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Gene: ENSG00000110446 |
Summary for SLC15A3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000110446 | Gene symbol | SLC15A3 |
| Gene name | solute carrier family 15 member 3 | |
| HGNC | 18068 | |
| Entrez ID | 51296 | |
| Gene type | protein_coding | |
| Synonyms | SLC15A3|PHT2|hPTR3 | |
| UniProtAcc | Q8IY34 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SLC15A3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC15A3 | 9.82e+02 | 1.01e+00 | 2.67e-01 | 3.79e+00 | 1.49e-04 | 5.07e-04 | THCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for SLC15A3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SLC15A3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18151345 | chr11:60952757 | CGI:chr11:60950956-60951521 | promoter | 4.78e-01 | 6.17e-01 | -2.08e+00 | 3.72e-02 | 4.46e-02 | -1.40e-01 |
| DLBC | cg14130459 | chr11:60951096 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 3.79e-01 | 5.39e-01 | -2.50e+00 | 1.23e-02 | 2.61e-02 | -1.60e-01 |
| CHOL | cg18151345 | chr11:60952757 | CGI:chr11:60950956-60951521 | promoter | 4.85e-01 | 3.19e-01 | 2.20e+00 | 2.80e-02 | 3.90e-02 | 1.66e-01 |
| CHOL | cg23572944 | chr11:60952658 | CGI:chr11:60950956-60951521 | promoter | 4.24e-01 | 2.91e-01 | 2.23e+00 | 2.58e-02 | 3.76e-02 | 1.33e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg14130459 | chr11:60951096 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 6.09e-01 | 4.68e-01 | 3.49e+00 | 4.89e-04 | 8.26e-04 | 1.40e-01 |
| KIRC | cg18151345 | chr11:60952757 | CGI:chr11:60950956-60951521 | promoter | 4.86e-01 | 6.00e-01 | -3.12e+00 | 1.82e-03 | 2.64e-03 | -1.14e-01 |
| HNSC | cg14130459 | chr11:60951096 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 5.26e-01 | 6.69e-01 | -3.09e+00 | 2.01e-03 | 3.28e-03 | -1.43e-01 |
| HNSC | cg26090107 | chr11:60951410 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 2.08e-01 | 3.13e-01 | -2.28e+00 | 2.28e-02 | 2.57e-02 | -1.05e-01 |
| LUSC | cg14130459 | chr11:60951096 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 6.79e-01 | 5.10e-01 | 2.88e+00 | 4.00e-03 | 6.91e-03 | 1.69e-01 |
| LUSC | cg18151345 | chr11:60952757 | CGI:chr11:60950956-60951521 | promoter | 3.01e-01 | 1.04e-01 | 3.52e+00 | 4.26e-04 | 1.50e-03 | 1.97e-01 |
| LUSC | cg26980692 | chr11:60952475 | CGI:chr11:60950956-60951521 | promoter,gene body | 2.62e-01 | 1.33e-01 | 3.04e+00 | 2.34e-03 | 4.68e-03 | 1.28e-01 |
| LUSC | cg23572944 | chr11:60952658 | CGI:chr11:60950956-60951521 | promoter | 3.38e-01 | 1.42e-01 | 3.81e+00 | 1.39e-04 | 8.07e-04 | 1.96e-01 |
| COAD | cg14130459 | chr11:60951096 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 8.36e-01 | 7.32e-01 | 3.85e+00 | 1.18e-04 | 3.99e-04 | 1.04e-01 |
| COAD | cg18151345 | chr11:60952757 | CGI:chr11:60950956-60951521 | promoter | 1.67e-01 | 2.81e-01 | -4.07e+00 | 4.73e-05 | 1.94e-04 | -1.14e-01 |
| ESCA | cg23572944 | chr11:60952658 | CGI:chr11:60950956-60951521 | promoter | 2.70e-01 | 1.47e-01 | 2.31e+00 | 2.07e-02 | 4.06e-02 | 1.23e-01 |
| CHOL | cg26090107 | chr11:60951410 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 4.99e-01 | 1.25e-01 | 2.43e+00 | 1.50e-02 | 2.65e-02 | 3.74e-01 |
| CHOL | cg21992250 | chr11:60951237 | CGI:chr11:60950956-60951521 | promoter,gene body,CDS,UTR,exon | 5.01e-01 | 3.30e-01 | 2.36e+00 | 1.83e-02 | 2.92e-02 | 1.71e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg26090107 | chr11:60951410 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 6.45e-01 | 3.40e-01 | 1.20e+01 | 3.29e-33 | 7.32e-32 | 3.05e-01 |
| BRCA | cg18151345 | chr11:60952757 | CGI:chr11:60950956-60951521 | promoter | 4.78e-01 | 3.74e-01 | 4.81e+00 | 1.53e-06 | 2.80e-06 | 1.04e-01 |
| BRCA | cg21992250 | chr11:60951237 | CGI:chr11:60950956-60951521 | promoter,gene body,CDS,UTR,exon | 6.12e-01 | 4.19e-01 | 1.22e+01 | 3.80e-34 | 9.73e-33 | 1.93e-01 |
| BRCA | cg26980692 | chr11:60952475 | CGI:chr11:60950956-60951521 | promoter,gene body | 3.55e-01 | 2.45e-01 | 5.18e+00 | 2.26e-07 | 4.47e-07 | 1.10e-01 |
| BRCA | cg23572944 | chr11:60952658 | CGI:chr11:60950956-60951521 | promoter | 4.67e-01 | 3.26e-01 | 7.36e+00 | 1.86e-13 | 6.05e-13 | 1.40e-01 |
| HNSC | cg23572944 | chr11:60952658 | CGI:chr11:60950956-60951521 | promoter | 2.37e-01 | 3.95e-01 | -3.19e+00 | 1.42e-03 | 9.21e-03 | -1.58e-01 |
| LIHC | cg26090107 | chr11:60951410 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 3.85e-01 | 1.68e-01 | 2.16e+00 | 3.04e-02 | 3.37e-02 | 2.17e-01 |
| KIRP | cg26090107 | chr11:60951410 | CGI:chr11:60950956-60951521 | promoter,exon,CDS,gene body | 2.92e-01 | 1.09e-01 | 2.04e+00 | 4.11e-02 | 4.37e-02 | 1.83e-01 |
Top |
Exon skipping events with PSI in TCGA for SLC15A3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_71438 | 6.35e-01 | 7.36e-01 | -2.42e+00 | 1.55e-02 | 2.84e-02 | -1.01e-01 |
Top |
RNA A-to-I editing events in TCGA for SLC15A3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SLC15A3 |
| TFs related to SLC15A3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC15A3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SLC15A3 |
| RBPs related to ES in SLC15A3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | RBM4 | exon_skip_71430 | 1.14e+01 | 9.87e-01 | 1.10e+01 | 1.18e-02 | Male-biased |
| DLBC | RBM4 | exon_skip_71430 | 1.06e+01 | 1.08e-02 | 1.09e+01 | 9.88e-01 | Female-biased |
| BRCA | ZC3H10 | exon_skip_71438 | 5.60e+00 | 1.17e-03 | 6.95e+00 | 9.84e-01 | Female-biased |
| MESO | YB-1 | exon_skip_71449 | 9.40e+00 | 1.48e-02 | 9.72e+00 | 9.83e-01 | Female-biased |
| KIRC | RBM4 | exon_skip_71430 | 1.11e+01 | 8.74e-03 | 1.15e+01 | 9.90e-01 | Female-biased |
| KICH | RBM4 | exon_skip_71430 | 1.11e+01 | 1.90e-02 | 1.14e+01 | 9.80e-01 | Female-biased |
| BLCA | RBM4 | exon_skip_71430 | 1.10e+01 | 9.84e-01 | 1.07e+01 | 1.45e-02 | Male-biased |
| SKCM | YB-1 | exon_skip_71449 | 9.62e+00 | 9.87e-01 | 9.26e+00 | 1.02e-02 | Male-biased |
| SLC15A3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74516317 | chr11:69418748:C:G | - | 0.0894993758233929 | 0.0241917587764666 | SARC | Female-baised eQTL |
| rs11263654 | chr11:69423355:C:T | - | 0.0894286593564539 | 0.0246266429894089 | SARC | Female-baised eQTL |
| rs11263655 | chr11:69423831:C:G | - | 0.0846362825588246 | 0.039988351723379 | SARC | Female-baised eQTL |
| rs116825285 | chr11:56919787:C:G | - | 0.133574142207923 | 0.0477567046084101 | KIRP | Female-baised eQTL |
| rs12576184 | chr11:56921896:G:A | - | 0.133574142207923 | 0.0477567046084101 | KIRP | Female-baised eQTL |
| rs17151364 | chr11:56923095:T:C | - | 0.133574142207923 | 0.0477567046084101 | KIRP | Female-baised eQTL |
| rs11237082 | chr11:70654324:A:G | - | 0.0906735387694325 | 0.0385249658920328 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11229351 | chr11:58305960:C:T | - | 0.0500753649733642 | 0.043868831770247 | KIRC | Male-baised eQTL |
| rs10896751 | chr11:58316855:G:A | - | 0.0500651547791651 | 0.0446661056237656 | KIRC | Male-baised eQTL |
| rs7109465 | chr11:56919184:T:G | - | 0.0987335819513913 | 0.0178912614941554 | COAD | Male-baised eQTL |
| rs7926776 | chr11:56923245:T:C | - | 0.0987335819513913 | 0.0178912614941554 | COAD | Male-baised eQTL |
| rs66984226 | chr11:56131948:A:G | - | 0.0887186264225204 | 0.0267704342923609 | COAD | Male-baised eQTL |
| rs10896993 | chr11:55535934:A:G | - | 0.0504330220922675 | 0.0267930026567791 | COAD | Male-baised eQTL |
| rs12804887 | chr11:56149109:T:C | - | 0.0871656267440938 | 0.0321435113570205 | COAD | Male-baised eQTL |
| rs12803369 | chr11:56154501:A:G | - | 0.0871656267440938 | 0.0321435113570205 | COAD | Male-baised eQTL |
| rs66533465 | chr11:56024614:G:C | - | 0.0858543890381239 | 0.0396574592096009 | COAD | Male-baised eQTL |
| rs67823542 | chr11:56033194:G:A | - | 0.0858543890381239 | 0.0396574592096009 | COAD | Male-baised eQTL |
| rs12574105 | chr11:56040450:A:G | - | 0.0858543890381239 | 0.0396574592096009 | COAD | Male-baised eQTL |
| rs66506626 | chr11:56046021:G:T | - | 0.0858543890381239 | 0.0396574592096009 | COAD | Male-baised eQTL |
| rs12798312 | chr11:56064043:A:T | - | 0.0858543890381239 | 0.0396574592096009 | COAD | Male-baised eQTL |
| rs55711122 | chr11:55716572:C:T | - | 0.0842198589238714 | 0.0404227676741859 | COAD | Male-baised eQTL |
| rs12792068 | chr11:55723391:C:T | - | 0.0808506144505653 | 0.0445310507006525 | COAD | Male-baised eQTL |
| rs12791001 | chr11:56023696:C:T | - | 0.0842679066533645 | 0.0470011318462217 | COAD | Male-baised eQTL |
| rs35461380 | chr11:55923481:A:G | - | 0.0831092244831258 | 0.0488896066285102 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000110446 |
| CpG Site: cg14130459 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: -0.395038860850207 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14130459 | chr11:60951096 | gene,exon,CDS,promoter | -0.395038860850207 | 9.54400811231532e-07 | -0.3996742490095894 | 5.82883748741288e-10 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_71438 | chr11:60941121:60941290 | Frame-shift | rs200246863 | chr11:60438652:G:A | Distant downstream | -0.106510613390728 | 0.0201341724686989 | STAD | Female-baised sQTL |
| exon_skip_71438 | chr11:60941121:60941290 | Frame-shift | rs60549630 | chr11:60450763:C:T | Distant downstream | -0.113207450089043 | 0.032933997941422 | STAD | Female-baised sQTL |
| exon_skip_71438 | chr11:60941121:60941290 | Frame-shift | rs138842837 | chr11:60451127:C:G | Distant downstream | -0.113207450089043 | 0.032933997941422 | STAD | Female-baised sQTL |
| exon_skip_71438 | chr11:60941121:60941290 | Frame-shift | rs17154972 | chr11:60432169:C:T | Distant downstream | -0.103524385072564 | 0.0366490364188292 | STAD | Female-baised sQTL |
| exon_skip_71438 | chr11:60941121:60941290 | Frame-shift | rs76807498 | chr11:60443281:C:T | Distant downstream | -0.101425699184273 | 0.0497930251360429 | STAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SLC15A3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000110446 | SLC15A3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
