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Gene: ENSG00000107736 |
Summary for CDH23 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000107736 | Gene symbol | CDH23 |
| Gene name | cadherin related 23 | |
| HGNC | 13733 | |
| Entrez ID | 64072 | |
| Gene type | protein_coding | |
| Synonyms | CDH23|CDHR23 | |
| UniProtAcc | Q9H251 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CDH23 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for CDH23 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CDH23 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg12827632 | chr10:71397081 | CGI:chr10:71396407-71398174 | UTR,promoter,exon,gene body | 6.28e-02 | 1.75e-01 | -2.46e+00 | 1.40e-02 | 3.04e-02 | -1.13e-01 |
| ESCA | cg09796583 | chr10:71396890 | CGI:chr10:71396407-71398174 | promoter | 4.47e-01 | 3.44e-01 | 2.58e+00 | 9.76e-03 | 2.62e-02 | 1.03e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg24331301 | chr10:71396620 | CGI:chr10:71396407-71398174 | promoter | 2.25e-01 | 8.24e-02 | 3.04e+00 | 2.34e-03 | 3.29e-03 | 1.43e-01 |
| KIRC | cg15323528 | chr10:71396670 | CGI:chr10:71396407-71398174 | promoter | 2.15e-01 | 9.79e-02 | 3.92e+00 | 8.92e-05 | 1.85e-04 | 1.17e-01 |
| KIRC | cg01160241 | chr10:71398196 | CGI:chr10:71396407-71398174 | promoter,gene body | 1.81e-01 | 6.42e-02 | 5.46e+00 | 4.65e-08 | 2.61e-07 | 1.17e-01 |
| LUAD | cg15323528 | chr10:71396670 | CGI:chr10:71396407-71398174 | promoter | 2.42e-01 | 9.01e-02 | 2.81e+00 | 4.90e-03 | 7.36e-03 | 1.51e-01 |
| COAD | cg25798987 | chr10:71397465 | CGI:chr10:71396407-71398174 | promoter,gene body | 3.07e-01 | 2.49e-02 | 3.63e+00 | 2.86e-04 | 8.14e-04 | 2.82e-01 |
| KIRP | cg15323528 | chr10:71396670 | CGI:chr10:71396407-71398174 | promoter | 2.93e-01 | 1.60e-01 | 2.67e+00 | 7.48e-03 | 1.00e-02 | 1.33e-01 |
| ESCA | cg18608017 | chr10:71398315 | CGI:chr10:71396407-71398174 | promoter,gene body | 3.01e-01 | 1.97e-01 | 2.56e+00 | 1.04e-02 | 3.64e-02 | 1.05e-01 |
| CHOL | cg25798987 | chr10:71397465 | CGI:chr10:71396407-71398174 | promoter,gene body | 2.14e-01 | 1.81e-02 | 2.29e+00 | 2.23e-02 | 3.24e-02 | 1.96e-01 |
| CHOL | cg24094513 | chr10:71398154 | CGI:chr10:71396407-71398174 | promoter,gene body | 3.29e-01 | 1.55e-01 | 2.29e+00 | 2.23e-02 | 3.24e-02 | 1.74e-01 |
| CHOL | cg01160241 | chr10:71398196 | CGI:chr10:71396407-71398174 | promoter,gene body | 2.64e-01 | 8.09e-02 | 1.99e+00 | 4.65e-02 | 4.65e-02 | 1.83e-01 |
| CHOL | cg18608017 | chr10:71398315 | CGI:chr10:71396407-71398174 | promoter,gene body | 3.20e-01 | 1.68e-01 | 2.88e+00 | 4.04e-03 | 1.47e-02 | 1.52e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg24331301 | chr10:71396620 | CGI:chr10:71396407-71398174 | promoter | 4.31e-01 | 9.40e-02 | 8.79e+00 | 1.44e-18 | 6.92e-18 | 3.37e-01 |
| BRCA | cg15323528 | chr10:71396670 | CGI:chr10:71396407-71398174 | promoter | 4.10e-01 | 1.10e-01 | 9.25e+00 | 2.17e-20 | 1.21e-19 | 3.01e-01 |
| BRCA | cg01000831 | chr10:71396703 | CGI:chr10:71396407-71398174 | promoter | 2.80e-01 | 1.13e-01 | 1.00e+01 | 1.42e-23 | 1.05e-22 | 1.67e-01 |
| BRCA | cg24094513 | chr10:71398154 | CGI:chr10:71396407-71398174 | promoter,gene body | 3.24e-01 | 1.46e-01 | 1.03e+01 | 9.04e-25 | 7.52e-24 | 1.78e-01 |
| BRCA | cg01160241 | chr10:71398196 | CGI:chr10:71396407-71398174 | promoter,gene body | 2.43e-01 | 7.23e-02 | 9.47e+00 | 2.70e-21 | 1.63e-20 | 1.70e-01 |
| BRCA | cg18608017 | chr10:71398315 | CGI:chr10:71396407-71398174 | promoter,gene body | 4.07e-01 | 2.13e-01 | 1.23e+01 | 1.68e-34 | 4.54e-33 | 1.94e-01 |
| HNSC | cg09796583 | chr10:71396890 | CGI:chr10:71396407-71398174 | promoter | 2.52e-01 | 1.11e-01 | 3.03e+00 | 2.44e-03 | 1.03e-02 | 1.41e-01 |
| LIHC | cg09796583 | chr10:71396890 | CGI:chr10:71396407-71398174 | promoter | 2.94e-01 | 1.64e-01 | 4.47e+00 | 7.95e-06 | 5.80e-05 | 1.29e-01 |
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Exon skipping events with PSI in TCGA for CDH23 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CDH23 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CDH23 |
| TFs related to CDH23. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CDH23 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CDH23 |
| RBPs related to ES in CDH23. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CDH23 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000107736 |
| CpG Site: cg09810750 | |
| Position to Gene: gene | |
| Male Effect: 0.591008392378001 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09810750 | chr10:71773692 | gene | 0.591008392378001 | 3.59501898830946e-08 | 0.412523758333398 | 3.1323499770155655e-06 | SARC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CDH23 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000107736 | CDH23 | C0004681 | Bagassosis | 1 | CTD_human |
| ENSG00000107736 | CDH23 | C0032273 | Pneumoconiosis | 1 | CTD_human |
| ENSG00000107736 | CDH23 | C1832394 | Deafness, Autosomal Recessive 12 | 1 | CTD_human |
| ENSG00000107736 | CDH23 | C2931208 | Usher syndrome, type 1D | 1 | CTD_human |
