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Gene: ENSG00000111254 |
Summary for AKAP3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000111254 | Gene symbol | AKAP3 |
| Gene name | A-kinase anchoring protein 3 | |
| HGNC | 373 | |
| Entrez ID | 10566 | |
| Gene type | protein_coding | |
| Synonyms | AKAP3|FSP95|SOB1|AKAP110|CT82 | |
| UniProtAcc | O75969 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for AKAP3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for AKAP3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for AKAP3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for AKAP3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for AKAP3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for AKAP3 |
| TFs related to AKAP3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | AIRE | AKAP3 | 3.93e+00 | 5.80e-03 | 4.91e+00 | 9.91e-01 | Female-biased |
| ACC | CDX2 | AKAP3 | 3.47e+00 | 2.13e-03 | 4.69e+00 | 9.94e-01 | Female-biased |
| ACC | DUX4 | AKAP3 | 4.44e+00 | 4.69e-03 | 5.47e+00 | 9.94e-01 | Female-biased |
| ACC | EVX2 | AKAP3 | 3.72e+00 | 3.10e-03 | 4.85e+00 | 9.94e-01 | Female-biased |
| ACC | FOXA1 | AKAP3 | 3.01e+00 | 3.16e-04 | 4.65e+00 | 9.96e-01 | Female-biased |
| ACC | FOXB1 | AKAP3 | 3.25e+00 | 8.21e-04 | 4.69e+00 | 9.95e-01 | Female-biased |
| ACC | HOXB7 | AKAP3 | 4.00e+00 | 2.90e-03 | 5.14e+00 | 9.95e-01 | Female-biased |
| ACC | HOXC10 | AKAP3 | 3.66e+00 | 2.65e-03 | 4.82e+00 | 9.94e-01 | Female-biased |
| ACC | HSF4 | AKAP3 | 3.71e+00 | 1.11e-02 | 4.52e+00 | 9.84e-01 | Female-biased |
| ACC | IRF2 | AKAP3 | 3.47e+00 | 6.75e-03 | 4.40e+00 | 9.87e-01 | Female-biased |
| ACC | NFE2L1 | AKAP3 | 4.30e+00 | 8.18e-03 | 5.19e+00 | 9.90e-01 | Female-biased |
| ACC | NR2E1 | AKAP3 | 3.61e+00 | 5.35e-03 | 4.60e+00 | 9.90e-01 | Female-biased |
| ACC | NRL | AKAP3 | 4.24e+00 | 1.14e-02 | 5.05e+00 | 9.86e-01 | Female-biased |
| ACC | ZFP64 | AKAP3 | 3.87e+00 | 9.86e-01 | 1.54e+00 | 1.09e-05 | Male-biased |
| ACC | ZIC3 | AKAP3 | 3.76e+00 | 9.81e-01 | 2.34e+00 | 6.60e-04 | Male-biased |
| ACC | ZNF25 | AKAP3 | 3.31e+00 | 1.41e-03 | 4.62e+00 | 9.94e-01 | Female-biased |
| ACC | ZNF320 | AKAP3 | 3.73e+00 | 9.81e-01 | 1.32e+00 | 7.62e-06 | Male-biased |
| CHOL | CDX2 | AKAP3 | 3.00e+00 | 2.55e-03 | 4.26e+00 | 9.89e-01 | Female-biased |
| CHOL | EVX2 | AKAP3 | 3.33e+00 | 9.61e-03 | 4.27e+00 | 9.82e-01 | Female-biased |
| CHOL | FOXA1 | AKAP3 | 2.58e+00 | 1.78e-03 | 3.92e+00 | 9.84e-01 | Female-biased |
| CHOL | FOXB1 | AKAP3 | 2.89e+00 | 4.60e-03 | 4.01e+00 | 9.83e-01 | Female-biased |
| CHOL | HOXB7 | AKAP3 | 3.65e+00 | 8.24e-03 | 4.63e+00 | 9.87e-01 | Female-biased |
| CHOL | HOXC10 | AKAP3 | 3.20e+00 | 5.86e-03 | 4.26e+00 | 9.86e-01 | Female-biased |
| CHOL | IRF2 | AKAP3 | 3.19e+00 | 7.12e-03 | 4.21e+00 | 9.84e-01 | Female-biased |
| CHOL | MXI1 | AKAP3 | 4.25e+00 | 9.80e-01 | 3.33e+00 | 1.23e-02 | Male-biased |
| CHOL | ZNF25 | AKAP3 | 2.67e+00 | 1.80e-03 | 4.01e+00 | 9.86e-01 | Female-biased |
