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Gene: ENSG00000101331 |
Summary for CCM2L |
Gene summary |
| Gene information | Ensembl ID | ENSG00000101331 | Gene symbol | CCM2L |
| Gene name | CCM2 like scaffold protein | |
| HGNC | 16153 | |
| Entrez ID | 140706 | |
| Gene type | protein_coding | |
| Synonyms | CCM2L|dJ310O13.5 | |
| UniProtAcc | Q9NUG4 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CCM2L |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CCM2L | 2.40e+02 | -1.67e+00 | 8.76e-02 | -1.91e+01 | 5.73e-81 | 1.38e-79 | BRCA |
Top |
Sex-biased somatic mutation for CCM2L |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for CCM2L |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg11801374 | chr20:32009891 | CGI:chr20:32018689-32019060 | promoter | 5.80e-01 | 6.89e-01 | -2.55e+00 | 1.08e-02 | 2.65e-02 | -1.09e-01 |
| ACC | cg12084436 | chr20:32009861 | CGI:chr20:32018689-32019060 | promoter | 5.55e-01 | 6.71e-01 | -2.24e+00 | 2.52e-02 | 3.88e-02 | -1.17e-01 |
| ACC | cg24691461 | chr20:32010698 | CGI:chr20:32018689-32019060 | promoter,gene body | 4.94e-01 | 5.99e-01 | -2.06e+00 | 3.96e-02 | 4.56e-02 | -1.05e-01 |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg09685763 | chr20:32009787 | CGI:chr20:32018689-32019060 | promoter | 5.33e-01 | 6.84e-01 | -3.95e+00 | 7.96e-05 | 2.32e-04 | -1.51e-01 |
| LUAD | cg12084436 | chr20:32009861 | CGI:chr20:32018689-32019060 | promoter | 4.54e-01 | 5.90e-01 | -3.01e+00 | 2.59e-03 | 4.31e-03 | -1.35e-01 |
| THCA | cg12084436 | chr20:32009861 | CGI:chr20:32018689-32019060 | promoter | 6.56e-01 | 7.89e-01 | -3.62e+00 | 2.95e-04 | 1.29e-03 | -1.33e-01 |
| LIHC | cg24691461 | chr20:32010698 | CGI:chr20:32018689-32019060 | promoter,gene body | 2.53e-01 | 3.56e-01 | -5.45e+00 | 5.03e-08 | 2.97e-07 | -1.03e-01 |
| CHOL | cg24691461 | chr20:32010698 | CGI:chr20:32018689-32019060 | promoter,gene body | 4.52e-01 | 3.18e-01 | 1.99e+00 | 4.65e-02 | 4.65e-02 | 1.34e-01 |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for CCM2L |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Landscape of exon skipping events across multiple cancer types. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CCM2L |
| ∗Please access CAeditome for RNA editing annotation. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CCM2L |
TFs related to CCM2L.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | EGR1 | CCM2L | 4.14e+00 | 9.84e-01 | 3.34e+00 | 6.19e-03 | Male-biased |
| ESCA | EGR3 | CCM2L | 3.88e+00 | 9.83e-01 | 2.91e+00 | 2.23e-03 | Male-biased |
| ESCA | KLF10 | CCM2L | 3.79e+00 | 9.81e-01 | 2.69e+00 | 1.08e-03 | Male-biased |
| ESCA | PLAGL2 | CCM2L | 4.06e+00 | 9.87e-01 | 3.09e+00 | 2.31e-03 | Male-biased |
| ESCA | RBAK | CCM2L | 3.86e+00 | 9.82e-01 | 2.86e+00 | 1.94e-03 | Male-biased |
| ESCA | RELA | CCM2L | 4.23e+00 | 9.85e-01 | 3.44e+00 | 6.89e-03 | Male-biased |
| ESCA | ZNF28 | CCM2L | 3.85e+00 | 9.83e-01 | 2.74e+00 | 9.96e-04 | Male-biased |
| ESCA | ZNF37A | CCM2L | 4.14e+00 | 9.89e-01 | 3.12e+00 | 1.79e-03 | Male-biased |
