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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000104221

Summary for BRF2

check button Gene summary

Gene informationEnsembl ID

ENSG00000104221

Gene symbol

BRF2

Gene nameBRF2 RNA polymerase III transcription initiation factor subunit
HGNC

17298

Entrez ID

55290

Gene typeprotein_coding
SynonymsBRF2|FLJ11052|BRFU|TFIIIB50
UniProtAcc

Q9HAW0


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for BRF2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BRF27.37e+021.09e+001.73e-016.26e+003.89e-101.00e-09LUSC

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for BRF2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for BRF2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg22871204chr8:37851387CGI:chr8:37849631-37849989promoter8.16e-019.40e-01-4.07e+004.73e-051.38e-04-1.24e-01
LUSCcg20466478chr8:37851091CGI:chr8:37849631-37849989promoter4.70e-018.49e-01-3.50e+004.58e-041.57e-03-3.79e-01
LUSCcg19904653chr8:37850174CGI:chr8:37849631-37849989promoter1.40e-012.69e-01-2.84e+004.51e-037.55e-03-1.29e-01
LUSCcg22871204chr8:37851387CGI:chr8:37849631-37849989promoter7.77e-019.45e-01-3.28e+001.04e-032.67e-03-1.67e-01
BLCAcg22871204chr8:37851387CGI:chr8:37849631-37849989promoter7.61e-019.38e-01-3.79e+001.50e-045.37e-04-1.77e-01
LIHCcg02894896chr8:37849203CGI:chr8:37849631-37849989promoter,gene body3.50e-014.69e-01-4.26e+002.04e-055.09e-05-1.19e-01
LIHCcg19904653chr8:37850174CGI:chr8:37849631-37849989promoter1.98e-013.00e-01-2.09e+003.67e-023.82e-02-1.02e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for BRF2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for BRF2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for BRF2

check buttonTFs related to BRF2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCMSX2BRF24.60e+009.80e-013.90e+001.54e-02Male-biased
ACCSPI1BRF24.09e+009.82e-013.23e+007.66e-03Male-biased
ACCSPIBBRF24.14e+009.82e-013.31e+008.50e-03Male-biased
BLCABARX1BRF24.72e+009.93e-013.50e+002.50e-03Male-biased
BLCABCL6BBRF24.37e+009.84e-013.50e+007.86e-03Male-biased
BLCAELF3BRF24.24e+009.89e-012.69e+007.82e-04Male-biased
BLCAMSX1BRF24.58e+009.93e-013.12e+001.07e-03Male-biased
BLCAMSX2BRF24.53e+009.93e-013.11e+001.24e-03Male-biased
BLCASOX8BRF24.28e+009.88e-013.07e+002.37e-03Male-biased
BLCATCF7L2BRF24.21e+009.81e-013.37e+008.22e-03Male-biased
BLCAZNF45BRF24.23e+009.85e-013.18e+004.15e-03Male-biased
BLCAZNF653BRF25.76e+009.84e-015.05e+001.47e-02Male-biased
BLCAZNF8BRF24.51e+009.88e-013.52e+005.18e-03Male-biased
BLCAZNF85BRF24.19e+009.86e-013.03e+002.78e-03Male-biased
MESOBARX1BRF23.65e+003.84e-035.23e+009.94e-01Female-biased
MESOELF3BRF23.04e+007.58e-045.04e+009.96e-01Female-biased
MESOELK4BRF24.79e+009.86e-013.56e+009.40e-03Male-biased
MESOGABPABRF24.69e+009.92e-013.14e+003.29e-03Male-biased
MESOKLF2BRF23.86e+009.82e-011.80e+004.70e-04Male-biased
MESOKLF6BRF23.97e+009.84e-012.18e+001.24e-03Male-biased
MESOMSX1BRF23.26e+007.76e-045.26e+009.97e-01Female-biased
MESOMSX2BRF23.23e+007.57e-045.24e+009.97e-01Female-biased
MESOSOX8BRF23.26e+002.47e-034.96e+009.94e-01Female-biased
MESOSPI1BRF22.67e+001.98e-034.41e+009.90e-01Female-biased
MESOSPIBBRF22.90e+003.91e-034.45e+009.88e-01Female-biased
MESOSPICBRF22.99e+004.81e-034.49e+009.88e-01Female-biased
MESOTCF4BRF23.28e+008.44e-034.60e+009.85e-01Female-biased
MESOTCF7L2BRF23.45e+001.06e-024.70e+009.84e-01Female-biased
MESOZNF121BRF24.17e+009.86e-012.58e+002.60e-03Male-biased
MESOZNF181BRF24.15e+009.86e-012.60e+003.04e-03Male-biased
MESOZNF200BRF24.74e+009.90e-013.32e+004.96e-03Male-biased
MESOZNF33ABRF24.20e+009.87e-012.61e+002.63e-03Male-biased
MESOZNF443BRF24.20e+009.83e-012.85e+006.15e-03Male-biased
MESOZNF45BRF23.36e+006.03e-034.79e+009.89e-01Female-biased
MESOZNF519BRF24.04e+009.86e-012.00e+005.16e-04Male-biased
MESOZNF653BRF24.92e+001.67e-026.04e+009.82e-01Female-biased
MESOZNF770BRF24.12e+009.88e-011.76e+001.69e-04Male-biased
MESOZNF774BRF23.82e+009.80e-011.83e+006.03e-04Male-biased
MESOZNF8BRF23.69e+001.09e-024.95e+009.85e-01Female-biased
MESOZNF85BRF23.26e+002.26e-034.98e+009.94e-01Female-biased
SARCBARX1BRF24.58e+009.81e-014.06e+001.28e-02Male-biased
SARCELF3BRF24.16e+009.81e-013.52e+006.10e-03Male-biased
SARCPRDM6BRF24.30e+009.83e-013.67e+006.42e-03Male-biased
SARCZNF22BRF24.35e+009.81e-013.79e+009.76e-03Male-biased
SARCZNF225BRF24.32e+009.85e-013.66e+005.55e-03Male-biased
SARCZNF235BRF24.57e+009.87e-013.94e+006.79e-03Male-biased
SARCZNF287BRF24.42e+009.86e-013.78e+006.07e-03Male-biased
SARCZNF384BRF24.14e+009.80e-013.51e+006.62e-03Male-biased
SARCZNF487BRF24.42e+009.84e-013.81e+007.36e-03Male-biased
SARCZNF492BRF24.24e+009.82e-013.62e+006.89e-03Male-biased
SARCZNF613BRF24.21e+009.81e-013.59e+007.01e-03Male-biased
SARCZNF98BRF24.32e+009.82e-013.73e+008.21e-03Male-biased

check buttonBRF2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for BRF2

check buttonRBPs related to ES in BRF2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
THYMSRSF9exon_skip_4891368.32e+009.85e-017.98e+007.68e-03Male-biased
COADSRSF9exon_skip_4891367.91e+001.17e-028.23e+009.81e-01Female-biased
BRCAZNF638exon_skip_4891441.50e+019.97e-011.42e+013.04e-03Male-biased
PCPGZNF638exon_skip_4891441.45e+018.79e-041.51e+019.99e-01Female-biased
MESOSRSF9exon_skip_4891368.27e+009.85e-017.89e+007.38e-03Male-biased
PAADZNF638exon_skip_4891441.44e+014.53e-041.49e+019.99e-01Female-biased
SKCMSRSF9exon_skip_4891367.91e+009.00e-038.27e+009.84e-01Female-biased
SARCZNF638exon_skip_4891441.46e+011.19e-031.52e+019.99e-01Female-biased

check buttonBRF2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs76863471chr8:40474758:C:T-0.1289063447278890.020956333136641SARCFemale-baised eQTL
rs79271245chr8:40465179:T:A-0.1216652508287440.0308458356688652SARCFemale-baised eQTL
rs60440912chr8:30946113:G:C-0.1047244555765110.0317707617156698SARCFemale-baised eQTL
rs4733207chr8:30950540:C:T-0.1047244555765110.0317707617156698SARCFemale-baised eQTL
rs6982626chr8:43656344:A:G--0.080701369450210.0343032785148553SARCFemale-baised eQTL
rs7462003chr8:43655551:C:A--0.08046943334518220.0355270235047792SARCFemale-baised eQTL
rs13272907chr8:43652260:A:G--0.07800575973541480.0417776533123831SARCFemale-baised eQTL
rs9643896chr8:43653060:T:G--0.07761282595647310.0441753799168867SARCFemale-baised eQTL
rs12234987chr8:40709355:G:A-0.2134400757987330.0109282849803391LUSCFemale-baised eQTL
rs62642759chr8:40797336:T:C-0.2065853622913620.0196282819209574LUSCFemale-baised eQTL
rs4999666chr8:40763991:A:C-0.2132164207337590.0298504145352823LUSCFemale-baised eQTL
rs11787332chr8:29371119:A:G-0.1478130304957350.0033521137569199LGGFemale-baised eQTL
rs9643874chr8:40346272:G:A-0.1450591840477650.00481700722795116LGGFemale-baised eQTL
rs116999589chr8:29380035:C:T-0.1365103906266350.0175769374346611LGGFemale-baised eQTL
rs1362888chr8:41843800:C:T--0.1183315591773840.0342527309592696LGGFemale-baised eQTL
rs2517396chr8:38131787:A:C--0.1349705568577260.0270659065432978BLCAFemale-baised eQTL
rs16879920chr8:32753550:T:C-0.09785770229185940.0278717023886444BLCAFemale-baised eQTL
rs16879927chr8:32755187:T:C-0.09785770229185940.0278717023886444BLCAFemale-baised eQTL
rs16884778chr8:36290090:T:C-0.1199395279286810.0407627261747289BLCAFemale-baised eQTL
rs1425778chr8:41441197:A:G--0.1472712933968210.0478854005588536BLCAFemale-baised eQTL
rs1425779chr8:41441738:G:C--0.1472712933968210.0478854005588536BLCAFemale-baised eQTL
rs2347500chr8:32435562:A:G-0.08257625811991010.000491741682126019LUADFemale-baised eQTL
rs72612107chr8:32436836:A:C-0.08017131035730820.000935387740252933LUADFemale-baised eQTL
rs13265329chr8:28201295:T:C--0.04588436072024570.0133245549270093LUADFemale-baised eQTL
rs2445013chr8:38516304:G:C-0.04411964976177180.0206009651420297LUADFemale-baised eQTL
rs2461328chr8:38516875:A:G-0.04411964976177180.0206009651420297LUADFemale-baised eQTL
rs35418033chr8:41558671:A:T-0.03490997851774970.0257167479714494LUADFemale-baised eQTL
rs879293chr8:42197628:C:T-0.06341276995408870.0310637677364747COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs67882526chr8:39533297:C:T-0.0988509672986150.0219894609929599HNSCMale-baised eQTL
rs13268839chr8:39540213:T:C-0.0988509672986150.0219894609929599HNSCMale-baised eQTL
rs7829181chr8:39532700:C:T-0.09866975189803680.0227311999570782HNSCMale-baised eQTL
rs1996510chr8:37261170:C:T-0.04954764212642360.0261925969480898HNSCMale-baised eQTL
rs12155955chr8:32096986:G:C-0.1131574249139580.0249724767724845THCAMale-baised eQTL
rs6987535chr8:27848771:A:C-0.05452433393231940.0302882280225011LIHCMale-baised eQTL
rs12545052chr8:39730819:A:C-0.04956339581980420.0486081525642229LIHCMale-baised eQTL
rs7819030chr8:34604741:C:T-0.05476997912112970.000317214860345031BLCAMale-baised eQTL
rs2974297chr8:42516255:G:C--0.04118895750775960.00927338506785341BLCAMale-baised eQTL
rs4739513chr8:37503128:C:G-0.03569368324868140.0133891056561471BLCAMale-baised eQTL
rs10093400chr8:28068279:A:T-0.04242136724438170.0436977160991384BLCAMale-baised eQTL
rs7014045chr8:31147780:T:A--0.08242183298318070.0139842540667998COADMale-baised eQTL
rs16876093chr8:29875137:T:G--0.07561107368632920.0190784619634772COADMale-baised eQTL
rs2737344chr8:31159342:G:A-0.08157972752631220.0206286173999618COADMale-baised eQTL
rs2737342chr8:31156444:G:A-0.08044067531070980.0243144532678908COADMale-baised eQTL
rs62506103chr8:31159020:C:T--0.07955868075597440.0277762236186605COADMale-baised eQTL
rs17652261chr8:31146927:T:C--0.07574435388245910.0379170954076738COADMale-baised eQTL
rs6996520chr8:31149213:C:T--0.07574435388245910.0379170954076738COADMale-baised eQTL
rs11574360chr8:31147999:C:T--0.07505811304663470.0412035715140384COADMale-baised eQTL
rs17652297chr8:31146949:T:A--0.07431544445000450.0492636993566322COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000104221
CpG Site: cg02894896
Position to Gene: gene,promoter
Male Effect: -0.0483115836124448
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg02894896chr8:37849203gene,promoter-0.04831158361244482.24722239993308e-05-0.34190555590307481.993420141187854e-07STAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of BRF2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource