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Gene: ENSG00000100558 |
Summary for PLEK2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000100558 | Gene symbol | PLEK2 |
| Gene name | pleckstrin 2 | |
| HGNC | 19238 | |
| Entrez ID | 26499 | |
| Gene type | protein_coding | |
| Synonyms | PLEK2| | |
| UniProtAcc | Q9NYT0 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PLEK2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PLEK2 | 2.88e+03 | 1.14e+00 | 4.30e-01 | 2.65e+00 | 8.17e-03 | 3.24e-02 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PLEK2 | 6.86e+02 | -1.89e+00 | 3.87e-01 | -4.88e+00 | 1.05e-06 | 5.28e-06 | LIHC |
| PLEK2 | 4.81e+02 | 1.38e+00 | 9.19e-02 | 1.51e+01 | 2.61e-51 | 2.75e-50 | BRCA |
Top |
Sex-biased somatic mutation for PLEK2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PLEK2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg17641252 | chr14:67411818 | CGI:chr14:67411817-67412450 | promoter,gene body | 5.85e-01 | 7.61e-01 | -2.40e+00 | 1.65e-02 | 3.24e-02 | -1.77e-01 |
| ESCA | cg17641252 | chr14:67411818 | CGI:chr14:67411817-67412450 | promoter,gene body | 3.37e-01 | 2.31e-01 | 2.97e+00 | 3.00e-03 | 1.14e-02 | 1.06e-01 |
| MESO | cg17641252 | chr14:67411818 | CGI:chr14:67411817-67412450 | promoter,gene body | 4.13e-01 | 5.57e-01 | -2.20e+00 | 2.77e-02 | 4.33e-02 | -1.44e-01 |
| KICH | cg17641252 | chr14:67411818 | CGI:chr14:67411817-67412450 | promoter,gene body | 4.86e-01 | 3.55e-01 | 2.02e+00 | 4.32e-02 | 4.75e-02 | 1.31e-01 |
| DLBC | cg07540634 | chr14:67411425 | CGI:chr14:67411817-67412450 | promoter,gene body | 5.02e-01 | 6.24e-01 | -2.13e+00 | 3.31e-02 | 4.38e-02 | -1.23e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg07540634 | chr14:67411425 | CGI:chr14:67411817-67412450 | promoter,gene body | 6.55e-01 | 8.18e-01 | -4.91e+00 | 9.07e-07 | 3.34e-06 | -1.62e-01 |
| LUSC | cg17641252 | chr14:67411818 | CGI:chr14:67411817-67412450 | promoter,gene body | 4.16e-01 | 5.23e-01 | -2.29e+00 | 2.21e-02 | 2.58e-02 | -1.07e-01 |
| LUSC | cg07540634 | chr14:67411425 | CGI:chr14:67411817-67412450 | promoter,gene body | 5.39e-01 | 6.99e-01 | -3.24e+00 | 1.19e-03 | 2.92e-03 | -1.60e-01 |
| BLCA | cg07540634 | chr14:67411425 | CGI:chr14:67411817-67412450 | promoter,gene body | 4.39e-01 | 5.73e-01 | -3.01e+00 | 2.60e-03 | 4.83e-03 | -1.34e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg24995657 | chr14:67412409 | CGI:chr14:67411817-67412450 | promoter | 1.39e-01 | 3.09e-01 | -3.75e+00 | 1.79e-04 | 2.90e-03 | -1.70e-01 |
| BLCA | cg18306861 | chr14:67412384 | CGI:chr14:67411817-67412450 | promoter | 1.62e-01 | 3.47e-01 | -3.94e+00 | 8.09e-05 | 2.86e-03 | -1.86e-01 |
| BLCA | cg26225496 | chr14:67412449 | CGI:chr14:67411817-67412450 | promoter | 1.69e-01 | 2.80e-01 | -3.65e+00 | 2.62e-04 | 3.04e-03 | -1.11e-01 |
Top |
Exon skipping events with PSI in TCGA for PLEK2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PLEK2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PLEK2 |
| TFs related to PLEK2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | DMRT2 | PLEK2 | 3.41e+00 | 3.27e-03 | 4.63e+00 | 9.92e-01 | Female-biased |
| CHOL | ONECUT3 | PLEK2 | 3.51e+00 | 5.48e-03 | 4.60e+00 | 9.90e-01 | Female-biased |
| CHOL | TBP | PLEK2 | 3.02e+00 | 3.56e-03 | 4.21e+00 | 9.87e-01 | Female-biased |
| CHOL | ZFP82 | PLEK2 | 2.72e+00 | 1.95e-03 | 4.05e+00 | 9.87e-01 | Female-biased |
| PLEK2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PLEK2 |
| RBPs related to ES in PLEK2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | SAMD4A | exon_skip_113946 | 7.09e+00 | 9.86e-01 | 6.39e+00 | 1.89e-03 | Male-biased |
| READ | MATR3 | exon_skip_113951 | 8.45e+00 | 9.86e-01 | 8.09e+00 | 6.94e-03 | Male-biased |
| PLEK2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10483824 | chr14:70161414:C:T | - | 0.221055961215822 | 0.0405392170612553 | READ | Female-baised eQTL |
| rs1092015 | chr14:57734007:A:G | - | -0.143717664604066 | 0.018960272733648 | HNSC | Female-baised eQTL |
| rs1092021 | chr14:57730311:C:T | - | -0.12539966255652 | 0.0259787679681912 | HNSC | Female-baised eQTL |
| rs28395471 | chr14:57735329:A:C | - | 0.147759295753432 | 0.0404320020978151 | HNSC | Female-baised eQTL |
| rs193548 | chr14:72191973:C:T | - | 0.166426995463309 | 0.028685175247646 | KIRP | Female-baised eQTL |
| rs758238 | chr14:74455350:C:T | - | 0.140935041721057 | 0.000179769291831183 | LUSC | Female-baised eQTL |
| rs58821647 | chr14:74460509:C:T | - | 0.143668373536241 | 0.00115524714651171 | LUSC | Female-baised eQTL |
| rs58216005 | chr14:74440803:G:T | - | 0.141239396081147 | 0.00180992828093453 | LUSC | Female-baised eQTL |
| rs60147521 | chr14:74442680:G:C | - | 0.10758165366013 | 0.00521373732542635 | LUSC | Female-baised eQTL |
| rs17827024 | chr14:66253031:C:T | - | 0.0943640072312359 | 0.00702824395584718 | LUSC | Female-baised eQTL |
| rs59098568 | chr14:66251426:T:G | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs60356521 | chr14:66258801:T:C | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs17103412 | chr14:66259057:C:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs8010962 | chr14:66260061:C:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs60458183 | chr14:66260978:G:A | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs2164195 | chr14:66261165:G:C | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs7144229 | chr14:66262559:C:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs60713996 | chr14:66265035:T:C | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs10483786 | chr14:66266808:C:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs55918163 | chr14:66273747:G:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs17103447 | chr14:66274320:A:G | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs59773917 | chr14:66277910:C:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs4438241 | chr14:66279315:C:T | - | 0.0862914702568191 | 0.0186172555690938 | LUSC | Female-baised eQTL |
| rs8010443 | chr14:66259629:G:A | - | 0.0813499164144024 | 0.0360646359283765 | LUSC | Female-baised eQTL |
| rs950197 | chr14:66269450:C:T | - | 0.0813499164144024 | 0.0360646359283765 | LUSC | Female-baised eQTL |
| rs60467718 | chr14:66280152:T:C | - | 0.0813499164144024 | 0.0360646359283765 | LUSC | Female-baised eQTL |
| rs311854 | chr14:58726302:G:A | - | -0.068673589152893 | 0.0403426188465624 | LUSC | Female-baised eQTL |
| rs8019057 | chr14:63641617:T:C | - | 0.125910742459903 | 0.00246770846740078 | KIRC | Female-baised eQTL |
| rs7154883 | chr14:63662746:A:T | - | 0.120169048910492 | 0.00488579446449031 | KIRC | Female-baised eQTL |
| rs11847188 | chr14:63664859:A:G | - | 0.120169048910492 | 0.00488579446449031 | KIRC | Female-baised eQTL |
| rs56247501 | chr14:63670753:G:C | - | 0.120169048910492 | 0.00488579446449031 | KIRC | Female-baised eQTL |
| rs55986487 | chr14:61646264:C:T | - | 0.114730135609095 | 0.00698235529406582 | KIRC | Female-baised eQTL |
| rs11845359 | chr14:61645923:C:T | - | 0.114522208549621 | 0.00727986883899058 | KIRC | Female-baised eQTL |
| rs73263680 | chr14:63675064:T:A | - | 0.106801472733602 | 0.0111239502671992 | KIRC | Female-baised eQTL |
| rs7494064 | chr14:65821192:C:T | - | -0.0676332798991253 | 0.0244824044889643 | LUAD | Female-baised eQTL |
| rs7494181 | chr14:65820987:T:C | - | -0.0731531949457396 | 0.0335557871003799 | LUAD | Female-baised eQTL |
| rs45518539 | chr14:77275860:T:C | - | 0.132270703184108 | 0.016354931868409 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17781612 | chr14:72824001:G:A | - | 0.0766714727853277 | 0.0269787166106743 | LIHC | Male-baised eQTL |
| rs34500622 | chr14:72824661:G:A | - | 0.0863661349394555 | 0.0294796100636021 | LIHC | Male-baised eQTL |
| rs12590668 | chr14:70639070:T:C | - | 0.0546152953482843 | 0.0114178866057243 | LUSC | Male-baised eQTL |
| rs12590135 | chr14:73720454:G:T | - | 0.10740199619591 | 2.07211901486851e-07 | KIRC | Male-baised eQTL |
