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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000099284

Summary for H2AFY2

check button Gene summary

Gene informationEnsembl ID

ENSG00000099284

Gene symbol

H2AFY2

Gene namemacroH2A.2 histone
HGNC

14453

Entrez ID

55506

Gene typeprotein_coding
SynonymsMACROH2A2|
UniProtAcc

Q9P0M6


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for H2AFY2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
H2AFY21.73e+03-1.42e+003.74e-01-3.81e+001.38e-042.63e-03BRCA

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
H2AFY29.27e+02-1.02e+002.86e-01-3.58e+003.38e-049.80e-04KICH
H2AFY29.74e+021.49e+005.77e-012.58e+009.78e-032.45e-02CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
H2AFY21.00e+031.41e+003.47e-014.06e+004.86e-051.68e-04LIHC

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Sex-biased somatic mutation for H2AFY2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for H2AFY2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg13626863chr10:70054156CGI:chr10:70052562-70053937promoter,gene body3.04e-014.70e-01-2.29e+002.23e-023.65e-02-1.66e-01
DLBCcg14165614chr10:70052345CGI:chr10:70052562-70053937promoter5.73e-016.76e-012.05e+004.05e-024.68e-02-1.02e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg13626863chr10:70054156CGI:chr10:70052562-70053937promoter,gene body2.99e-011.77e-015.45e+004.95e-082.74e-071.22e-01
LUADcg19726179chr10:70053597CGI:chr10:70052562-70053937promoter,gene body1.24e-011.83e-023.89e+001.01e-042.83e-041.06e-01
LUSCcg18009000chr10:70052171CGI:chr10:70052562-70053937promoter5.36e-017.32e-01-3.41e+006.49e-041.96e-03-1.97e-01
LUSCcg20336571chr10:70052378CGI:chr10:70052562-70053937promoter4.22e-015.31e-01-2.79e+005.22e-038.43e-03-1.09e-01
CHOLcg20336571chr10:70052378CGI:chr10:70052562-70053937promoter5.09e-016.52e-01-1.99e+004.65e-024.65e-02-1.43e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg13626863chr10:70054156CGI:chr10:70052562-70053937promoter,gene body3.04e-011.98e-018.43e+003.40e-171.47e-161.06e-01
KIRCcg18009000chr10:70052171CGI:chr10:70052562-70053937promoter8.05e-016.79e-013.03e+002.48e-037.26e-031.26e-01
LUADcg13626863chr10:70054156CGI:chr10:70052562-70053937promoter,gene body4.12e-012.83e-013.19e+001.41e-034.02e-031.29e-01
HNSCcg13626863chr10:70054156CGI:chr10:70052562-70053937promoter,gene body3.99e-012.62e-012.62e+008.69e-031.73e-021.37e-01
COADcg20336571chr10:70052378CGI:chr10:70052562-70053937promoter4.78e-013.47e-012.76e+005.82e-031.06e-021.31e-01
LIHCcg20336571chr10:70052378CGI:chr10:70052562-70053937promoter5.61e-016.97e-01-2.58e+009.75e-031.36e-02-1.36e-01

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Exon skipping events with PSI in TCGA for H2AFY2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for H2AFY2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for H2AFY2

check buttonTFs related to H2AFY2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonH2AFY2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for H2AFY2

check buttonRBPs related to ES in H2AFY2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonH2AFY2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4546981chr10:65755859:T:A-0.8080255157180370.0432741083508244GBMFemale-baised eQTL
rs10824533chr10:77356791:C:T-0.0345855146997260.0480173992027885THCAFemale-baised eQTL
rs67734810chr10:77360098:A:C-0.0345855146997260.0480173992027885THCAFemale-baised eQTL
rs1439785chr10:77371524:T:G-0.0344940349157480.0483665946225256THCAFemale-baised eQTL
rs16928098chr10:70907019:C:T-0.1600899634285730.00266638846872082SARCFemale-baised eQTL
rs2758984chr10:76304028:T:C--0.1214142732755990.00339165875579165LIHCFemale-baised eQTL
rs2579789chr10:76300621:G:C--0.1070976368345990.0088591665424877LIHCFemale-baised eQTL
rs2579786chr10:76304465:G:A--0.1149238472185390.00923977228794534LIHCFemale-baised eQTL
rs989301chr10:76308982:T:G--0.1144341341925250.0176410052015301LIHCFemale-baised eQTL
rs2758965chr10:76319775:A:G--0.1144341341925250.0176410052015301LIHCFemale-baised eQTL
rs2573555chr10:76302813:A:G--0.1106174729828330.0196714355003547LIHCFemale-baised eQTL
rs2579777chr10:76329906:A:C--0.1103660844662370.0219201146248549LIHCFemale-baised eQTL
rs2758983chr10:76305877:A:T--0.1112659364962580.0259222696475705LIHCFemale-baised eQTL
rs1923614chr10:76305017:A:G--0.1099813655517380.0307577806692636LIHCFemale-baised eQTL
rs2395373chr10:76339557:C:T--0.1052630397134240.031534710235292LIHCFemale-baised eQTL
rs2395374chr10:76344169:A:C--0.1052630397134240.031534710235292LIHCFemale-baised eQTL
rs2758977chr10:76310278:T:A--0.1097740159006660.0327009671426867LIHCFemale-baised eQTL
rs2758970chr10:76317580:G:T--0.1097740159006660.0327009671426867LIHCFemale-baised eQTL
rs2104206chr10:76315669:G:A--0.1071634953216840.033916121560823LIHCFemale-baised eQTL
rs2758978chr10:76308484:G:A--0.1077089357599320.0386010047938493LIHCFemale-baised eQTL
rs2758964chr10:76319861:A:G--0.1077089357599320.0386010047938493LIHCFemale-baised eQTL
rs2758961chr10:76320554:G:A--0.1077089357599320.0386010047938493LIHCFemale-baised eQTL
rs967948chr10:76318401:T:C--0.1055100631647420.0388293436987425LIHCFemale-baised eQTL
rs4745813chr10:76337014:A:T--0.1019282154397370.0406189398756895LIHCFemale-baised eQTL
rs2758975chr10:76311796:C:T--0.1046206887105330.0440479367778321LIHCFemale-baised eQTL
rs72809242chr10:70383461:C:G-0.2111666188906521.86473514281139e-05STADFemale-baised eQTL
rs1904594chr10:70384502:A:C-0.2111666188906521.86473514281139e-05STADFemale-baised eQTL
rs9415644chr10:62115403:A:G-0.1239066474532840.000298863704904932STADFemale-baised eQTL
rs9415643chr10:62111663:C:T-0.1252506281967380.000307500019563843STADFemale-baised eQTL
rs9414765chr10:62119962:A:G-0.1286210653674640.00056161826524704STADFemale-baised eQTL
rs9415647chr10:62122435:C:T-0.1286360490353530.000571657670157354STADFemale-baised eQTL
rs9415649chr10:62126011:T:C-0.1286360490353530.000571657670157354STADFemale-baised eQTL
rs9414766chr10:62131356:G:A-0.1284121284797570.000611310451596536STADFemale-baised eQTL
rs7078374chr10:62071879:G:A--0.1151081438041950.00081300652437722STADFemale-baised eQTL
rs9415637chr10:62080506:T:G-0.1097708903061510.00136625250745525STADFemale-baised eQTL
rs9414759chr10:62080910:C:T-0.1097708903061510.00136625250745525STADFemale-baised eQTL
rs3125731chr10:62187235:T:C--0.1351226475970170.00272643938998828STADFemale-baised eQTL
rs3125732chr10:62187637:C:T--0.1351226475970170.00272643938998828STADFemale-baised eQTL
rs4979769chr10:62161071:T:C--0.1348161875945680.0029232704508688STADFemale-baised eQTL
rs17363658chr10:75946649:A:G-0.1006895669559920.0119220147922449STADFemale-baised eQTL
rs10999304chr10:70376244:C:T-0.121035870621790.0151197741528569STADFemale-baised eQTL
rs72809238chr10:70369561:G:A-0.1244497845068220.0180130591718491STADFemale-baised eQTL
rs10997701chr10:67540736:T:C-0.07877732999104370.00527822404572461KIRCFemale-baised eQTL
rs7101097chr10:70362053:T:C--0.1289229267518650.00576162587976435KIRCFemale-baised eQTL
rs7071129chr10:70362331:T:C--0.1319322228464070.006036931913491KIRCFemale-baised eQTL
rs12252661chr10:67592708:A:T-0.06734825509207510.00928304066412387KIRCFemale-baised eQTL
rs7097343chr10:73602031:C:A-0.07163171569709480.00940818389961373KIRCFemale-baised eQTL
rs2394407chr10:67593586:G:C-0.06608169581637260.0129911918386628KIRCFemale-baised eQTL
rs12256629chr10:67594533:A:G-0.06608169581637260.0129911918386628KIRCFemale-baised eQTL
rs10823074chr10:67596063:A:G-0.06608169581637260.0129911918386628KIRCFemale-baised eQTL
rs10823070chr10:67580358:A:C-0.06398409196788270.0215131027015566KIRCFemale-baised eQTL
rs368656203chr10:67580490:A:G-0.06398409196788270.0215131027015566KIRCFemale-baised eQTL
rs117297607chr10:67581197:C:G-0.06398409196788270.0215131027015566KIRCFemale-baised eQTL
rs2088716chr10:67584704:A:G-0.0637028163542050.0227056607607645KIRCFemale-baised eQTL
rs7920668chr10:67585818:A:T-0.06364958597594640.0232786076721212KIRCFemale-baised eQTL
rs12263974chr10:65594458:T:A-0.1016217924245680.0329236586441337KIRCFemale-baised eQTL
rs10997730chr10:67574066:A:G-0.06487885340372090.0332550641861015KIRCFemale-baised eQTL
rs10509290chr10:67542727:G:T-0.06898779568569520.0474264060960951KIRCFemale-baised eQTL
rs10128376chr10:67531389:A:G-0.06896538867129150.0482032859667589KIRCFemale-baised eQTL
rs6480270chr10:67534174:T:C-0.06896538867129150.0482032859667589KIRCFemale-baised eQTL
rs10996565chr10:65645600:C:T-0.09527581101954670.0494338167503588KIRCFemale-baised eQTL
rs10823021chr10:67294976:G:C-0.2033484524291150.000603222144205406BLCAFemale-baised eQTL
rs2616679chr10:67310892:A:G--0.143938517935330.0273674062017888BLCAFemale-baised eQTL
rs2616681chr10:67311624:C:T--0.143938517935330.0273674062017888BLCAFemale-baised eQTL
rs58957937chr10:70706399:G:A-0.1276656785810550.0461643703926985BLCAFemale-baised eQTL
rs58433219chr10:70706319:C:T-0.1268690011429990.0480951464200388BLCAFemale-baised eQTL
rs72814564chr10:70710832:C:T-0.1268690011429990.0480951464200388BLCAFemale-baised eQTL
rs59538488chr10:70705530:G:T-0.1267810333931850.0492967222382262BLCAFemale-baised eQTL
rs7083975chr10:65325723:T:C-0.06007928776751180.0293606359739391LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs1259504chr10:75233257:C:T-0.07384910777314530.0102514058927784KIRCMale-baised eQTL
rs10824290chr10:75204210:G:A-0.06135994829333550.0146519208982065KIRCMale-baised eQTL
rs2657289chr10:75206705:C:T-0.06029152037230220.0185487314393116KIRCMale-baised eQTL
rs11001287chr10:75075572:C:A-0.0674102905043220.0214171345838889KIRCMale-baised eQTL
rs1259500chr10:75230355:A:G-0.05806320423619090.022189991545157KIRCMale-baised eQTL
rs11001286chr10:75075224:C:T-0.06541913344235080.0240037458434636KIRCMale-baised eQTL
rs1259503chr10:75232686:C:G-0.05751702706962320.025313517036235KIRCMale-baised eQTL
rs1149715chr10:75289591:C:T--0.06219493031760890.028220144924625KIRCMale-baised eQTL
rs1149716chr10:75290629:T:C--0.06122272079632290.0332539281849621KIRCMale-baised eQTL
rs1777414chr10:75274305:T:C--0.05634224683797070.0347463424513188KIRCMale-baised eQTL
rs191798086chr10:67692102:C:G-0.0558491753519880.0456063928510326BLCAMale-baised eQTL
rs17455801chr10:78550302:T:C-0.08583477327239150.0120568861260884LUADMale-baised eQTL
rs16927349chr10:70137439:C:T-0.1006758291984140.0138012184797873LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000099284
CpG Site: cg20336571
Position to Gene: promoter
Male Effect: -
Female Effect: -0.382675466909801
eQTM boxplot analysisGene ID: ENSG00000099284
CpG Site: cg20336571
Position to Gene: promoter
Male Effect: -0.438789718382783
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg20336571chr10:70052378promoter-0.4387897183827833.102465939757e-06-0.367905322872638441.8622032237102885e-08STAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg20336571chr10:70052378promoter-0.3826754669098012.69810749134777e-15-0.516168754943969.139719270845089e-19LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of H2AFY2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource