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Gene: ENSG00000101391 |
Summary for CDK5RAP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000101391 | Gene symbol | CDK5RAP1 |
| Gene name | CDK5 regulatory subunit associated protein 1 | |
| HGNC | 15880 | |
| Entrez ID | 51654 | |
| Gene type | protein_coding | |
| Synonyms | CDK5RAP1|CGI-05|HSPC167|C42 | |
| UniProtAcc | Q96SZ6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CDK5RAP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CDK5RAP1 | 1.50e+03 | 1.31e+00 | 2.12e-01 | 6.16e+00 | 7.39e-10 | 1.60e-08 | READ |
Top |
Sex-biased somatic mutation for CDK5RAP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CDK5RAP1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| DLBC | cg01060964 | chr20:33402177 | CGI:chr20:33401338-33401612 | promoter | 3.56e-01 | 4.82e-01 | -2.26e+00 | 2.41e-02 | 3.84e-02 | -1.26e-01 |
| DLBC | cg26688574 | chr20:33402183 | CGI:chr20:33401338-33401612 | promoter | 3.70e-01 | 5.12e-01 | -2.13e+00 | 3.31e-02 | 4.38e-02 | -1.42e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg01060964 | chr20:33402177 | CGI:chr20:33401338-33401612 | promoter | 5.88e-01 | 7.14e-01 | -2.79e+00 | 5.22e-03 | 7.37e-03 | -1.26e-01 |
| LUSC | cg01060964 | chr20:33402177 | CGI:chr20:33401338-33401612 | promoter | 5.09e-01 | 6.97e-01 | -3.27e+00 | 1.06e-03 | 2.70e-03 | -1.88e-01 |
| LUSC | cg26688574 | chr20:33402183 | CGI:chr20:33401338-33401612 | promoter | 5.43e-01 | 6.97e-01 | -2.70e+00 | 6.86e-03 | 1.04e-02 | -1.55e-01 |
| BLCA | cg26688574 | chr20:33402183 | CGI:chr20:33401338-33401612 | promoter | 5.31e-01 | 7.42e-01 | -3.41e+00 | 6.40e-04 | 1.61e-03 | -2.11e-01 |
| CHOL | cg01060964 | chr20:33402177 | CGI:chr20:33401338-33401612 | promoter | 5.30e-01 | 8.21e-01 | -2.29e+00 | 2.23e-02 | 3.24e-02 | -2.91e-01 |
| CHOL | cg26688574 | chr20:33402183 | CGI:chr20:33401338-33401612 | promoter | 5.37e-01 | 8.37e-01 | -2.58e+00 | 9.87e-03 | 2.15e-02 | -3.00e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for CDK5RAP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CDK5RAP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CDK5RAP1 |
| TFs related to CDK5RAP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | HESX1 | CDK5RAP1 | 3.21e+00 | 9.97e-03 | 4.26e+00 | 9.81e-01 | Female-biased |
| GBM | ZNF235 | CDK5RAP1 | 2.19e+00 | 1.60e-03 | 3.94e+00 | 9.82e-01 | Female-biased |
| GBM | ZNF554 | CDK5RAP1 | 4.14e+00 | 9.86e-01 | 2.14e+00 | 4.81e-04 | Male-biased |
| GBM | ZNF619 | CDK5RAP1 | 4.13e+00 | 9.86e-01 | 1.94e+00 | 2.28e-04 | Male-biased |
| GBM | ZNF780A | CDK5RAP1 | 4.20e+00 | 9.87e-01 | 2.40e+00 | 1.01e-03 | Male-biased |
| CDK5RAP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CDK5RAP1 |
| RBPs related to ES in CDK5RAP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PCPG | BRUNOL6 | exon_skip_355821 | 6.88e+00 | 9.81e-01 | 6.50e+00 | 4.63e-03 | Male-biased |
| GBM | HNRNPH2 | exon_skip_355859 | 6.74e+00 | 9.83e-01 | 6.20e+00 | 1.31e-03 | Male-biased |
| SARC | HNRNPH2 | exon_skip_355859 | 6.21e+00 | 3.30e-03 | 6.69e+00 | 9.80e-01 | Female-biased |
| CDK5RAP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4813595 | chr20:25979080:G:A | - | 0.211046136982699 | 0.044724414019109 | GBM | Female-baised eQTL |
| rs1569706 | chr20:38612094:G:T | - | -0.146289245117714 | 0.000163672549752805 | LUSC | Female-baised eQTL |
| rs1569707 | chr20:38612123:A:G | - | -0.134207139371698 | 0.000418672934102097 | LUSC | Female-baised eQTL |
| rs6064763 | chr20:38611563:A:G | - | -0.12978817139485 | 0.000773299971678052 | LUSC | Female-baised eQTL |
| rs6029161 | chr20:40509673:A:G | - | 0.126216535470892 | 0.0105492730306534 | LUSC | Female-baised eQTL |
| rs6016370 | chr20:40510492:A:G | - | 0.126216535470892 | 0.0105492730306534 | LUSC | Female-baised eQTL |
| rs6016368 | chr20:40506465:T:C | - | 0.125241120759249 | 0.0118024173853429 | LUSC | Female-baised eQTL |
| rs76380536 | chr20:40513482:A:C | - | 0.118962956827764 | 0.0149413174838383 | LUSC | Female-baised eQTL |
| rs79009390 | chr20:40514360:G:C | - | 0.118962956827764 | 0.0149413174838383 | LUSC | Female-baised eQTL |
| rs6029159 | chr20:40506642:C:T | - | 0.119371184088394 | 0.0207580087475236 | LUSC | Female-baised eQTL |
| rs6029160 | chr20:40507867:T:C | - | 0.120844955035117 | 0.021294288044667 | LUSC | Female-baised eQTL |
| rs6029155 | chr20:40503291:T:C | - | 0.103820592437204 | 0.045646368858237 | LUSC | Female-baised eQTL |
| rs6083481 | chr20:24303888:T:G | - | 0.0887603931235232 | 0.0213687754608651 | LUAD | Female-baised eQTL |
| rs733976 | chr20:42743224:T:C | - | 0.124111943456299 | 0.025417061623039 | LUAD | Female-baised eQTL |
| rs4256012 | chr20:37605937:A:G | - | -0.0712793702747383 | 0.0320816438589372 | LUAD | Female-baised eQTL |
| rs6049571 | chr20:24296083:A:T | - | 0.0861450231016353 | 0.0338744927826249 | LUAD | Female-baised eQTL |
| rs6049572 | chr20:24296559:A:G | - | 0.0861450231016353 | 0.0338744927826249 | LUAD | Female-baised eQTL |
| rs6049573 | chr20:24297031:A:C | - | 0.0861450231016353 | 0.0338744927826249 | LUAD | Female-baised eQTL |
| rs6063365 | chr20:37604601:G:C | - | -0.070122664259435 | 0.0372980282607174 | LUAD | Female-baised eQTL |
| rs4465828 | chr20:37604602:G:A | - | -0.070122664259435 | 0.0372980282607174 | LUAD | Female-baised eQTL |
| rs6063367 | chr20:37604673:T:C | - | -0.070122664259435 | 0.0372980282607174 | LUAD | Female-baised eQTL |
| rs4440023 | chr20:37604891:G:A | - | -0.070122664259435 | 0.0372980282607174 | LUAD | Female-baised eQTL |
| rs4499483 | chr20:37604900:G:T | - | -0.070122664259435 | 0.0372980282607174 | LUAD | Female-baised eQTL |
| rs4810925 | chr20:37605133:C:A | - | -0.070122664259435 | 0.0372980282607174 | LUAD | Female-baised eQTL |
| rs6036726 | chr20:24301474:A:T | - | 0.0829914759936057 | 0.0375017837354313 | LUAD | Female-baised eQTL |
| rs8116232 | chr20:37603572:A:C | - | -0.0679914444326074 | 0.0443353855408277 | LUAD | Female-baised eQTL |
| rs6066996 | chr20:37603675:A:G | - | -0.0679914444326074 | 0.0443353855408277 | LUAD | Female-baised eQTL |
| rs6066997 | chr20:37603705:C:T | - | -0.0679914444326074 | 0.0443353855408277 | LUAD | Female-baised eQTL |
| rs4809740 | chr20:37603954:A:G | - | -0.0679914444326074 | 0.0443353855408277 | LUAD | Female-baised eQTL |
| rs730744 | chr20:24293834:T:C | - | 0.0837199962307181 | 0.0468022116397741 | LUAD | Female-baised eQTL |
| rs6049567 | chr20:24288348:G:A | - | 0.0831734445542339 | 0.0490465166766006 | LUAD | Female-baised eQTL |
| rs6049568 | chr20:24289806:C:T | - | 0.0831734445542339 | 0.0490465166766006 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6115130 | chr20:25290650:A:G | - | 0.0686787103376831 | 0.00186423990380004 | BLCA | Male-baised eQTL |
| rs16987806 | chr20:25511554:C:T | - | 0.0634225892509127 | 0.00329006397303979 | BLCA | Male-baised eQTL |
| rs7272126 | chr20:25508248:C:T | - | 0.0630643667165783 | 0.0040660469961656 | BLCA | Male-baised eQTL |
| rs6115211 | chr20:25566111:T:C | - | 0.0630643667165783 | 0.0040660469961656 | BLCA | Male-baised eQTL |
| rs56243008 | chr20:25512429:T:G | - | 0.0634694580177525 | 0.00409319313748456 | BLCA | Male-baised eQTL |
| rs73111242 | chr20:25553880:A:T | - | 0.0627304936362109 | 0.00451951447639975 | BLCA | Male-baised eQTL |
| rs6115208 | chr20:25559001:G:T | - | 0.0607586438268966 | 0.00497933039776118 | BLCA | Male-baised eQTL |
| rs6115223 | chr20:25600022:A:C | - | 0.0625613328375092 | 0.00585315249652512 | BLCA | Male-baised eQTL |
| rs73113144 | chr20:25604579:C:T | - | 0.0620796879502395 | 0.00660058508699526 | BLCA | Male-baised eQTL |
| rs17244452 | chr20:25608483:T:C | - | 0.0620796879502395 | 0.00660058508699526 | BLCA | Male-baised eQTL |
| rs6115193 | chr20:25476386:T:C | - | 0.0600016569699923 | 0.010962392672506 | BLCA | Male-baised eQTL |
| rs11905437 | chr20:25479128:T:G | - | 0.0600016569699923 | 0.010962392672506 | BLCA | Male-baised eQTL |
| rs6115097 | chr20:25235180:C:T | - | 0.0566248068987748 | 0.0143764351590637 | BLCA | Male-baised eQTL |
| rs6065196 | chr20:40061399:C:A | - | 0.0518383029466823 | 0.0190223491690576 | BLCA | Male-baised eQTL |
| rs6016236 | chr20:40063791:C:T | - | 0.0517871543732683 | 0.0193366772320846 | BLCA | Male-baised eQTL |
| rs6016241 | chr20:40073460:G:T | - | 0.0510776149814861 | 0.0202078531897324 | BLCA | Male-baised eQTL |
| rs6065203 | chr20:40084808:C:T | - | 0.0504593871901826 | 0.0251513528286685 | BLCA | Male-baised eQTL |
| rs56206219 | chr20:40084341:C:T | - | 0.0496871097521064 | 0.0294615868345397 | BLCA | Male-baised eQTL |
| rs6071928 | chr20:40084690:G:A | - | 0.0496871097521064 | 0.0294615868345397 | BLCA | Male-baised eQTL |
| rs73111336 | chr20:40057478:A:G | - | 0.0473167558002651 | 0.0397854499268949 | BLCA | Male-baised eQTL |
| rs12480110 | chr20:40061955:T:A | - | 0.0473167558002651 | 0.0397854499268949 | BLCA | Male-baised eQTL |
| rs12106026 | chr20:40090931:T:A | - | 0.0470800600252643 | 0.0398765104511394 | BLCA | Male-baised eQTL |
| rs6065195 | chr20:40059709:G:A | - | 0.0472653697656803 | 0.0403638362930872 | BLCA | Male-baised eQTL |
| rs6101825 | chr20:40062407:A:T | - | 0.0472653697656803 | 0.0403638362930872 | BLCA | Male-baised eQTL |
| rs2889434 | chr20:26328147:A:G | - | -0.0352710255020181 | 0.0450740274820336 | BLCA | Male-baised eQTL |
| rs1569549 | chr20:42162879:G:A | - | 0.0510749784431324 | 0.0132095279590721 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_355879 | chr20:33387322:33387533 | Frame-shift | rs6088323 | chr20:33868060:A:T | Distant upstream | -0.0311856932414927 | 0.0210099747097097 | LUAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_355879 |
| CpG Site: cg22369703 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.214594539434524 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_355879 | chr20:33387322:33387533 | cg22369703 | chr20:33936475 | Distant upstream | 0.214594539434524 | 6.33048360074412e-10 | 0.4342226896927386 | 3.7769026835452766e-07 | Frame-shift | SARC |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CDK5RAP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
