|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000106991 |
Summary for ENG |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000106991 | Gene symbol | ENG |
| Gene name | endoglin | |
| HGNC | 3349 | |
| Entrez ID | 2022 | |
| Gene type | protein_coding | |
| Synonyms | ENG|END|HHT1|CD105 | |
| UniProtAcc | P17813 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000106991 | ENG | DB06322 | Carotuximab | BiotechDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ENG |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for ENG |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ENG |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg01937819 | chr9:127853831 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.53e-01 | 6.99e-01 | -2.78e+00 | 5.45e-03 | 2.11e-02 | -1.46e-01 |
| BRCA | cg24910675 | chr9:127854638 | CGI:chr9:127854340-127854579 | UTR,promoter,exon,gene body | 1.41e-01 | 3.11e-01 | -2.20e+00 | 2.76e-02 | 3.96e-02 | -1.70e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg01937819 | chr9:127853831 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.41e-01 | 6.45e-01 | -4.58e+00 | 4.68e-06 | 1.40e-05 | -1.04e-01 |
| LUSC | cg14185922 | chr9:127852909 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.55e-01 | 4.33e-01 | 3.50e+00 | 4.66e-04 | 1.59e-03 | 1.22e-01 |
| LUSC | cg01937819 | chr9:127853831 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.23e-01 | 3.26e-01 | 3.70e+00 | 2.14e-04 | 1.01e-03 | 1.96e-01 |
| LUSC | cg24910675 | chr9:127854638 | CGI:chr9:127854340-127854579 | UTR,promoter,exon,gene body | 2.53e-01 | 8.91e-02 | 3.03e+00 | 2.42e-03 | 4.78e-03 | 1.64e-01 |
| LUSC | cg05050341 | chr9:127855255 | CGI:chr9:127854340-127854579 | promoter | 8.32e-01 | 6.56e-01 | 3.88e+00 | 1.06e-04 | 7.14e-04 | 1.76e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg14185922 | chr9:127852909 | CGI:chr9:127854340-127854579 | promoter,gene body | 6.73e-01 | 5.56e-01 | 8.59e+00 | 8.66e-18 | 3.91e-17 | 1.16e-01 |
| BRCA | cg01937819 | chr9:127853831 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.53e-01 | 2.53e-01 | 1.27e+01 | 7.76e-37 | 3.13e-35 | 3.00e-01 |
| HNSC | cg01937819 | chr9:127853831 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.21e-01 | 6.51e-01 | -2.35e+00 | 1.86e-02 | 2.64e-02 | -1.30e-01 |
| HNSC | cg24910675 | chr9:127854638 | CGI:chr9:127854340-127854579 | UTR,promoter,exon,gene body | 2.75e-01 | 1.56e-01 | 2.00e+00 | 4.53e-02 | 4.65e-02 | 1.19e-01 |
| COAD | cg14185922 | chr9:127852909 | CGI:chr9:127854340-127854579 | promoter,gene body | 4.54e-01 | 5.69e-01 | -3.52e+00 | 4.35e-04 | 1.67e-03 | -1.15e-01 |
| BLCA | cg01937819 | chr9:127853831 | CGI:chr9:127854340-127854579 | promoter,gene body | 5.41e-01 | 4.31e-01 | 2.56e+00 | 1.05e-02 | 1.79e-02 | 1.10e-01 |
Top |
Exon skipping events with PSI in TCGA for ENG |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ENG |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for ENG |
| TFs related to ENG. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PLAGL2 | ENG | 4.00e+00 | 9.83e-01 | 2.67e+00 | 1.59e-03 | Male-biased |
| ENG related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ENG |
| RBPs related to ES in ENG. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | FXR2 | exon_skip_507121 | 7.41e+00 | 3.46e-03 | 7.87e+00 | 9.88e-01 | Female-biased |
| ACC | BRUNOL6 | exon_skip_507133 | 8.45e+00 | 1.06e-02 | 8.86e+00 | 9.84e-01 | Female-biased |
| UVM | HNRNPH2 | exon_skip_507124 | 6.06e+00 | 8.74e-05 | 6.80e+00 | 9.84e-01 | Female-biased |
| UVM | RBM28 | exon_skip_507121 | 1.00e+01 | 4.87e-03 | 1.04e+01 | 9.94e-01 | Female-biased |
| THYM | BRUNOL6 | exon_skip_507133 | 8.81e+00 | 9.83e-01 | 8.50e+00 | 1.14e-02 | Male-biased |
| THYM | RBM28 | exon_skip_507121 | 9.96e+00 | 3.05e-03 | 1.04e+01 | 9.96e-01 | Female-biased |
| LIHC | RBM4 | exon_skip_507124 | 9.35e+00 | 1.05e-02 | 9.73e+00 | 9.87e-01 | Female-biased |
| LUSC | FXR2 | exon_skip_507121 | 7.49e+00 | 8.20e-03 | 7.86e+00 | 9.83e-01 | Female-biased |
| LUSC | RBM4 | exon_skip_507124 | 9.28e+00 | 9.95e-03 | 9.64e+00 | 9.88e-01 | Female-biased |
| COAD | RBM28 | exon_skip_507121 | 9.88e+00 | 9.57e-03 | 1.02e+01 | 9.89e-01 | Female-biased |
| DLBC | BRUNOL6 | exon_skip_507133 | 8.88e+00 | 9.91e-01 | 8.47e+00 | 4.33e-03 | Male-biased |
| LUAD | HNRNPH2 | exon_skip_507124 | 6.40e+00 | 1.64e-03 | 6.92e+00 | 9.84e-01 | Female-biased |
| LUAD | RBM4 | exon_skip_507124 | 9.34e+00 | 1.52e-02 | 9.63e+00 | 9.82e-01 | Female-biased |
| KIRP | BRUNOL6 | exon_skip_507133 | 8.72e+00 | 9.85e-01 | 8.38e+00 | 8.94e-03 | Male-biased |
| READ | RBM28 | exon_skip_507121 | 9.75e+00 | 3.24e-03 | 1.02e+01 | 9.95e-01 | Female-biased |
| THCA | BRUNOL6 | exon_skip_507133 | 8.69e+00 | 9.89e-01 | 8.36e+00 | 5.78e-03 | Male-biased |
| PCPG | RBM28 | exon_skip_507121 | 1.04e+01 | 9.94e-01 | 1.00e+01 | 4.37e-03 | Male-biased |
| PCPG | RBM4 | exon_skip_507124 | 9.45e+00 | 9.95e-01 | 9.00e+00 | 2.49e-03 | Male-biased |
| GBM | RBM28 | exon_skip_507121 | 9.67e+00 | 1.52e-03 | 1.02e+01 | 9.97e-01 | Female-biased |
| KICH | RBM4 | exon_skip_507124 | 9.23e+00 | 5.76e-03 | 9.60e+00 | 9.92e-01 | Female-biased |
| BLCA | RBM28 | exon_skip_507121 | 9.93e+00 | 1.50e-02 | 1.02e+01 | 9.83e-01 | Female-biased |
| ENG related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11103684 | chr9:135120224:G:A | - | 0.228478755252487 | 0.0363630823006448 | BLCA | Female-baised eQTL |
| rs11834 | chr9:135120566:G:A | - | 0.233332955423858 | 0.0385358031423733 | BLCA | Female-baised eQTL |
| rs200548 | chr9:120334044:A:G | - | 0.0528375230458394 | 0.0124320423055786 | LUAD | Female-baised eQTL |
| rs10733660 | chr9:123331057:G:A | - | -0.053439250178087 | 0.0195277939259015 | LUAD | Female-baised eQTL |
| rs200545 | chr9:120335781:A:G | - | 0.0457588492300476 | 0.0199501532505682 | LUAD | Female-baised eQTL |
| rs12235121 | chr9:136024181:G:T | - | 0.0427782876642966 | 0.0304990640499038 | LUAD | Female-baised eQTL |
| rs4842078 | chr9:136028032:G:C | - | 0.042348437647107 | 0.033591259183153 | LUAD | Female-baised eQTL |
| rs10114591 | chr9:130984888:A:G | - | 0.0283638189435933 | 0.0344057252011104 | LUAD | Female-baised eQTL |
| rs10117848 | chr9:132473736:C:T | - | 0.0955305509875371 | 0.0416025472077211 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7021948 | chr9:133871951:A:C | - | 0.0891036379603752 | 0.0219885857665362 | KIRC | Male-baised eQTL |
| rs9657700 | chr9:133872210:C:T | - | 0.0883127609275757 | 0.0244715694682701 | KIRC | Male-baised eQTL |
| rs10821531 | chr9:133871440:T:G | - | 0.0861790519579268 | 0.0345151888457783 | KIRC | Male-baised eQTL |
| rs10821528 | chr9:133868924:C:T | - | 0.0837763460845446 | 0.0468081693698757 | KIRC | Male-baised eQTL |
| rs2073830 | chr9:133870252:G:A | - | 0.0827454574990889 | 0.0490785010797521 | KIRC | Male-baised eQTL |
| rs16910566 | chr9:121364340:G:A | - | 0.0584870841569924 | 0.0223492331594909 | BLCA | Male-baised eQTL |
| rs12554081 | chr9:121363046:C:A | - | 0.0565874730845048 | 0.0266102886724704 | BLCA | Male-baised eQTL |
| rs10819014 | chr9:124951199:G:T | - | 0.0408295874279649 | 0.0339963536016678 | COAD | Male-baised eQTL |
| rs58483583 | chr9:122063517:T:A | - | 0.0416506751854076 | 0.0379956287451464 | COAD | Male-baised eQTL |
| rs71497050 | chr9:121995919:C:T | - | 0.0410663713444672 | 0.0395115465005218 | COAD | Male-baised eQTL |
| rs1530369 | chr9:124938382:G:C | - | 0.0401786005692696 | 0.0406984745361049 | COAD | Male-baised eQTL |
| rs6478555 | chr9:122063308:G:A | - | 0.0409776384983223 | 0.0423393796578368 | COAD | Male-baised eQTL |
| rs10987619 | chr9:127369717:A:T | - | 0.0444472928283949 | 0.0438190895116172 | COAD | Male-baised eQTL |
| rs71497049 | chr9:121995917:A:G | - | 0.0404315284918723 | 0.0461202942231145 | COAD | Male-baised eQTL |
| rs71497051 | chr9:121995922:G:A | - | 0.0404315284918723 | 0.0461202942231145 | COAD | Male-baised eQTL |
| rs10819018 | chr9:124979243:A:C | - | 0.038674428400816 | 0.0472861565635294 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000106991 |
| CpG Site: cg14185922 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.258197631653009 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14185922 | chr9:127852909 | gene,promoter | -0.258197631653009 | 1.60647899742387e-16 | -0.534848712840025 | 2.854516170435894e-20 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ENG |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000106991 | ENG | C0010674 | Cystic Fibrosis | 1 | CTD_human |
| ENSG00000106991 | ENG | C0039445 | Hereditary hemorrhagic telangiectasia | 2 | CTD_human |
| ENSG00000106991 | ENG | C0392164 | Pulmonary Cystic Fibrosis | 1 | CTD_human |
| ENSG00000106991 | ENG | C1527396 | Fibrocystic Disease of Pancreas | 1 | CTD_human |
| ENSG00000106991 | ENG | C4551861 | Telangiectasia, Hereditary Hemorrhagic, Type 1 | 2 | CTD_human |
