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Gene: ENSG00000110900 |
Summary for TSPAN11 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000110900 | Gene symbol | TSPAN11 |
| Gene name | tetraspanin 11 | |
| HGNC | 30795 | |
| Entrez ID | 441631 | |
| Gene type | protein_coding | |
| Synonyms | TSPAN11| | |
| UniProtAcc | A1L157 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TSPAN11 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TSPAN11 | 3.55e+02 | -2.10e+00 | 4.93e-01 | -4.26e+00 | 2.02e-05 | 1.11e-04 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TSPAN11 | 5.00e+02 | -1.78e+00 | 3.95e-01 | -4.50e+00 | 6.85e-06 | 4.69e-05 | READ |
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Sex-biased somatic mutation for TSPAN11 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TSPAN11 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg00509207 | chr12:30926045 | CGI:chr12:30926309-30926944 | promoter | 5.74e-01 | 4.62e-01 | 3.61e+00 | 3.12e-04 | 1.64e-03 | 1.13e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg21701379 | chr12:30926760 | CGI:chr12:30926309-30926944 | UTR,promoter,exon,gene body | 2.30e-01 | 1.16e-01 | 2.87e+00 | 4.04e-03 | 6.28e-03 | 1.14e-01 |
| LUSC | cg21701379 | chr12:30926760 | CGI:chr12:30926309-30926944 | UTR,promoter,exon,gene body | 2.06e-01 | 1.05e-01 | 2.54e+00 | 1.10e-02 | 1.49e-02 | 1.01e-01 |
| LIHC | cg16138602 | chr12:30925856 | CGI:chr12:30926309-30926944 | promoter | 5.58e-01 | 6.78e-01 | -2.57e+00 | 1.03e-02 | 1.25e-02 | -1.20e-01 |
| CHOL | cg00509207 | chr12:30926045 | CGI:chr12:30926309-30926944 | promoter | 7.94e-01 | 5.78e-01 | 2.58e+00 | 9.87e-03 | 2.15e-02 | 2.16e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21701379 | chr12:30926760 | CGI:chr12:30926309-30926944 | UTR,promoter,exon,gene body | 3.25e-01 | 1.18e-01 | 9.56e+00 | 1.12e-21 | 7.02e-21 | 2.07e-01 |
| BRCA | cg15526671 | chr12:30927118 | CGI:chr12:30926309-30926944 | promoter,gene body | 8.12e-01 | 6.80e-01 | 1.14e+01 | 3.68e-30 | 5.46e-29 | 1.32e-01 |
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Exon skipping events with PSI in TCGA for TSPAN11 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TSPAN11 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TSPAN11 |
| TFs related to TSPAN11. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | ZNF460 | TSPAN11 | 4.01e+00 | 9.82e-01 | 3.19e+00 | 5.53e-03 | Male-biased |
| ESCA | ZNF674 | TSPAN11 | 4.07e+00 | 9.85e-01 | 3.21e+00 | 4.50e-03 | Male-biased |
| TSPAN11 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TSPAN11 |
| RBPs related to ES in TSPAN11. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TSPAN11 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000110900 | TCL6,hsa-mir-629,TSPAN11 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000110900 | CPEB1-AS1,hsa-mir-629,TSPAN11 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000110900 | TCL6,hsa-mir-665,TSPAN11 | Male-specific ceRNA | TCGA-BLCA |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61914382 | chr12:26401185:C:T | - | 0.178491493879258 | 0.00333930819542194 | PAAD | Female-baised eQTL |
| rs61914385 | chr12:26407236:G:T | - | 0.178405084121166 | 0.00345335531317886 | PAAD | Female-baised eQTL |
| rs699026 | chr12:24990456:A:T | - | 0.0881299134334551 | 0.0195950757977962 | LUAD | Female-baised eQTL |
| rs699022 | chr12:24985347:C:T | - | 0.0850556167054883 | 0.0295031084148892 | LUAD | Female-baised eQTL |
| rs699024 | chr12:24985774:G:C | - | 0.0850556167054883 | 0.0295031084148892 | LUAD | Female-baised eQTL |
| rs2728652 | chr12:24982820:G:A | - | -0.0850556167054883 | 0.0295031084148892 | LUAD | Female-baised eQTL |
| rs2728653 | chr12:24984220:G:A | - | -0.0850556167054883 | 0.0295031084148892 | LUAD | Female-baised eQTL |
| rs7305440 | chr12:24973637:C:T | - | 0.0762831350583341 | 0.0431681977552643 | LUAD | Female-baised eQTL |
| rs2086598 | chr12:40079535:T:C | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs17458396 | chr12:40082957:C:T | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs17458403 | chr12:40083074:A:T | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs147422081 | chr12:40085916:C:T | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs1482282 | chr12:40088250:G:T | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs11564133 | chr12:40089657:C:T | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs11564160 | chr12:40090308:T:C | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs55707305 | chr12:40091088:A:G | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs17442469 | chr12:40095003:T:C | - | 0.0943464612857986 | 0.0144694609559767 | COAD | Female-baised eQTL |
| rs11564137 | chr12:40127785:C:T | - | 0.0905677486407396 | 0.016083910951735 | COAD | Female-baised eQTL |
| rs17458585 | chr12:40119150:G:A | - | 0.0906012518990588 | 0.0217089112312801 | COAD | Female-baised eQTL |
| rs7296203 | chr12:40130828:T:C | - | 0.0906012518990588 | 0.0217089112312801 | COAD | Female-baised eQTL |
| rs17442805 | chr12:40148074:A:C | - | 0.0880544144235779 | 0.0219520713697478 | COAD | Female-baised eQTL |
| rs10506145 | chr12:40151816:G:T | - | 0.0879192601991234 | 0.0239430697459771 | COAD | Female-baised eQTL |
| rs75748985 | chr12:40153076:A:T | - | 0.0879192601991234 | 0.0239430697459771 | COAD | Female-baised eQTL |
| rs78801254 | chr12:40155861:C:T | - | 0.0879192601991234 | 0.0239430697459771 | COAD | Female-baised eQTL |
| rs2404574 | chr12:40138199:C:T | - | 0.084782625527257 | 0.0253887660127442 | COAD | Female-baised eQTL |
| rs80070285 | chr12:40048922:T:C | - | 0.0908050039842976 | 0.0270882156964047 | COAD | Female-baised eQTL |
| rs11833426 | chr12:40132724:G:A | - | 0.108426745285277 | 0.0301474600710981 | COAD | Female-baised eQTL |
| rs17458299 | chr12:40071120:T:C | - | 0.0890840454128506 | 0.0315685715736601 | COAD | Female-baised eQTL |
| rs17442304 | chr12:40071170:T:C | - | 0.0890840454128506 | 0.0315685715736601 | COAD | Female-baised eQTL |
| rs17442108 | chr12:40036632:T:C | - | 0.0885426222019891 | 0.0355274449384922 | COAD | Female-baised eQTL |
| rs12312535 | chr12:40009564:G:A | - | 0.0856795344233444 | 0.0410995881572478 | COAD | Female-baised eQTL |
| rs11564139 | chr12:39990032:G:A | - | 0.0869087139107905 | 0.0434889364095663 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs77707267 | chr12:23966154:T:C | - | 0.0408121255955392 | 0.0416119911038469 | HNSC | Male-baised eQTL |
| rs79168377 | chr12:23965960:A:G | - | 0.0405239665369089 | 0.0421516259924781 | HNSC | Male-baised eQTL |
| rs12424756 | chr12:23964499:A:G | - | 0.0407392813677069 | 0.0472650084993385 | HNSC | Male-baised eQTL |
| rs74234902 | chr12:23964715:C:A | - | 0.0407392813677069 | 0.0472650084993385 | HNSC | Male-baised eQTL |
| rs17444096 | chr12:40326499:A:C | - | 0.103251063826389 | 0.0109618401706271 | SARC | Male-baised eQTL |
| rs11564147 | chr12:40345691:G:A | - | 0.0984264810957228 | 0.0203679716183446 | SARC | Male-baised eQTL |
| rs191099092 | chr12:40353383:C:T | - | 0.0984826506048839 | 0.0205628913096433 | SARC | Male-baised eQTL |
| rs10771631 | chr12:30088437:C:T | - | -0.072889597909003 | 0.000646277781865472 | COAD | Male-baised eQTL |
| rs117439560 | chr12:33925202:A:C | - | 0.0714063200094142 | 0.00667869408708346 | COAD | Male-baised eQTL |
| rs117767462 | chr12:33521630:C:G | - | 0.0471231166433002 | 0.0219937268852519 | COAD | Male-baised eQTL |
| rs17637624 | chr12:33537115:A:T | - | 0.0470518691069827 | 0.0222578904954867 | COAD | Male-baised eQTL |
| rs145717620 | chr12:33015077:C:G | - | 0.0532714898923358 | 0.0233196400194348 | COAD | Male-baised eQTL |
| rs3932069 | chr12:30571206:T:C | - | 0.0593683448919193 | 0.0263708218097107 | COAD | Male-baised eQTL |
| rs4142890 | chr12:33293695:G:C | - | -0.0270995480059959 | 0.0317732528534716 | COAD | Male-baised eQTL |
| rs1905423 | chr12:33329669:A:C | - | -0.0255623168524562 | 0.037684179323951 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000110900 |
| CpG Site: cg00509207 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.459939600126288 | |
 | Gene ID: ENSG00000110900 |
| CpG Site: cg16138602 | |
| Position to Gene: promoter | |
| Male Effect: -0.213045815032761 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16138602 | chr12:30925856 | promoter | -0.213045815032761 | 1.8960898495982e-10 | -0.4084396206438442 | 3.6225342313300277e-13 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00509207 | chr12:30926045 | promoter | -0.459939600126288 | 8.94256601579028e-08 | -0.39323048627657486 | 7.376531164166365e-11 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TSPAN11 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
