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Gene: ENSG00000105875 |
Summary for WDR91 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000105875 | Gene symbol | WDR91 |
| Gene name | WD repeat domain 91 | |
| HGNC | 24997 | |
| Entrez ID | 29062 | |
| Gene type | protein_coding | |
| Synonyms | WDR91|HSPC049|SORF-1 | |
| UniProtAcc | A4D1P6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for WDR91 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| WDR91 | 1.55e+03 | 1.03e+00 | 2.86e-01 | 3.62e+00 | 2.96e-04 | 1.15e-03 | BLCA |
| WDR91 | 6.54e+03 | 1.05e+00 | 1.71e-01 | 6.12e+00 | 9.27e-10 | 5.30e-09 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for WDR91 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for WDR91 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for WDR91 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for WDR91 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for WDR91 |
| TFs related to WDR91. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| WDR91 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for WDR91 |
| RBPs related to ES in WDR91. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | ANKHD1 | exon_skip_479590 | 1.38e+01 | 1.04e-03 | 1.44e+01 | 9.99e-01 | Female-biased |
| THYM | ANKHD1 | exon_skip_479590 | 1.49e+01 | 1.92e-04 | 1.55e+01 | 1.00e+00 | Female-biased |
| THYM | FXR1 | exon_skip_479585 | 9.07e+00 | 1.16e-02 | 9.37e+00 | 9.85e-01 | Female-biased |
| THYM | RBM46 | exon_skip_479585 | 8.64e+00 | 1.53e-03 | 9.13e+00 | 9.94e-01 | Female-biased |
| LUAD | ANKHD1 | exon_skip_479590 | 1.41e+01 | 6.89e-04 | 1.48e+01 | 9.99e-01 | Female-biased |
| KIRP | ANKHD1 | exon_skip_479590 | 1.43e+01 | 1.36e-04 | 1.51e+01 | 1.00e+00 | Female-biased |
| KIRP | RBM8A | exon_skip_479582 | 1.03e+01 | 1.32e-02 | 1.06e+01 | 9.86e-01 | Female-biased |
| ESCA | ANKHD1 | exon_skip_479590 | 1.39e+01 | 1.66e-03 | 1.46e+01 | 9.98e-01 | Female-biased |
| ESCA | RBM8A | exon_skip_479582 | 1.05e+01 | 9.81e-01 | 1.02e+01 | 1.78e-02 | Male-biased |
| THCA | ANKHD1 | exon_skip_479590 | 1.45e+01 | 2.21e-03 | 1.49e+01 | 9.98e-01 | Female-biased |
| THCA | FXR1 | exon_skip_479585 | 9.12e+00 | 9.95e-01 | 8.70e+00 | 1.66e-03 | Male-biased |
| THCA | RBM46 | exon_skip_479585 | 8.97e+00 | 9.94e-01 | 8.54e+00 | 1.77e-03 | Male-biased |
| PCPG | FXR1 | exon_skip_479585 | 9.24e+00 | 9.93e-01 | 8.82e+00 | 3.17e-03 | Male-biased |
| PCPG | RBM46 | exon_skip_479585 | 9.18e+00 | 9.89e-01 | 8.83e+00 | 7.32e-03 | Male-biased |
| MESO | ANKHD1 | exon_skip_479590 | 1.39e+01 | 3.00e-03 | 1.44e+01 | 9.97e-01 | Female-biased |
| GBM | ANKHD1 | exon_skip_479590 | 1.40e+01 | 6.39e-04 | 1.47e+01 | 9.99e-01 | Female-biased |
| GBM | FXR1 | exon_skip_479585 | 8.57e+00 | 1.63e-03 | 9.09e+00 | 9.94e-01 | Female-biased |
| GBM | RBM46 | exon_skip_479585 | 8.61e+00 | 1.85e-03 | 9.11e+00 | 9.94e-01 | Female-biased |
| PAAD | ANKHD1 | exon_skip_479590 | 1.47e+01 | 1.00e+00 | 1.40e+01 | 2.12e-04 | Male-biased |
| KIRC | FXR1 | exon_skip_479585 | 8.61e+00 | 2.37e-03 | 9.06e+00 | 9.94e-01 | Female-biased |
| WDR91 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000105875 | IBA57-DT,hsa-mir-483,WDR91 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000105875 | AC026362.1,hsa-mir-483,WDR91 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000105875 | AC015712.2,hsa-mir-483,WDR91 | Male-specific ceRNA | TCGA-KIRP |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs34648047 | chr7:138909904:G:A | - | 0.125384564299455 | 0.00445894568246405 | LUSC | Female-baised eQTL |
| rs66511422 | chr7:128407454:C:T | - | 0.144623802212759 | 0.0160790131688669 | LUSC | Female-baised eQTL |
| rs11766548 | chr7:128408118:G:A | - | 0.144623802212759 | 0.0160790131688669 | LUSC | Female-baised eQTL |
