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Gene: ENSG00000111725 |
Summary for PRKAB1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000111725 | Gene symbol | PRKAB1 |
| Gene name | protein kinase AMP-activated non-catalytic subunit beta 1 | |
| HGNC | 9378 | |
| Entrez ID | 5564 | |
| Gene type | protein_coding | |
| Synonyms | PRKAB1| | |
| UniProtAcc | Q9Y478 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000111725 | PRKAB1 | DB00131 | Adenosine phosphate | SmallMoleculeDrug |
| ENSG00000111725 | PRKAB1 | DB00331 | Metformin | SmallMoleculeDrug |
| ENSG00000111725 | PRKAB1 | DB00131 | Adenosine phosphate | SmallMoleculeDrug |
| ENSG00000111725 | PRKAB1 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |
| ENSG00000111725 | PRKAB1 | DB12010 | Fostamatinib | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PRKAB1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PRKAB1 | 3.35e+03 | -1.02e+00 | 2.25e-01 | -4.51e+00 | 6.59e-06 | 1.12e-04 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for PRKAB1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PRKAB1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for PRKAB1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PRKAB1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PRKAB1 |
| TFs related to PRKAB1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF334 | PRKAB1 | 4.27e+00 | 9.83e-01 | 2.87e+00 | 5.84e-03 | Male-biased |
| PRKAB1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PRKAB1 |
| RBPs related to ES in PRKAB1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | KHDRBS3 | exon_skip_87554 | 8.16e+00 | 4.40e-03 | 8.53e+00 | 9.89e-01 | Female-biased |
| LIHC | ANKHD1 | exon_skip_87560 | 1.37e+01 | 3.94e-03 | 1.42e+01 | 9.96e-01 | Female-biased |
| LUAD | ANKHD1 | exon_skip_87560 | 1.28e+01 | 1.55e-03 | 1.33e+01 | 9.98e-01 | Female-biased |
| KIRP | ANKHD1 | exon_skip_87560 | 1.30e+01 | 6.41e-04 | 1.36e+01 | 9.99e-01 | Female-biased |
| BRCA | ANKHD1 | exon_skip_87560 | 1.34e+01 | 9.88e-01 | 1.28e+01 | 1.17e-02 | Male-biased |
| READ | ANKHD1 | exon_skip_87560 | 1.27e+01 | 3.18e-04 | 1.34e+01 | 9.99e-01 | Female-biased |
| MESO | KHDRBS3 | exon_skip_87554 | 7.97e+00 | 4.90e-03 | 8.39e+00 | 9.88e-01 | Female-biased |
| PAAD | ANKHD1 | exon_skip_87560 | 1.28e+01 | 1.71e-03 | 1.32e+01 | 9.98e-01 | Female-biased |
| KIRC | ANKHD1 | exon_skip_87560 | 1.33e+01 | 1.00e+00 | 1.26e+01 | 2.16e-04 | Male-biased |
| HNSC | ANKHD1 | exon_skip_87560 | 1.23e+01 | 9.21e-04 | 1.29e+01 | 9.99e-01 | Female-biased |
| SARC | ANKHD1 | exon_skip_87560 | 1.28e+01 | 1.50e-03 | 1.34e+01 | 9.98e-01 | Female-biased |
| SARC | FXR2 | exon_skip_87554 | 6.52e+00 | 1.06e-03 | 7.15e+00 | 9.86e-01 | Female-biased |
| PRKAB1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs77966432 | chr12:129135549:G:T | - | 0.128206860128643 | 0.0344118373949985 | PCPG | Female-baised eQTL |
| rs11611271 | chr12:116903172:G:A | - | 0.150454781557033 | 0.0201902283380992 | READ | Female-baised eQTL |
| rs112843069 | chr12:116901605:G:C | - | 0.148846439117593 | 0.0215922847132817 | READ | Female-baised eQTL |
| rs7959463 | chr12:128991490:G:C | - | 0.22128184288302 | 0.00964768492169554 | PAAD | Female-baised eQTL |
| rs7306948 | chr12:122860800:G:A | - | -0.161703699630388 | 0.0233694407499621 | HNSC | Female-baised eQTL |
| rs6489240 | chr12:122790483:T:C | - | -0.159644850576291 | 0.0380975291475952 | HNSC | Female-baised eQTL |
| rs839363 | chr12:122792377:C:T | - | -0.159644850576291 | 0.0380975291475952 | HNSC | Female-baised eQTL |
| rs3847967 | chr12:120284261:T:C | - | -0.105742193089824 | 0.0197052808968133 | THCA | Female-baised eQTL |
| rs11067288 | chr12:114773211:T:C | - | 0.122121109314499 | 0.0297201014760542 | SARC | Female-baised eQTL |
| rs73197964 | chr12:111203835:A:G | - | 0.225047225865964 | 0.0357380082788066 | LUSC | Female-baised eQTL |
| rs11066954 | chr12:114124768:C:G | - | 0.0599592098789754 | 0.0444878267566419 | LUAD | Female-baised eQTL |
| rs10850276 | chr12:114125648:G:A | - | 0.0599592098789754 | 0.0444878267566419 | LUAD | Female-baised eQTL |
| rs11066956 | chr12:114127221:A:G | - | 0.0599592098789754 | 0.0444878267566419 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11067055 | chr12:114335088:T:C | - | 0.0540060447684125 | 0.0381825132907804 | BLCA | Male-baised eQTL |
| rs11065898 | chr12:111424771:C:T | - | 0.0431109188852927 | 0.045024343454873 | BLCA | Male-baised eQTL |
| rs10466924 | chr12:111148871:C:T | - | 0.11349631672356 | 0.0360859826955742 | COAD | Male-baised eQTL |
| rs2037085 | chr12:128166605:C:G | - | -0.0496812476445118 | 0.0396768719346354 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000111725 |
| CpG Site: cg10168009 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.377957949116381 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg10168009 | chr12:119670894 | gene,enhancer | -0.377957949116381 | 1.21528253305019e-05 | -0.5146516646274458 | 6.936872133291233e-08 | PAAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PRKAB1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000111725 | PRKAB1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| ENSG00000111725 | PRKAB1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| ENSG00000111725 | PRKAB1 | C0235874 | Disease Exacerbation | 1 | CTD_human |
| ENSG00000111725 | PRKAB1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