| rs9652296 | chr14:73718893:C:T | - | 0.101828929275314 | 4.93988911129876e-07 | KIRC | Male-baised eQTL |
| rs9944000 | chr14:76469129:T:C | - | 0.0584222311971705 | 6.83434535285987e-07 | KIRC | Male-baised eQTL |
| rs113651131 | chr14:76459050:G:C | - | 0.0502287798029887 | 5.12358235070025e-05 | KIRC | Male-baised eQTL |
| rs61989969 | chr14:65379238:T:C | - | 0.0911358591766721 | 0.000185169525751134 | KIRC | Male-baised eQTL |
| rs61989971 | chr14:65389253:G:A | - | 0.090008665036648 | 0.000186062245146229 | KIRC | Male-baised eQTL |
| rs149946155 | chr14:65466753:A:G | - | 0.0879334154608357 | 0.000245338850830408 | KIRC | Male-baised eQTL |
| rs61989970 | chr14:65380736:C:G | - | 0.0885279354572849 | 0.000282772454932291 | KIRC | Male-baised eQTL |
| rs111810177 | chr14:65700413:C:T | - | 0.0834679173539219 | 0.000657342257250831 | KIRC | Male-baised eQTL |
| rs927005 | chr14:65752364:G:C | - | 0.0823770619713607 | 0.000892056899590243 | KIRC | Male-baised eQTL |
| rs11845391 | chr14:65715660:A:G | - | 0.0811748170569231 | 0.000946128548779222 | KIRC | Male-baised eQTL |
| rs61987776 | chr14:65720393:G:A | - | 0.0811748170569231 | 0.000946128548779222 | KIRC | Male-baised eQTL |
| rs61987779 | chr14:65726036:G:A | - | 0.0811748170569231 | 0.000946128548779222 | KIRC | Male-baised eQTL |
| rs61987781 | chr14:65728865:G:A | - | 0.0811748170569231 | 0.000946128548779222 | KIRC | Male-baised eQTL |
| rs182483296 | chr14:65717080:G:A | - | 0.0811386970032294 | 0.000986691356950342 | KIRC | Male-baised eQTL |
| rs61987814 | chr14:65755062:G:T | - | 0.0806770940520267 | 0.00108591690705187 | KIRC | Male-baised eQTL |
| rs61987985 | chr14:65578522:C:A | - | 0.0792448822592629 | 0.00126793554664824 | KIRC | Male-baised eQTL |
| rs28489447 | chr14:65758434:T:A | - | 0.0792688816595739 | 0.00127625414862678 | KIRC | Male-baised eQTL |
| rs55793205 | chr14:65550799:T:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs17102760 | chr14:65551168:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs10138701 | chr14:65559222:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs11849408 | chr14:65560515:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987981 | chr14:65564920:T:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs7153718 | chr14:65567112:T:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs56192128 | chr14:65568048:G:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs17102783 | chr14:65581301:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs55648350 | chr14:65588060:T:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987988 | chr14:65593979:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs6573620 | chr14:65596677:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987989 | chr14:65597610:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs115999275 | chr14:65602949:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs7155055 | chr14:65609634:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs8019214 | chr14:65610070:T:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987995 | chr14:65613553:G:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987996 | chr14:65623221:C:T | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs8013098 | chr14:65624819:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs117447583 | chr14:65635546:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61988016 | chr14:65638046:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs17102807 | chr14:65638361:T:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs11851934 | chr14:65638615:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs11846196 | chr14:65640954:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61988017 | chr14:65646453:T:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs17779210 | chr14:65647536:A:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61988019 | chr14:65658932:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs8004852 | chr14:65665730:C:T | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61988021 | chr14:65666468:C:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs7148883 | chr14:65667187:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61988022 | chr14:65674728:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs11846827 | chr14:65676397:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs17102845 | chr14:65677912:A:C | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987768 | chr14:65684901:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs11846051 | chr14:65693263:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs61987770 | chr14:65697062:G:A | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs7154526 | chr14:65697899:C:T | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs7154876 | chr14:65698082:C:T | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs7144234 | chr14:65699513:A:G | - | 0.0791651962288321 | 0.00129117467316592 | KIRC | Male-baised eQTL |
| rs8008705 | chr14:65595903:G:A | - | 0.0789978271375321 | 0.0013590394137769 | KIRC | Male-baised eQTL |
| rs10483783 | chr14:65616485:A:G | - | 0.0780031958046138 | 0.00141947020250959 | KIRC | Male-baised eQTL |
| rs61987837 | chr14:65272389:C:T | - | 0.0657475449615445 | 0.0014768157274577 | KIRC | Male-baised eQTL |
| rs55853120 | chr14:65754343:C:G | - | 0.0784501537417069 | 0.00157367312001066 | KIRC | Male-baised eQTL |
| rs28666667 | chr14:65759382:C:T | - | 0.0784501537417069 | 0.00157367312001066 | KIRC | Male-baised eQTL |
| rs28402125 | chr14:65759743:C:G | - | 0.0784501537417069 | 0.00157367312001066 | KIRC | Male-baised eQTL |
| rs61989974 | chr14:65395438:C:T | - | 0.0774977585235438 | 0.00163328720001371 | KIRC | Male-baised eQTL |
| rs56024518 | chr14:65762641:T:C | - | 0.078126151060641 | 0.00172108555955302 | KIRC | Male-baised eQTL |
| rs61990027 | chr14:65536627:A:T | - | 0.0760201548291538 | 0.00240286720936259 | KIRC | Male-baised eQTL |
| rs8003093 | chr14:65542076:G:A | - | 0.0760201548291538 | 0.00240286720936259 | KIRC | Male-baised eQTL |
| rs17102910 | chr14:65748124:A:T | - | 0.0752790595862411 | 0.00294924501419706 | KIRC | Male-baised eQTL |
| rs61987810 | chr14:65749115:G:T | - | 0.0752790595862411 | 0.00294924501419706 | KIRC | Male-baised eQTL |
| rs61989977 | chr14:65397734:A:G | - | 0.0743848696564478 | 0.00300263789667088 | KIRC | Male-baised eQTL |
| rs11849792 | chr14:65715718:T:C | - | 0.0743180401179351 | 0.00305633726788308 | KIRC | Male-baised eQTL |
| rs61989975 | chr14:65395556:C:A | - | 0.0743315476445885 | 0.0030574856902314 | KIRC | Male-baised eQTL |
| rs8005892 | chr14:65407203:T:C | - | 0.0733437891803812 | 0.00325667529361396 | KIRC | Male-baised eQTL |
| rs12436381 | chr14:65554851:A:T | - | 0.0725971781688459 | 0.00393122328593483 | KIRC | Male-baised eQTL |
| rs10131727 | chr14:65556779:G:A | - | 0.0725971781688459 | 0.00393122328593483 | KIRC | Male-baised eQTL |
| rs10149311 | chr14:65550082:A:G | - | 0.0724380342686761 | 0.00410570944403262 | KIRC | Male-baised eQTL |
| rs17102894 | chr14:65737089:C:T | - | 0.0725244917602537 | 0.00478789518141506 | KIRC | Male-baised eQTL |
| rs2268965 | chr14:65737871:C:T | - | 0.0725244917602537 | 0.00478789518141506 | KIRC | Male-baised eQTL |
| rs76710655 | chr14:59407824:C:T | - | 0.0612073765388771 | 0.00540974388960929 | KIRC | Male-baised eQTL |
| rs148202193 | chr14:65267156:C:T | - | 0.0587786669559078 | 0.00544153454948431 | KIRC | Male-baised eQTL |
| rs4902378 | chr14:65267422:T:C | - | 0.0580779924941789 | 0.00610467867165586 | KIRC | Male-baised eQTL |
| rs7160754 | chr14:65363987:T:C | - | 0.0697985465664641 | 0.00621567039092049 | KIRC | Male-baised eQTL |
| rs11848647 | chr14:65547489:A:T | - | 0.0682001697653787 | 0.00742683423026462 | KIRC | Male-baised eQTL |
| rs55760239 | chr14:65794994:T:C | - | 0.0668611613615748 | 0.0102787082534572 | KIRC | Male-baised eQTL |
| rs61990002 | chr14:65466383:T:C | - | 0.0656110568324548 | 0.011729751977471 | KIRC | Male-baised eQTL |
| rs7156029 | chr14:65492121:C:T | - | 0.0656110568324548 | 0.011729751977471 | KIRC | Male-baised eQTL |
| rs11852179 | chr14:65517205:T:C | - | 0.0656110568324548 | 0.011729751977471 | KIRC | Male-baised eQTL |
| rs56191137 | chr14:65538863:G:T | - | 0.0656110568324548 | 0.011729751977471 | KIRC | Male-baised eQTL |
| rs7143112 | chr14:65529901:T:C | - | 0.065447075331701 | 0.0122036954049226 | KIRC | Male-baised eQTL |
| rs7342545 | chr14:65677037:C:T | - | 0.0653910779215359 | 0.0123377615871835 | KIRC | Male-baised eQTL |
| rs61990000 | chr14:65456909:G:A | - | 0.0644706198205398 | 0.0132945472758767 | KIRC | Male-baised eQTL |
| rs55780087 | chr14:65353874:A:C | - | 0.0637536828013927 | 0.014336249236731 | KIRC | Male-baised eQTL |
| rs4243623 | chr14:62615521:T:C | - | -0.0410876004739617 | 0.0256629090338774 | KIRC | Male-baised eQTL |
| rs17102898 | chr14:65739250:A:G | - | 0.0567922061435476 | 0.0306551963622008 | KIRC | Male-baised eQTL |
| rs6573846 | chr14:68625850:G:C | - | -0.0393644949455102 | 0.0316914727053811 | KIRC | Male-baised eQTL |
| rs8004564 | chr14:65714670:G:A | - | 0.0561627529830666 | 0.0319306463182795 | KIRC | Male-baised eQTL |
| rs2898701 | chr14:65719431:A:C | - | 0.0561627529830666 | 0.0319306463182795 | KIRC | Male-baised eQTL |
| rs11849249 | chr14:65727301:T:C | - | 0.0561627529830666 | 0.0319306463182795 | KIRC | Male-baised eQTL |
| rs59036531 | chr14:65727704:A:G | - | 0.0561627529830666 | 0.0319306463182795 | KIRC | Male-baised eQTL |
| rs11847101 | chr14:65734655:G:C | - | 0.0561627529830666 | 0.0319306463182795 | KIRC | Male-baised eQTL |
| rs956582 | chr14:65735158:A:G | - | 0.0561481932540858 | 0.0321967196060435 | KIRC | Male-baised eQTL |
| rs6573597 | chr14:65254165:G:A | - | 0.0488482109464154 | 0.0325450556113109 | KIRC | Male-baised eQTL |
| rs8016230 | chr14:65253838:G:A | - | 0.0487911494957152 | 0.0331050878817914 | KIRC | Male-baised eQTL |
| rs1253177 | chr14:59428326:T:C | - | 0.0412458015989578 | 0.0373093349445231 | KIRC | Male-baised eQTL |
| rs61987778 | chr14:65724488:T:C | - | 0.0549528758537847 | 0.0374906016617883 | KIRC | Male-baised eQTL |
| rs997794 | chr14:65726009:T:C | - | 0.0549528758537847 | 0.0374906016617883 | KIRC | Male-baised eQTL |
| rs1253178 | chr14:59428528:G:C | - | 0.0413499566045651 | 0.0375634851469338 | KIRC | Male-baised eQTL |
| rs56182635 | chr14:65722900:G:A | - | 0.0545356633668147 | 0.0377368042275348 | KIRC | Male-baised eQTL |
| rs73268558 | chr14:65654895:G:T | - | 0.0532850235887841 | 0.0392058554145021 | KIRC | Male-baised eQTL |
| rs2151754 | chr14:65239297:T:C | - | 0.0476647637972052 | 0.042704441633989 | KIRC | Male-baised eQTL |
| rs10444729 | chr14:62611642:G:A | - | -0.0384629855113805 | 0.0427319650151722 | KIRC | Male-baised eQTL |
| rs28484937 | chr14:62603310:A:C | - | 0.038957006727618 | 0.0428467121615613 | KIRC | Male-baised eQTL |
| rs8022737 | chr14:65249449:C:T | - | 0.0468760863781373 | 0.0432026774842406 | KIRC | Male-baised eQTL |
| rs12880103 | chr14:73263076:G:C | - | 0.0337878243923847 | 0.0464558319120425 | KIRC | Male-baised eQTL |
| rs882319 | chr14:72664465:C:T | - | 0.114051549370718 | 0.0245550231227457 | BLCA | Male-baised eQTL |
| rs34130298 | chr14:57951056:G:C | - | 0.0723449021761578 | 0.0310156159071526 | BLCA | Male-baised eQTL |
| rs10130343 | chr14:65062169:A:T | - | 0.0783180665224647 | 0.0327976351199744 | BLCA | Male-baised eQTL |
| rs11848817 | chr14:65062174:T:C | - | 0.0783180665224647 | 0.0327976351199744 | BLCA | Male-baised eQTL |
| rs423737 | chr14:58791235:G:T | - | -0.0779086125218372 | 0.0323466647100341 | LUAD | Male-baised eQTL |
| rs8022288 | chr14:70380407:C:T | - | -0.074721545206386 | 0.0331385689463117 | LUAD | Male-baised eQTL |
| rs7157399 | chr14:70380237:T:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs8022315 | chr14:70380438:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7146414 | chr14:70381388:T:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7145450 | chr14:70381407:G:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs2332368 | chr14:70381974:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10146573 | chr14:70382371:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10146506 | chr14:70382397:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10146684 | chr14:70382540:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs2332369 | chr14:70382977:C:A | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs2877660 | chr14:70383295:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7146493 | chr14:70383437:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7148114 | chr14:70383541:T:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7147906 | chr14:70384091:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs6573958 | chr14:70384319:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7152584 | chr14:70384331:C:A | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10710090 | chr14:70384490:A:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs115058122 | chr14:70384492:G:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs6573959 | chr14:70384594:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10148810 | chr14:70385104:T:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs8021610 | chr14:70385280:T:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7150558 | chr14:70387954:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs6573960 | chr14:70390305:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10139233 | chr14:70392714:C:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs8008400 | chr14:70396171:A:T | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7158315 | chr14:70397547:T:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs2332371 | chr14:70398242:T:A | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs9788537 | chr14:70398384:C:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs2332374 | chr14:70400378:A:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs10140263 | chr14:70403483:A:C | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs2332375 | chr14:70404675:C:A | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7146553 | chr14:70405078:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7158117 | chr14:70406715:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7159747 | chr14:70406761:T:A | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs7159039 | chr14:70407237:A:G | - | -0.0713361131980755 | 0.0493551382316798 | LUAD | Male-baised eQTL |
| rs8008633 | chr14:58952592:C:T | - | -0.063533504078149 | 0.0175859439869087 | COAD | Male-baised eQTL |
| rs927052 | chr14:58954819:G:A | - | -0.063533504078149 | 0.0175859439869087 | COAD | Male-baised eQTL |
| rs1270051 | chr14:63944585:A:G | - | -0.0566293562513113 | 0.0265239435242273 | COAD | Male-baised eQTL |
| rs1954486 | chr14:62075983:G:C | - | -0.05120031031342 | 0.0372293340908433 | COAD | Male-baised eQTL |
| rs9323442 | chr14:63942264:A:G | - | -0.0531054413314638 | 0.0400641065917754 | COAD | Male-baised eQTL |
| rs11622025 | chr14:72779718:C:A | - | 0.0716696629251824 | 0.0450548087367348 | COAD | Male-baised eQTL |
| rs1255857 | chr14:63944637:T:C | - | -0.0526114457334554 | 0.0481031310479789 | COAD | Male-baised eQTL |
| rs4027383 | chr14:64000150:G:T | - | 0.0467467973795559 | 0.0490302980118094 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000100558 |
| CpG Site: cg14437634 | |
| Position to Gene: promoter | |
| Male Effect: -0.451427433663769 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14437634 | chr14:67412668 | promoter | -0.451427433663769 | 5.86823868395988e-10 | -0.4596427791554622 | 1.0910459528569318e-12 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PLEK2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000100558 | PLEK2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000100558 | PLEK2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
