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Gene: ENSG00000100373 |
Summary for UPK3A |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000100373 | Gene symbol | UPK3A |
| Gene name | uroplakin 3A | |
| HGNC | 12580 | |
| Entrez ID | 7380 | |
| Gene type | protein_coding | |
| Synonyms | UPK3A| | |
| UniProtAcc | O75631 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for UPK3A |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| UPK3A | 7.26e+01 | -2.70e+00 | 6.40e-01 | -4.22e+00 | 2.49e-05 | 7.18e-04 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| UPK3A | 1.07e+01 | 1.52e+00 | 3.96e-01 | 3.83e+00 | 1.29e-04 | 3.20e-04 | KIRP |
| UPK3A | 1.12e+02 | 4.74e+00 | 8.33e-01 | 5.68e+00 | 1.33e-08 | 1.46e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for UPK3A |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for UPK3A |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg16891104 | chr22:45285134 | CGI:chr22:45284763-45285135 | promoter,gene body | 3.36e-01 | 4.86e-01 | -3.02e+00 | 2.51e-03 | 1.19e-02 | -1.49e-01 |
| CHOL | cg11523020 | chr22:45285155 | CGI:chr22:45284763-45285135 | promoter,gene body | 2.70e-01 | 3.87e-01 | -2.51e+00 | 1.22e-02 | 2.39e-02 | -1.17e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg07366660 | chr22:45284617 | CGI:chr22:45284763-45285135 | promoter | 2.66e-01 | 3.75e-01 | -3.80e+00 | 1.44e-04 | 5.06e-04 | -1.09e-01 |
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Exon skipping events with PSI in TCGA for UPK3A |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for UPK3A |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for UPK3A |
| TFs related to UPK3A. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | ZNF157 | UPK3A | 3.14e+00 | 9.09e-03 | 4.22e+00 | 9.81e-01 | Female-biased |
| UPK3A related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for UPK3A |
| RBPs related to ES in UPK3A. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UPK3A related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs738412 | chr22:43737174:A:G | - | -0.0773204547970423 | 0.0319085692646222 | STAD | Female-baised eQTL |
| rs138595 | chr22:44570247:A:G | - | -0.163687119110612 | 0.0273648482243664 | BLCA | Female-baised eQTL |
| rs138582 | chr22:44560044:A:G | - | -0.160504582686027 | 0.0311846462060225 | BLCA | Female-baised eQTL |
| rs138586 | chr22:44563442:T:A | - | -0.160504582686027 | 0.0311846462060225 | BLCA | Female-baised eQTL |
| rs138587 | chr22:44564163:T:C | - | -0.160504582686027 | 0.0311846462060225 | BLCA | Female-baised eQTL |
| rs138588 | chr22:44564774:A:G | - | -0.160504582686027 | 0.0311846462060225 | BLCA | Female-baised eQTL |
| rs138591 | chr22:44568675:A:C | - | -0.160504582686027 | 0.0311846462060225 | BLCA | Female-baised eQTL |
| rs138594 | chr22:44569860:G:T | - | -0.160504582686027 | 0.0311846462060225 | BLCA | Female-baised eQTL |
| rs138592 | chr22:44569233:T:C | - | -0.150503754255814 | 0.0399753785591101 | BLCA | Female-baised eQTL |
| rs138590 | chr22:44567144:C:A | - | -0.157869896326408 | 0.0448543975631212 | BLCA | Female-baised eQTL |
| rs4594555 | chr22:44780272:T:G | - | -0.0642760931928212 | 0.00212534147423016 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs16995468 | chr22:46586988:C:T | - | 0.0415162737996608 | 0.0348953981190631 | BLCA | Male-baised eQTL |
| rs117479378 | chr22:46588101:C:T | - | 0.0413732846409752 | 0.0359086889937481 | BLCA | Male-baised eQTL |
| rs79627293 | chr22:46587058:G:A | - | 0.0413483494355304 | 0.0361341652149388 | BLCA | Male-baised eQTL |
| rs5767280 | chr22:46590836:G:A | - | 0.041120238331304 | 0.0383731094231428 | BLCA | Male-baised eQTL |
| rs5769003 | chr22:46592084:C:T | - | 0.041113705648881 | 0.0385894068969402 | BLCA | Male-baised eQTL |
| rs74939508 | chr22:46589940:C:G | - | 0.0412163261727975 | 0.0394381887813749 | BLCA | Male-baised eQTL |
| rs135702 | chr22:46713628:A:G | - | -0.0499175402847307 | 0.0478230103373747 | LUAD | Male-baised eQTL |
| rs5755752 | chr22:35566527:T:G | - | 0.0649222675126947 | 0.00515205192700981 | COAD | Male-baised eQTL |
| rs5755754 | chr22:35566593:A:G | - | 0.0649222675126947 | 0.00515205192700981 | COAD | Male-baised eQTL |
| rs5755755 | chr22:35566630:G:A | - | 0.0649222675126947 | 0.00515205192700981 | COAD | Male-baised eQTL |
| rs5755756 | chr22:35566672:A:G | - | 0.0649222675126947 | 0.00515205192700981 | COAD | Male-baised eQTL |
| rs2858524 | chr22:49277809:G:A | - | 0.0461931286583604 | 0.0126954505305039 | COAD | Male-baised eQTL |
| rs12485173 | chr22:39213510:G:C | - | 0.0340862266359072 | 0.0461621347497428 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000100373 |
| CpG Site: cg11523020 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.0619177951085909 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg11523020 | chr22:45285155 | gene,promoter | -0.0619177951085909 | 5.42046497327246e-05 | -0.3167655235113379 | 2.3767481427882414e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of UPK3A |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
