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Gene: ENSG00000106070 |
Summary for GRB10 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000106070 | Gene symbol | GRB10 |
| Gene name | growth factor receptor bound protein 10 | |
| HGNC | 4564 | |
| Entrez ID | 2887 | |
| Gene type | protein_coding | |
| Synonyms | GRB10| | |
| UniProtAcc | Q13322 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for GRB10 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| GRB10 | 3.65e+03 | 1.00e+00 | 1.88e-01 | 5.32e+00 | 1.03e-07 | 7.40e-07 | THCA |
| GRB10 | 1.52e+03 | -1.51e+00 | 3.59e-01 | -4.20e+00 | 2.62e-05 | 1.39e-04 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| GRB10 | 1.29e+03 | 1.06e+00 | 1.52e-01 | 6.98e+00 | 3.03e-12 | 2.15e-11 | COAD |
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Sex-biased somatic mutation for GRB10 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for GRB10 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| MESO | cg18454288 | chr7:50793910 | CGI:chr7:50793693-50793941 | promoter | 9.99e-02 | 2.44e-01 | -2.02e+00 | 4.34e-02 | 4.84e-02 | -1.44e-01 |
| MESO | cg26163537 | chr7:50793895 | CGI:chr7:50793693-50793941 | promoter | 1.66e-01 | 2.81e-01 | -2.27e+00 | 2.32e-02 | 4.08e-02 | -1.15e-01 |
| MESO | cg21517389 | chr7:50793905 | CGI:chr7:50793693-50793941 | promoter | 1.10e-01 | 2.26e-01 | -2.60e+00 | 9.31e-03 | 2.70e-02 | -1.15e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg26957150 | chr7:50794042 | CGI:chr7:50793693-50793941 | promoter | 5.65e-01 | 4.30e-01 | 4.39e+00 | 1.16e-05 | 1.37e-04 | 1.35e-01 |
| THCA | cg16535493 | chr7:50794053 | CGI:chr7:50793693-50793941 | promoter | 4.85e-01 | 3.84e-01 | 2.13e+00 | 3.30e-02 | 3.79e-02 | 1.01e-01 |
| HNSC | cg13459606 | chr7:50794137 | CGI:chr7:50793693-50793941 | promoter | 7.24e-01 | 8.26e-01 | -2.18e+00 | 2.95e-02 | 3.20e-02 | -1.02e-01 |
| LUSC | cg18454288 | chr7:50793910 | CGI:chr7:50793693-50793941 | promoter | 1.72e-01 | 4.03e-02 | 3.25e+00 | 1.17e-03 | 2.89e-03 | 1.31e-01 |
| LUSC | cg26163537 | chr7:50793895 | CGI:chr7:50793693-50793941 | promoter | 2.34e-01 | 1.20e-01 | 3.49e+00 | 4.74e-04 | 1.60e-03 | 1.14e-01 |
| LUSC | cg21517389 | chr7:50793905 | CGI:chr7:50793693-50793941 | promoter | 1.87e-01 | 7.55e-02 | 3.72e+00 | 1.98e-04 | 9.67e-04 | 1.11e-01 |
| LUSC | cg19392396 | chr7:50793957 | CGI:chr7:50793693-50793941 | promoter | 2.65e-01 | 1.22e-01 | 3.99e+00 | 6.49e-05 | 5.96e-04 | 1.44e-01 |
| LUSC | cg13459606 | chr7:50794137 | CGI:chr7:50793693-50793941 | promoter | 7.26e-01 | 5.59e-01 | 3.23e+00 | 1.25e-03 | 3.02e-03 | 1.67e-01 |
| LUSC | cg25975369 | chr7:50794458 | CGI:chr7:50793693-50793941 | promoter | 7.85e-01 | 6.55e-01 | 3.35e+00 | 8.11e-04 | 2.26e-03 | 1.30e-01 |
| COAD | cg16535493 | chr7:50794053 | CGI:chr7:50793693-50793941 | promoter | 2.29e-01 | 3.36e-01 | -3.85e+00 | 1.18e-04 | 3.99e-04 | -1.08e-01 |
| COAD | cg13459606 | chr7:50794137 | CGI:chr7:50793693-50793941 | promoter | 3.06e-01 | 4.08e-01 | -3.10e+00 | 1.96e-03 | 3.88e-03 | -1.02e-01 |
