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Gene: ENSG00000100918 |
Summary for REC8 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000100918 | Gene symbol | REC8 |
| Gene name | REC8 meiotic recombination protein | |
| HGNC | 16879 | |
| Entrez ID | 9985 | |
| Gene type | protein_coding | |
| Synonyms | REC8|Rec8p|kleisin-alpha | |
| UniProtAcc | O95072 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for REC8 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| REC8 | 4.95e+02 | -1.01e+00 | 1.67e-01 | -6.08e+00 | 1.17e-09 | 2.98e-09 | KIRC |
| REC8 | 5.25e+02 | 1.25e+00 | 2.76e-01 | 4.55e+00 | 5.31e-06 | 2.57e-05 | THCA |
| REC8 | 1.07e+03 | -1.13e+00 | 3.95e-01 | -2.86e+00 | 4.29e-03 | 1.97e-02 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| REC8 | 4.35e+02 | 1.03e+00 | 1.40e-01 | 7.37e+00 | 1.65e-13 | 4.19e-13 | BRCA |
Top |
Sex-biased somatic mutation for REC8 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for REC8 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| GBM | cg18556834 | chr14:24171861 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 1.16e-01 | 2.16e-01 | -2.97e+00 | 2.96e-03 | 1.02e-02 | -1.00e-01 |
| GBM | cg01574481 | chr14:24172643 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 3.07e-01 | 4.38e-01 | -2.12e+00 | 3.36e-02 | 4.37e-02 | -1.31e-01 |
| GBM | cg16473141 | chr14:24172292 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 2.69e-01 | 3.92e-01 | -2.68e+00 | 7.35e-03 | 2.02e-02 | -1.23e-01 |
| GBM | cg18512948 | chr14:24172497 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 2.89e-01 | 4.17e-01 | -2.46e+00 | 1.40e-02 | 2.97e-02 | -1.28e-01 |
| DLBC | cg16473141 | chr14:24172292 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 4.48e-01 | 5.68e-01 | -2.23e+00 | 2.54e-02 | 3.93e-02 | -1.20e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg16094352 | chr14:24173108 | CGI:chr14:24171844-24173011 | promoter,exon,gene body | 7.42e-01 | 8.51e-01 | -5.17e+00 | 2.35e-07 | 1.04e-06 | -1.09e-01 |
| LUAD | cg01574481 | chr14:24172643 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.66e-01 | 5.04e-01 | 5.24e+00 | 1.57e-07 | 1.72e-06 | 1.63e-01 |
| LUAD | cg10137231 | chr14:24171812 | CGI:chr14:24171844-24173011 | promoter | 6.39e-01 | 4.78e-01 | 5.39e+00 | 7.17e-08 | 1.01e-06 | 1.61e-01 |
| LUAD | cg18512948 | chr14:24172497 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.31e-01 | 4.58e-01 | 5.18e+00 | 2.23e-07 | 2.21e-06 | 1.73e-01 |
| LUSC | cg18556834 | chr14:24171861 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.26e-01 | 3.59e-01 | 3.83e+00 | 1.28e-04 | 7.80e-04 | 1.66e-01 |
| LUSC | cg01574481 | chr14:24172643 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.41e-01 | 5.28e-01 | 3.30e+00 | 9.60e-04 | 2.53e-03 | 1.13e-01 |
| LUSC | cg24127861 | chr14:24171738 | CGI:chr14:24171844-24173011 | promoter | 3.42e-01 | 1.83e-01 | 2.61e+00 | 8.94e-03 | 1.27e-02 | 1.59e-01 |
| LUSC | cg10137231 | chr14:24171812 | CGI:chr14:24171844-24173011 | promoter | 6.55e-01 | 5.00e-01 | 3.81e+00 | 1.39e-04 | 8.07e-04 | 1.56e-01 |
| LUSC | cg19989295 | chr14:24171868 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.35e-01 | 3.49e-01 | 3.90e+00 | 9.43e-05 | 6.81e-04 | 1.86e-01 |
| LUSC | cg16425038 | chr14:24171985 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.24e-01 | 4.05e-01 | 3.92e+00 | 8.72e-05 | 6.61e-04 | 2.19e-01 |
| LUSC | cg03431846 | chr14:24171974 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.58e-01 | 3.51e-01 | 4.04e+00 | 5.31e-05 | 5.65e-04 | 2.07e-01 |