| ESCA | ZNF530 | CCM2L | 3.93e+00 | 9.84e-01 | 2.98e+00 | 2.57e-03 | Male-biased |
| ESCA | ZNF534 | CCM2L | 4.05e+00 | 9.86e-01 | 3.06e+00 | 2.19e-03 | Male-biased |
| ESCA | ZNF891 | CCM2L | 3.92e+00 | 9.84e-01 | 2.91e+00 | 1.80e-03 | Male-biased |
| MESO | CDX2 | CCM2L | 4.51e+00 | 9.82e-01 | 3.34e+00 | 1.12e-02 | Male-biased |
| MESO | ZNF28 | CCM2L | 3.01e+00 | 8.88e-03 | 4.31e+00 | 9.81e-01 | Female-biased |
CCM2L related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CCM2L |
RBPs related to ES in CCM2L.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
CCM2L related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs112531310 | chr20:38712121:T:C | - | 0.283308828103431 | 0.000962131063489837 | PCPG | Female-baised eQTL |
| rs36104651 | chr20:32819057:A:T | - | 0.183473134980921 | 0.0163337432764136 | LUSC | Female-baised eQTL |
| rs35065789 | chr20:32817316:G:A | - | 0.183144974629937 | 0.0170040206737695 | LUSC | Female-baised eQTL |
| rs17283440 | chr20:41729657:T:C | - | 0.152094649007167 | 1.00783965638397e-05 | LUAD | Female-baised eQTL |
| rs73102671 | chr20:32000338:C:T | - | 0.136948319246127 | 3.67783816715114e-05 | LUAD | Female-baised eQTL |
| rs61750849 | chr20:31996907:C:T | - | 0.134992893217808 | 4.56507231341915e-05 | LUAD | Female-baised eQTL |
| rs73104605 | chr20:32017138:T:G | gene | 0.130365231436959 | 7.40382638324528e-05 | LUAD | Female-baised eQTL |
| rs73102700 | chr20:32015798:C:T | gene | 0.130267862102998 | 7.59393294697759e-05 | LUAD | Female-baised eQTL |
| rs111968647 | chr20:32015976:C:T | gene | 0.130267862102998 | 7.59393294697759e-05 | LUAD | Female-baised eQTL |
| rs117921981 | chr20:32016429:G:A | gene | 0.130267862102998 | 7.59393294697759e-05 | LUAD | Female-baised eQTL |
| rs73102694 | chr20:32012022:C:T | gene,promoter | 0.129463189117318 | 8.88909906506176e-05 | LUAD | Female-baised eQTL |
| rs73102690 | chr20:32010934:C:T | gene,promoter | 0.127649781118372 | 0.000103487723705251 | LUAD | Female-baised eQTL |
| rs55715184 | chr20:41728387:T:G | - | 0.133877244960783 | 0.000135558846174385 | LUAD | Female-baised eQTL |
| rs73129069 | chr20:41748289:C:T | - | 0.139173972005515 | 0.000156365950700526 | LUAD | Female-baised eQTL |
| rs56396296 | chr20:41729443:C:G | - | 0.131238345181985 | 0.000176772714704643 | LUAD | Female-baised eQTL |
| rs56108496 | chr20:41729475:T:C | - | 0.128028495188416 | 0.000261223696307281 | LUAD | Female-baised eQTL |
| rs73127309 | chr20:41724451:T:C | - | 0.127925007016215 | 0.000267884775531425 | LUAD | Female-baised eQTL |
| rs17283552 | chr20:41731994:T:C | - | 0.130545216765425 | 0.000270762770380482 | LUAD | Female-baised eQTL |
| rs73127321 | chr20:41732344:G:A | - | 0.130545216765425 | 0.000270762770380482 | LUAD | Female-baised eQTL |
| rs73129062 | chr20:41746545:C:T | - | 0.133617529049072 | 0.000322396943218666 | LUAD | Female-baised eQTL |
| rs73127326 | chr20:41737138:T:C | - | 0.129211220246357 | 0.000344428222423432 | LUAD | Female-baised eQTL |
