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Gene: ENSG00000108576 |
Summary for SLC6A4 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000108576 | Gene symbol | SLC6A4 |
| Gene name | solute carrier family 6 member 4 | |
| HGNC | 11050 | |
| Entrez ID | 6532 | |
| Gene type | protein_coding | |
| Synonyms | SLC6A4|5-HTT|SERT1 | |
| UniProtAcc | P31645 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000108576 | SLC6A4 | DB00176 | Fluvoxamine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00182 | Amphetamine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00191 | Phentermine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00193 | Tramadol | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00215 | Citalopram | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00245 | Benzatropine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00285 | Venlafaxine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00289 | Atomoxetine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00321 | Amitriptyline | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00344 | Protriptyline | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00408 | Loxapine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00454 | Meperidine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00458 | Imipramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00472 | Fluoxetine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00476 | Duloxetine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00514 | Dextromethorphan | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00540 | Nortriptyline | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00543 | Amoxapine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00574 | Fenfluramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00579 | Mazindol | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00656 | Trazodone | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00661 | Verapamil | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00715 | Paroxetine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00726 | Trimipramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00805 | Minaprine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00852 | Pseudoephedrine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00907 | Cocaine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00924 | Cyclobenzaprine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB00988 | Dopamine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01104 | Sertraline | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01105 | Sibutramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01114 | Chlorpheniramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01142 | Doxepin | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01149 | Nefazodone | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01151 | Desipramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01175 | Escitalopram | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01191 | Dexfenfluramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01238 | Aripiprazole | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01242 | Clomipramine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01363 | Ephedra sinica root | BiotechDrug |
| ENSG00000108576 | SLC6A4 | DB01442 | MMDA | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01454 | Midomafetamine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01472 | 4-Methoxyamphetamine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB01577 | Metamfetamine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB04821 | Nomifensine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB04832 | Zimelidine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB04836 | Amineptine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB04889 | Bicifadine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB04896 | Milnacipran | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB05422 | OPC-14523 | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB05688 | CRx-119 | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB05964 | Amitifadine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06077 | Lumateperone | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06148 | Mianserin | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06156 | Tesofensine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06204 | Tapentadol | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06684 | Vilazodone | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06700 | Desvenlafaxine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB06701 | Dexmethylphenidate | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB08839 | Serotonin | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB08918 | Levomilnacipran | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB09016 | Butriptyline | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB09068 | Vortioxetine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB09167 | Dosulepin | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB09186 | Nisoxetine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB09195 | Lorpiprazole | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB09225 | Zotepine | SmallMoleculeDrug |
| ENSG00000108576 | SLC6A4 | DB12305 | Dasotraline | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SLC6A4 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC6A4 | 7.76e+02 | 3.95e+00 | 2.61e-01 | 1.51e+01 | 1.22e-51 | 1.30e-50 | BRCA |
| SLC6A4 | 2.48e+02 | 3.64e+00 | 7.30e-01 | 4.99e+00 | 6.16e-07 | 5.67e-06 | READ |
Top |
Sex-biased somatic mutation for SLC6A4 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SLC6A4 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg22584138 | chr17:30235202 | CGI:chr17:30235369-30236168 | promoter,gene body | 6.57e-01 | 3.91e-01 | 3.33e+00 | 8.84e-04 | 8.76e-03 | 2.66e-01 |
| GBM | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 2.13e-01 | 3.18e-01 | -2.67e+00 | 7.66e-03 | 2.07e-02 | -1.05e-01 |
| CHOL | cg18584905 | chr17:30236282 | CGI:chr17:30235369-30236168 | promoter | 3.48e-01 | 2.47e-01 | 2.04e+00 | 4.16e-02 | 4.59e-02 | 1.01e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg05016953 | chr17:30235795 | CGI:chr17:30235369-30236168 | UTR,promoter,exon,gene body | 1.54e-01 | 5.14e-02 | 4.20e+00 | 2.68e-05 | 6.44e-05 | 1.02e-01 |
| LUSC | cg22584138 | chr17:30235202 | CGI:chr17:30235369-30236168 | promoter,gene body | 5.26e-01 | 3.07e-01 | 2.88e+00 | 4.00e-03 | 6.91e-03 | 2.19e-01 |
| LUSC | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 4.74e-01 | 2.32e-01 | 3.80e+00 | 1.47e-04 | 8.29e-04 | 2.43e-01 |
| ESCA | cg22584138 | chr17:30235202 | CGI:chr17:30235369-30236168 | promoter,gene body | 5.89e-01 | 4.07e-01 | 2.08e+00 | 3.71e-02 | 4.58e-02 | 1.82e-01 |
| ESCA | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 5.55e-01 | 3.80e-01 | 2.13e+00 | 3.28e-02 | 4.47e-02 | 1.75e-01 |
| CHOL | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 5.51e-01 | 4.11e-01 | 2.36e+00 | 1.83e-02 | 2.92e-02 | 1.41e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 5.44e-01 | 2.88e-01 | 1.26e+01 | 1.63e-36 | 6.19e-35 | 2.56e-01 |
| COAD | cg05016953 | chr17:30235795 | CGI:chr17:30235369-30236168 | UTR,promoter,exon,gene body | 1.75e-01 | 3.75e-02 | 2.16e+00 | 3.08e-02 | 3.54e-02 | 1.38e-01 |
| BLCA | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 4.78e-01 | 3.45e-01 | 2.48e+00 | 1.30e-02 | 2.06e-02 | 1.33e-01 |
| LIHC | cg14692377 | chr17:30235667 | CGI:chr17:30235369-30236168 | UTR,promoter,exon,gene body | 3.57e-01 | 2.14e-01 | 2.48e+00 | 1.32e-02 | 1.73e-02 | 1.44e-01 |
| LIHC | cg27569822 | chr17:30236101 | CGI:chr17:30235369-30236168 | promoter | 1.32e-01 | 2.12e-02 | 2.77e+00 | 5.67e-03 | 8.86e-03 | 1.11e-01 |
| LIHC | cg03363743 | chr17:30235456 | CGI:chr17:30235369-30236168 | promoter,gene body | 5.24e-01 | 3.81e-01 | 3.63e+00 | 2.88e-04 | 8.62e-04 | 1.43e-01 |
Top |
Exon skipping events with PSI in TCGA for SLC6A4 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SLC6A4 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SLC6A4 |
| TFs related to SLC6A4. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | PRDM6 | SLC6A4 | 2.82e+00 | 5.22e-03 | 4.12e+00 | 9.83e-01 | Female-biased |
| GBM | ZNF22 | SLC6A4 | 3.08e+00 | 7.29e-03 | 4.26e+00 | 9.84e-01 | Female-biased |
| GBM | ZNF225 | SLC6A4 | 2.89e+00 | 5.46e-03 | 4.17e+00 | 9.84e-01 | Female-biased |
| GBM | ZNF235 | SLC6A4 | 3.06e+00 | 3.32e-03 | 4.55e+00 | 9.91e-01 | Female-biased |
| GBM | ZNF287 | SLC6A4 | 3.02e+00 | 5.35e-03 | 4.31e+00 | 9.86e-01 | Female-biased |
| GBM | ZNF487 | SLC6A4 | 2.94e+00 | 6.35e-03 | 4.16e+00 | 9.83e-01 | Female-biased |
| GBM | ZNF879 | SLC6A4 | 2.72e+00 | 5.01e-03 | 4.03e+00 | 9.81e-01 | Female-biased |
| SARC | ZNF777 | SLC6A4 | 4.36e+00 | 9.83e-01 | 3.77e+00 | 8.09e-03 | Male-biased |
| SKCM | HOXC10 | SLC6A4 | 4.48e+00 | 9.84e-01 | 3.05e+00 | 3.19e-03 | Male-biased |
| SKCM | PBX4 | SLC6A4 | 4.92e+00 | 9.88e-01 | 3.65e+00 | 5.23e-03 | Male-biased |
| SKCM | ZNF25 | SLC6A4 | 4.49e+00 | 9.87e-01 | 2.52e+00 | 5.08e-04 | Male-biased |
| SKCM | ZNF879 | SLC6A4 | 4.21e+00 | 9.82e-01 | 2.04e+00 | 2.52e-04 | Male-biased |
| SLC6A4 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SLC6A4 |
| RBPs related to ES in SLC6A4. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC6A4 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000108576 | HNF1A-AS1,hsa-mir-372,SLC6A4 | Male-specific ceRNA | TCGA-BLCA |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs57212122 | chr17:34029047:C:T | - | 0.0945084707373473 | 0.000787659487097059 | LUAD | Female-baised eQTL |
| rs373321384 | chr17:34087316:C:T | - | 0.0810612357704249 | 0.00101217080898507 | LUAD | Female-baised eQTL |
| rs369429900 | chr17:34086405:A:G | - | 0.0795054910563979 | 0.0040560871364421 | LUAD | Female-baised eQTL |
| rs150557928 | chr17:34083330:T:C | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs112052561 | chr17:34083849:G:A | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs146906233 | chr17:34085207:T:C | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs4283268 | chr17:34087020:G:A | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs4491581 | chr17:34087032:C:T | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs9890755 | chr17:34090616:C:T | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs9897848 | chr17:34090702:T:C | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs62059035 | chr17:34091281:T:C | - | 0.0758566951960927 | 0.00532920497222789 | LUAD | Female-baised eQTL |
| rs1003839 | chr17:34078700:G:A | - | 0.0758385179121419 | 0.00540248723893102 | LUAD | Female-baised eQTL |
| rs16969133 | chr17:34076768:T:C | - | 0.0758170182690317 | 0.00547276374361827 | LUAD | Female-baised eQTL |
| rs9892620 | chr17:34077662:T:C | - | 0.0758170182690317 | 0.00547276374361827 | LUAD | Female-baised eQTL |
| rs9897564 | chr17:34091200:C:G | - | 0.0754082115054851 | 0.00663256012275553 | LUAD | Female-baised eQTL |
| rs113379327 | chr17:34069309:C:T | - | 0.073326462081926 | 0.00808798311963839 | LUAD | Female-baised eQTL |
| rs9899242 | chr17:34070239:C:G | - | 0.073326462081926 | 0.00808798311963839 | LUAD | Female-baised eQTL |
| rs2189332 | chr17:34081686:C:G | - | 0.0736122758518263 | 0.00852086527732514 | LUAD | Female-baised eQTL |
| rs148530645 | chr17:34085052:G:C | - | 0.0736122758518263 | 0.00852086527732514 | LUAD | Female-baised eQTL |
| rs140140000 | chr17:34085351:T:C | - | 0.0736122758518263 | 0.00852086527732514 | LUAD | Female-baised eQTL |
| rs7207627 | chr17:34088968:C:T | - | 0.0736122758518263 | 0.00852086527732514 | LUAD | Female-baised eQTL |
| rs1003838 | chr17:34078777:A:G | - | 0.0735943461581765 | 0.0086176020672749 | LUAD | Female-baised eQTL |
| rs9899503 | chr17:34078238:T:C | - | 0.0732750616773751 | 0.00925565343254321 | LUAD | Female-baised eQTL |
| rs12950960 | chr17:34028994:C:T | - | 0.0734561262907479 | 0.0110334477633645 | LUAD | Female-baised eQTL |
| rs35228312 | chr17:34029269:T:G | - | 0.0727881659698551 | 0.0118627635901084 | LUAD | Female-baised eQTL |
| rs11870762 | chr17:34030537:C:T | - | 0.0727881659698551 | 0.0118627635901084 | LUAD | Female-baised eQTL |
| rs59694375 | chr17:34054998:C:T | - | 0.0667725392923565 | 0.0242244072855531 | LUAD | Female-baised eQTL |
| rs9892990 | chr17:34055147:A:G | - | 0.0667725392923565 | 0.0242244072855531 | LUAD | Female-baised eQTL |
| rs16969118 | chr17:34050655:T:C | - | 0.0631014610018898 | 0.0253823834931664 | LUAD | Female-baised eQTL |
| rs944724 | chr17:27782391:C:T | - | 0.0553227012076906 | 0.0344092112284901 | LUAD | Female-baised eQTL |
| rs614434 | chr17:28524483:G:A | - | -0.0462959847319728 | 0.0379483322260731 | LUAD | Female-baised eQTL |
| rs2346388 | chr17:32970009:T:C | - | -0.0659500418692558 | 0.0393589749205289 | LUAD | Female-baised eQTL |
| rs2346389 | chr17:32970619:C:A | - | -0.0659500418692558 | 0.0393589749205289 | LUAD | Female-baised eQTL |
| rs2009125 | chr17:32971285:G:A | - | -0.0659500418692558 | 0.0393589749205289 | LUAD | Female-baised eQTL |
| rs8078840 | chr17:32971688:A:G | - | -0.0659500418692558 | 0.0393589749205289 | LUAD | Female-baised eQTL |
| rs6505320 | chr17:32972364:A:G | - | -0.0659500418692558 | 0.0393589749205289 | LUAD | Female-baised eQTL |
| rs7211635 | chr17:32973387:G:A | - | -0.065907959317486 | 0.0398074135709787 | LUAD | Female-baised eQTL |
| rs11080227 | chr17:33525383:C:T | - | 0.0576060928892791 | 0.0420962241914119 | LUAD | Female-baised eQTL |
| rs9911117 | chr17:33524698:C:T | - | 0.0571746514397054 | 0.0443822133149892 | LUAD | Female-baised eQTL |
| rs66477321 | chr17:33523806:C:G | - | 0.057141482346226 | 0.0450251814691064 | LUAD | Female-baised eQTL |
| rs71373685 | chr17:33126899:C:T | - | 0.0561165206170076 | 0.0493523961714859 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61132937 | chr17:38671344:C:T | - | 0.0498386040644964 | 0.00629817110559922 | LUSC | Male-baised eQTL |
| rs12947499 | chr17:38671178:G:A | - | 0.0487591320865571 | 0.00811947587416297 | LUSC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000108576 |
| CpG Site: cg03363743 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.102685051604155 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03363743 | chr17:30235456 | gene,promoter | -0.102685051604155 | 5.91532571989866e-05 | -0.30618573634335927 | 6.176080656639028e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SLC6A4 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000108576 | SLC6A4 | C0001723 | Affective Disorders, Psychotic | 2 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0001956 | Alcohol Use Disorder | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0001973 | Alcoholic Intoxication, Chronic | 7 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0003944 | As If Personality | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0004352 | Autistic Disorder | 5 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0004444 | Avoidant Personality Disorder | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0005586 | Bipolar Disorder | 7 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0005587 | Depression, Bipolar | 4 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0009171 | Cocaine Abuse | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0009241 | Cognition Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0011570 | Mental Depression | 5 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0011573 | Endogenous depression | 4 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0011574 | Involutional Depression | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0011581 | Depressive disorder | 9 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0013146 | Drug abuse | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0013170 | Drug habituation | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0013222 | Drug Use Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0013415 | Dysthymic Disorder | 1 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0021124 | Impulse-Ridden Personality | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0021139 | Inadequate Personality | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0024713 | Manic Disorder | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0025193 | Melancholia | 9 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0025261 | Memory Disorders | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0028768 | Obsessive-Compulsive Disorder | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0031212 | Personality Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0036341 | Schizophrenia | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0038580 | Substance Dependence | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0038586 | Substance Use Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0038644 | Sudden infant death syndrome | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0041696 | Unipolar Depression | 9 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0085159 | Seasonal Affective Disorder | 5 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0085762 | Alcohol abuse | 4 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0086133 | Depressive Syndrome | 4 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0086189 | Drug Withdrawal Symptoms | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0087169 | Withdrawal Symptoms | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0178417 | Anhedonia | 2 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0221074 | Depression, Postpartum | 5 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0221480 | Recurrent depression | 3 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0233477 | Dysphoric mood | 3 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0233794 | Memory impairment | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0236792 | Asperger Syndrome | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0236804 | Amphetamine Addiction | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0236807 | Amphetamine Abuse | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0282126 | Depression, Neurotic | 4 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0338715 | Drug-induced depressive state | 2 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0338831 | Manic | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0344315 | Depressed mood | 5 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0376280 | Anxiety States, Neurotic | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0525045 | Mood Disorders | 6 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0581391 | Chronic depression | 4 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0588008 | Severe depression | 1 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C0600427 | Cocaine Dependence | 5 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C0740858 | Substance abuse problem | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0751292 | Age-Related Memory Disorders | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0751293 | Memory Disorder, Semantic | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0751294 | Memory Disorder, Spatial | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C0751295 | Memory Loss | 2 | CTD_human |
| ENSG00000108576 | SLC6A4 | C1269683 | Major Depressive Disorder | 6 | PSYGENET,CTD_human |
| ENSG00000108576 | SLC6A4 | C1279420 | Anxiety neurosis (finding) | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C1510472 | Drug Dependence | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C1571983 | Involutional paraphrenia | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C1571984 | Psychosis, Involutional | 1 | CTD_human |
| ENSG00000108576 | SLC6A4 | C2063866 | Depressive Disorder, Treatment-Resistant | 3 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C3160814 | Cannabis use | 1 | PSYGENET |
| ENSG00000108576 | SLC6A4 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