| LUSC | cg18628371 | chr14:24171980 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.61e-01 | 4.05e-01 | 3.57e+00 | 3.63e-04 | 1.36e-03 | 1.56e-01 |
| LUSC | cg07516252 | chr14:24171992 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 4.99e-01 | 3.10e-01 | 3.98e+00 | 6.89e-05 | 6.07e-04 | 1.89e-01 |
| LUSC | cg16473141 | chr14:24172292 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.15e-01 | 4.58e-01 | 3.76e+00 | 1.71e-04 | 8.95e-04 | 1.57e-01 |
| COAD | cg18556834 | chr14:24171861 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.02e-01 | 4.87e-01 | 3.87e+00 | 1.09e-04 | 3.76e-04 | 1.15e-01 |
| COAD | cg01574481 | chr14:24172643 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 7.01e-01 | 5.96e-01 | 3.20e+00 | 1.35e-03 | 2.87e-03 | 1.05e-01 |
| COAD | cg10137231 | chr14:24171812 | CGI:chr14:24171844-24173011 | promoter | 7.38e-01 | 6.17e-01 | 4.10e+00 | 4.15e-05 | 1.75e-04 | 1.21e-01 |
| COAD | cg19989295 | chr14:24171868 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.19e-01 | 4.98e-01 | 3.76e+00 | 1.70e-04 | 5.34e-04 | 1.21e-01 |
| COAD | cg16425038 | chr14:24171985 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 7.14e-01 | 5.53e-01 | 4.04e+00 | 5.24e-05 | 2.10e-04 | 1.61e-01 |
| COAD | cg03431846 | chr14:24171974 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.59e-01 | 5.28e-01 | 3.80e+00 | 1.47e-04 | 4.75e-04 | 1.31e-01 |
| COAD | cg07516252 | chr14:24171992 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.83e-01 | 4.48e-01 | 4.01e+00 | 5.96e-05 | 2.33e-04 | 1.35e-01 |
| COAD | cg16473141 | chr14:24172292 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.95e-01 | 5.51e-01 | 3.89e+00 | 9.88e-05 | 3.47e-04 | 1.44e-01 |
| COAD | cg18512948 | chr14:24172497 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 7.12e-01 | 6.04e-01 | 3.18e+00 | 1.47e-03 | 3.07e-03 | 1.08e-01 |
| LIHC | cg16425038 | chr14:24171985 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 7.60e-01 | 6.34e-01 | 4.93e+00 | 8.15e-07 | 3.12e-06 | 1.26e-01 |
| LIHC | cg03431846 | chr14:24171974 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.81e-01 | 5.74e-01 | 4.82e+00 | 1.44e-06 | 5.07e-06 | 1.07e-01 |
| LIHC | cg07516252 | chr14:24171992 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.16e-01 | 5.09e-01 | 4.66e+00 | 3.18e-06 | 1.01e-05 | 1.07e-01 |
| ESCA | cg18556834 | chr14:24171861 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.70e-01 | 3.86e-01 | 2.03e+00 | 4.28e-02 | 4.76e-02 | 1.84e-01 |
| ESCA | cg24127861 | chr14:24171738 | CGI:chr14:24171844-24173011 | promoter | 3.55e-01 | 1.38e-01 | 2.90e+00 | 3.75e-03 | 3.38e-02 | 2.18e-01 |
| ESCA | cg19989295 | chr14:24171868 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.90e-01 | 3.65e-01 | 2.15e+00 | 3.12e-02 | 4.42e-02 | 2.25e-01 |
| ESCA | cg16425038 | chr14:24171985 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.93e-01 | 4.37e-01 | 2.04e+00 | 4.18e-02 | 4.72e-02 | 2.56e-01 |
| ESCA | cg06351481 | chr14:24173010 | CGI:chr14:24171844-24173011 | promoter,gene body,CDS,UTR,exon | 8.27e-01 | 6.84e-01 | 2.78e+00 | 5.44e-03 | 3.46e-02 | 1.44e-01 |
| ESCA | cg16094352 | chr14:24173108 | CGI:chr14:24171844-24173011 | promoter,exon,gene body | 6.64e-01 | 5.28e-01 | 2.73e+00 | 6.33e-03 | 3.50e-02 | 1.36e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg24127861 | chr14:24171738 | CGI:chr14:24171844-24173011 | promoter | 4.58e-01 | 2.58e-01 | 9.49e+00 | 2.41e-21 | 1.46e-20 | 2.00e-01 |