| rs73127332 | chr20:41737568:A:G | - | 0.129211220246357 | 0.000344428222423432 | LUAD | Female-baised eQTL |
| rs73127333 | chr20:41739015:T:G | - | 0.129211220246357 | 0.000344428222423432 | LUAD | Female-baised eQTL |
| rs73127335 | chr20:41741439:A:G | - | 0.128881883641118 | 0.000369055857650052 | LUAD | Female-baised eQTL |
| rs73127338 | chr20:41741541:C:A | - | 0.128881883641118 | 0.000369055857650052 | LUAD | Female-baised eQTL |
| rs56040140 | chr20:41742142:G:A | - | 0.128881883641118 | 0.000369055857650052 | LUAD | Female-baised eQTL |
| rs73125293 | chr20:41722442:A:C | - | 0.124953031615151 | 0.000377250439196306 | LUAD | Female-baised eQTL |
| rs73125301 | chr20:41722819:G:C | - | 0.124953031615151 | 0.000377250439196306 | LUAD | Female-baised eQTL |
| rs73127305 | chr20:41723031:T:C | - | 0.124953031615151 | 0.000377250439196306 | LUAD | Female-baised eQTL |
| rs73127308 | chr20:41723395:C:T | - | 0.124953031615151 | 0.000377250439196306 | LUAD | Female-baised eQTL |
| rs56325401 | chr20:41729174:T:C | - | 0.124871974656757 | 0.000385499949516027 | LUAD | Female-baised eQTL |
| rs73125286 | chr20:41722128:C:T | - | 0.124786617908855 | 0.000391314548181699 | LUAD | Female-baised eQTL |
| rs16985243 | chr20:41730448:G:A | - | 0.119169127216928 | 0.000649575278422825 | LUAD | Female-baised eQTL |
| rs55910440 | chr20:41738096:G:A | - | 0.121917274787765 | 0.000838336706694246 | LUAD | Female-baised eQTL |
| rs113205691 | chr20:41731608:C:T | - | 0.110424298715895 | 0.00295673634200038 | LUAD | Female-baised eQTL |
| rs73127320 | chr20:41732337:T:C | - | 0.110424298715895 | 0.00295673634200038 | LUAD | Female-baised eQTL |
| rs73127322 | chr20:41732361:A:G | - | 0.110424298715895 | 0.00295673634200038 | LUAD | Female-baised eQTL |
| rs16985244 | chr20:41730619:C:T | - | 0.10525998932655 | 0.00309463096279866 | LUAD | Female-baised eQTL |
| rs6049370 | chr20:24066199:A:G | - | 0.127176204493328 | 0.00324705271054041 | LUAD | Female-baised eQTL |
| rs6119305 | chr20:32921267:C:T | - | 0.121181522110483 | 0.00330051183421089 | LUAD | Female-baised eQTL |
| rs112019405 | chr20:41734299:C:T | - | 0.109027908131864 | 0.00367280859348828 | LUAD | Female-baised eQTL |
| rs59514389 | chr20:24063927:G:C | - | 0.143477322470554 | 0.00573977950646257 | LUAD | Female-baised eQTL |
| rs1884865 | chr20:32234059:T:G | - | 0.0691977146531179 | 0.00958720542172194 | LUAD | Female-baised eQTL |
| rs6121388 | chr20:32208300:T:C | - | 0.0723941422695709 | 0.0109729543846101 | LUAD | Female-baised eQTL |
| rs1884866 | chr20:32233888:A:G | - | 0.0712915252834343 | 0.0124776034539509 | LUAD | Female-baised eQTL |
| rs6049297 | chr20:24000419:C:A | - | 0.0798911935817713 | 0.012608728133402 | LUAD | Female-baised eQTL |
| rs6119792 | chr20:32245640:A:G | - | 0.0690329634391684 | 0.0145543210240976 | LUAD | Female-baised eQTL |
| rs6036631 | chr20:24065786:A:G | - | 0.106541406829713 | 0.0180139520372149 | LUAD | Female-baised eQTL |
| rs11905172 | chr20:32209825:T:C | - | 0.0654812020651129 | 0.0219618633851002 | LUAD | Female-baised eQTL |
| rs6058556 | chr20:32220729:T:C | - | 0.0654812020651129 | 0.0219618633851002 | LUAD | Female-baised eQTL |
| rs3803990 | chr20:32221709:A:G | - | 0.0654812020651129 | 0.0219618633851002 | LUAD | Female-baised eQTL |
| rs6036630 | chr20:24065596:C:T | - | 0.102975329293522 | 0.023931721052903 | LUAD | Female-baised eQTL |
| rs6089216 | chr20:32214371:T:C | - | 0.0646460945961336 | 0.02504404705859 | LUAD | Female-baised eQTL |
| rs55935733 | chr20:32401561:C:T | - | -0.060947146580421 | 0.0256926958797442 | LUAD | Female-baised eQTL |
| rs1056776 | chr20:32194740:C:G | - | 0.0636297133881112 | 0.0265918965043145 | LUAD | Female-baised eQTL |
| rs6036628 | chr20:24063759:A:G | - | 0.100081325144636 | 0.0293449592793281 | LUAD | Female-baised eQTL |
| rs113844904 | chr20:32248805:C:T | - | 0.0640389018206661 | 0.0383763029693159 | LUAD | Female-baised eQTL |
| rs8114511 | chr20:38580475:A:C | - | 0.102011228987207 | 0.0412371079307866 | LUAD | Female-baised eQTL |
| rs117984630 | chr20:37221219:G:A | - | 0.0838754003667664 | 0.0416275427434167 | LUAD | Female-baised eQTL |
| rs2235460 | chr20:37852641:G:A | - | 0.0522712034280644 | 0.0421435194336036 | LUAD | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4813595 | chr20:25979080:G:A | - | 0.0551251436044293 | 0.0050422558616461 | LUSC | Male-baised eQTL |
| rs59334735 | chr20:40993012:C:G | - | 0.0495413588147844 | 0.0282098170158674 | LGG | Male-baised eQTL |
| rs60073330 | chr20:40995494:A:G | - | 0.0495533255436781 | 0.0284068707725585 | LGG | Male-baised eQTL |
| rs6129714 | chr20:40993154:G:A | - | 0.0494702850343711 | 0.0290518696534149 | LGG | Male-baised eQTL |
| rs6072224 | chr20:40994233:C:T | - | 0.0494819379272055 | 0.0292968259511626 | LGG | Male-baised eQTL |
| rs6072226 | chr20:40995723:T:C | - | 0.0494819379272055 | 0.0292968259511626 | LGG | Male-baised eQTL |
| rs6072227 | chr20:40995829:C:T | - | 0.0494819379272055 | 0.0292968259511626 | LGG | Male-baised eQTL |
| rs6072228 | chr20:40995956:C:A | - | 0.0494819379272055 | 0.0292968259511626 | LGG | Male-baised eQTL |
| rs6129717 | chr20:40996124:A:G | - | 0.0494819379272055 | 0.0292968259511626 | LGG | Male-baised eQTL |
| rs4812524 | chr20:41551142:A:G | - | 0.0639884900713862 | 0.0325303187996631 | LGG | Male-baised eQTL |
| rs2011809 | chr20:40986305:C:T | - | 0.0487627760673937 | 0.0332626402373244 | LGG | Male-baised eQTL |
| rs6072225 | chr20:40995084:T:C | - | 0.0491263725228355 | 0.0333435172483545 | LGG | Male-baised eQTL |
| rs2272959 | chr20:41556625:A:G | - | 0.0631667414214652 | 0.0334989691752419 | LGG | Male-baised eQTL |
| rs6124296 | chr20:40986555:C:T | - | 0.0488717288768052 | 0.0350055709946159 | LGG | Male-baised eQTL |
| rs6124297 | chr20:40987628:A:C | - | 0.047373572335882 | 0.0464730258677154 | LGG | Male-baised eQTL |
| rs11167262 | chr20:35258430:T:G | - | 0.0619726907236282 | 0.0474384135011772 | LUAD | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CCM2L |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |