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Gene: ENSG00000108175 |
Summary for ZMIZ1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000108175 | Gene symbol | ZMIZ1 |
| Gene name | zinc finger MIZ-type containing 1 | |
| HGNC | 16493 | |
| Entrez ID | 57178 | |
| Gene type | protein_coding | |
| Synonyms | ZMIZ1|RP11-519K18.1|KIAA1224|FLJ13541|hZIMP10|Zimp10|MIZ | |
| UniProtAcc | Q9ULJ6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ZMIZ1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ZMIZ1 | 4.29e+03 | 1.12e+00 | 3.63e-01 | 3.08e+00 | 2.06e-03 | 6.38e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for ZMIZ1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ZMIZ1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg04634493 | chr10:79068885 | CGI:chr10:79067007-79070458 | promoter | 1.49e-01 | 3.41e-02 | 4.29e+00 | 1.78e-05 | 5.26e-04 | 1.15e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for ZMIZ1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_42844 | 6.76e-01 | 4.39e-01 | 1.62e+01 | 7.68e-59 | 2.50e-55 | 2.37e-01 |
| LUAD | exon_skip_42844 | 5.51e-01 | 4.43e-01 | 5.50e+00 | 3.87e-08 | 4.98e-07 | 1.08e-01 |
Top |
RNA A-to-I editing events in TCGA for ZMIZ1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ZMIZ1 |
| TFs related to ZMIZ1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | PLAGL2 | ZMIZ1 | 4.21e+00 | 9.86e-01 | 2.60e+00 | 4.90e-04 | Male-biased |
| READ | ZNF423 | ZMIZ1 | 4.30e+00 | 9.81e-01 | 3.41e+00 | 7.47e-03 | Male-biased |
| ZMIZ1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ZMIZ1 |
| RBPs related to ES in ZMIZ1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | FXR1 | exon_skip_42839 | 1.22e+01 | 9.99e-01 | 1.17e+01 | 5.92e-04 | Male-biased |
| LUSC | FXR1 | exon_skip_42839 | 1.14e+01 | 1.62e-03 | 1.20e+01 | 9.98e-01 | Female-biased |
| KIRP | BRUNOL6 | exon_skip_42841 | 8.49e+00 | 4.66e-03 | 8.89e+00 | 9.90e-01 | Female-biased |
| KIRP | FXR1 | exon_skip_42839 | 1.16e+01 | 1.28e-03 | 1.21e+01 | 9.98e-01 | Female-biased |
| BRCA | FXR1 | exon_skip_42839 | 1.20e+01 | 9.90e-01 | 1.14e+01 | 9.89e-03 | Male-biased |
| MESO | BRUNOL6 | exon_skip_42841 | 8.80e+00 | 9.87e-01 | 8.43e+00 | 8.23e-03 | Male-biased |
| LGG | SAMD4A | exon_skip_42831 | 8.62e+00 | 9.92e-01 | 8.15e+00 | 2.41e-03 | Male-biased |
| KICH | ESRP2 | exon_skip_42832 | 8.69e+00 | 9.81e-01 | 8.39e+00 | 1.38e-02 | Male-biased |
| BLCA | BRUNOL6 | exon_skip_42841 | 8.33e+00 | 5.27e-03 | 8.75e+00 | 9.89e-01 | Female-biased |
| ZMIZ1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2573555 | chr10:76302813:A:G | - | -0.175085003382403 | 0.00293421593188585 | READ | Female-baised eQTL |
| rs2758985 | chr10:76303574:A:T | - | -0.175085003382403 | 0.00293421593188585 | READ | Female-baised eQTL |
| rs56053227 | chr10:78526820:G:A | - | 0.169412486028201 | 0.00624729142349265 | READ | Female-baised eQTL |
| rs72810278 | chr10:78560998:C:T | - | 0.169412486028201 | 0.00624729142349265 | READ | Female-baised eQTL |
| rs59916858 | chr10:78561950:G:A | - | 0.169412486028201 | 0.00624729142349265 | READ | Female-baised eQTL |
| rs2579786 | chr10:76304465:G:A | - | -0.15930585577995 | 0.0112762376296836 | READ | Female-baised eQTL |
| rs1923614 | chr10:76305017:A:G | - | -0.15930585577995 | 0.0112762376296836 | READ | Female-baised eQTL |
| rs72810250 | chr10:78529126:G:A | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs72810251 | chr10:78529153:G:A | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs55750209 | chr10:78530964:G:A | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs56174913 | chr10:78532518:C:T | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs16936045 | chr10:78543792:G:C | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs56390301 | chr10:78549517:A:G | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs10509399 | chr10:78552278:T:C | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs55983992 | chr10:78556145:C:T | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs16936070 | chr10:78556270:C:A | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs16936074 | chr10:78557912:A:T | - | 0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs7090749 | chr10:78550879:G:A | - | -0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs2019432 | chr10:78552650:G:A | - | -0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs2007065 | chr10:78555102:G:A | - | -0.153242842690434 | 0.0228752184976906 | READ | Female-baised eQTL |
| rs12219399 | chr10:78550290:G:A | - | 0.152924361175972 | 0.0242017626900802 | READ | Female-baised eQTL |
| rs2758964 | chr10:76319861:A:G | - | -0.141084162370273 | 0.0242065970718521 | READ | Female-baised eQTL |
| rs2758961 | chr10:76320554:G:A | - | -0.140636244754596 | 0.0261164819480097 | READ | Female-baised eQTL |
| rs77010803 | chr10:78377735:G:A | - | 0.132395874365847 | 0.0444334761703886 | READ | Female-baised eQTL |
| rs76900708 | chr10:78380053:G:A | - | 0.132395874365847 | 0.0444334761703886 | READ | Female-baised eQTL |
| rs12411352 | chr10:78208884:A:G | - | 0.13516406609731 | 0.0477254515375215 | READ | Female-baised eQTL |
| rs718708 | chr10:78229394:G:A | - | 0.146516464092275 | 0.0478552155040545 | READ | Female-baised eQTL |
| rs164235 | chr10:78569871:T:C | - | 0.132160643997968 | 0.0480767603629161 | READ | Female-baised eQTL |
| rs164241 | chr10:78574404:C:T | - | 0.132160643997968 | 0.0480767603629161 | READ | Female-baised eQTL |
| rs164242 | chr10:78574484:G:A | - | 0.132160643997968 | 0.0480767603629161 | READ | Female-baised eQTL |
| rs1653840 | chr10:88799486:T:C | - | 0.0898465711430381 | 0.0478903595232669 | LGG | Female-baised eQTL |
| rs3812699 | chr10:70311892:G:A | - | 0.0555495778210315 | 0.0112822334396475 | LUAD | Female-baised eQTL |
| rs12255261 | chr10:82109075:A:T | - | -0.0557126406837919 | 0.0484732181237137 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2353275 | chr10:86305355:T:C | - | -0.194873674231304 | 0.000448758983754347 | READ | Male-baised eQTL |
| rs4980050 | chr10:79237033:G:A | gene | 0.0966877674082728 | 0.0473001029659166 | READ | Male-baised eQTL |
| rs16933996 | chr10:76900032:T:G | - | 0.0789169797102141 | 0.000979224898218804 | LIHC | Male-baised eQTL |
| rs11001926 | chr10:76908145:T:C | - | 0.078269503304026 | 0.00119146079976375 | LIHC | Male-baised eQTL |
| rs74952235 | chr10:76907073:C:T | - | 0.0768322933853621 | 0.00334698116018687 | LIHC | Male-baised eQTL |
| rs10882491 | chr10:81011788:C:T | - | 0.0470244245174787 | 0.0301138361735225 | LIHC | Male-baised eQTL |
| rs1994193 | chr10:81012705:A:G | - | 0.0470244245174787 | 0.0301138361735225 | LIHC | Male-baised eQTL |
| rs12240379 | chr10:81014439:C:T | - | 0.0470244245174787 | 0.0301138361735225 | LIHC | Male-baised eQTL |
| rs10882490 | chr10:81009543:A:T | - | 0.0465776250533158 | 0.0333164818004597 | LIHC | Male-baised eQTL |
| rs7916201 | chr10:81010951:A:G | - | 0.0451204695877313 | 0.0443483975917717 | LIHC | Male-baised eQTL |
| rs3750770 | chr10:70100197:C:T | - | 0.0931066459846298 | 0.0353071856562043 | LUAD | Male-baised eQTL |
| rs72812195 | chr10:69230966:T:C | - | 0.0534555951559013 | 0.0435006777134119 | LUAD | Male-baised eQTL |
| rs2068877 | chr10:81891764:A:G | - | 0.115203879248098 | 0.0277476167712876 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg23865980 | |
| Position to Gene: gene | |
| Male Effect: -0.412036461610529 | |
| Female Effect: - | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg13676902 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.412036461610529 | |
| Female Effect: - | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg16815157 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg09936762 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg19215199 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg06308720 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg17753789 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg02795981 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg03707696 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg26300785 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.400665631173435 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg13676902 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.400361371245142 | |
 | Gene ID: ENSG00000108175 |
| CpG Site: cg04714939 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.363921998500022 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23865980 | chr10:79144619 | gene | -0.412036461610529 | 4.74676022952217e-14 | -0.5270442227324827 | 2.4308204241153453e-17 | LUAD |
| cg13676902 | chr10:79315721 | gene,exon,UTR | -0.412036461610529 | 4.74676022952217e-14 | -0.5270442227324827 | 2.4308204241153453e-17 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16815157 | chr10:79134165 | gene | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg09936762 | chr10:79199931 | gene | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg19215199 | chr10:79245527 | gene | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg06308720 | chr10:79246309 | gene | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg17753789 | chr10:79267009 | gene | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg02795981 | chr10:79285362 | gene | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg03707696 | chr10:79315710 | gene,exon,UTR | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg26300785 | chr10:79315735 | gene,exon,UTR | -0.400665631173435 | 9.23133561562741e-06 | -0.4893417202161895 | 1.8766991383508946e-08 | STAD |
| cg13676902 | chr10:79315721 | gene,exon,UTR | -0.400361371245142 | 9.4624021223128e-06 | -0.48934874686879853 | 2.1596518334858273e-08 | STAD |
| cg04714939 | chr10:79157863 | gene | -0.363921998500022 | 8.13959147214579e-05 | -0.41906431396223975 | 4.6671860456176395e-07 | HNSC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_42844 | chr10:79310923:79311184 | In-frame | rs11002982 | chr10:79436666:C:G | Distant downstream | 0.0287284670269848 | 0.0200459080618608 | THCA | Female-baised sQTL |
| exon_skip_42844 | chr10:79310923:79311184 | In-frame | rs11002983 | chr10:79437519:C:T | Distant downstream | 0.0305351966719091 | 0.028595736294456 | THCA | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_42844 | chr10:79310923:79311184 | In-frame | rs892542 | chr10:78738300:G:A | Distant upstream | -0.0528818366705505 | 0.00744153817813519 | COAD | Male-baised sQTL |
| exon_skip_42844 | chr10:79310923:79311184 | In-frame | rs61851259 | chr10:78737627:G:A | Distant upstream | -0.05283623528529 | 0.00763202709138813 | COAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ZMIZ1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000108175 | ZMIZ1 | C0007570 | Celiac Disease | 1 | CTD_human |
| ENSG00000108175 | ZMIZ1 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| ENSG00000108175 | ZMIZ1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