| BRCA | cg19989295 | chr14:24171868 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.26e-01 | 5.05e-01 | 6.93e+00 | 4.09e-12 | 1.20e-11 | 1.21e-01 |
| BRCA | cg16425038 | chr14:24171985 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 7.40e-01 | 6.40e-01 | 5.26e+00 | 1.44e-07 | 2.91e-07 | 1.00e-01 |
| BRCA | cg18628371 | chr14:24171980 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.36e-01 | 4.84e-01 | 1.00e+01 | 9.51e-24 | 7.17e-23 | 1.52e-01 |
| BRCA | cg07516252 | chr14:24171992 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.88e-01 | 4.75e-01 | 7.30e+00 | 2.89e-13 | 9.23e-13 | 1.12e-01 |
| KIRC | cg24127861 | chr14:24171738 | CGI:chr14:24171844-24173011 | promoter | 1.45e-01 | 4.44e-02 | 3.44e+00 | 5.77e-04 | 3.59e-03 | 1.00e-01 |
| HNSC | cg18556834 | chr14:24171861 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.20e-01 | 3.62e-01 | 3.34e+00 | 8.48e-04 | 9.05e-03 | 1.58e-01 |
| HNSC | cg01574481 | chr14:24172643 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.27e-01 | 4.63e-01 | 2.92e+00 | 3.52e-03 | 1.16e-02 | 1.64e-01 |
| HNSC | cg10137231 | chr14:24171812 | CGI:chr14:24171844-24173011 | promoter | 6.33e-01 | 4.80e-01 | 3.35e+00 | 8.14e-04 | 9.05e-03 | 1.53e-01 |
| HNSC | cg19989295 | chr14:24171868 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.26e-01 | 3.53e-01 | 3.18e+00 | 1.48e-03 | 9.25e-03 | 1.73e-01 |
| HNSC | cg16425038 | chr14:24171985 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.03e-01 | 4.09e-01 | 2.78e+00 | 5.40e-03 | 1.38e-02 | 1.94e-01 |
| HNSC | cg03431846 | chr14:24171974 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.38e-01 | 3.55e-01 | 3.36e+00 | 7.81e-04 | 9.05e-03 | 1.83e-01 |
| HNSC | cg07516252 | chr14:24171992 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 4.79e-01 | 3.00e-01 | 3.37e+00 | 7.50e-04 | 9.05e-03 | 1.79e-01 |
| HNSC | cg16473141 | chr14:24172292 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 5.91e-01 | 4.52e-01 | 2.95e+00 | 3.16e-03 | 1.11e-02 | 1.39e-01 |
| HNSC | cg18512948 | chr14:24172497 | CGI:chr14:24171844-24173011 | UTR,promoter,exon,gene body | 6.04e-01 | 4.54e-01 | 2.90e+00 | 3.79e-03 | 1.19e-02 | 1.49e-01 |
| HNSC | cg06351481 | chr14:24173010 | CGI:chr14:24171844-24173011 | promoter,gene body,CDS,UTR,exon | 8.12e-01 | 6.30e-01 | 3.45e+00 | 5.61e-04 | 9.05e-03 | 1.82e-01 |
| HNSC | cg16094352 | chr14:24173108 | CGI:chr14:24171844-24173011 | promoter,exon,gene body | 6.83e-01 | 5.35e-01 | 3.21e+00 | 1.32e-03 | 9.14e-03 | 1.48e-01 |
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Exon skipping events with PSI in TCGA for REC8 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for REC8 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for REC8 |
| TFs related to REC8. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | ZIC2 | REC8 | 4.17e+00 | 9.82e-01 | 2.99e+00 | 3.52e-03 | Male-biased |
| LAML | ZNF692 | REC8 | 4.36e+00 | 9.82e-01 | 3.37e+00 | 7.41e-03 | Male-biased |
| REC8 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for REC8 |
| RBPs related to ES in REC8. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | HNRNPH2 | exon_skip_105720 | 8.38e+00 | 9.91e-01 | 7.91e+00 | 2.28e-03 | Male-biased |
| ESCA | HNRNPH2 | exon_skip_105720 | 7.95e+00 | 1.05e-02 | 8.39e+00 | 9.83e-01 | Female-biased |
| REC8 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2145567 | chr14:23463116:A:C | - | 0.141416818891778 | 0.0262033032410205 | BLCA | Female-baised eQTL |
| rs4982757 | chr14:23467460:G:A | - | 0.140218444629369 | 0.0300813863778912 | BLCA | Female-baised eQTL |
| rs10137472 | chr14:32346302:G:C | - | 0.116169910935295 | 0.0380085560466235 | BLCA | Female-baised eQTL |
| rs7153548 | chr14:28739894:C:A | - | 0.0669989093022706 | 0.012777386443784 | LUAD | Female-baised eQTL |
| rs72669740 | chr14:28740944:G:A | - | 0.0669989093022706 | 0.012777386443784 | LUAD | Female-baised eQTL |
| rs7145624 | chr14:28743944:C:G | - | 0.0638226097844809 | 0.0127989172094801 | LUAD | Female-baised eQTL |
| rs8018168 | chr14:25806074:C:G | - | 0.0621315373858521 | 0.0243393895351436 | LUAD | Female-baised eQTL |
| rs10483404 | chr14:32278852:T:C | - | 0.0529796689727423 | 0.027142221405692 | LUAD | Female-baised eQTL |
| rs72662593 | chr14:28422646:G:C | - | 0.0581327667061041 | 0.0402966454423715 | LUAD | Female-baised eQTL |
| rs1245464 | chr14:27192357:G:T | - | -0.0529345686622846 | 0.0481590200565745 | LUAD | Female-baised eQTL |
| rs1075300 | chr14:28271884:A:T | - | 0.0605316781143788 | 0.00244975865208517 | COAD | Female-baised eQTL |
| rs12323487 | chr14:28368565:C:A | - | 0.064373114292428 | 0.0036522174285135 | COAD | Female-baised eQTL |
| rs2093991 | chr14:28272188:T:C | - | 0.053904715270955 | 0.00868768031701249 | COAD | Female-baised eQTL |
| rs2104386 | chr14:28272432:C:G | - | 0.053904715270955 | 0.00868768031701249 | COAD | Female-baised eQTL |
| rs67551453 | chr14:28273731:T:C | - | 0.053904715270955 | 0.00868768031701249 | COAD | Female-baised eQTL |
| rs112965022 | chr14:20761939:C:T | - | 0.0531759548064892 | 0.00948522309700667 | COAD | Female-baised eQTL |
| rs729827 | chr14:20757304:T:C | - | 0.0505845340053029 | 0.0133195230174385 | COAD | Female-baised eQTL |
| rs7144702 | chr14:20757932:C:T | - | 0.0505845340053029 | 0.0133195230174385 | COAD | Female-baised eQTL |
| rs10147276 | chr14:28368695:A:G | - | 0.0530938132858588 | 0.017731746526501 | COAD | Female-baised eQTL |
| rs7158651 | chr14:28371208:C:T | - | 0.0517012402691951 | 0.0216697248157717 | COAD | Female-baised eQTL |
| rs28535446 | chr14:28374667:A:T | - | 0.0516700728549285 | 0.0219310870781696 | COAD | Female-baised eQTL |
| rs55771011 | chr14:22734066:A:G | - | 0.0492927059594508 | 0.0231984356907983 | COAD | Female-baised eQTL |
| rs72679881 | chr14:22732283:A:G | - | 0.0492388615896919 | 0.0236136450710482 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs78425993 | chr14:33229811:G:A | - | 0.138338849354549 | 0.0483695051494825 | PAAD | Male-baised eQTL |
| rs75381513 | chr14:34086533:G:A | - | 0.04692618646927 | 0.0053680250683829 | LUSC | Male-baised eQTL |
| rs141885319 | chr14:30514322:C:T | - | 0.115559825833409 | 0.0167859510576475 | LGG | Male-baised eQTL |
| rs117842165 | chr14:30514411:A:C | - | 0.115559825833409 | 0.0167859510576475 | LGG | Male-baised eQTL |
| rs10135437 | chr14:20655664:A:G | - | 0.0307664448132296 | 0.0490966078847193 | BLCA | Male-baised eQTL |
| rs7160432 | chr14:20072035:T:G | - | 0.0596840278515894 | 0.000515872990669053 | LUAD | Male-baised eQTL |
| rs113611606 | chr14:20337370:G:A | - | 0.0593615003335075 | 0.00144574664868254 | LUAD | Male-baised eQTL |
| rs17308324 | chr14:20339864:A:G | - | 0.0593404593476034 | 0.00146382506270328 | LUAD | Male-baised eQTL |
| rs8020492 | chr14:20347346:A:G | - | 0.0577472480524168 | 0.00215352254065722 | LUAD | Male-baised eQTL |
| rs2332326 | chr14:24366653:G:C | - | -0.0537954355031611 | 0.00234913806706953 | LUAD | Male-baised eQTL |
| rs1760914 | chr14:20355053:A:G | - | 0.054216291810823 | 0.0040988112407245 | LUAD | Male-baised eQTL |
| rs1760916 | chr14:20353233:T:G | - | 0.0538886342211844 | 0.00452809093778861 | LUAD | Male-baised eQTL |
| rs7153417 | chr14:20338136:G:T | - | 0.0536191552573154 | 0.00486753845415996 | LUAD | Male-baised eQTL |
| rs1760925 | chr14:20346209:A:G | - | 0.0536169862771857 | 0.00496075955027954 | LUAD | Male-baised eQTL |
| rs57336845 | chr14:20347708:G:A | - | 0.0536169862771857 | 0.00496075955027954 | LUAD | Male-baised eQTL |
| rs10129213 | chr14:24386996:T:G | - | -0.0518996576834265 | 0.00547324803947473 | LUAD | Male-baised eQTL |
| rs1760917 | chr14:20352868:T:G | - | 0.0526458898914265 | 0.0057958710068674 | LUAD | Male-baised eQTL |
| rs2249141 | chr14:20353026:G:A | - | 0.0526458898914265 | 0.0057958710068674 | LUAD | Male-baised eQTL |
| rs56960933 | chr14:20320033:C:T | - | 0.0539210122637036 | 0.00746452076192193 | LUAD | Male-baised eQTL |
| rs6575167 | chr14:20324685:A:G | - | 0.0539210122637036 | 0.00746452076192193 | LUAD | Male-baised eQTL |
| rs112745625 | chr14:20325254:T:A | - | 0.0539210122637036 | 0.00746452076192193 | LUAD | Male-baised eQTL |
| rs79246438 | chr14:20330125:A:C | - | 0.0539210122637036 | 0.00746452076192193 | LUAD | Male-baised eQTL |
| rs74685374 | chr14:24500238:G:A | - | 0.0411843944691985 | 0.0256454959026123 | LUAD | Male-baised eQTL |
| rs77824435 | chr14:24500916:A:G | - | 0.0411843944691985 | 0.0256454959026123 | LUAD | Male-baised eQTL |
| rs7493691 | chr14:31270153:G:A | - | 0.0461553447234925 | 0.0273875993841664 | LUAD | Male-baised eQTL |
| rs1956925 | chr14:24502506:G:A | - | 0.0404858285643798 | 0.0294696548259586 | LUAD | Male-baised eQTL |
| rs60280766 | chr14:24503625:A:G | - | 0.0404858285643798 | 0.0294696548259586 | LUAD | Male-baised eQTL |
| rs5250 | chr14:24505415:G:A | - | 0.0404858285643798 | 0.0294696548259586 | LUAD | Male-baised eQTL |
| rs12100565 | chr14:24505714:T:A | - | 0.0404858285643798 | 0.0294696548259586 | LUAD | Male-baised eQTL |
| rs1812760 | chr14:31268342:C:A | - | 0.0451332771834942 | 0.03215177068982 | LUAD | Male-baised eQTL |
| rs80114024 | chr14:27343456:T:C | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs79361612 | chr14:27343517:G:C | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs17112552 | chr14:27345910:C:T | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs17112556 | chr14:27346146:A:G | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs17112561 | chr14:27347208:C:A | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs17112564 | chr14:27347344:C:A | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs17112567 | chr14:27347468:A:G | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs75634652 | chr14:27348513:A:T | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs79891470 | chr14:27348595:T:G | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs1156691 | chr14:27349229:A:G | - | 0.0425054931080745 | 0.034147089055863 | LUAD | Male-baised eQTL |
| rs55950138 | chr14:24511775:C:T | - | 0.0399284565957936 | 0.0352934961266614 | LUAD | Male-baised eQTL |
| rs142421216 | chr14:27359462:G:T | - | -0.0419052223099728 | 0.0382913123762076 | LUAD | Male-baised eQTL |
| rs74041300 | chr14:27340636:G:A | - | 0.0415134345745499 | 0.041149590037532 | LUAD | Male-baised eQTL |
| rs56941856 | chr14:22282726:A:G | - | 0.107314669902495 | 0.000103679254847102 | COAD | Male-baised eQTL |
| rs117598849 | chr14:22283451:T:C | - | 0.119665035208701 | 0.000142869268886473 | COAD | Male-baised eQTL |
| rs7142052 | chr14:33006392:C:T | - | 0.0726947656649692 | 0.00236663185627817 | COAD | Male-baised eQTL |
| rs28401454 | chr14:29867284:C:T | - | 0.0991664984787568 | 0.00241265610475865 | COAD | Male-baised eQTL |
| rs10047861 | chr14:31804729:C:T | - | 0.0803614747211941 | 0.00361561209422232 | COAD | Male-baised eQTL |
| rs28806946 | chr14:31805184:G:C | - | 0.0803614747211941 | 0.00361561209422232 | COAD | Male-baised eQTL |
| rs60790048 | chr14:31769662:T:A | - | 0.0769785274997597 | 0.0041578510347811 | COAD | Male-baised eQTL |
| rs58097888 | chr14:31775441:G:C | - | 0.0705901681570009 | 0.0105264507746109 | COAD | Male-baised eQTL |
| rs10151156 | chr14:31766276:C:T | - | 0.0688483697901809 | 0.0125613079138556 | COAD | Male-baised eQTL |
| rs392101 | chr14:30645345:A:G | - | 0.0728024531427292 | 0.0138405732110653 | COAD | Male-baised eQTL |
| rs230342 | chr14:30657653:T:A | - | 0.0728024531427292 | 0.0138405732110653 | COAD | Male-baised eQTL |
| rs7150042 | chr14:31722214:G:T | - | 0.0667631853377532 | 0.0148628351982224 | COAD | Male-baised eQTL |
| rs117721207 | chr14:30708278:G:C | - | 0.0785795608580794 | 0.0168147779967465 | COAD | Male-baised eQTL |
| rs185245429 | chr14:31689945:G:A | - | 0.0668525027081425 | 0.0178545011097989 | COAD | Male-baised eQTL |
| rs72642516 | chr14:26827204:G:A | - | 0.0781094030693445 | 0.0199985321475291 | COAD | Male-baised eQTL |
| rs230354 | chr14:30665230:G:C | - | 0.0665228823997928 | 0.0238151672000216 | COAD | Male-baised eQTL |
| rs230357 | chr14:30665651:A:T | - | 0.0665228823997928 | 0.0238151672000216 | COAD | Male-baised eQTL |
| rs229241 | chr14:30613710:A:T | - | 0.0820279367507943 | 0.0286626695084548 | COAD | Male-baised eQTL |
| rs60654485 | chr14:31801222:C:T | - | 0.0698245553575669 | 0.0294520395480921 | COAD | Male-baised eQTL |
| rs28679478 | chr14:30615018:T:G | - | 0.0740154414010362 | 0.0313521481092096 | COAD | Male-baised eQTL |
| rs229242 | chr14:30614032:T:C | - | 0.0723941696740812 | 0.0336681740551371 | COAD | Male-baised eQTL |
| rs4048494 | chr14:25290599:G:C | - | -0.034102587015759 | 0.0346745375681497 | COAD | Male-baised eQTL |
| rs2100825 | chr14:25290650:G:A | - | -0.0338798321417756 | 0.0360587488519257 | COAD | Male-baised eQTL |
| rs2085891 | chr14:25290855:C:T | - | -0.0337215054552621 | 0.037154572821009 | COAD | Male-baised eQTL |
| rs229204 | chr14:30648349:A:T | - | 0.0694814833264544 | 0.0377495097711612 | COAD | Male-baised eQTL |
| rs230344 | chr14:30658000:T:G | - | 0.0694814833264544 | 0.0377495097711612 | COAD | Male-baised eQTL |
| rs10143144 | chr14:31721640:G:T | - | 0.0653315795887151 | 0.0401666945579069 | COAD | Male-baised eQTL |
| rs111688693 | chr14:31744712:C:T | - | 0.0653315795887151 | 0.0401666945579069 | COAD | Male-baised eQTL |
| rs57442002 | chr14:28529911:A:C | - | 0.0606234474579014 | 0.0448117120029494 | COAD | Male-baised eQTL |
| rs7142606 | chr14:28533859:G:T | - | 0.0606234474579014 | 0.0448117120029494 | COAD | Male-baised eQTL |
| rs80004265 | chr14:28533989:T:G | - | 0.0606234474579014 | 0.0448117120029494 | COAD | Male-baised eQTL |
| rs11625039 | chr14:28535884:T:C | - | 0.0606234474579014 | 0.0448117120029494 | COAD | Male-baised eQTL |
| rs176341 | chr14:28538744:C:T | - | 0.0606234474579014 | 0.0448117120029494 | COAD | Male-baised eQTL |
| rs176340 | chr14:28538954:C:T | - | 0.0606234474579014 | 0.0448117120029494 | COAD | Male-baised eQTL |
| rs2333059 | chr14:27580835:A:C | - | -0.0487554742594034 | 0.0450865810200621 | COAD | Male-baised eQTL |
| rs17198314 | chr14:22294414:T:C | - | 0.0428777433236628 | 0.046475012442814 | COAD | Male-baised eQTL |
| rs12147775 | chr14:25291248:C:T | - | -0.0326531166767996 | 0.0468898609854206 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg10137231 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.342378159560947 | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg06351481 | |
| Position to Gene: gene,CDS,UTR,promoter,exon | |
| Male Effect: - | |
| Female Effect: -0.342378159560947 | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg07004075 | |
| Position to Gene: gene,exon,CDS,UTR | |
| Male Effect: - | |
| Female Effect: -0.256709498089003 | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg18512948 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.464677432867908 | |
| Female Effect: - | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg16473141 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.222224444794214 | |
| Female Effect: - | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg01574481 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.222224444794214 | |
| Female Effect: - | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg01574481 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.489835644331989 | |
| Female Effect: - | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg10137231 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.299557551206861 | |
 | Gene ID: ENSG00000100918 |
| CpG Site: cg18512948 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.274292438121222 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg18512948 | chr14:24172497 | gene,exon,promoter,UTR | -0.464677432867908 | 3.50265468537711e-15 | -0.5638188705241267 | 2.915506890192298e-18 | KIRP |
| cg16473141 | chr14:24172292 | gene,exon,promoter,UTR | -0.222224444794214 | 5.38945118577345e-06 | -0.3733980501015601 | 4.772759020188128e-08 | KIRP |
| cg01574481 | chr14:24172643 | gene,exon,promoter,UTR | -0.222224444794214 | 5.38945118577345e-06 | -0.3733980501015601 | 4.772759020188128e-08 | KIRP |
| cg01574481 | chr14:24172643 | gene,exon,promoter,UTR | -0.489835644331989 | 1.59655251863178e-94 | -0.9324551073007707 | 1.1076334659661376e-99 | LUAD |
| cg18512948 | chr14:24172497 | gene,exon,promoter,UTR | -0.274292438121222 | 1.04922211987249e-20 | -0.4979260551481584 | 1.881280339979407e-24 | HNSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg10137231 | chr14:24171812 | promoter | -0.342378159560947 | 7.01647217714563e-08 | -0.6741696952469796 | 7.149657866193242e-12 | PAAD |
| cg06351481 | chr14:24173010 | gene,CDS,UTR,promoter,exon | -0.342378159560947 | 7.01647217714563e-08 | -0.6741696952469796 | 7.149657866193242e-12 | PAAD |
| cg07004075 | chr14:24180129 | gene,exon,CDS,UTR | -0.256709498089003 | 9.17476252388839e-08 | -0.320252135460784 | 3.195206309049421e-10 | THCA |
| cg10137231 | chr14:24171812 | promoter | -0.299557551206861 | 4.06201668239351e-05 | -0.5203522731309909 | 5.510754517331621e-08 | LUSC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of REC8 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000100918 | REC8 | C0025202 | melanoma | 1 | CTD_human |
| ENSG00000100918 | REC8 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000100918 | REC8 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
