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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000105193

Summary for RPS16

check button Gene summary

Gene informationEnsembl ID

ENSG00000105193

Gene symbol

RPS16

Gene nameribosomal protein S16
HGNC

10396

Entrez ID

6217

Gene typeprotein_coding
SynonymsRPS16|S16
UniProtAcc

P62249


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for RPS16

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for RPS16

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for RPS16

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg11374355chr19:39435020CGI:chr19:39435584-39436223promoter,exon,gene body5.01e-016.12e-01-3.48e+004.96e-048.36e-04-1.11e-01
LUSCcg11374355chr19:39435020CGI:chr19:39435584-39436223promoter,exon,gene body3.58e-015.97e-01-4.27e+001.94e-055.26e-04-2.40e-01
CHOLcg11374355chr19:39435020CGI:chr19:39435584-39436223promoter,exon,gene body3.94e-015.94e-01-2.80e+005.09e-031.63e-02-2.00e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg20641794chr19:39436855CGI:chr19:39435584-39436223promoter6.51e-015.49e-017.77e+007.72e-152.77e-141.02e-01
BRCAcg11374355chr19:39435020CGI:chr19:39435584-39436223promoter,exon,gene body3.73e-014.91e-01-8.88e+006.83e-193.37e-18-1.18e-01

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Exon skipping events with PSI in TCGA for RPS16

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for RPS16

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for RPS16

check buttonTFs related to RPS16.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
BRCAPLAGL2RPS163.74e+001.20e-024.89e+009.83e-01Female-biased
READPLAGL2RPS164.60e+009.89e-013.56e+004.22e-03Male-biased
READZNF101RPS164.20e+009.81e-013.24e+005.56e-03Male-biased
SARCPLAGL2RPS164.07e+009.84e-013.21e+001.76e-03Male-biased

check buttonRPS16 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for RPS16

check buttonRBPs related to ES in RPS16.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
STADRBM8Aexon_skip_3185151.17e+018.12e-031.21e+019.91e-01Female-biased
THYMRBM4exon_skip_3185159.68e+009.90e-019.33e+007.03e-03Male-biased
THYMRBM8Aexon_skip_3185151.24e+019.97e-011.19e+012.25e-03Male-biased
LIHCRBM4exon_skip_3185159.94e+009.94e-019.41e+003.36e-03Male-biased
LIHCRBM8Aexon_skip_3185151.25e+019.97e-011.19e+012.14e-03Male-biased
LUADRBM4exon_skip_3185159.56e+002.97e-031.00e+019.95e-01Female-biased
LUADRBM8Aexon_skip_3185151.22e+011.36e-031.27e+019.98e-01Female-biased
KIRPRBM8Aexon_skip_3185151.21e+014.76e-031.25e+019.95e-01Female-biased
ESCARBM8Aexon_skip_3185151.19e+019.58e-031.23e+019.90e-01Female-biased
READRBM8Aexon_skip_3185151.25e+011.05e-021.28e+019.89e-01Female-biased
MESORBM8Aexon_skip_3185151.20e+012.32e-031.25e+019.97e-01Female-biased
LGGRBM4exon_skip_3185159.55e+001.53e-029.85e+009.83e-01Female-biased
LGGRBM8Aexon_skip_3185151.21e+011.95e-031.26e+019.98e-01Female-biased
KIRCRBM4exon_skip_3185159.77e+008.34e-031.01e+019.90e-01Female-biased
KIRCRBM8Aexon_skip_3185151.24e+011.59e-031.29e+019.98e-01Female-biased
BLCARBM4exon_skip_3185159.29e+005.76e-039.70e+009.92e-01Female-biased
BLCARBM8Aexon_skip_3185151.19e+015.06e-031.24e+019.94e-01Female-biased

check buttonRPS16 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs1972723chr19:48054483:G:T--0.1748577184295620.0353150949153055READFemale-baised eQTL
rs1972722chr19:48054486:G:T--0.1748577184295620.0353150949153055READFemale-baised eQTL
rs744399chr19:48054746:A:C--0.1748577184295620.0353150949153055READFemale-baised eQTL
rs1529479chr19:48055131:T:C--0.1748577184295620.0353150949153055READFemale-baised eQTL
rs10412833chr19:42304191:C:G-0.1526696593938820.00155251977573937HNSCFemale-baised eQTL
rs7246789chr19:42306394:T:C-0.1526696593938820.00155251977573937HNSCFemale-baised eQTL
rs1206009chr19:42316378:A:G-0.1526696593938820.00155251977573937HNSCFemale-baised eQTL
rs1676220chr19:42326931:T:C-0.1526696593938820.00155251977573937HNSCFemale-baised eQTL
rs1676221chr19:42328209:A:G-0.1526696593938820.00155251977573937HNSCFemale-baised eQTL
rs13346991chr19:42360426:A:G-0.1526696593938820.00155251977573937HNSCFemale-baised eQTL
rs1676217chr19:42306029:A:G-0.1526419445388960.00158251507895892HNSCFemale-baised eQTL
rs1206035chr19:42337631:T:C-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs7255956chr19:42338450:A:C-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs7260287chr19:42338642:T:G-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs862228chr19:42341242:T:C-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs865436chr19:42342599:G:T-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206044chr19:42344663:T:C-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206042chr19:42346101:T:C-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1676211chr19:42348328:G:A-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206029chr19:42349849:T:G-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206027chr19:42353293:A:G-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206041chr19:42357141:G:A-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206040chr19:42357700:A:G-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1206038chr19:42358883:A:G-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1613100chr19:42363395:G:T-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1676215chr19:42365272:T:C-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1654623chr19:42365404:T:G-0.1388753500874140.00672159586740463HNSCFemale-baised eQTL
rs1676213chr19:42363917:T:C-0.1384175128072070.00725309456306671HNSCFemale-baised eQTL
rs185434905chr19:40086134:T:G-0.1299080642482020.0107251438274924HNSCFemale-baised eQTL
rs62105841chr19:29705085:C:T-0.1015134648096070.0153891662563352HNSCFemale-baised eQTL
rs62105838chr19:29699194:G:T-0.1012084251506840.0159841566346692HNSCFemale-baised eQTL
rs62105840chr19:29701567:C:T-0.1012084251506840.0159841566346692HNSCFemale-baised eQTL
rs137952348chr19:29703482:G:A-0.1012084251506840.0159841566346692HNSCFemale-baised eQTL
rs851296chr19:42372142:T:C-0.1318057013849150.018182494940874HNSCFemale-baised eQTL
rs62105835chr19:29697634:C:T-0.1001238627856230.0189100441300194HNSCFemale-baised eQTL
rs62105836chr19:29697755:C:T-0.1001238627856230.0189100441300194HNSCFemale-baised eQTL
rs79337477chr19:29698804:A:T-0.1001238627856230.0189100441300194HNSCFemale-baised eQTL
rs17304618chr19:35379534:A:G-0.1247356506003690.0264971598462619HNSCFemale-baised eQTL
rs8106032chr19:40080794:A:C-0.1038321322275540.0454485432729355HNSCFemale-baised eQTL
rs851294chr19:42373240:G:A-0.1198070638488460.0470481595291957HNSCFemale-baised eQTL
rs57569766chr19:41723244:G:A-0.2718278965037390.0013591866056365KIRPFemale-baised eQTL
rs2239509chr19:36120359:C:T-0.1688484434000040.0252822321938198LIHCFemale-baised eQTL
rs241950chr19:37778493:C:G-0.0904699132494250.00477844640683337KIRCFemale-baised eQTL
rs856304chr19:37770270:G:A-0.08662650285375040.00664764642424184KIRCFemale-baised eQTL
rs171376chr19:37776353:C:T-0.08662650285375040.00664764642424184KIRCFemale-baised eQTL
rs241933chr19:37765477:G:A-0.08564444087919720.00793909409759618KIRCFemale-baised eQTL
rs241932chr19:37766056:G:T-0.08564444087919720.00793909409759618KIRCFemale-baised eQTL
rs11673023chr19:37748881:A:C--0.08371706971481550.0124044647890789KIRCFemale-baised eQTL
rs12974225chr19:37749458:G:T--0.08371706971481550.0124044647890789KIRCFemale-baised eQTL
rs1291chr19:37738477:G:A--0.08091451278619830.0150443288191336KIRCFemale-baised eQTL
rs4803195chr19:37524104:G:T-0.08261199544236480.0218399204676387KIRCFemale-baised eQTL
rs7255952chr19:37497895:A:G-0.08381427285450710.0416122995822468KIRCFemale-baised eQTL
rs10048511chr19:37769026:G:A-0.08253595334187520.0425722883080967KIRCFemale-baised eQTL
rs62108337chr19:37694112:G:A--0.0784298554950480.045153993862529KIRCFemale-baised eQTL
rs7246461chr19:37705680:C:G--0.07824009154586620.0456254345327239KIRCFemale-baised eQTL
rs12979640chr19:37688255:T:C--0.07822830559472290.0466530333184258KIRCFemale-baised eQTL
rs10420746chr19:37783825:G:A-0.08151363875447350.0476397111190493KIRCFemale-baised eQTL
rs6508742chr19:37785051:C:T-0.08151363875447350.0476397111190493KIRCFemale-baised eQTL
rs9304569chr19:37787493:C:G-0.08151363875447350.0476397111190493KIRCFemale-baised eQTL
rs10409402chr19:37794226:G:A-0.08151363875447350.0476397111190493KIRCFemale-baised eQTL
rs10409487chr19:37794471:A:G-0.08151363875447350.0476397111190493KIRCFemale-baised eQTL
rs11083432chr19:37691732:A:G--0.07774394368497570.049297120017636KIRCFemale-baised eQTL
rs958305chr19:37698539:T:C--0.07774394368497570.049297120017636KIRCFemale-baised eQTL
rs56317671chr19:37704004:A:G--0.07774394368497570.049297120017636KIRCFemale-baised eQTL
rs3760932chr19:32344285:T:C-0.2700428969478950.0149477425320176BLCAFemale-baised eQTL
rs1633919chr19:35203303:A:G-0.04518399589465820.0103522557036306LUADFemale-baised eQTL
rs1633918chr19:35203136:A:T-0.04412503372567810.0132107353364116LUADFemale-baised eQTL
rs1633920chr19:35203416:A:G-0.04385567543486770.0141834677670869LUADFemale-baised eQTL
rs1687990chr19:35203870:A:G-0.04327366354229110.0172081544641752LUADFemale-baised eQTL
rs12609432chr19:46499075:A:C-0.07386448766062250.0278176651332575LUADFemale-baised eQTL
rs77480971chr19:46499089:T:C-0.07386448766062250.0278176651332575LUADFemale-baised eQTL
rs60477322chr19:48145873:C:T-0.07176601927684170.0314904977465536LUADFemale-baised eQTL
rs16980543chr19:46499658:C:A-0.06770228884947950.0388570904670213LUADFemale-baised eQTL
rs77640585chr19:46499848:C:T-0.06941990213437050.0406169719034328LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs56346609chr19:39430280:A:C-0.07330047191683610.0226182738714939HNSCMale-baised eQTL
rs8111775chr19:39461212:T:C-0.06787834280161410.0306137532813339HNSCMale-baised eQTL
rs35904652chr19:39462156:G:T-0.06787834280161410.0306137532813339HNSCMale-baised eQTL
rs12975657chr19:39462378:T:C-0.06787834280161410.0306137532813339HNSCMale-baised eQTL
rs68180880chr19:39462900:T:C-0.06787834280161410.0306137532813339HNSCMale-baised eQTL
rs2304217chr19:39464893:G:A-0.06777407285941850.0324441835464457HNSCMale-baised eQTL
rs12985456chr19:39465606:G:A-0.06777407285941850.0324441835464457HNSCMale-baised eQTL
rs8106596chr19:39467206:A:G-0.06777407285941850.0324441835464457HNSCMale-baised eQTL
rs35837334chr19:39440741:C:Genhancer0.06864431568899020.0333795182858002HNSCMale-baised eQTL
rs66667783chr19:39437059:G:Apromoter0.06868139336486540.0370060906717377HNSCMale-baised eQTL
rs34892537chr19:39456442:G:A-0.06705753596590270.0407306837259612HNSCMale-baised eQTL
rs55824805chr19:39448809:G:A-0.06700996303920570.0440822904196499HNSCMale-baised eQTL
rs67509161chr19:39449695:G:A-0.06700996303920570.0440822904196499HNSCMale-baised eQTL
rs35061477chr19:39463611:C:T-0.06610483160713190.0499444832260103HNSCMale-baised eQTL
rs16975124chr19:41276791:A:G-0.06757223797875830.015873993743609LIHCMale-baised eQTL
rs1989583chr19:46170754:T:C--0.1063197455300640.0148337225228047LGGMale-baised eQTL
rs62103132chr19:34020897:C:T-0.05742048985913190.014782008478886BLCAMale-baised eQTL
rs78167885chr19:34017868:G:T-0.05433166705722880.0246562222695591BLCAMale-baised eQTL
rs55897610chr19:34023790:C:A-0.05502403167416540.0249356138551521BLCAMale-baised eQTL
rs62103104chr19:34005508:A:G-0.05261903201107620.0328086169416463BLCAMale-baised eQTL
rs62103105chr19:34009775:C:T-0.05261903201107620.0328086169416463BLCAMale-baised eQTL
rs74460433chr19:34012386:C:T-0.05261903201107620.0328086169416463BLCAMale-baised eQTL
rs55722288chr19:34016070:G:T-0.05033812342054880.0334901166408047BLCAMale-baised eQTL
rs62103100chr19:33992789:G:C-0.05246245343019620.0340868342903841BLCAMale-baised eQTL
rs62103102chr19:33994969:G:A-0.05246245343019620.0340868342903841BLCAMale-baised eQTL
rs62103103chr19:33995407:T:C-0.05246245343019620.0340868342903841BLCAMale-baised eQTL
rs6510408chr19:34014040:C:T-0.0486596559391060.0445334407983065BLCAMale-baised eQTL
rs56359001chr19:39800446:C:T-0.08384474575375650.00791367695103126LUADMale-baised eQTL
rs79104930chr19:36033677:A:G-0.08990207784981310.0221903446167361LUADMale-baised eQTL
rs137979608chr19:39786727:G:A-0.07920055393765230.0427849224200072LUADMale-baised eQTL
rs142554971chr19:39786728:G:A-0.07920055393765230.0427849224200072LUADMale-baised eQTL
rs2198895chr19:30878287:A:G-0.05901333950761280.000826493326618111COADMale-baised eQTL
rs4802446chr19:38439276:A:G--0.1266441212563470.00241289175447719COADMale-baised eQTL
rs599951chr19:48776883:C:T-0.04591074412796880.0374272572258602COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000105193
CpG Site: cg20641794
Position to Gene: promoter
Male Effect: -0.320330168116226
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg20641794chr19:39436855promoter-0.3203301681162262.2625668767663e-12-0.436707867172957236.901275542328056e-15LGG

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of RPS16

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource