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Gene: ENSG00000100056 |
Summary for DGCR14 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000100056 | Gene symbol | DGCR14 |
| Gene name | ess-2 splicing factor homolog | |
| HGNC | 16817 | |
| Entrez ID | 8220 | |
| Gene type | protein_coding | |
| Synonyms | ESS2|DGSI|Es2el|ES2|DGS-H|ESS-2|bis1 | |
| UniProtAcc | Q96DF8 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for DGCR14 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for DGCR14 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for DGCR14 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for DGCR14 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for DGCR14 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for DGCR14 |
| TFs related to DGCR14. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF100 | DGCR14 | 4.27e+00 | 9.89e-01 | 3.22e+00 | 3.38e-03 | Male-biased |
| ACC | ZNF30 | DGCR14 | 4.25e+00 | 9.84e-01 | 3.41e+00 | 8.45e-03 | Male-biased |
| ACC | ZNF311 | DGCR14 | 4.32e+00 | 9.88e-01 | 3.36e+00 | 5.11e-03 | Male-biased |
| ACC | ZNF44 | DGCR14 | 4.17e+00 | 9.80e-01 | 3.40e+00 | 1.11e-02 | Male-biased |
| ACC | ZNF611 | DGCR14 | 4.50e+00 | 9.90e-01 | 3.51e+00 | 4.52e-03 | Male-biased |
| READ | PRDM6 | DGCR14 | 4.46e+00 | 9.84e-01 | 3.56e+00 | 7.16e-03 | Male-biased |
| READ | ZNF182 | DGCR14 | 4.57e+00 | 9.85e-01 | 3.70e+00 | 7.87e-03 | Male-biased |
| READ | ZNF22 | DGCR14 | 4.64e+00 | 9.87e-01 | 3.72e+00 | 6.44e-03 | Male-biased |
| READ | ZNF235 | DGCR14 | 4.87e+00 | 9.90e-01 | 3.90e+00 | 5.42e-03 | Male-biased |
| READ | ZNF418 | DGCR14 | 4.31e+00 | 9.88e-01 | 2.85e+00 | 8.35e-04 | Male-biased |
| READ | ZNF98 | DGCR14 | 4.38e+00 | 9.80e-01 | 3.56e+00 | 9.70e-03 | Male-biased |
| DGCR14 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for DGCR14 |
| RBPs related to ES in DGCR14. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | HNRNPA1L2 | exon_skip_367399 | 1.32e+01 | 9.99e-01 | 1.26e+01 | 6.46e-04 | Male-biased |
| LIHC | HNRNPA1L2 | exon_skip_367399 | 1.27e+01 | 1.43e-03 | 1.34e+01 | 9.98e-01 | Female-biased |
| LUAD | HNRNPA1L2 | exon_skip_367399 | 1.33e+01 | 9.98e-01 | 1.28e+01 | 1.59e-03 | Male-biased |
| KIRP | HNRNPA1L2 | exon_skip_367399 | 1.33e+01 | 9.99e-01 | 1.28e+01 | 1.13e-03 | Male-biased |
| BRCA | HNRNPA1L2 | exon_skip_367399 | 1.34e+01 | 9.94e-01 | 1.27e+01 | 5.85e-03 | Male-biased |
| ESCA | HNRNPA1L2 | exon_skip_367399 | 1.26e+01 | 4.30e-03 | 1.31e+01 | 9.95e-01 | Female-biased |
| THCA | HNRNPA1L2 | exon_skip_367399 | 1.34e+01 | 9.99e-01 | 1.28e+01 | 4.24e-04 | Male-biased |
| MESO | NOVA2 | exon_skip_367400 | 7.37e+00 | 9.21e-03 | 7.73e+00 | 9.81e-01 | Female-biased |
| LGG | HNRNPA1L2 | exon_skip_367399 | 1.27e+01 | 2.59e-03 | 1.32e+01 | 9.97e-01 | Female-biased |
| LGG | SRSF9 | exon_skip_367400 | 6.76e+00 | 9.82e-01 | 6.29e+00 | 2.24e-03 | Male-biased |
| PAAD | HNRNPA1L2 | exon_skip_367399 | 1.34e+01 | 9.99e-01 | 1.28e+01 | 5.03e-04 | Male-biased |
| KICH | HNRNPA1L2 | exon_skip_367399 | 1.31e+01 | 9.99e-01 | 1.24e+01 | 3.69e-04 | Male-biased |
| SARC | HNRNPA1L2 | exon_skip_367399 | 1.33e+01 | 9.98e-01 | 1.27e+01 | 1.39e-03 | Male-biased |
| DGCR14 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs144503696 | chr22:20687983:C:G | - | 0.147645961570088 | 0.0140822426335804 | HNSC | Female-baised eQTL |
| rs143777398 | chr22:23309028:A:G | - | 0.11340798945697 | 0.00172151039245944 | LUSC | Female-baised eQTL |
| rs635829 | chr22:25525786:G:A | - | 0.11737066922752 | 0.0106064001106852 | LUSC | Female-baised eQTL |
| rs555682 | chr22:25525816:T:C | - | 0.114418073081044 | 0.0112671147034194 | LUSC | Female-baised eQTL |
| rs73167602 | chr22:24396695:A:T | - | 0.121114153060408 | 0.0123769720674283 | LUSC | Female-baised eQTL |
| rs5761165 | chr22:25758541:C:T | - | 0.116778837890442 | 0.0216955376264819 | LUSC | Female-baised eQTL |
| rs5996752 | chr22:24711009:G:A | - | 0.0919169973869329 | 0.025316990735753 | LUSC | Female-baised eQTL |
| rs500570 | chr22:25517754:C:T | - | 0.11811189022958 | 0.025643152510164 | LUSC | Female-baised eQTL |
| rs28641760 | chr22:25529641:A:G | - | 0.105715698858749 | 0.0279943553862035 | LUSC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs5997102 | chr22:20970974:G:C | - | 0.101490239743028 | 0.0239439161408692 | LIHC | Male-baised eQTL |
| rs9967 | chr22:17728439:T:C | - | 0.0475443041348581 | 0.0398755762748405 | LIHC | Male-baised eQTL |
| rs4822713 | chr22:26365217:A:G | - | 0.0443095797328438 | 0.0332194475674876 | KIRC | Male-baised eQTL |
| rs1534917 | chr22:25144875:A:G | - | 0.041821546292279 | 0.00251490309003096 | BLCA | Male-baised eQTL |
| rs73162205 | chr22:25148064:T:C | - | 0.0415740691900399 | 0.00275835043256986 | BLCA | Male-baised eQTL |
| rs134730 | chr22:26120164:G:A | - | 0.0416374130075232 | 0.0430656046360288 | BLCA | Male-baised eQTL |
| rs134731 | chr22:26120564:A:C | - | 0.0416374130075232 | 0.0430656046360288 | BLCA | Male-baised eQTL |
| rs134732 | chr22:26120637:A:G | - | 0.0416374130075232 | 0.0430656046360288 | BLCA | Male-baised eQTL |
| rs134729 | chr22:26119665:A:T | - | 0.0415424110155681 | 0.0442576573893453 | BLCA | Male-baised eQTL |
| rs17606056 | chr22:25137829:G:A | - | 0.0367076565914414 | 0.0459710369418266 | BLCA | Male-baised eQTL |
| rs5993606 | chr22:19335739:G:A | - | -0.0525677899003915 | 0.00351527099365919 | COAD | Male-baised eQTL |
| rs13058398 | chr22:17344542:T:A | - | -0.0489803490009963 | 0.00384060451580871 | COAD | Male-baised eQTL |
| rs2283649 | chr22:19347926:G:A | - | -0.0524790267482755 | 0.0038751298250998 | COAD | Male-baised eQTL |
| rs11090514 | chr22:27762661:C:T | - | -0.0921251615843982 | 0.00994841089547585 | COAD | Male-baised eQTL |
| rs853295 | chr22:20700300:T:C | - | 0.0452898229123667 | 0.0218812378296481 | COAD | Male-baised eQTL |
| rs132546 | chr22:28919797:A:G | - | -0.066054021998847 | 0.0256529503661627 | COAD | Male-baised eQTL |
| rs5760196 | chr22:20722465:T:G | - | 0.0462539595129088 | 0.0260442712147357 | COAD | Male-baised eQTL |
| rs5760197 | chr22:20722466:T:C | - | 0.0462539595129088 | 0.0260442712147357 | COAD | Male-baised eQTL |
| rs5746723 | chr22:19341828:G:A | - | -0.0453779386108912 | 0.0287541191318129 | COAD | Male-baised eQTL |
| rs5751786 | chr22:20711644:A:T | - | 0.0439869185685876 | 0.0343942073205871 | COAD | Male-baised eQTL |
| rs200593427 | chr22:20696587:C:T | - | 0.0438215920661651 | 0.0356203326064365 | COAD | Male-baised eQTL |
| rs5760087 | chr22:20699382:C:T | - | 0.0438215920661651 | 0.0356203326064365 | COAD | Male-baised eQTL |
| rs1807692 | chr22:20718834:G:A | - | 0.0448297420594538 | 0.0361835208494411 | COAD | Male-baised eQTL |
| rs4822424 | chr22:23535546:G:C | - | -0.0544824146854826 | 0.0389854005489526 | COAD | Male-baised eQTL |
| rs12165475 | chr22:28721228:A:T | - | -0.0675701803538378 | 0.0414451695184173 | COAD | Male-baised eQTL |
| rs6004026 | chr22:20712214:T:C | - | 0.0425076113168465 | 0.0422091190209814 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of DGCR14 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
