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Gene: ENSG00000112787 |
Summary for FBRSL1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000112787 | Gene symbol | FBRSL1 |
| Gene name | fibrosin like 1 | |
| HGNC | 29308 | |
| Entrez ID | 57666 | |
| Gene type | protein_coding | |
| Synonyms | FBRSL1|KIAA1545 | |
| UniProtAcc | Q9HCM7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for FBRSL1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| FBRSL1 | 3.74e+03 | 1.28e+00 | 2.95e-01 | 4.33e+00 | 1.52e-05 | 9.35e-05 | READ |
Top |
Sex-biased somatic mutation for FBRSL1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for FBRSL1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg00360256 | chr12:132489138 | CGI:chr12:132489257-132491149 | promoter | 4.42e-01 | 6.10e-01 | -2.61e+00 | 9.15e-03 | 2.58e-02 | -1.68e-01 |
| BRCA | cg17152423 | chr12:132489143 | CGI:chr12:132489257-132491149 | promoter | 3.99e-01 | 5.87e-01 | -2.94e+00 | 3.30e-03 | 1.72e-02 | -1.88e-01 |
| BRCA | cg20214067 | chr12:132489190 | CGI:chr12:132489257-132491149 | promoter | 5.44e-01 | 6.82e-01 | -2.52e+00 | 1.17e-02 | 2.83e-02 | -1.39e-01 |
| GBM | cg23681339 | chr12:132489222 | CGI:chr12:132489257-132491149 | promoter | 1.29e-01 | 2.32e-01 | -2.57e+00 | 1.02e-02 | 2.48e-02 | -1.04e-01 |
| GBM | cg07688604 | chr12:132489342 | CGI:chr12:132489257-132491149 | promoter | 1.26e-01 | 2.30e-01 | -2.62e+00 | 8.66e-03 | 2.25e-02 | -1.04e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg00360256 | chr12:132489138 | CGI:chr12:132489257-132491149 | promoter | 1.71e-01 | 3.15e-01 | -4.29e+00 | 1.82e-05 | 1.32e-04 | -1.44e-01 |
| BLCA | cg20214067 | chr12:132489190 | CGI:chr12:132489257-132491149 | promoter | 1.92e-01 | 3.00e-01 | -3.63e+00 | 2.83e-04 | 8.59e-04 | -1.08e-01 |
| LIHC | cg23681339 | chr12:132489222 | CGI:chr12:132489257-132491149 | promoter | 3.49e-01 | 2.46e-01 | 2.95e+00 | 3.20e-03 | 4.44e-03 | 1.03e-01 |
| LIHC | cg00370303 | chr12:132489470 | CGI:chr12:132489257-132491149 | promoter | 1.62e-01 | 1.99e-02 | 2.29e+00 | 2.20e-02 | 2.43e-02 | 1.42e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg23681339 | chr12:132489222 | CGI:chr12:132489257-132491149 | promoter | 3.19e-01 | 9.30e-02 | 8.61e+00 | 7.53e-18 | 3.42e-17 | 2.26e-01 |
| BRCA | cg07688604 | chr12:132489342 | CGI:chr12:132489257-132491149 | promoter | 3.08e-01 | 4.90e-02 | 7.81e+00 | 5.63e-15 | 2.05e-14 | 2.59e-01 |
| BRCA | cg24800655 | chr12:132489355 | CGI:chr12:132489257-132491149 | promoter | 3.06e-01 | 5.36e-02 | 6.58e+00 | 4.73e-11 | 1.28e-10 | 2.53e-01 |
| BRCA | cg26860182 | chr12:132489468 | CGI:chr12:132489257-132491149 | promoter | 1.42e-01 | 2.47e-02 | 5.94e+00 | 2.83e-09 | 6.61e-09 | 1.18e-01 |
| BRCA | cg25694349 | chr12:132489320 | CGI:chr12:132489257-132491149 | promoter | 2.78e-01 | 3.33e-02 | 7.92e+00 | 2.37e-15 | 8.85e-15 | 2.45e-01 |
| BRCA | cg10304922 | chr12:132489338 | CGI:chr12:132489257-132491149 | promoter | 3.35e-01 | 6.48e-02 | 8.39e+00 | 4.72e-17 | 2.01e-16 | 2.71e-01 |
| BRCA | cg19595750 | chr12:132489353 | CGI:chr12:132489257-132491149 | promoter | 3.31e-01 | 4.82e-02 | 7.83e+00 | 4.81e-15 | 1.76e-14 | 2.83e-01 |
| BRCA | cg17152423 | chr12:132489143 | CGI:chr12:132489257-132491149 | promoter | 3.99e-01 | 2.83e-01 | 5.69e+00 | 1.29e-08 | 2.85e-08 | 1.17e-01 |
| BRCA | cg20214067 | chr12:132489190 | CGI:chr12:132489257-132491149 | promoter | 5.44e-01 | 3.83e-01 | 9.26e+00 | 2.10e-20 | 1.17e-19 | 1.61e-01 |
| BRCA | cg24846573 | chr12:132489220 | CGI:chr12:132489257-132491149 | promoter | 3.99e-01 | 2.19e-01 | 8.53e+00 | 1.45e-17 | 6.42e-17 | 1.81e-01 |
| LIHC | cg23097155 | chr12:132489483 | CGI:chr12:132489257-132491149 | promoter | 1.22e-01 | 1.95e-02 | 4.43e+00 | 9.47e-06 | 6.60e-05 | 1.03e-01 |
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Exon skipping events with PSI in TCGA for FBRSL1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for FBRSL1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for FBRSL1 |
| TFs related to FBRSL1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| FBRSL1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for FBRSL1 |
| RBPs related to ES in FBRSL1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | SAMD4A | exon_skip_88938 | 6.96e+00 | 9.86e-01 | 6.21e+00 | 5.64e-04 | Male-biased |
| ACC | SAMD4A | exon_skip_88915 | 8.69e+00 | 9.92e-01 | 8.00e+00 | 1.82e-03 | Male-biased |
| ACC | SAMD4A | exon_skip_88938 | 7.24e+00 | 9.86e-01 | 6.44e+00 | 1.06e-03 | Male-biased |
| ACC | SRSF7 | exon_skip_88848 | 1.20e+01 | 9.94e-01 | 1.15e+01 | 5.66e-03 | Male-biased |
| THYM | SRSF7 | exon_skip_88848 | 1.21e+01 | 9.98e-01 | 1.16e+01 | 9.88e-04 | Male-biased |
| LIHC | SAMD4A | exon_skip_88915 | 8.22e+00 | 2.28e-03 | 8.81e+00 | 9.92e-01 | Female-biased |
| LIHC | SAMD4A | exon_skip_88938 | 7.22e+00 | 9.87e-01 | 6.16e+00 | 1.42e-04 | Male-biased |
| DLBC | SAMD4A | exon_skip_88938 | 7.04e+00 | 9.85e-01 | 6.45e+00 | 9.32e-04 | Male-biased |
| KIRP | SRSF7 | exon_skip_88848 | 1.16e+01 | 4.65e-03 | 1.20e+01 | 9.95e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_88864 | 6.72e+00 | 9.81e-01 | 6.10e+00 | 2.99e-03 | Male-biased |
| ESCA | ZC3H10 | exon_skip_88864 | 7.42e+00 | 9.87e-01 | 6.80e+00 | 3.02e-03 | Male-biased |
| PCPG | SRSF7 | exon_skip_88848 | 1.20e+01 | 9.98e-01 | 1.14e+01 | 1.01e-03 | Male-biased |
| MESO | hnRNPK | exon_skip_88959 | 8.66e+00 | 3.47e-03 | 9.11e+00 | 9.92e-01 | Female-biased |
| MESO | SAMD4A | exon_skip_88915 | 8.20e+00 | 5.74e-03 | 8.60e+00 | 9.88e-01 | Female-biased |
| MESO | SRSF7 | exon_skip_88848 | 1.16e+01 | 1.49e-03 | 1.22e+01 | 9.98e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_88915 | 7.93e+00 | 4.94e-03 | 8.33e+00 | 9.88e-01 | Female-biased |
| LGG | SRSF7 | exon_skip_88848 | 1.17e+01 | 9.82e-01 | 1.14e+01 | 1.70e-02 | Male-biased |
| GBM | SAMD4A | exon_skip_88915 | 8.32e+00 | 8.80e-03 | 8.67e+00 | 9.85e-01 | Female-biased |
| PAAD | SAMD4A | exon_skip_88915 | 8.16e+00 | 4.64e-03 | 8.52e+00 | 9.89e-01 | Female-biased |
| PAAD | SRSF7 | exon_skip_88848 | 1.16e+01 | 1.75e-03 | 1.20e+01 | 9.98e-01 | Female-biased |
| KICH | SAMD4A | exon_skip_88915 | 8.32e+00 | 7.88e-03 | 8.66e+00 | 9.86e-01 | Female-biased |
| BLCA | SAMD4A | exon_skip_88915 | 7.91e+00 | 2.75e-03 | 8.39e+00 | 9.90e-01 | Female-biased |
| HNSC | SAMD4A | exon_skip_88938 | 7.06e+00 | 9.85e-01 | 6.50e+00 | 1.46e-03 | Male-biased |
| SARC | SAMD4A | exon_skip_88938 | 6.92e+00 | 9.85e-01 | 6.13e+00 | 3.64e-04 | Male-biased |
| FBRSL1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11058644 | chr12:126437202:T:C | - | 0.0746466444068846 | 0.0200110054052308 | THCA | Female-baised eQTL |
| rs11058643 | chr12:126435791:C:A | - | 0.0719278356060734 | 0.0425773196647871 | THCA | Female-baised eQTL |
| rs58236611 | chr12:126435977:G:A | - | 0.0719278356060734 | 0.0425773196647871 | THCA | Female-baised eQTL |
| rs9738317 | chr12:128138753:A:C | - | -0.112153567873103 | 0.0393568652768506 | SARC | Female-baised eQTL |
| rs115617935 | chr12:131522955:G:A | - | 0.0887066174560151 | 0.043026862552919 | KIRC | Female-baised eQTL |
| rs10773909 | chr12:131508913:A:T | - | -0.054790289452633 | 0.044797120502138 | KIRC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7957706 | chr12:130421934:C:T | - | 0.0327295998051337 | 0.00909376878225812 | KIRC | Male-baised eQTL |
| rs870948 | chr12:130196242:A:G | - | 0.0566127886035999 | 0.00385754638984669 | COAD | Male-baised eQTL |
| rs10848034 | chr12:130204766:C:G | - | 0.0532774325812863 | 0.00627058199133174 | COAD | Male-baised eQTL |
| rs1402328 | chr12:127413434:C:T | - | -0.0549432917560979 | 0.0106277116532061 | COAD | Male-baised eQTL |
| rs10773406 | chr12:127510634:C:T | - | 0.0477741555408497 | 0.030431559516404 | COAD | Male-baised eQTL |
| rs7294415 | chr12:129427488:T:A | - | -0.0473133338123345 | 0.0331506658461447 | COAD | Male-baised eQTL |
| rs7975543 | chr12:127515992:C:T | - | 0.0480443904615545 | 0.0348332834484645 | COAD | Male-baised eQTL |
| rs7975048 | chr12:127516308:G:C | - | 0.0477826491362145 | 0.0383788280456107 | COAD | Male-baised eQTL |
| rs11059036 | chr12:127238221:C:G | - | -0.0478198244877926 | 0.0412416161266496 | COAD | Male-baised eQTL |
| rs2046479 | chr12:127513013:A:G | - | 0.0474730430404941 | 0.045820333664729 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000112787 |
| CpG Site: cg20664313 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.387273880229222 | |
 | Gene ID: ENSG00000112787 |
| CpG Site: cg03700001 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.387273880229222 | |
 | Gene ID: ENSG00000112787 |
| CpG Site: cg10378521 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.387273880229222 | |
 | Gene ID: ENSG00000112787 |
| CpG Site: cg20454518 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.212178152273026 | |
 | Gene ID: ENSG00000112787 |
| CpG Site: cg18158306 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.362013940248369 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20664313 | chr12:132494711 | gene | -0.387273880229222 | 1.13399616698635e-05 | -0.5947319764429906 | 5.991429182711615e-09 | PAAD |
| cg03700001 | chr12:132496634 | gene | -0.387273880229222 | 1.13399616698635e-05 | -0.5947319764429906 | 5.991429182711615e-09 | PAAD |
| cg10378521 | chr12:132525026 | gene | -0.387273880229222 | 1.13399616698635e-05 | -0.5947319764429906 | 5.991429182711615e-09 | PAAD |
| cg20454518 | chr12:132558877 | gene | -0.212178152273026 | 1.51129185770569e-08 | -0.3336503883161971 | 5.103046452755357e-11 | THCA |
| cg18158306 | chr12:132558446 | gene | -0.362013940248369 | 3.6378776667673e-05 | -0.3318218642658384 | 5.721788638830711e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of FBRSL1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000112787 | FBRSL1 | C0004238 | Atrial Fibrillation | 2 | CTD_human |
| ENSG00000112787 | FBRSL1 | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human |
| ENSG00000112787 | FBRSL1 | C2585653 | Persistent atrial fibrillation | 2 | CTD_human |
| ENSG00000112787 | FBRSL1 | C2931456 | Prostate cancer, familial | 1 | CTD_human |
| ENSG00000112787 | FBRSL1 | C3468561 | familial atrial fibrillation | 2 | CTD_human |
| ENSG00000112787 | FBRSL1 | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |
