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Gene: ENSG00000109689 |
Summary for STIM2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000109689 | Gene symbol | STIM2 |
| Gene name | stromal interaction molecule 2 | |
| HGNC | 19205 | |
| Entrez ID | 57620 | |
| Gene type | protein_coding | |
| Synonyms | STIM2| | |
| UniProtAcc | Q9P246 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for STIM2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for STIM2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for STIM2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg13621396 | chr4:26859639 | CGI:chr4:26860409-26861616 | promoter,gene body | 6.71e-01 | 5.48e-01 | 3.61e+00 | 3.08e-04 | 5.50e-04 | 1.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13621396 | chr4:26859639 | CGI:chr4:26860409-26861616 | promoter,gene body | 3.22e-01 | 4.77e-01 | -9.24e+00 | 2.48e-20 | 1.38e-19 | -1.55e-01 |
| HNSC | cg13621396 | chr4:26859639 | CGI:chr4:26860409-26861616 | promoter,gene body | 4.04e-01 | 2.04e-01 | 2.78e+00 | 5.40e-03 | 1.38e-02 | 2.00e-01 |
| LIHC | cg13621396 | chr4:26859639 | CGI:chr4:26860409-26861616 | promoter,gene body | 4.08e-01 | 2.66e-01 | 2.07e+00 | 3.84e-02 | 4.05e-02 | 1.42e-01 |
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Exon skipping events with PSI in TCGA for STIM2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for STIM2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for STIM2 |
| TFs related to STIM2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | BBX | STIM2 | 4.06e+00 | 1.48e-02 | 4.86e+00 | 9.80e-01 | Female-biased |
| LAML | DMRTA1 | STIM2 | 2.61e+00 | 6.24e-04 | 4.19e+00 | 9.86e-01 | Female-biased |
| LAML | DMRTA2 | STIM2 | 2.72e+00 | 6.30e-04 | 4.31e+00 | 9.88e-01 | Female-biased |
| LAML | FOXO6 | STIM2 | 3.06e+00 | 2.15e-03 | 4.35e+00 | 9.87e-01 | Female-biased |
| LAML | HNF1A | STIM2 | 2.69e+00 | 1.36e-03 | 4.08e+00 | 9.83e-01 | Female-biased |
| LAML | HOXB3 | STIM2 | 3.92e+00 | 1.17e-02 | 4.78e+00 | 9.83e-01 | Female-biased |
| LAML | POU1F1 | STIM2 | 3.42e+00 | 2.99e-03 | 4.63e+00 | 9.90e-01 | Female-biased |
| LAML | POU2F2 | STIM2 | 2.58e+00 | 5.36e-04 | 4.20e+00 | 9.86e-01 | Female-biased |
| LAML | POU2F3 | STIM2 | 3.16e+00 | 2.03e-03 | 4.46e+00 | 9.89e-01 | Female-biased |
| LAML | POU3F3 | STIM2 | 2.09e+00 | 8.56e-05 | 4.11e+00 | 9.85e-01 | Female-biased |
| LAML | POU4F1 | STIM2 | 2.57e+00 | 4.61e-04 | 4.23e+00 | 9.87e-01 | Female-biased |
| LAML | POU4F2 | STIM2 | 2.32e+00 | 4.76e-04 | 3.97e+00 | 9.80e-01 | Female-biased |
| LAML | POU4F3 | STIM2 | 2.68e+00 | 7.10e-04 | 4.23e+00 | 9.87e-01 | Female-biased |
| LAML | POU5F1 | STIM2 | 2.56e+00 | 8.75e-04 | 4.06e+00 | 9.82e-01 | Female-biased |
| LAML | POU5F1B | STIM2 | 2.76e+00 | 9.86e-04 | 4.24e+00 | 9.87e-01 | Female-biased |
| LAML | POU6F1 | STIM2 | 3.38e+00 | 3.04e-03 | 4.59e+00 | 9.90e-01 | Female-biased |
| LAML | SOX8 | STIM2 | 2.68e+00 | 1.14e-03 | 4.12e+00 | 9.84e-01 | Female-biased |
| LAML | ZNF232 | STIM2 | 3.34e+00 | 2.86e-03 | 4.56e+00 | 9.89e-01 | Female-biased |
| LAML | ZNF354B | STIM2 | 2.51e+00 | 6.65e-04 | 4.07e+00 | 9.83e-01 | Female-biased |
| LAML | ZNF525 | STIM2 | 3.26e+00 | 2.42e-03 | 4.52e+00 | 9.89e-01 | Female-biased |
| PCPG | POU3F3 | STIM2 | 2.85e+00 | 2.67e-03 | 3.94e+00 | 9.82e-01 | Female-biased |
| PCPG | POU4F1 | STIM2 | 3.09e+00 | 4.49e-03 | 4.06e+00 | 9.83e-01 | Female-biased |
| PCPG | ZNF334 | STIM2 | 2.73e+00 | 1.10e-03 | 4.00e+00 | 9.85e-01 | Female-biased |
| PCPG | ZNF418 | STIM2 | 2.66e+00 | 9.60e-04 | 3.96e+00 | 9.84e-01 | Female-biased |
| PCPG | ZNF79 | STIM2 | 2.73e+00 | 1.70e-03 | 3.92e+00 | 9.83e-01 | Female-biased |
| SKCM | ZNF418 | STIM2 | 4.70e+00 | 7.25e-03 | 5.79e+00 | 9.91e-01 | Female-biased |
| THYM | ZNF418 | STIM2 | 3.90e+00 | 9.82e-01 | 1.59e+00 | 1.52e-05 | Male-biased |
| STIM2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for STIM2 |
| RBPs related to ES in STIM2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| COAD | Fusip1 | exon_skip_422957 | 9.03e+00 | 9.92e-01 | 8.61e+00 | 4.13e-03 | Male-biased |
| GBM | RBM28 | exon_skip_422953 | 8.55e+00 | 9.90e-01 | 8.12e+00 | 3.78e-03 | Male-biased |
| KICH | RBM28 | exon_skip_422953 | 8.36e+00 | 7.49e-03 | 8.71e+00 | 9.87e-01 | Female-biased |
| KICH | RBM46 | exon_skip_422953 | 7.98e+00 | 3.42e-03 | 8.39e+00 | 9.90e-01 | Female-biased |
| STIM2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10024879 | chr4:32069896:G:A | - | 0.164422412450153 | 0.00841478747333367 | STAD | Female-baised eQTL |
| rs73225190 | chr4:31910742:T:C | - | 0.154413262776506 | 0.0311330679558585 | STAD | Female-baised eQTL |
| rs28532926 | chr4:31927420:A:G | - | 0.154413262776506 | 0.0311330679558585 | STAD | Female-baised eQTL |
| rs10015080 | chr4:31901545:A:C | - | 0.154232926836242 | 0.0319350319186213 | STAD | Female-baised eQTL |
| rs68138742 | chr4:32036585:G:A | - | 0.144058039894425 | 0.0396597482425404 | STAD | Female-baised eQTL |
| rs13101571 | chr4:36349277:G:A | - | 0.1090154182049 | 0.0172924257425447 | LGG | Female-baised eQTL |
| rs2375870 | chr4:36373745:T:C | - | 0.0982095807070923 | 0.0375762819522181 | LGG | Female-baised eQTL |
| rs71604025 | chr4:36374103:G:A | - | 0.0982095807070923 | 0.0375762819522181 | LGG | Female-baised eQTL |
| rs35780396 | chr4:36375142:G:A | - | 0.0982095807070923 | 0.0375762819522181 | LGG | Female-baised eQTL |
| rs140352239 | chr4:36378726:C:G | - | 0.0982095807070923 | 0.0375762819522181 | LGG | Female-baised eQTL |
| rs10939729 | chr4:17507214:C:T | - | 0.171795452456717 | 0.0362460926602861 | BLCA | Female-baised eQTL |
| rs16870076 | chr4:20812510:G:T | - | 0.0921050203966879 | 9.46190963357787e-05 | LUAD | Female-baised eQTL |
| rs59893351 | chr4:20766422:C:A | - | 0.0923668140913816 | 0.000667776482512222 | LUAD | Female-baised eQTL |
| rs16870017 | chr4:20806354:C:T | - | 0.0884590787323531 | 0.00131844774050489 | LUAD | Female-baised eQTL |
| rs75201447 | chr4:20769799:C:A | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs113584736 | chr4:20771892:G:A | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs1491366 | chr4:20773760:A:T | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs73110259 | chr4:20775833:G:A | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs73112222 | chr4:20780815:A:T | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs111955311 | chr4:20782817:G:A | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs73112236 | chr4:20801350:A:G | - | 0.0879738287243432 | 0.00144748096819548 | LUAD | Female-baised eQTL |
| rs77067154 | chr4:24136466:G:A | - | 0.10162052356614 | 0.0155801829758252 | COAD | Female-baised eQTL |
| rs16874317 | chr4:23904465:T:A | - | 0.0771422955300907 | 0.0404681649618407 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10222776 | chr4:19303850:A:T | - | 0.0563543097180545 | 0.00584558939591199 | LGG | Male-baised eQTL |
| rs16880030 | chr4:27970770:A:G | - | 0.0327863777599194 | 0.0449431002522516 | LGG | Male-baised eQTL |
| rs7677061 | chr4:35931615:T:C | - | -0.0442580569945357 | 0.0466502548835122 | BLCA | Male-baised eQTL |
| rs625499 | chr4:17181336:G:A | - | 0.0645916604753615 | 0.0150051616161374 | COAD | Male-baised eQTL |
| rs16871284 | chr4:21508102:C:T | - | -0.101679833994788 | 0.017280079205604 | COAD | Male-baised eQTL |
| rs625498 | chr4:17181335:G:A | - | 0.0803583146855553 | 0.0278970463516775 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000109689 |
| CpG Site: cg27025079 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.212327662668478 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg27025079 | chr4:26863688 | gene | -0.212327662668478 | 1.04685654146092e-05 | -0.34883183018840974 | 1.2374914045066572e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of STIM2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000109689 | STIM2 | C0043094 | Weight Gain | 1 | CTD_human |
