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Gene: ENSG00000104892 |
Summary for KLC3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000104892 | Gene symbol | KLC3 |
| Gene name | kinesin light chain 3 | |
| HGNC | 20717 | |
| Entrez ID | 147700 | |
| Gene type | protein_coding | |
| Synonyms | KLC3|KLC2L|KNS2B|KLCt | |
| UniProtAcc | Q6P597 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for KLC3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KLC3 | 5.17e+02 | 4.46e+00 | 5.53e-01 | 8.06e+00 | 7.42e-16 | 6.14e-14 | BLCA |
| KLC3 | 1.97e+02 | 4.16e+00 | 6.64e-01 | 6.26e+00 | 3.90e-10 | 5.94e-09 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for KLC3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for KLC3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for KLC3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for KLC3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for KLC3 |
| TFs related to KLC3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | KLC3 | 3.30e+00 | 8.43e-03 | 4.56e+00 | 9.83e-01 | Female-biased |
| LGG | ZNF235 | KLC3 | 4.03e+00 | 9.81e-01 | 3.29e+00 | 2.25e-03 | Male-biased |
| KLC3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for KLC3 |
| RBPs related to ES in KLC3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KICH | ZC3H10 | exon_skip_308386 | 7.23e+00 | 6.48e-03 | 7.59e+00 | 9.83e-01 | Female-biased |
| HNSC | ZC3H10 | exon_skip_308385 | 6.89e+00 | 9.83e-01 | 6.37e+00 | 2.09e-03 | Male-biased |
| KLC3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000104892 | AC108676.1,hsa-mir-665,KLC3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000104892 | MIR4435-2HG,hsa-mir-665,KLC3 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000104892 | OGFRP1,hsa-mir-665,KLC3 | Male-specific ceRNA | TCGA-BLCA |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs230259 | chr19:35865667:T:C | - | 0.116227515256046 | 0.0386058196341663 | LUSC | Female-baised eQTL |
| rs230260 | chr19:35867661:T:C | - | 0.116227515256046 | 0.0386058196341663 | LUSC | Female-baised eQTL |
| rs376240 | chr19:35870188:T:C | - | 0.116227515256046 | 0.0386058196341663 | LUSC | Female-baised eQTL |
| rs56264349 | chr19:35879953:G:A | - | 0.113984444053608 | 0.0407895218005525 | LUSC | Female-baised eQTL |
| rs112400286 | chr19:35886629:A:G | - | 0.113984444053608 | 0.0407895218005525 | LUSC | Female-baised eQTL |
| rs7251744 | chr19:35886838:C:T | - | 0.113984444053608 | 0.0407895218005525 | LUSC | Female-baised eQTL |
| rs7258909 | chr19:35887097:T:G | - | 0.113984444053608 | 0.0407895218005525 | LUSC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs683856 | chr19:50319151:T:G | - | -0.0561941988909009 | 0.00318302320624917 | BLCA | Male-baised eQTL |
| rs77003470 | chr19:38492894:C:A | - | 0.0869346531703075 | 0.0396545008807579 | BLCA | Male-baised eQTL |
| rs10426462 | chr19:54340652:C:T | - | -0.0729512437454395 | 0.00166487862010609 | LUAD | Male-baised eQTL |
| rs58899236 | chr19:40092055:G:A | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| rs337784 | chr19:40092852:C:A | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| rs337785 | chr19:40092925:T:C | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| rs337786 | chr19:40093067:G:A | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| rs337789 | chr19:40093696:C:A | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| rs337790 | chr19:40093813:C:A | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| rs337791 | chr19:40094114:C:A | - | 0.122299859075082 | 0.0146400007876236 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000104892 |
| CpG Site: cg13668450 | |
| Position to Gene: gene | |
| Male Effect: -0.241898508267897 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13668450 | chr19:45341338 | gene | -0.241898508267897 | 4.96765683224376e-08 | -0.4184499020403962 | 7.264342670716054e-11 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of KLC3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
