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Gene: ENSG00000110628 |
Summary for SLC22A18 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000110628 | Gene symbol | SLC22A18 |
| Gene name | solute carrier family 22 member 18 | |
| HGNC | 10964 | |
| Entrez ID | 5002 | |
| Gene type | protein_coding | |
| Synonyms | SLC22A18|BWR1A|TSSC5|ITM | |
| UniProtAcc | Q96BI1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SLC22A18 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC22A18 | 2.62e+03 | 1.06e+00 | 1.65e-01 | 6.42e+00 | 1.40e-10 | 1.79e-09 | THCA |
| SLC22A18 | 2.66e+03 | -1.42e+00 | 4.05e-01 | -3.50e+00 | 4.62e-04 | 1.71e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC22A18 | 1.47e+03 | 1.23e+00 | 9.90e-02 | 1.24e+01 | 2.29e-35 | 1.43e-34 | BRCA |
Top |
Sex-biased somatic mutation for SLC22A18 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SLC22A18 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18419977 | chr11:2898822 | CGI:chr11:2902071-2902587 | promoter | 5.72e-01 | 7.29e-01 | -2.22e+00 | 2.64e-02 | 3.89e-02 | -1.56e-01 |
| BRCA | cg16129800 | chr11:2899184 | CGI:chr11:2902071-2902587 | promoter | 5.41e-01 | 6.50e-01 | -3.05e+00 | 2.31e-03 | 1.46e-02 | -1.09e-01 |
| BRCA | cg16346422 | chr11:2899589 | CGI:chr11:2902071-2902587 | promoter | 4.02e-01 | 5.18e-01 | -2.01e+00 | 4.42e-02 | 4.77e-02 | -1.16e-01 |
| BRCA | cg16873863 | chr11:2899946 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.32e-01 | 7.91e-01 | -2.53e+00 | 1.14e-02 | 2.80e-02 | -1.59e-01 |
| BRCA | cg09198782 | chr11:2901532 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.14e-01 | 8.40e-01 | -3.53e+00 | 4.11e-04 | 5.24e-03 | -1.26e-01 |
| KIRP | cg15739881 | chr11:2901234 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.23e-01 | 6.13e-01 | 3.90e+00 | 9.55e-05 | 7.40e-04 | 1.10e-01 |
| KIRP | cg12563184 | chr11:2901261 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.93e-01 | 5.52e-01 | 4.24e+00 | 2.24e-05 | 2.03e-04 | 1.41e-01 |
| KIRP | cg09198782 | chr11:2901532 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.99e-01 | 5.93e-01 | 3.48e+00 | 5.09e-04 | 2.91e-03 | 1.06e-01 |
| KICH | cg05457684 | chr11:2898578 | CGI:chr11:2902071-2902587 | promoter | 8.51e-01 | 7.18e-01 | 2.36e+00 | 1.84e-02 | 3.60e-02 | 1.33e-01 |
| KICH | cg24205453 | chr11:2901104 | CGI:chr11:2902071-2902587 | promoter,gene body | 5.96e-01 | 7.40e-01 | -2.22e+00 | 2.62e-02 | 4.10e-02 | -1.44e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg18419977 | chr11:2898822 | CGI:chr11:2902071-2902587 | promoter | 1.11e-01 | 3.72e-01 | -6.13e+00 | 8.67e-10 | 1.08e-08 | -2.61e-01 |
| KIRC | cg13485320 | chr11:2898898 | CGI:chr11:2902071-2902587 | promoter | 6.76e-02 | 1.83e-01 | -6.89e+00 | 5.49e-12 | 1.08e-09 | -1.16e-01 |
| LUAD | cg25427871 | chr11:2899505 | CGI:chr11:2902071-2902587 | promoter | 6.48e-01 | 4.84e-01 | 3.60e+00 | 3.19e-04 | 7.43e-04 | 1.64e-01 |
| LUAD | cg16346422 | chr11:2899589 | CGI:chr11:2902071-2902587 | promoter | 6.56e-01 | 5.08e-01 | 3.44e+00 | 5.72e-04 | 1.21e-03 | 1.48e-01 |
| THCA | cg05457684 | chr11:2898578 | CGI:chr11:2902071-2902587 | promoter | 6.92e-01 | 8.53e-01 | -3.86e+00 | 1.13e-04 | 6.52e-04 | -1.61e-01 |
| HNSC | cg13485320 | chr11:2898898 | CGI:chr11:2902071-2902587 | promoter | 9.07e-02 | 2.09e-01 | -5.44e+00 | 5.28e-08 | 6.07e-07 | -1.18e-01 |
| LUSC | cg25427871 | chr11:2899505 | CGI:chr11:2902071-2902587 | promoter | 6.24e-01 | 4.53e-01 | 2.40e+00 | 1.63e-02 | 2.03e-02 | 1.71e-01 |
| LUSC | cg21019522 | chr11:2899559 | CGI:chr11:2902071-2902587 | promoter | 5.10e-01 | 3.32e-01 | 3.81e+00 | 1.39e-04 | 8.07e-04 | 1.78e-01 |
| LUSC | cg16346422 | chr11:2899589 | CGI:chr11:2902071-2902587 | promoter | 6.75e-01 | 5.39e-01 | 2.61e+00 | 8.94e-03 | 1.27e-02 | 1.36e-01 |
| LUSC | cg24205453 | chr11:2901104 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.10e-01 | 9.16e-01 | -3.25e+00 | 1.13e-03 | 2.83e-03 | -1.06e-01 |
| LUSC | cg12563184 | chr11:2901261 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.11e-01 | 9.25e-01 | -3.29e+00 | 9.93e-04 | 2.59e-03 | -1.14e-01 |
| LUSC | cg09198782 | chr11:2901532 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.59e-01 | 7.98e-01 | -3.47e+00 | 5.27e-04 | 1.71e-03 | -1.39e-01 |
| LUSC | cg10943932 | chr11:2901603 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.11e-01 | 9.25e-01 | -2.70e+00 | 6.96e-03 | 1.05e-02 | -1.14e-01 |
| LUSC | cg05385260 | chr11:2901622 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.12e-01 | 8.47e-01 | -3.62e+00 | 2.92e-04 | 1.20e-03 | -1.35e-01 |
| COAD | cg05385260 | chr11:2901622 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.60e-01 | 7.70e-01 | -3.54e+00 | 3.96e-04 | 1.06e-03 | -1.10e-01 |
| BLCA | cg26665035 | chr11:2898533 | CGI:chr11:2902071-2902587 | promoter | 6.10e-01 | 7.44e-01 | -2.16e+00 | 3.06e-02 | 3.41e-02 | -1.34e-01 |
| BLCA | cg16587707 | chr11:2899035 | CGI:chr11:2902071-2902587 | promoter | 5.51e-01 | 7.16e-01 | -2.86e+00 | 4.30e-03 | 7.21e-03 | -1.65e-01 |
| BLCA | cg24205453 | chr11:2901104 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.20e-01 | 8.99e-01 | -3.59e+00 | 3.27e-04 | 9.58e-04 | -1.79e-01 |
| BLCA | cg09198782 | chr11:2901532 | CGI:chr11:2902071-2902587 | promoter,gene body | 5.78e-01 | 7.38e-01 | -3.44e+00 | 5.81e-04 | 1.49e-03 | -1.60e-01 |
| LIHC | cg24033661 | chr11:2898825 | CGI:chr11:2902071-2902587 | promoter | 3.90e-01 | 2.45e-01 | 4.27e+00 | 1.99e-05 | 4.99e-05 | 1.46e-01 |
| KIRP | cg21853021 | chr11:2898916 | CGI:chr11:2902071-2902587 | promoter | 6.80e-02 | 1.71e-01 | -5.28e+00 | 1.30e-07 | 1.04e-06 | -1.03e-01 |
| KIRP | cg10943932 | chr11:2901603 | CGI:chr11:2902071-2902587 | promoter,gene body | 5.97e-01 | 6.99e-01 | -2.02e+00 | 4.39e-02 | 4.48e-02 | -1.02e-01 |
| ESCA | cg26665035 | chr11:2898533 | CGI:chr11:2902071-2902587 | promoter | 5.99e-01 | 7.43e-01 | -2.42e+00 | 1.54e-02 | 3.84e-02 | -1.44e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg16346422 | chr11:2899589 | CGI:chr11:2902071-2902587 | promoter | 4.02e-01 | 5.16e-01 | -6.77e+00 | 1.31e-11 | 3.68e-11 | -1.15e-01 |
| BRCA | cg15739881 | chr11:2901234 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.14e-01 | 6.59e-01 | 1.25e+01 | 7.16e-36 | 2.43e-34 | 1.55e-01 |
| BRCA | cg12563184 | chr11:2901261 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.16e-01 | 6.70e-01 | 1.07e+01 | 6.39e-27 | 6.55e-26 | 1.46e-01 |
| BRCA | cg09198782 | chr11:2901532 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.14e-01 | 6.02e-01 | 9.30e+00 | 1.37e-20 | 7.80e-20 | 1.12e-01 |
| KIRC | cg02081198 | chr11:2901615 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.48e-01 | 9.71e-01 | -3.15e+00 | 1.64e-03 | 5.79e-03 | -1.23e-01 |
| KIRC | cg21019522 | chr11:2899559 | CGI:chr11:2902071-2902587 | promoter | 5.34e-01 | 4.31e-01 | 2.90e+00 | 3.69e-03 | 9.14e-03 | 1.02e-01 |
| KIRC | cg16873863 | chr11:2899946 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.14e-01 | 7.07e-01 | 2.23e+00 | 2.58e-02 | 3.19e-02 | 1.07e-01 |
| KIRC | cg24041239 | chr11:2901405 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.75e-01 | 8.78e-01 | -2.57e+00 | 1.01e-02 | 1.72e-02 | -1.03e-01 |
| LUAD | cg18458509 | chr11:2898959 | CGI:chr11:2902071-2902587 | promoter | 2.20e-01 | 3.20e-01 | -3.28e+00 | 1.02e-03 | 3.24e-03 | -1.01e-01 |
| LUAD | cg21599100 | chr11:2899207 | CGI:chr11:2902071-2902587 | promoter | 5.61e-01 | 6.79e-01 | -2.96e+00 | 3.10e-03 | 6.88e-03 | -1.18e-01 |
| LUAD | cg16873863 | chr11:2899946 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.69e-01 | 8.28e-01 | -2.25e+00 | 2.45e-02 | 2.99e-02 | -1.59e-01 |
| HNSC | cg05752118 | chr11:2899334 | CGI:chr11:2902071-2902587 | promoter | 5.06e-01 | 4.05e-01 | 2.34e+00 | 1.92e-02 | 2.69e-02 | 1.01e-01 |
| HNSC | cg21019522 | chr11:2899559 | CGI:chr11:2902071-2902587 | promoter | 4.26e-01 | 3.12e-01 | 2.50e+00 | 1.24e-02 | 2.09e-02 | 1.14e-01 |
| HNSC | cg16873863 | chr11:2899946 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.42e-01 | 5.29e-01 | 2.90e+00 | 3.79e-03 | 1.19e-02 | 2.12e-01 |
| HNSC | cg05385260 | chr11:2901622 | CGI:chr11:2902071-2902587 | promoter,gene body | 7.74e-01 | 6.13e-01 | 2.78e+00 | 5.40e-03 | 1.38e-02 | 1.61e-01 |
| COAD | cg09198782 | chr11:2901532 | CGI:chr11:2902071-2902587 | promoter,gene body | 6.13e-01 | 4.97e-01 | 3.36e+00 | 7.90e-04 | 2.52e-03 | 1.16e-01 |
| LIHC | cg22040301 | chr11:2898568 | CGI:chr11:2902071-2902587 | promoter | 7.51e-01 | 8.70e-01 | -2.65e+00 | 7.96e-03 | 1.16e-02 | -1.19e-01 |
| KIRP | cg26665035 | chr11:2898533 | CGI:chr11:2902071-2902587 | promoter | 7.47e-01 | 8.74e-01 | -2.50e+00 | 1.24e-02 | 1.94e-02 | -1.28e-01 |
| KIRP | cg24033661 | chr11:2898825 | CGI:chr11:2902071-2902587 | promoter | 8.34e-02 | 2.04e-01 | -2.17e+00 | 3.01e-02 | 3.53e-02 | -1.21e-01 |
| KIRP | cg16346422 | chr11:2899589 | CGI:chr11:2902071-2902587 | promoter | 7.30e-01 | 5.75e-01 | 2.80e+00 | 5.08e-03 | 1.08e-02 | 1.56e-01 |
| KIRP | cg24205453 | chr11:2901104 | CGI:chr11:2902071-2902587 | promoter,gene body | 8.36e-01 | 7.21e-01 | 3.39e+00 | 7.05e-04 | 3.16e-03 | 1.15e-01 |
Top |
Exon skipping events with PSI in TCGA for SLC22A18 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SLC22A18 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SLC22A18 |
| TFs related to SLC22A18. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC22A18 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SLC22A18 |
| RBPs related to ES in SLC22A18. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | SAMD4A | exon_skip_56383 | 8.15e+00 | 5.94e-03 | 8.53e+00 | 9.87e-01 | Female-biased |
| CHOL | G3BP2 | exon_skip_56338 | 7.42e+00 | 9.81e-01 | 6.99e+00 | 8.07e-03 | Male-biased |
| BRCA | SAMD4A | exon_skip_56383 | 8.60e+00 | 4.81e-03 | 9.45e+00 | 9.92e-01 | Female-biased |
| READ | RBM4 | exon_skip_56333 | 8.48e+00 | 2.51e-03 | 8.93e+00 | 9.93e-01 | Female-biased |
| MESO | NOVA2 | exon_skip_56338 | 7.32e+00 | 7.48e-03 | 7.69e+00 | 9.83e-01 | Female-biased |
| PAAD | SAMD4A | exon_skip_56383 | 8.87e+00 | 9.95e-01 | 8.27e+00 | 2.96e-04 | Male-biased |
| KICH | HNRNPH2 | exon_skip_56343 | 6.72e+00 | 9.84e-01 | 6.02e+00 | 3.66e-04 | Male-biased |
| KICH | NOVA2 | exon_skip_56338 | 7.24e+00 | 3.54e-03 | 7.66e+00 | 9.87e-01 | Female-biased |
| KICH | RBM6 | exon_skip_56327 | 9.55e+00 | 7.98e-03 | 9.89e+00 | 9.90e-01 | Female-biased |
| KICH | SAMD4A | exon_skip_56383 | 8.78e+00 | 9.93e-01 | 8.30e+00 | 1.99e-03 | Male-biased |
| SKCM | SAMD4A | exon_skip_56383 | 8.80e+00 | 2.50e-03 | 9.31e+00 | 9.94e-01 | Female-biased |
| HNSC | HNRNPH2 | exon_skip_56343 | 6.31e+00 | 2.68e-03 | 6.77e+00 | 9.82e-01 | Female-biased |
| SLC22A18 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1045502 | chr11:252818:G:A | - | 0.125466939441857 | 0.0163998740101151 | SARC | Female-baised eQTL |
| rs1045577 | chr11:252942:G:A | - | 0.125466939441857 | 0.0163998740101151 | SARC | Female-baised eQTL |
| rs532483 | chr11:257030:G:A | - | 0.124883368935884 | 0.01784300703172 | SARC | Female-baised eQTL |
| rs41401046 | chr11:1084428:G:A | - | 0.194604656668521 | 0.000182403758671249 | COAD | Female-baised eQTL |
| rs11245932 | chr11:1084986:C:T | - | 0.182922215784447 | 0.000223061465134557 | COAD | Female-baised eQTL |
| rs11245936 | chr11:1086366:G:A | - | 0.173723017182248 | 0.000537316651561173 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12286813 | chr11:7949826:C:G | - | 0.150104707891369 | 0.0477834116027962 | THCA | Male-baised eQTL |
| rs4259814 | chr11:7950941:T:A | - | 0.150104707891369 | 0.0477834116027962 | THCA | Male-baised eQTL |
| rs2136907 | chr11:7951686:C:T | - | 0.150104707891369 | 0.0477834116027962 | THCA | Male-baised eQTL |
| rs957645 | chr11:11096939:C:T | - | 0.057151605554741 | 0.0280659802201209 | BLCA | Male-baised eQTL |
| rs6484611 | chr11:11013068:G:C | - | -0.0733684461227895 | 0.0194887738396569 | LUAD | Male-baised eQTL |
| rs2129285 | chr11:11013950:G:A | - | -0.064993699103569 | 0.0267215875318579 | LUAD | Male-baised eQTL |
| rs4910215 | chr11:10987966:A:T | - | -0.0715071987053827 | 0.0273031185327396 | LUAD | Male-baised eQTL |
| rs9804699 | chr11:10994744:A:G | - | -0.0715071987053827 | 0.0273031185327396 | LUAD | Male-baised eQTL |
| rs35998740 | chr11:11002665:A:G | - | -0.0707587062514247 | 0.0275750493950189 | LUAD | Male-baised eQTL |
| rs6484590 | chr11:10990254:A:C | - | -0.064978740894614 | 0.0316854122356001 | LUAD | Male-baised eQTL |
| rs78554753 | chr11:11014544:G:A | - | 0.0677860745697211 | 0.0354653833104275 | LUAD | Male-baised eQTL |
| rs7104468 | chr11:11014750:C:T | - | 0.0671150690722615 | 0.0365820678160767 | LUAD | Male-baised eQTL |
| rs74605099 | chr11:10998399:A:G | - | 0.0845697438545046 | 0.0397226482800828 | LUAD | Male-baised eQTL |
| rs10770159 | chr11:11016785:G:A | - | -0.0654142519714774 | 0.0437469752802806 | LUAD | Male-baised eQTL |
| rs7930378 | chr11:7336975:T:C | - | -0.0968125700025242 | 0.0189786077050486 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000110628 |
| CpG Site: cg08827700 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.298819583054772 | |
 | Gene ID: ENSG00000110628 |
| CpG Site: cg22272492 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.298819583054772 | |
 | Gene ID: ENSG00000110628 |
| CpG Site: cg24205453 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.410025920128358 | |
 | Gene ID: ENSG00000110628 |
| CpG Site: cg16873863 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.215746705495477 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16873863 | chr11:2899946 | gene,promoter | -0.215746705495477 | 1.28212810606193e-08 | -0.37604415722579954 | 3.058613175319563e-11 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg08827700 | chr11:2904739 | gene | -0.298819583054772 | 5.40121461363185e-05 | -0.4323704283784072 | 4.5326509426480366e-08 | COAD |
| cg22272492 | chr11:2904766 | gene | -0.298819583054772 | 5.40121461363185e-05 | -0.4323704283784072 | 4.5326509426480366e-08 | COAD |
| cg24205453 | chr11:2901104 | gene,promoter | -0.410025920128358 | 6.02385088907487e-07 | -0.3691915980738449 | 1.2731987114733807e-09 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SLC22A18 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000110628 | SLC22A18 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| ENSG00000110628 | SLC22A18 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C1849385 | Rhabdomyosarcoma 1 | 1 | CTD_human |
| ENSG00000110628 | SLC22A18 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