| rs11769333 | chr7:128407703:T:G | - | 0.130393854114753 | 0.0424307463499479 | LUSC | Female-baised eQTL |
| rs149175557 | chr7:131291377:C:T | - | 0.214652330729395 | 0.0200950659458346 | BLCA | Female-baised eQTL |
| rs2290359 | chr7:134870747:G:A | - | 0.132306696846554 | 0.0308220009050988 | BLCA | Female-baised eQTL |
| rs7781307 | chr7:134871567:G:A | - | 0.132306696846554 | 0.0308220009050988 | BLCA | Female-baised eQTL |
| rs12668115 | chr7:137227291:T:C | - | 0.0835164347193119 | 0.00606165775267244 | LUAD | Female-baised eQTL |
| rs2166639 | chr7:130931470:A:G | - | 0.0923468940990624 | 0.0181604883507913 | LUAD | Female-baised eQTL |
| rs832970 | chr7:137146875:T:C | - | 0.0912995487242594 | 0.0187072287149255 | LUAD | Female-baised eQTL |
| rs11505752 | chr7:137228156:A:G | - | 0.0499479400820602 | 0.0227936958313674 | LUAD | Female-baised eQTL |
| rs10954577 | chr7:137230068:A:G | - | 0.0489505575854501 | 0.0258529029395149 | LUAD | Female-baised eQTL |
| rs17168993 | chr7:137232004:G:C | - | 0.0490185524417136 | 0.0270518617790174 | LUAD | Female-baised eQTL |
| rs207248 | chr7:130932354:T:C | - | -0.0876805649651541 | 0.0287988360573189 | LUAD | Female-baised eQTL |
| rs1579354 | chr7:137219639:T:C | - | 0.0478987425376163 | 0.0373577718944515 | LUAD | Female-baised eQTL |
| rs1376610 | chr7:137223894:A:G | - | 0.046664012704282 | 0.0427341484114558 | LUAD | Female-baised eQTL |
| rs1376611 | chr7:137223898:T:C | - | 0.046664012704282 | 0.0427341484114558 | LUAD | Female-baised eQTL |
| rs1477523 | chr7:137120391:C:T | - | 0.07743167323829 | 0.0492843240634957 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs35081291 | chr7:128116463:C:T | - | 0.103476677709093 | 0.0245111385258882 | STAD | Male-baised eQTL |
| rs13232763 | chr7:127216175:T:C | - | 0.081420795899642 | 0.0454473220697755 | STAD | Male-baised eQTL |
| rs3808096 | chr7:127720376:G:C | - | 0.0895845206018548 | 0.0470626666995762 | STAD | Male-baised eQTL |
| rs66594425 | chr7:139472131:G:A | - | 0.0794749042146089 | 0.0264577283795379 | KIRC | Male-baised eQTL |
| rs67371091 | chr7:139472141:A:G | - | 0.0794749042146089 | 0.0264577283795379 | KIRC | Male-baised eQTL |
| rs3250 | chr7:135160680:G:A | - | -0.0415949687858645 | 0.0380272592339821 | KIRC | Male-baised eQTL |
| rs7790371 | chr7:135156851:G:C | - | -0.0418677163769709 | 0.0434158065663382 | KIRC | Male-baised eQTL |
| rs143401884 | chr7:135070676:T:C | - | -0.0419403508733245 | 0.0452905608377392 | KIRC | Male-baised eQTL |
| rs1035695 | chr7:135159223:A:G | - | -0.0411366377730603 | 0.0464253842254149 | KIRC | Male-baised eQTL |
| rs1080421 | chr7:135156487:G:A | - | -0.0413844395673126 | 0.0475267689757906 | KIRC | Male-baised eQTL |
| rs6948631 | chr7:125940698:C:T | - | 0.136100094192281 | 0.00213142156103125 | COAD | Male-baised eQTL |
| rs11770190 | chr7:125931177:T:A | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs78979976 | chr7:125934555:G:A | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs75117886 | chr7:125936540:G:A | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs11767202 | chr7:125936931:G:A | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs117786475 | chr7:125940109:A:C | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs141333220 | chr7:125940182:G:A | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs118066470 | chr7:125941423:C:T | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs77304425 | chr7:125941823:G:A | - | 0.141049797747092 | 0.00215210265156466 | COAD | Male-baised eQTL |
| rs79520850 | chr7:125957424:A:G | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs76622171 | chr7:125960073:G:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11764215 | chr7:125963394:G:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11764312 | chr7:125963721:G:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs77641952 | chr7:125966361:T:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs75898084 | chr7:125967050:C:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs113684181 | chr7:125968417:A:G | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs74376893 | chr7:125968751:T:C | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs79037194 | chr7:125969799:A:C | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs77052497 | chr7:125969855:G:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs115852569 | chr7:125969898:T:C | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs74418987 | chr7:125970383:G:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11772082 | chr7:125972033:C:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs75393581 | chr7:125974395:A:G | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs75059720 | chr7:125975138:C:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs77532128 | chr7:125975895:T:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs79451102 | chr7:125977349:G:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11760922 | chr7:125979593:C:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11761071 | chr7:125980195:C:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11761112 | chr7:125980235:G:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs76296444 | chr7:125981220:T:C | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs78678626 | chr7:125982399:T:C | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11761716 | chr7:125983864:A:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs11768643 | chr7:125984067:G:A | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs114412966 | chr7:125986758:C:T | - | 0.116615778727318 | 0.0138356223822249 | COAD | Male-baised eQTL |
| rs78577329 | chr7:125968807:C:T | - | 0.113710519000755 | 0.015385412883821 | COAD | Male-baised eQTL |
| rs6947104 | chr7:125945803:A:C | - | 0.114513456331414 | 0.0155018703076058 | COAD | Male-baised eQTL |
| rs75073140 | chr7:125946349:A:G | - | 0.114513456331414 | 0.0155018703076058 | COAD | Male-baised eQTL |
| rs28621973 | chr7:125948390:A:G | - | 0.114513456331414 | 0.0155018703076058 | COAD | Male-baised eQTL |
| rs76659164 | chr7:125952586:T:C | - | 0.114513456331414 | 0.0155018703076058 | COAD | Male-baised eQTL |
| rs76598458 | chr7:125939023:A:G | - | 0.114617278032676 | 0.0184664556494858 | COAD | Male-baised eQTL |
| rs113603357 | chr7:125949749:G:A | - | 0.114990991851771 | 0.0197185837680115 | COAD | Male-baised eQTL |
| rs11760285 | chr7:128539076:A:G | - | 0.108950050878144 | 0.0198775531125874 | COAD | Male-baised eQTL |
| rs11764707 | chr7:125833878:G:A | - | 0.1138713844129 | 0.0379412038861469 | COAD | Male-baised eQTL |
| rs41734 | chr7:139933369:C:T | - | -0.119633823419686 | 0.0398229865704387 | COAD | Male-baised eQTL |
| rs4275146 | chr7:125850588:C:T | - | 0.111713629781113 | 0.0410932891915347 | COAD | Male-baised eQTL |
| rs10248445 | chr7:125820891:T:C | - | 0.104961511310757 | 0.0441440641016925 | COAD | Male-baised eQTL |
| rs10248470 | chr7:125820954:T:A | - | 0.104961511310757 | 0.0441440641016925 | COAD | Male-baised eQTL |
| rs7784642 | chr7:128531217:G:T | - | 0.0853906570274738 | 0.0470607351877309 | COAD | Male-baised eQTL |
| rs6467181 | chr7:128533335:C:A | - | 0.0853906570274738 | 0.0470607351877309 | COAD | Male-baised eQTL |
| rs11766319 | chr7:128538771:C:G | - | 0.0853906570274738 | 0.0470607351877309 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of WDR91 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