| COAD | cg00754947 | chr7:50794270 | CGI:chr7:50793693-50793941 | promoter | 4.53e-01 | 5.92e-01 | -2.71e+00 | 6.74e-03 | 1.05e-02 | -1.39e-01 |
| BLCA | cg05493751 | chr7:50794338 | CGI:chr7:50793693-50793941 | promoter | 7.82e-01 | 9.14e-01 | -3.15e+00 | 1.63e-03 | 3.34e-03 | -1.32e-01 |
| ESCA | cg00754947 | chr7:50794270 | CGI:chr7:50793693-50793941 | promoter | 7.60e-01 | 5.59e-01 | 2.66e+00 | 7.80e-03 | 3.55e-02 | 2.01e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18454288 | chr7:50793910 | CGI:chr7:50793693-50793941 | promoter | 2.22e-01 | 4.66e-02 | 9.47e+00 | 2.77e-21 | 1.67e-20 | 1.75e-01 |
| BRCA | cg26163537 | chr7:50793895 | CGI:chr7:50793693-50793941 | promoter | 2.80e-01 | 1.68e-01 | 5.69e+00 | 1.27e-08 | 2.82e-08 | 1.12e-01 |
| BRCA | cg21517389 | chr7:50793905 | CGI:chr7:50793693-50793941 | promoter | 2.19e-01 | 8.48e-02 | 9.18e+00 | 4.49e-20 | 2.44e-19 | 1.35e-01 |
| LUAD | cg23104539 | chr7:50793838 | CGI:chr7:50793693-50793941 | promoter | 1.96e-01 | 7.82e-02 | 3.67e+00 | 2.46e-04 | 1.36e-03 | 1.18e-01 |
| HNSC | cg23104539 | chr7:50793838 | CGI:chr7:50793693-50793941 | promoter | 2.30e-01 | 1.24e-01 | 2.00e+00 | 4.53e-02 | 4.65e-02 | 1.06e-01 |
| HNSC | cg26163537 | chr7:50793895 | CGI:chr7:50793693-50793941 | promoter | 2.56e-01 | 1.48e-01 | 2.43e+00 | 1.50e-02 | 2.33e-02 | 1.08e-01 |
| HNSC | cg21517389 | chr7:50793905 | CGI:chr7:50793693-50793941 | promoter | 1.98e-01 | 9.25e-02 | 2.71e+00 | 6.64e-03 | 1.52e-02 | 1.06e-01 |
| LIHC | cg13459606 | chr7:50794137 | CGI:chr7:50793693-50793941 | promoter | 6.55e-01 | 5.54e-01 | 2.52e+00 | 1.17e-02 | 1.57e-02 | 1.01e-01 |
| KIRP | cg18454288 | chr7:50793910 | CGI:chr7:50793693-50793941 | promoter | 1.59e-01 | 3.03e-02 | 2.18e+00 | 2.89e-02 | 3.43e-02 | 1.28e-01 |
| KIRP | cg23104539 | chr7:50793838 | CGI:chr7:50793693-50793941 | promoter | 1.77e-01 | 7.01e-02 | 2.42e+00 | 1.54e-02 | 2.25e-02 | 1.07e-01 |
| KIRP | cg21517389 | chr7:50793905 | CGI:chr7:50793693-50793941 | promoter | 1.80e-01 | 6.13e-02 | 2.94e+00 | 3.24e-03 | 8.06e-03 | 1.18e-01 |
| KIRP | cg16535493 | chr7:50794053 | CGI:chr7:50793693-50793941 | promoter | 6.31e-01 | 5.15e-01 | 2.36e+00 | 1.83e-02 | 2.52e-02 | 1.16e-01 |
Top |
Exon skipping events with PSI in TCGA for GRB10 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for GRB10 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for GRB10 |
| TFs related to GRB10. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GRB10 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for GRB10 |
| RBPs related to ES in GRB10. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | DAZAP1 | exon_skip_475565 | 1.45e+01 | 4.39e-04 | 1.53e+01 | 1.00e+00 | Female-biased |
| ACC | DAZAP1 | exon_skip_475565 | 1.54e+01 | 9.97e-01 | 1.48e+01 | 3.01e-03 | Male-biased |
| UVM | DAZAP1 | exon_skip_475565 | 1.47e+01 | 2.51e-04 | 1.54e+01 | 1.00e+00 | Female-biased |
| LIHC | SAMD4A | exon_skip_475569 | 8.99e+00 | 9.91e-01 | 8.48e+00 | 3.86e-03 | Male-biased |
| COAD | SAMD4A | exon_skip_475569 | 8.50e+00 | 9.91e-01 | 8.00e+00 | 2.08e-03 | Male-biased |
