF141 | HYAL1 | 4.13e+00 | 9.81e-01 | 2.81e+00 | 4.86e-03 | Male-biased |
| GBM | ZNF28 | HYAL1 | 4.22e+00 | 9.82e-01 | 2.99e+00 | 6.28e-03 | Male-biased |
| GBM | ZNF692 | HYAL1 | 4.30e+00 | 9.82e-01 | 3.14e+00 | 7.76e-03 | Male-biased |
| PAAD | ZNF692 | HYAL1 | 3.93e+00 | 9.82e-01 | 2.78e+00 | 1.82e-03 | Male-biased |
| HYAL1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for HYAL1 |
| RBPs related to ES in HYAL1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| HYAL1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11718847 | chr3:43010166:T:A | - | 0.126549610064447 | 0.00539962352014043 | LUSC | Female-baised eQTL |
| rs11707627 | chr3:43081731:C:T | - | 0.166671235682861 | 0.00617995149287038 | LUSC | Female-baised eQTL |
| rs28376397 | chr3:43099045:G:A | - | 0.121500341905379 | 0.0491578329194319 | LUSC | Female-baised eQTL |
| rs6785349 | chr3:59760803:C:T | - | 0.146445084140724 | 0.0463340123268231 | BLCA | Female-baised eQTL |
| rs34363656 | chr3:59390090:T:C | - | 0.0717856584420311 | 0.0170375653565483 | LUAD | Female-baised eQTL |
| rs935217 | chr3:59385947:C:T | - | 0.0722596866033511 | 0.0190954286277811 | LUAD | Female-baised eQTL |
| rs2034129 | chr3:59382567:C:A | - | -0.0695546520331357 | 0.0196878797588439 | LUAD | Female-baised eQTL |
| rs6794518 | chr3:59385409:G:A | - | 0.0720166213367104 | 0.0198589769915904 | LUAD | Female-baised eQTL |
| rs7628370 | chr3:59384874:A:C | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs7638608 | chr3:59385051:G:A | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs7638710 | chr3:59385166:G:A | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs6785895 | chr3:59385574:A:G | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs6785990 | chr3:59385631:A:T | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs935215 | chr3:59385769:G:A | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs935216 | chr3:59385798:G:A | - | 0.0709781201470891 | 0.0228063830013948 | LUAD | Female-baised eQTL |
| rs34347438 | chr3:59389705:G:A | - | 0.0697633133843357 | 0.0243287660703961 | LUAD | Female-baised eQTL |
| rs7617069 | chr3:59384969:C:A | - | 0.0674582998425541 | 0.0382180614277015 | LUAD | Female-baised eQTL |
| rs75289188 | chr3:45080819:C:T | - | 0.112636614347775 | 0.0112153166864726 | COAD | Female-baised eQTL |
| rs17077124 | chr3:45020668:G:T | - | 0.0845732411209442 | 0.0147420220041951 | COAD | Female-baised eQTL |
| rs6805148 | chr3:45060147:A:C | - | 0.10092673523782 | 0.0171079805211659 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs62249811 | chr3:56831594:G:A | - | 0.12459251665938 | 0.0346417275889534 | SARC | Male-baised eQTL |
| rs62249812 | chr3:56831673:C:T | - | 0.12459251665938 | 0.0346417275889534 | SARC | Male-baised eQTL |
| rs75600034 | chr3:57830379:A:G | - | 0.096230820612272 | 0.012902923305288 | LUSC | Male-baised eQTL |
| rs78481961 | chr3:57907565:C:G | - | 0.0952445366854391 | 0.0134639022417024 | LUSC | Male-baised eQTL |
| rs4681756 | chr3:57761527:T:C | - | 0.0940560202269024 | 0.0167855930094684 | LUSC | Male-baised eQTL |
| rs2361350 | chr3:57778470:A:G | - | -0.0838737830189532 | 0.0185327613255 | LUSC | Male-baised eQTL |
| rs78053301 | chr3:58024201:G:T | - | 0.0892042761551872 | 0.0269519238124376 | LUSC | Male-baised eQTL |
| rs9873524 | chr3:57671764:T:C | - | -0.0579923253952351 | 0.0481402108530318 | LUSC | Male-baised eQTL |
| rs7629727 | chr3:57683413:C:T | - | -0.0579923253952351 | 0.0481402108530318 | LUSC | Male-baised eQTL |
| rs2361342 | chr3:57684509:C:T | - | -0.0579923253952351 | 0.0481402108530318 | LUSC | Male-baised eQTL |
| rs13060758 | chr3:54051926:A:C | - | 0.0590471097784247 | 0.0419038289108829 | KIRC | Male-baised eQTL |
| rs62249072 | chr3:55367419:C:T | - | 0.15252417190208 | 4.5118187032393e-05 | LUAD | Male-baised eQTL |
| rs11925054 | chr3:55356858:G:T | - | 0.118983276778276 | 0.00226363897710109 | LUAD | Male-baised eQTL |
| rs503022 | chr3:55457408:C:A | - | 0.0992939886476537 | 0.00701400465494412 | LUAD | Male-baised eQTL |
| rs74693395 | chr3:59997984:G:A | - | 0.148120493860223 | 0.0135154466291323 | LUAD | Male-baised eQTL |
| rs13093337 | chr3:59132960:T:C | - | -0.0916493622903255 | 0.0230630316030751 | LUAD | Male-baised eQTL |
| rs9877046 | chr3:50315027:T:G | enhancer | -0.0519540770743153 | 0.0365033764025182 | COAD | Male-baised eQTL |
| rs2171574 | chr3:44308772:A:G | - | -0.0730863676812437 | 0.0368581060913225 | COAD | Male-baised eQTL |
| rs79672978 | chr3:48823190:G:C | - | 0.100618728293112 | 0.0377796332528213 | COAD | Male-baised eQTL |
| rs12497045 | chr3:44877429:G:T | - | 0.0784654422472356 | 0.0421798804254314 | COAD | Male-baised eQTL |
| rs17076998 | chr3:44876358:C:A | - | 0.0784766464367525 | 0.0423220852591948 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000114378 |
| CpG Site: cg06360465 | |
| Position to Gene: gene | |
| Male Effect: -0.441898292449445 | |
| Female Effect: - | |
 | Gene ID: ENSG00000114378 |
| CpG Site: cg12930727 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.353910770593211 | |
| Female Effect: - | |
 | Gene ID: ENSG00000114378 |
| CpG Site: cg14943722 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.0441007925569751 | |
| Female Effect: - | |
 | Gene ID: ENSG00000114378 |
| CpG Site: cg06360465 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.456770237177461 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06360465 | chr3:50303752 | gene | -0.441898292449445 | 3.66822964647167e-19 | -0.5932509451111032 | 1.366108252661322e-22 | LUAD |
| cg12930727 | chr3:50303862 | gene,exon,UTR | -0.353910770593211 | 2.76682683269012e-15 | -0.5471420764463846 | 8.195809847552648e-19 | LUAD |
| cg14943722 | chr3:50303578 | gene,exon,UTR | -0.0441007925569751 | 4.67608911732739e-05 | -0.31774272199264564 | 2.424917225834185e-07 | LIHC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06360465 | chr3:50303752 | gene | -0.456770237177461 | 2.04913115397872e-19 | -0.7234464108517225 | 5.472779115946632e-23 | HNSC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of HYAL1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000114378 | HYAL1 | C1291490 | Hyaluronidase Deficiency | 1 | CTD_human |