| CHOL | ZNF320 | AKAP3 | 3.81e+00 | 9.84e-01 | 2.12e+00 | 4.35e-04 | Male-biased |
| CHOL | ZNF333 | AKAP3 | 4.04e+00 | 9.86e-01 | 2.80e+00 | 3.19e-03 | Male-biased |
| CHOL | ZNF816 | AKAP3 | 3.72e+00 | 9.80e-01 | 2.26e+00 | 1.23e-03 | Male-biased |
| CHOL | ZSCAN30 | AKAP3 | 3.75e+00 | 9.81e-01 | 2.29e+00 | 1.20e-03 | Male-biased |
| LGG | PRDM6 | AKAP3 | 4.53e+00 | 9.89e-01 | 3.90e+00 | 4.00e-03 | Male-biased |
| MESO | CDX2 | AKAP3 | 4.27e+00 | 9.83e-01 | 2.98e+00 | 7.46e-03 | Male-biased |
| MESO | FOXA1 | AKAP3 | 4.00e+00 | 9.85e-01 | 2.15e+00 | 1.01e-03 | Male-biased |
| MESO | FOXB1 | AKAP3 | 4.17e+00 | 9.87e-01 | 2.48e+00 | 1.80e-03 | Male-biased |
| MESO | HOXB7 | AKAP3 | 4.66e+00 | 9.82e-01 | 3.53e+00 | 1.29e-02 | Male-biased |
| MESO | HOXC10 | AKAP3 | 4.29e+00 | 9.83e-01 | 3.02e+00 | 8.02e-03 | Male-biased |
| MESO | ZNF25 | AKAP3 | 4.00e+00 | 9.85e-01 | 2.11e+00 | 8.71e-04 | Male-biased |
| PAAD | FOXA1 | AKAP3 | 3.86e+00 | 9.76e-03 | 4.67e+00 | 9.86e-01 | Female-biased |
| PAAD | HSF4 | AKAP3 | 3.82e+00 | 1.39e-02 | 4.55e+00 | 9.80e-01 | Female-biased |
| PAAD | IRF2 | AKAP3 | 3.71e+00 | 8.97e-03 | 4.54e+00 | 9.85e-01 | Female-biased |
| PAAD | NFE2L1 | AKAP3 | 4.38e+00 | 1.47e-02 | 5.11e+00 | 9.83e-01 | Female-biased |
| PAAD | TAL1 | AKAP3 | 3.64e+00 | 1.26e-02 | 4.39e+00 | 9.80e-01 | Female-biased |
| PAAD | ZSCAN16 | AKAP3 | 3.97e+00 | 1.44e-02 | 4.70e+00 | 9.81e-01 | Female-biased |
| PAAD | ZZZ3 | AKAP3 | 4.73e+00 | 1.60e-02 | 5.44e+00 | 9.82e-01 | Female-biased |
| THYM | ZNF25 | AKAP3 | 4.30e+00 | 1.48e-02 | 4.89e+00 | 9.81e-01 | Female-biased |
| AKAP3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for AKAP3 |
| RBPs related to ES in AKAP3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| AKAP3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11062005 | chr12:1853334:T:A | - | 0.0725809176611512 | 0.00015111717966021 | LGG | Male-baised eQTL |
| rs75991483 | chr12:1859274:G:T | - | 0.0694727351466986 | 0.000162455977409221 | LGG | Male-baised eQTL |
| rs181169602 | chr12:1848761:C:T | - | 0.0680761369945143 | 0.000413023522725764 | LGG | Male-baised eQTL |
| rs117572973 | chr12:1841089:T:G | - | 0.066641890769095 | 0.00781971209768392 | LGG | Male-baised eQTL |
| rs7967890 | chr12:1843824:T:C | - | 0.0595826300472385 | 0.0202234130623506 | LGG | Male-baised eQTL |
| rs61910065 | chr12:2045524:A:G | - | 0.0561033582161629 | 0.0261075126521531 | LGG | Male-baised eQTL |
| rs7304762 | chr12:1862172:T:C | - | 0.0443398028220677 | 0.0263682537912327 | LGG | Male-baised eQTL |
| rs7315910 | chr12:1861941:C:A | - | 0.0431950210900467 | 0.0271097329977007 | LGG | Male-baised eQTL |
| rs61910067 | chr12:2049080:C:A | - | 0.0543004052045146 | 0.0300252691912177 | LGG | Male-baised eQTL |
| rs11062009 | chr12:1863358:G:A | - | 0.0434558449935305 | 0.047359838011274 | LGG | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of AKAP3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