| KIRP | ESRP2 | exon_skip_475582 | 8.91e+00 | 9.93e-01 | 8.44e+00 | 2.20e-03 | Male-biased |
| ESCA | DAZAP1 | exon_skip_475565 | 1.44e+01 | 1.10e-03 | 1.51e+01 | 9.99e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_475569 | 8.55e+00 | 9.90e-01 | 7.97e+00 | 3.93e-03 | Male-biased |
| THCA | SAMD4A | exon_skip_475569 | 8.53e+00 | 9.92e-01 | 8.11e+00 | 1.86e-03 | Male-biased |
| GBM | DAZAP1 | exon_skip_475565 | 1.46e+01 | 1.42e-03 | 1.51e+01 | 9.99e-01 | Female-biased |
| KIRC | SAMD4A | exon_skip_475569 | 8.63e+00 | 9.85e-01 | 8.31e+00 | 8.90e-03 | Male-biased |
| HNSC | DAZAP1 | exon_skip_475565 | 1.47e+01 | 6.29e-04 | 1.53e+01 | 9.99e-01 | Female-biased |
| HNSC | SAMD4A | exon_skip_475569 | 8.48e+00 | 9.80e-01 | 8.16e+00 | 1.33e-02 | Male-biased |
| SARC | SAMD4A | exon_skip_475569 | 8.34e+00 | 2.32e-04 | 9.18e+00 | 9.96e-01 | Female-biased |
| GRB10 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000106070 | AC073254.1,hsa-mir-340,GRB10 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000106070 | BOLA3-AS1,hsa-mir-519b,GRB10 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000106070 | SLC26A4-AS1,hsa-mir-3613,GRB10 | Male-specific ceRNA | TCGA-THCA |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10807906 | chr7:41619272:C:T | - | -0.212591934266173 | 0.0123260128332041 | HNSC | Female-baised eQTL |
| rs496944 | chr7:41536555:T:C | - | -0.168559642387183 | 0.0439432991517359 | HNSC | Female-baised eQTL |
| rs35829286 | chr7:56120348:A:G | - | 0.271081214292599 | 0.00105429275002153 | LUSC | Female-baised eQTL |
| rs35630212 | chr7:56126137:C:A | - | 0.271081214292599 | 0.00105429275002153 | LUSC | Female-baised eQTL |
| rs13233028 | chr7:56128436:C:T | - | 0.271081214292599 | 0.00105429275002153 | LUSC | Female-baised eQTL |
| rs34337311 | chr7:56129885:A:G | - | 0.271081214292599 | 0.00105429275002153 | LUSC | Female-baised eQTL |
| rs35307785 | chr7:56082414:G:A | - | 0.269799680078259 | 0.00119787139084377 | LUSC | Female-baised eQTL |
| rs2242510 | chr7:56084123:C:G | - | 0.269799680078259 | 0.00119787139084377 | LUSC | Female-baised eQTL |
| rs13236894 | chr7:56099258:C:T | - | 0.269799680078259 | 0.00119787139084377 | LUSC | Female-baised eQTL |
| rs34372667 | chr7:56106932:C:T | - | 0.269799680078259 | 0.00119787139084377 | LUSC | Female-baised eQTL |
| rs34057777 | chr7:56107836:A:C | - | 0.269799680078259 | 0.00119787139084377 | LUSC | Female-baised eQTL |
| rs740155 | chr7:50755409:G:A | gene | 0.169937628430226 | 0.00138061901926196 | LUSC | Female-baised eQTL |
| rs13221255 | chr7:56110197:T:C | - | 0.232602106485852 | 0.00185284431813492 | LUSC | Female-baised eQTL |
| rs147495182 | chr7:50777687:T:A | gene | 0.183993847226431 | 0.00449581549586472 | LUSC | Female-baised eQTL |
| rs76519777 | chr7:56072855:T:C | - | 0.241909957299036 | 0.00473756139401639 | LUSC | Female-baised eQTL |
| rs3735066 | chr7:56078311:G:A | - | 0.241909957299036 | 0.00473756139401639 | LUSC | Female-baised eQTL |
| rs75544428 | chr7:56085846:T:C | - | 0.241679853318527 | 0.00482697262836866 | LUSC | Female-baised eQTL |
| rs7790423 | chr7:50771700:G:T | gene | 0.174681156042384 | 0.00528961641465698 | LUSC | Female-baised eQTL |
| rs60877714 | chr7:50772685:G:A | gene | 0.174681156042384 | 0.00528961641465698 | LUSC | Female-baised eQTL |
| rs55756207 | chr7:50773988:G:A | gene | 0.174681156042384 | 0.00528961641465698 | LUSC | Female-baised eQTL |
| rs2074723 | chr7:50767232:C:T | gene | 0.173752289116864 | 0.0060245192371778 | LUSC | Female-baised eQTL |
| rs3813504 | chr7:55962527:T:C | - | 0.240889908059167 | 0.0127587297834865 | LUSC | Female-baised eQTL |
| rs78864849 | chr7:56040878:A:G | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs35210477 | chr7:56044524:A:G | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs13241227 | chr7:56054722:A:G | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs13238152 | chr7:56057127:C:T | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs35704704 | chr7:56057366:G:T | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs74786312 | chr7:56064982:G:A | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs139342133 | chr7:56068066:G:A | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs71543784 | chr7:56069955:C:G | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs71543785 | chr7:56070238:A:T | - | 0.227488790737094 | 0.0145467812916311 | LUSC | Female-baised eQTL |
| rs143821544 | chr7:55964880:C:T | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs118175268 | chr7:55970055:G:A | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs34874704 | chr7:55975558:G:A | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs75703490 | chr7:55977029:T:C | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs71543773 | chr7:55979919:G:A | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs13232756 | chr7:55980139:C:T | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs13239795 | chr7:55987634:C:T | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs142097271 | chr7:55990490:C:T | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs35092795 | chr7:55995921:T:C | - | 0.226329744948932 | 0.016011650294894 | LUSC | Female-baised eQTL |
| rs28498258 | chr7:55958399:C:T | - | 0.21969337233916 | 0.0251418065475247 | LUSC | Female-baised eQTL |
| rs4948211 | chr7:51255395:A:C | - | 0.0947063883181609 | 0.025151991413855 | LUSC | Female-baised eQTL |
| rs9642623 | chr7:51259096:T:C | - | 0.0947063883181609 | 0.025151991413855 | LUSC | Female-baised eQTL |
| rs73330631 | chr7:51259304:A:G | - | 0.0951702286354915 | 0.025923553485226 | LUSC | Female-baised eQTL |
| rs13241263 | chr7:56166500:T:C | - | 0.162432806697048 | 0.0263323151206011 | LUSC | Female-baised eQTL |
| rs10280143 | chr7:56168102:A:G | - | 0.162432806697048 | 0.0263323151206011 | LUSC | Female-baised eQTL |
| rs10280258 | chr7:56168168:A:G | - | 0.162432806697048 | 0.0263323151206011 | LUSC | Female-baised eQTL |
| rs61552283 | chr7:50752894:T:C | gene | 0.165607094814098 | 0.0277808490921779 | LUSC | Female-baised eQTL |
| rs13340526 | chr7:55967615:C:T | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs4360246 | chr7:55968913:G:C | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs73343714 | chr7:55976127:C:G | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs56917729 | chr7:55977193:C:T | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs73343719 | chr7:55978728:A:G | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs34719521 | chr7:55984425:G:C | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs13243725 | chr7:55988665:C:T | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs112542046 | chr7:55998525:G:A | - | 0.180031924013681 | 0.0324824969009673 | LUSC | Female-baised eQTL |
| rs17733974 | chr7:51347000:T:G | - | 0.138560417478128 | 0.0327201828076534 | LUSC | Female-baised eQTL |
| rs62448342 | chr7:51347338:G:A | - | 0.138560417478128 | 0.0327201828076534 | LUSC | Female-baised eQTL |
| rs79291328 | chr7:51348185:T:G | - | 0.138560417478128 | 0.0327201828076534 | LUSC | Female-baised eQTL |
| rs62448343 | chr7:51348194:A:T | - | 0.138560417478128 | 0.0327201828076534 | LUSC | Female-baised eQTL |
| rs2329730 | chr7:51345361:G:A | - | -0.138560417478128 | 0.0327201828076534 | LUSC | Female-baised eQTL |
| rs1370495 | chr7:51346005:C:T | - | -0.138560417478128 | 0.0327201828076534 | LUSC | Female-baised eQTL |
| rs35160834 | chr7:55970258:T:C | - | 0.179335400147434 | 0.0345305668971077 | LUSC | Female-baised eQTL |
| rs2302151 | chr7:51231915:G:A | - | 0.0921274691139029 | 0.0371033732392673 | LUSC | Female-baised eQTL |
| rs4948207 | chr7:51240609:C:G | - | 0.0917473216641391 | 0.0373134364239397 | LUSC | Female-baised eQTL |
| rs4948209 | chr7:51242072:C:A | - | 0.0917473216641391 | 0.0373134364239397 | LUSC | Female-baised eQTL |
| rs4948210 | chr7:51242249:C:T | - | 0.0917473216641391 | 0.0373134364239397 | LUSC | Female-baised eQTL |
| rs62448323 | chr7:51242858:C:T | - | 0.0917473216641391 | 0.0373134364239397 | LUSC | Female-baised eQTL |
| rs664523 | chr7:51355173:C:T | - | 0.137435683494595 | 0.0378147734835522 | LUSC | Female-baised eQTL |
| rs4948208 | chr7:51241780:G:A | - | 0.0916319178813507 | 0.0429362477535418 | LUSC | Female-baised eQTL |
| rs11238435 | chr7:51243573:A:C | - | 0.0916319178813507 | 0.0429362477535418 | LUSC | Female-baised eQTL |
| rs11238436 | chr7:51245082:T:C | - | 0.0916319178813507 | 0.0429362477535418 | LUSC | Female-baised eQTL |
| rs12673454 | chr7:51247445:G:A | - | 0.0916319178813507 | 0.0429362477535418 | LUSC | Female-baised eQTL |
| rs4948206 | chr7:51240300:A:C | - | 0.0888008291999103 | 0.0435275345807794 | LUSC | Female-baised eQTL |
| rs58466366 | chr7:51237047:C:A | - | 0.0910582747172346 | 0.044205846882286 | LUSC | Female-baised eQTL |
| rs6593340 | chr7:51244305:G:A | - | 0.0881162041839598 | 0.0465261225521435 | LUSC | Female-baised eQTL |
| rs13222893 | chr7:55892690:T:C | - | 0.209336235040607 | 0.0480622951341276 | LUSC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10233125 | chr7:45113641:T:G | - | 0.0526346594552985 | 0.0287708608329349 | HNSC | Male-baised eQTL |
| rs62452712 | chr7:46545410:C:T | - | 0.0481115186883112 | 0.0334318688712024 | HNSC | Male-baised eQTL |
| rs1986248 | chr7:46557757:T:C | - | 0.0480644822504039 | 0.0337779693454201 | HNSC | Male-baised eQTL |
| rs138188002 | chr7:43032280:C:T | - | 0.0461077677375144 | 0.0407827887378545 | HNSC | Male-baised eQTL |
| rs28790961 | chr7:44362591:A:G | - | 0.178941521886495 | 0.0073452396427506 | GBM | Male-baised eQTL |
| rs6963078 | chr7:44367001:G:A | - | 0.178941521886495 | 0.0073452396427506 | GBM | Male-baised eQTL |
| rs73101774 | chr7:44375200:A:C | - | 0.178941521886495 | 0.0073452396427506 | GBM | Male-baised eQTL |
| rs56034164 | chr7:44380548:G:C | - | 0.173961876212362 | 0.00852204720725049 | GBM | Male-baised eQTL |
| rs17172864 | chr7:44380639:A:G | - | 0.173961876212362 | 0.00852204720725049 | GBM | Male-baised eQTL |
| rs2686784 | chr7:48047181:A:G | - | -0.0519756483561887 | 0.0015542861232754 | LUSC | Male-baised eQTL |
| rs2686792 | chr7:48053250:C:A | - | -0.044412003334096 | 0.00830495845152693 | LUSC | Male-baised eQTL |
| rs2708855 | chr7:48045824:G:A | - | -0.0440490789379184 | 0.0100288840586233 | LUSC | Male-baised eQTL |
| rs6979927 | chr7:48044150:G:A | - | -0.044457083182552 | 0.0100504850337381 | LUSC | Male-baised eQTL |
| rs4724670 | chr7:48044497:G:T | - | -0.0443010766839432 | 0.0104696386328527 | LUSC | Male-baised eQTL |
| rs1879831 | chr7:48045479:C:T | - | -0.0439499007400835 | 0.0112742702300997 | LUSC | Male-baised eQTL |
| rs6463458 | chr7:48055340:G:A | - | -0.0434090285727205 | 0.0134120025358278 | LUSC | Male-baised eQTL |
| rs1879830 | chr7:48045535:G:C | - | -0.0412626997712279 | 0.0198966177078952 | LUSC | Male-baised eQTL |
| rs2686791 | chr7:48052889:T:C | - | -0.0418581873060846 | 0.0200850344840473 | LUSC | Male-baised eQTL |
| rs2708876 | chr7:48042832:G:A | - | -0.0426122773432134 | 0.0260490684969938 | LUSC | Male-baised eQTL |
| rs10233232 | chr7:48046564:T:C | - | -0.040115235434693 | 0.0330725256034251 | LUSC | Male-baised eQTL |
| rs2708856 | chr7:48045419:A:G | - | -0.0408902590641108 | 0.0368298698989276 | LUSC | Male-baised eQTL |
| rs2686782 | chr7:48030615:T:C | - | -0.0406602794872224 | 0.0396586897508155 | LUSC | Male-baised eQTL |
| rs7789233 | chr7:51879372:T:C | - | 0.0525770733991664 | 0.0455772901292376 | LUSC | Male-baised eQTL |
| rs62463058 | chr7:52183860:G:A | - | -0.0717278678181769 | 0.0270357148899036 | KIRC | Male-baised eQTL |
| rs10486704 | chr7:41015632:G:A | - | 0.125633436195143 | 0.0272465140020714 | KIRC | Male-baised eQTL |
| rs7795557 | chr7:42661202:C:T | - | 0.0802340425678407 | 0.0281224276982575 | KIRC | Male-baised eQTL |
| rs73101605 | chr7:42630000:C:T | - | 0.0781774680663625 | 0.0393881772838373 | KIRC | Male-baised eQTL |
| rs73101606 | chr7:42630606:A:G | - | 0.0767910301460085 | 0.0459156395384601 | KIRC | Male-baised eQTL |
| rs11767372 | chr7:52873981:G:A | - | 0.110747853990876 | 0.00834771480455275 | LUAD | Male-baised eQTL |
| rs10238973 | chr7:49105340:T:C | - | -0.105138307134339 | 0.0254886894164598 | LUAD | Male-baised eQTL |
| rs7805387 | chr7:49100990:A:G | - | 0.10749802660035 | 0.0300142808210908 | LUAD | Male-baised eQTL |
| rs74445254 | chr7:49105875:A:G | - | 0.10749802660035 | 0.0300142808210908 | LUAD | Male-baised eQTL |
| rs75891005 | chr7:52768465:A:G | - | 0.107531091772885 | 0.0398956124223252 | LUAD | Male-baised eQTL |
| rs10244860 | chr7:51641597:C:T | - | 0.123144146735977 | 0.00739760668018599 | COAD | Male-baised eQTL |
| rs10247436 | chr7:52453153:C:G | - | 0.0958197181332979 | 0.00896830004088496 | COAD | Male-baised eQTL |
| rs17134366 | chr7:51646419:G:A | - | 0.11706449753345 | 0.0117234444401492 | COAD | Male-baised eQTL |
| rs1476893 | chr7:52450415:A:G | - | 0.094717305691868 | 0.0123269247581025 | COAD | Male-baised eQTL |
| rs1476894 | chr7:52450431:G:A | - | 0.094717305691868 | 0.0123269247581025 | COAD | Male-baised eQTL |
| rs10240369 | chr7:51640420:C:T | - | 0.120053903883231 | 0.01323594937358 | COAD | Male-baised eQTL |
| rs11975223 | chr7:51644113:G:A | - | 0.116656410315659 | 0.0134087598990368 | COAD | Male-baised eQTL |
| rs10227253 | chr7:51647610:C:A | - | 0.114554186607088 | 0.0150108799903844 | COAD | Male-baised eQTL |
| rs58194529 | chr7:51656453:G:A | - | 0.117323046603818 | 0.0169626308039245 | COAD | Male-baised eQTL |
| rs10255530 | chr7:52446281:A:G | - | 0.0887329418412314 | 0.0176590176230719 | COAD | Male-baised eQTL |
| rs7458928 | chr7:52445642:C:A | - | 0.0893872993452565 | 0.0228718443364685 | COAD | Male-baised eQTL |
| rs4386930 | chr7:52447041:T:C | - | 0.0893872993452565 | 0.0228718443364685 | COAD | Male-baised eQTL |
| rs2330100 | chr7:52447836:G:A | - | 0.0893872993452565 | 0.0228718443364685 | COAD | Male-baised eQTL |
| rs1547472 | chr7:52449754:C:T | - | 0.0886304239380086 | 0.0249771889402581 | COAD | Male-baised eQTL |
| rs10247449 | chr7:52444397:A:T | - | 0.0877543158950936 | 0.0296011305731193 | COAD | Male-baised eQTL |
| rs2159810 | chr7:52448135:C:T | - | 0.0877543158950936 | 0.0296011305731193 | COAD | Male-baised eQTL |
| rs10268945 | chr7:52439223:A:G | - | 0.0819812131909862 | 0.0441618712078762 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000106070 |
| CpG Site: cg15565231 | |
| Position to Gene: promoter | |
| Male Effect: -0.405145492816214 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15565231 | chr7:50794569 | promoter | -0.405145492816214 | 1.88777116788969e-05 | -0.3462849336257767 | 1.1132751597699552e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_475596 | chr7:50703820:50703908 | Frame-shift | rs1456896 | chr7:50264865:C:T | Distant downstream | 0.025361494466943 | 0.0437902982330266 | KIRC | Male-baised sQTL |
| exon_skip_475596 | chr7:50703820:50703908 | Frame-shift | rs9656588 | chr7:50267184:T:C | Distant downstream | 0.0251554380834743 | 0.0447934800345639 | KIRC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of GRB10 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000106070 | GRB10 | C0036341 | Schizophrenia | 1 | PSYGENET |
